Article
Nutrition & Dietetics
Julianna M. Santos, Rui Wang, Viren Bhakta, Zarek Driver, Yakhnitsa Vadim, Takaki Kiritoshi, Guangchen Ji, Volker Neugebauer, Chwan-Li Shen
Summary: This study investigated the effects of turmeric bioactive compounds on neuropathic pain in rats. The results showed that curcumin and bisdemethoxycurcumin administration can reduce mechanical hypersensitivity and mitigate glial activation, oxidative stress, and mitochondrial dysfunction.
Article
Anesthesiology
Thaise Graziele L. de O. Toutain, Guzman Alba, Jose Garcia Vivas Miranda, Raphael Silva do Rosario, Miguel Munoz, Eduardo Ponde de Sena
Summary: The study revealed increased cerebral connectivity in the left hemisphere under pain condition. Women showed higher homophilic connections compared to men. Pain increased homophily in the left hemisphere, and emotions were able to modulate pain perception.
Review
Cell Biology
Supriya D. Mahajan, Nigel Smith Ordain, Hilliard Kutscher, Shanta Karki, Jessica L. Reynolds
Summary: Exosomes play a significant role in HIV neuroinflammation and neuropathogenesis, with potential as biomarkers and drug delivery vehicles for the treatment of HIV neuroinflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Anesthesiology
Megan M. Sperry, Eric J. Granquist, Beth A. Winkelstein
Summary: The study found differences in brain networks between persistent and transient pain groups, with increased clustering, node strength, network segregation, and activation of prefrontal-limbic pathways observed only in the group developing persistent pain on day 7. These early and sustained brain changes can differentiate persistent from transient pain, potentially serving as prognostic biomarkers for persistent pain.
Review
Nutrition & Dietetics
Rita Businaro, David Vauzour, Jerome Sarris, Gerald Munch, Erika Gyengesi, Laura Brogelli, Pedro Zuzarte
Summary: Nutrition plays a crucial role in neurodegenerative mental disorders, and supplementation of essential nutrients can help reduce inflammation and lower risk. Dietary supplementation has shown effectiveness in treating mild cognitive impairment and improving depression.
FRONTIERS IN NUTRITION
(2021)
Article
Neurosciences
Weiwei Peng, Wutao Lou, Xiaoxuan Huang, Qian Ye, Raymond Kai-Yu Tong, Fang Cui
Summary: This study found that when sharing painful experiences, individuals expecting high-intensity pain showed greater brain synchronization in the sensorimotor area, which facilitated emotional resonance and social bonding between them.
Article
Biochemistry & Molecular Biology
Silvia Castany, Anna Bago-Mas, Jose Miguel Vela, Enrique Verdu, Karolina Bretova, Viktorie Svobodova, Petr Dubovy, Pere Boadas-Vaello
Summary: This study aimed to determine whether neuroinflammatory factor over-expression in the spinal cord and supraspinal structures may be associated with reflexive and nonreflexive pain response development from acute spinal cord injury (SCI) phase to 12 weeks post-injury in female mice. The results show that transient reflexive responses were observed during the SCI acute phase associated with transient cytokine overexpression in the spinal cord. In contrast, increased nonreflexive pain responses were observed in the chronic phase associated with cytokine overexpression in supraspinal structures, especially in mPFC. In addition, results revealed the contribution of neuron-glia crosstalk in the development of nonreflexive pain responses in the chronic spinal cord injury phase, as indicated by increased glial activation and CX3CL1/CX3CR1 upregulation in the neurons in the mPFC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Soo-Eun Lee, Hyemin Shin, Gyumyoung Kim, Hyeri Moon, Ji-Won Hur
Summary: This study examined the gray matter volume patterns in individuals with NSSI and found significant decreases in the volume of the right anterior insula, bilateral secondary somatosensory cortex, and left inferior frontal gyrus. Individuals with smaller volume in these regions were more likely to engage in self-injury for affect regulation and sensation seeking, and experience higher pain intensity during self-injury.
PSYCHIATRY RESEARCH
(2023)
Article
Engineering, Electrical & Electronic
Yangjun Ou, Zhenzhong Chen, Feng Wu
Summary: The article introduces a multimodal local-global attention network (MMLGAN) for affective video content analysis, which obtains a global representation of affective video through a multimodal fusion unit. Experiments demonstrate the effectiveness of this approach compared to state-of-the-art methods.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2021)
Article
Clinical Neurology
Sreenath P. Kyathanahally, Michela Azzarito, Jan Rosner, Vince D. Calhoun, Claudia Blaiotta, John Ashburner, Nikolaus Weiskopf, Katja Wiech, Karl Friston, Gabriel Ziegler, Patrick Freund
Summary: This study tracked the structural changes in nociceptive pathways after spinal cord injury and their relationship to neuropathic pain intensity. Results showed differences in structural parameters in specific brain and spinal cord regions of individuals with neuropathic pain, indicating a critical role of microstructural changes in neuropathic pain maintenance.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Shunyi Zhao, Jiaying Zheng, Lingxiao Wang, Anthony D. Umpierre, Sebastian Parusel, Manling Xie, Aastha Dheer, Katayoun Ayasoufi, Aaron J. Johnson, Jason R. Richardson, Long-Jun Wu
Summary: Chemogenetic approaches using DREADD were employed in microglia, specifically targeting CX3CR1(+) cells. Activation of hM4Di on CX3CR1(+) cells induced hypolocomotion, which was unexpectedly preserved even when microglia were depleted. The expression of hM4Di in peripheral immune cells may be responsible for the observed hypolocomotion. Rigorous data analysis and interpretation are necessary when manipulating microglia using the Cx3cr1(CreER/+) mouse line.
