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Biochemistry & Molecular Biology
Hikaru Koizumi, Taichi Hiraga, Leandro K. Oharomari, Toshiaki Hata, Takeru Shima, Jang Soo Yook, Masahiro Okamoto, Akihiro Mouri, Toshitaka Nabeshima, Hideaki Soya
Summary: Schizophrenia may be attributed to perinatal neurodevelopmental deficits and influenced by environmental factors. Hypofrontality and dysfunction in glutamatergic and dopaminergic neurons are known factors, while early enriched environment and low-intensity exercise training during adolescence may help prevent and ameliorate the disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Congwu Du, Yueming Hua, Kevin Clare, Kicheon Park, Craig P. Allen, Nora D. Volkow, Xiu-Ti Hu, Yingtian Pan
Summary: Individuals with substance use disorder are at a higher risk of contracting HIV and progressing to AIDS. Neurotoxicity and neurodegeneration are characteristic of HIV-1-associated neurocognitive disorders. Studies have found that cocaine potentiates the neurotoxic effects of HIV-associated proteins. The NMDA antagonist drug memantine shows potential in attenuating the neurotoxicity caused by cocaine and HIV.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biology
Jennifer C. Robinson, Mark P. Brandon
Summary: The passage discusses the connection between envisioning the future and remembering the past, explaining the roles of the prefrontal cortex and hippocampus in memory and future planning, as well as how brain regions support the temporal organization of information.
Article
Neurosciences
Danilo Benette Marques, Rafael Naime Ruggiero, Lezio Soares Bueno-Junior, Matheus Teixeira Rossignoli, Joao Pereira Leite
Summary: The perception of control over a stressful experience may determine its impacts and generate resistance against future stressors. The study on male rats suggests that hippocampal-prefrontal network theta activity supports cognitive mechanisms of stress coping and is associated with escape performance and vulnerability to stress-related disorders.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Cristina Delgado-Sallent, Thomas Gener, Pau Nebot, Cristina Lopez-Cabezon, M. Victoria Puig
Summary: This study investigated the neural correlates of memory and auditory impairments in mice treated with subchronic PCP and the rescuing abilities of the atypical antipsychotic drug risperidone. The results showed that sPCP impaired short-term and long-term memories and disrupted the connectivity between the medial prefrontal cortex and the dorsal hippocampus. Risperidone rescued the memory deficits and partly restored hippocampal desynchronization.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Behavioral Sciences
Michael S. Totty, Stephen Maren
Summary: This article reviews the oscillatory correlates of fear and anxiety, with a focus on theta and gamma rhythms. The study finds that hippocampal network oscillations play a role in integrating spatial and motivational information during anxiety states, and these oscillations also synchronize different brain structures to guide adaptive behavior. Additionally, theta and gamma oscillations are important in the encoding and retrieval of fear memories.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Mikael Lundqvist, Scott L. Brincat, Jonas Rose, Melissa R. Warden, Timothy J. Buschman, Earl K. Miller, Pawel Herman
Summary: Working memory is achieved through interactions between beta and gamma oscillations, which allow the spatial flow of item-specific activity across the network. This spatial flow is independent of the detailed recurrent connectivity supporting the item-specific activity, and control-related information is stored in the spatial activity. Analysis of local field potentials and neuronal spiking confirms these predictions. Spatial computing can facilitate generalization and zero-shot learning by utilizing spatial component as an additional information encoding dimension.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Mareike A. Gann, Bradley R. King, Nina Dolfen, Menno P. Veldman, Kimberly L. Chan, Nicolaas A. J. Puts, Richard A. E. Edden, Marco Davare, Stephan P. Swinnen, Dante Mantini, Edwin M. Robertson, Genevieve Albouy
Summary: This study provides experimental evidence that targeted brain stimulation can alter functional responses in the striatum and hippocampus during motor learning in humans. While the stimulation did not directly affect motor performance or task-related brain activity, it did influence connectivity patterns within networks and the levels of GABA neurotransmitter.