MOLECULAR PSYCHIATRY
(2023)
Article
Anesthesiology
Daniel Martins, Ottavia Dipasquale, Mattia Veronese, Federico Turkheimer, Marco L. Loggia, Stephen McMahon, Matthew A. Howard, Steven C. R. Williams
Summary: This study examines alterations in morphometric similarity in chronic pain patients and identifies genetic and cellular correlates of these changes. The findings suggest that cortical remodeling in chronic pain may be influenced by multiple elements of the brain's cellular architecture and highlight potential pathways for future genetic association or drug development studies.
Review
Immunology
George Sideris-Lampretsas, Marzia Malcangio
Summary: This review summarizes the existing preclinical evidence on how the CNS compartment and sex impact microglia functions in health, emphasizing recent advances in transcriptomics analyses for characterizing disease-associated microglial states. The specific scenario of peripheral nerve or tissue injury inducing expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord is discussed, along with the possibility of a unique microglia transcriptional profile associated with chronic pain conditions. The evidence also suggests microglial activation in pain-related areas of the brain can be observed in models of neuropathic pain, highlighting the potential for future studies to further explore neuroimmune interactions in chronic pain using novel approaches like scRNA-seq and CYTOF.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Ettore Favaretto, Martin Gogele, Fulvio Bedani, Andrew A. Hicks, Andreas Erfurth, Giulio Perugi, Peter P. Pramstaller, Roberto Melotti
Summary: This study found that affective temperaments have a modulation effect on pain sensitivity, with hyperthymic temperament suggesting pain resilience and cyclothymic temperaments suggesting pain susceptibility. Trait anxiety was found to have a stronger effect on this association.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Cesc Bertran-Cobo, Catherine J. Wedderburn, Frances C. Robertson, Sivenesi Subramoney, Katherine L. Narr, Shantanu H. Joshi, Annerine Roos, Andrea M. Rehman, Nadia Hoffman, Heather J. Zar, Dan J. Stein, Kirsten A. Donald
Summary: This study explored the neurometabolic profiles of 2-3-year-old children who were HIV-exposed but uninfected and compared them to children who were HIV-unexposed. The findings indicated that HIV exposure was associated with neuroinflammatory processes in the parietal brain regions at an early age, which may contribute to developmental risks in this population.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Neurosciences
Ming D. Li, Yih-Ing Hser, Zhiwei Chen, Linda Chang
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2016)
Article
Neurosciences
Linda Chang, Ahnate Lim, Eric Lau, Daniel Alicata
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2017)
Article
Neurosciences
Huajun Liang, Linda Chang, Rong Chen, Kenichi Oishi, Thomas Ernst
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2018)
Article
Neurosciences
Linda Chang, Ming D. Li, Yih-Ing Hser
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2018)
Review
Neurosciences
Sheri L. Towe, Christina S. Meade, Christine C. Cloak, Ryan P. Bell, Julian Baptiste, Linda Chang
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
Muhammad G. Saleh, Richard A. E. Edden, Linda Chang, Thomas Ernst
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Immunology
Hannah A. Wang, Hua-Jun Liang, Thomas M. Ernst, Kenichi Oishi, Linda Chang
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Anatomy & Morphology
Yukako Kawasaki, Kenichi Oishi, Antonette Hernandez, Thomas Ernst, Dan Wu, Yoshihisa Otsuka, Can Ceritoglu, Linda Chang
Summary: Newborn infants with the BDNF-Val66Met variant exhibit smaller hippocampal and amygdala volumes, as well as slower age-dependent declines in total brain and white matter volumes, indicating a potential influence of this genetic variant on prenatal and postnatal developmental processes.
BRAIN STRUCTURE & FUNCTION
(2021)
Editorial Material
Neurosciences
Yu Lin, Johnny J. He, Roger Sorensen, Linda Chang
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Amal Isaiah, Thomas Ernst, Christine C. Cloak, Duncan B. Clark, Linda Chang
Summary: This study found an association between parent-reported symptoms of sleep disordered breathing (oSDB) and behavioral problems in adolescents, mediated by smaller volumes within multiple frontal lobe regions. The strongest negative associations with oSDB symptoms were seen in alterations of brain structure within the frontal lobe.
NATURE COMMUNICATIONS
(2021)
Article
Psychology, Developmental
Miriam S. Menken, Pedro J. Rodriguez Rivera, Amal Isaiah, Thomas Ernst, Christine C. Cloak, Linda Chang
Summary: Being a victim of bullying doubles the risk of attempting suicide in adulthood. Two brain morphometry studies have identified the fusiform gyrus and putamen as vulnerable areas to bullying. However, no study has identified how neural alterations may mediate the effect of bullying on cognition.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Review
Neurosciences
Linda Chang, Huajun Liang, Suresh R. Kandel, Johnny J. He
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Min-Ae Song, Thomas Ernst, Maarit Tiirikainen, Jorg Tost, Lynne R. Wilkens, Linda Chang, Laurence N. Kolonel, Loic Le Marchand, Unhee Lim