Article
Neurosciences
Anton Malkov, Liudmila Shevkova, Alexandra Latyshkova, Valentina Kitchigina
Summary: This study found that cortical oscillations in different brain structures are involved in the execution of episodic-like memory tasks in rats. Rats with kainate-induced status epilepticus exhibited impaired episodic memory and changes in theta and gamma rhythms compared to healthy rats. These findings provide insights into the mechanisms of cognitive deficits during epileptogenesis.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Behavioral Sciences
Ying Li, Weijia Zhi, Bing Qi, Lifeng Wang, Xiangjun Hu
Summary: Fear is an adaptive response to danger and fear memory plays a crucial role in warning individuals in dangerous situations, which is essential for survival. Abnormal fear memory can lead to neuropsychiatric disorders. The study of fear has advanced from brain regions to neural circuits and molecular mechanisms. This article outlines the basics of fear memory and reviews the neurobiological mechanisms of fear extinction and relapse, aiming to provide new insights for future research on fear emotions and potential treatments for trauma and fear-related disorders.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Review
Neurosciences
Lucinda J. Speers, David K. Bilkey
Summary: This article reviews the potential role of oscillatory circuits in schizophrenia, focusing on the hippocampus and frontal cortex. It discusses how a loss of oscillatory synchrony between brain regions may underlie some symptoms of the disorder. The disruption of phase precession in schizophrenia could contribute to cognitive symptoms such as deficits in memory and planning.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Pharmacology & Pharmacy
Kyrsten Kawazoe, Ryan McGlynn, Wilder Felix, Raquel Sevilla, Siyang Liao, Praveen Kulkarni, Craig F. Ferris
Summary: This study utilized phMRI to assess the immediate impact of esketamine on brain activity in awake mice, revealing a global change in brain activity across over 50 brain areas at different doses, with the lowest dose of 1.0 mg/kg showing the most significant effect.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Neurosciences
Joseph A. McQuail, Sofia Beas, Kyle B. Kelly, Caesar M. Hernandez, Jennifer L. Bizon, Charles J. Frazier
Summary: The study revealed that loss of NMDARs on interneurons in the PFC contributes to age-related impairment of cognitive flexibility, while a clear increase in AMPA/NMDA ratio in FSIs suggests a potential underlying mechanism for cognitive decline. These findings provide new insights into the neural mechanisms of cognitive decline.
Article
Neurosciences
Carlos Silva, Calvin K. Young, Neil McNaughton
Summary: Anxiety and panic appear to inhibit each other at the neural level and are associated with different brain regions. This study found that stimulation of the mid-posterior periaqueductal gray (mPAG) decreased theta power in the prefrontal cortex, while stimulation of the anterior periaqueductal gray (aPAG) had the opposite effect. These findings support the hypothesis that fear and anxiety are controlled by parallel neural hierarchies extending from the PAG to the prefrontal cortex.
Article
Neurosciences
Hristo Varbanov, Shaobo Jia, Gaga Kochlamazashvili, Subhrajit Bhattacharya, Manal Ali Buabeid, Mohamed El Tabbal, Hussam Hayani, Stoyan Stoyanov, Weilun Sun, Hauke Thiesler, Iris Roeckle, Herbert Hildebrandt, Oleg Senkov, Vishnu Suppiramaniam, Rita Gerardy-Schahn, Alexander Dityatev
Summary: Dysregulated cortical expression of NCAM and deficits of its associated polySia are found in Alzheimer's disease and schizophrenia. Acute enzymatic removal of polySia in the prefrontal cortex leads to increased transmission mediated by GluN1/GluN2B NMDARs, impaired LTP, and increased tonic currents. Treatment with polySia fragments or inhibition of GluN1/GluN2B receptors restores LTP and cognitive tasks in polySia-deficient mice and Alzheimer's disease models. The data highlight the crucial role of polySia-NCAM in balancing signaling through synaptic/extrasynaptic NMDARs and the therapeutic potential of polySia fragments.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Hans Michael Maric, Torben Johann Hausrat, Franziska Neubert, Nils Ole Dalbyl, Soeren Doose, Markus Sauer, Matthias Kneussel, Kristian Stromgaard
NATURE CHEMICAL BIOLOGY
(2017)
Article
Cell Biology
Celia Kjaerby, Jegath Athilingam, Sarah E. Robinson, Jillian Iafrati, Vikaas S. Sohal
Article
Endocrinology & Metabolism
Maria E. K. Lie, Emma K. Gowing, Nina B. Johansen, Nils Ole Dalby, Louise Thiesen, Petrine Wellendorph, Andrew N. Clarkson
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Article
Biochemistry & Molecular Biology
Celia Kjaerby, Rune Rasmussen, Mie Andersen, Maiken Nedergaard
NEUROCHEMICAL RESEARCH
(2017)
Article
Neurosciences
Nadia Lybol von Schoubye, Kristen Frederiksen, Uffe Kristiansen, Anders Victor Petersen, Nils Ole Dalby, Morten Grunnet, Henrik Sindal Jensen, Thomas Jespersen, Vikaas S. Sohal, Jean-Francois Perrier
NEUROSCIENCE LETTERS
(2018)
Article
Multidisciplinary Sciences
Mursel Karadas, Adam M. Wojciechowski, Alexander Huck, Nils Ole Dalby, Ulrik Lund Andersen, Axel Thielscher
SCIENTIFIC REPORTS
(2018)
Article
Neurosciences
Celia Kjaerby, Brian V. Broberg, Uffe Kristiansen, Nils Ole Dalby
Article
Pharmacology & Pharmacy
Nils Ole Dalby, Christina Birkedahl Falk-Petersen, Ulrike Leurs, Petra Scholze, Jacob Krall, Bente Frolund, Petrine Wellendorph
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Neurosciences
Agata Casado-Sainz, Frederik Gudmundsen, Simone L. Baerentzen, Denise Lange, Annemette Ringsted, Isabel Martinez-Tejada, Siria Medina, Hedok Lee, Claus Svarer, Sune H. Keller, Martin Schain, Celia Kjaerby, Patrick M. Fisher, Paul Cumming, Mikael Palner
Summary: Chemogenetic activation of dopamine neurons in the substantia nigra, which innervates the dorsal striatum, leads to increased movement, rearings, time spent in center, decreased self-grooming, and enhanced prepulse inhibition of startle response in females. Additionally, this activation results in reduced [F-18]FDG metabolism in the frontal cortex, while increasing total glutamate levels in the same region. These findings align with clinical studies showing similar metabolic and glutamate alterations in the brains of individuals with OCD, providing a mechanistic basis for the observed behaviors.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Celia Kjaerby, Mie Andersen, Natalie Hauglund, Verena Untiet, Camilla Dall, Bjorn Sigurdsson, Fengfei Ding, Jiesi Feng, Yulong Li, Pia Weikop, Hajime Hirase, Maiken Nedergaard
Summary: Kjaerby and Andersen et al. demonstrate the important role of norepinephrine (NE) in shaping sleep micro-architecture. NE oscillates during sleep and its amplitude affects memory consolidation and awakenings. Micro-arousals are generated in a periodic pattern during NREM sleep, while NE oscillations drive spindles. The amplitude of NE oscillations plays a crucial role in sleep micro-architecture and memory performance.
NATURE NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Celia Kjaerby, Mie Andersen, Natalie Hauglund, Verena Untiet, Camilla Dall, Fengfei Ding, Hajime Hirase, Maiken Nedergaard
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Verena Untiet, Felix R. M. Beinlich, Peter Kusk, Ning Kang, Antonio Ladron-de-Guevara, Wei Song, Celia Kjaerby, Mie Andersen, Natalie Hauglund, Zuzanna Bojarowska, Bjorn Sigurdsson, Saiyue Deng, Hajime Hirase, Nicolas C. C. Petersen, Alexei Verkhratsky, Maiken Nedergaard
Summary: Information transfer within neuronal circuits depends on the balance and recurrent activity of excitatory and inhibitory neurotransmission. Astrocytes, a type of glial cell, act as a dynamic Cl- reservoir regulating Cl- homeostasis in the central nervous system (CNS). Intracellular chloride concentration in astrocytes is higher and more stable during sleep, while it is lower and fluctuates in response to sensory input and motor activity during wakefulness. Efflux of Cl- from astrocytes supports inhibitory transmission in the CNS.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Christine Delle, Neza Cankar, Christian Digebjerg Holgersson, Helle Hvorup Knudsen, Elise Schioler Nielsen, Celia Kjaerby, Yuki Mori, Maiken Nedergaard, Pia Weikop
Summary: Obesity is associated with increased risk of cognitive decline, and this study investigated the glymphatic transport in mice with long-term obesity induced by high-fat diet. The results showed that although the obese mice developed hypertension, elevated heart rate, neuroinflammation, and gliosis, the glymphatic inflow was globally unaffected except in the hypothalamus. It suggests that long-term high-fat diet induced metabolic alteration and neuroinflammation in the hypothalamus, leading to enhanced glymphatic clearance in this specific brain region.
SCIENTIFIC REPORTS
(2023)
