Article
Biotechnology & Applied Microbiology
Yunfei Wang, Xiaobo Li, Huaqi Wang, Guojun Zhang
Summary: This study reveals a novel mechanism involving circCAMSAP1/miR-1182/BIRC5 axis that promotes the progression of non-small cell lung cancer (NSCLC).
Article
Medicine, Research & Experimental
Qi Li, Xiaoxia Liu, Weifang Liu, Yang Zhang, Mengying Wu, Zhirui Chen, Yin Zhao, Li Zou
Summary: In early-onset preeclampsia (EOPE), decreased expression of MALAT1 and PFKFB3 is associated with endothelial cell dysfunction. PFKFB3 modulates the proliferation, migration, and tube formation of ECs by regulating glycolysis, while MALAT1 regulates PFKFB3 expression by sponging miR-26a/26b. MALAT1 knockdown reduces EC angiogenesis by inhibiting PFKFB3-mediated glycolysis flux, suggesting that strategies targeting PFKFB3-driven glycolysis may be a promising approach for EOPE treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Dan Wang, Jianfei Chen, Bohan Li, Qingling Jiang, Ling Liu, Ziyi Xia, Qiusheng Zheng, Minjing Li, Defang Li
Summary: Emerging evidence suggests that lncRNA-Gm31932 is significantly decreased in ATRA and PB-4-induced mouse melanoma B16 cells. Silencing lncRNA-Gm31932 inhibits cell proliferation, induces cell cycle arrest and differentiation, and affects the expression of cell cycle-related proteins through the miR-344d-3-5p/Prc1 (and Nuf2) axis.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Reproductive Biology
Shijie Lyu, Yaying Zhai, Xiaoting Zhu, Qiaoting Shi, Fuying Chen, Geyang Zhang, Zijing Zhang, Eryao Wang
Summary: Embryonic mortality is a major factor contributing to reduced conception rates in the cattle industry. Insufficient endometrial receptivity is a key factor causing embryo implantation failure and losses. The study found that bta-miR-200b can influence the apoptosis of bovine endometrial epithelial cells by targeting the MYB gene.
Article
Medicine, Research & Experimental
Lei Wang, Yan Liu, Zhengtao Yu, Jianwu Gong, Zhiyong Deng, Nianjun Ren, Zhe Zhong, Hao Cai, Zhi Tang, Haofeng Cheng, Shuai Chen, Zhengwen He
Summary: The study investigates the pathogenesis and potential molecular markers of glioma by examining the differential expression of miRNA and mRNA. Several miRNAs and mRNAs were identified as having significant impact on glioma cell behavior, with miR-139-5p/GABRA1 axis suggested as a novel therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Physiology
Yan Su, Jiani Xu, Rufei Gao, Xiaoli Liu, Taihang Liu, Cong Li, Yubin Ding, Xuemei Chen, Junlin He, Xueqing Liu, Chunli Li, Hongbo Qi, Yingxiong Wang
Summary: In this study, we found that circ-CYP24A1 plays a role in RM by impairing the balance of cell proliferation and apoptosis by sponging miR-224, thereby regulating PRLR.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Ali Mohammadi, Behzad Mansoori, Pascal H. G. Duijf, Elham Safarzadeh, Leila Tebbi, Souzan Najafi, Behrooz Shokouhi, Grith L. Sorensen, Uffe Holmskov, Behzad Baradaran
Summary: Low miR-330 expression in lung cancer predicts poor prognosis, but stable restoration of miR-330 expression can reduce cell viability, increase apoptotic cells, induce G2/M cell cycle arrest, and inhibit cell migration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Xiang Ding, Qingyan Fu, Weixing Chen, Linjie Chen, Qingjun Zeng, Sanjun Zhang, Linfang He
Summary: This study reveals that miR-515-5p is an upstream miRNA of the MAD2L1 gene and can inhibit the proliferation of CRC cells and induce apoptosis by regulating MAD2L1 expression. This finding is important for understanding the mechanism of MAD2L1 in CRC.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Oncology
Miao Li, Yan Rui, Wenjia Peng, Junfeng Hu, Anbang Jiang, Zeyu Yang, Linian Huang
Summary: This study investigated a novel molecular therapeutic target, FIGNL1, for lung cancer and found that its high expression was associated with decreased function and enhanced cell death in lung cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Fatemeh Dodangeh, Zahra Sadeghi, Parichehr Maleki, Jamshid Raheb
Summary: This study demonstrates that long non-coding RNA SOX2 overlapping transcript (SOX2-OT) plays an oncogenic role in lung cancer by regulating the miR-122-3p/FOXO1 and miR-194-5p/FOXA1 pathways, affecting the biological behaviors of lung cancer cells.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Zhongjie Chen, Junjie Ying, Wenjun Shang, Dongxiao Ding, Min Guo, Haifeng Wang
Summary: The study revealed that microRNA-342-3p is downregulated in nonsmall cell lung cancer compared to normal cells and tissues. Overexpression of microRNA-342-3p suppressed cell proliferation and promoted apoptosis by repressing the expression of B-cell lymphoma-2, suggesting it as a potential target for nonsmall cell lung cancer treatment.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Immunology
Lei Yang, You-Ling Shi, Yan Ma, Wei-Wei Ren, Guang-Ming Pang, Jiao Liu
Summary: The study revealed that the upregulation of KLF16 expression in OSCC cells, interfering with KLF16 resulted in cell cycle arrest, inhibited cell growth, and promoted cell apoptosis.
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Article
Oncology
Fan Yang, Zhanwen Sun, Dengyun Wang, Tian Du
Summary: The study reveals that miR-106b-5p enhances proliferation, colony formation, adhesion, migration, and invasion, and induces cell cycle progression, while repressing apoptosis in esophageal squamous cell carcinoma (ESCC) by targeting HPGD. This finding suggests that the miR-106b-5p/HPGD axis may serve as a promising target for the diagnosis and treatment of ESCC.
Review
Endocrinology & Metabolism
Ahmed Ismail, Hesham A. El-Mahdy, Mahmoud Gomaa Eldeib, Ahmed S. Doghish
Summary: Diabetes mellitus is often accompanied by microvascular complications such as nephropathy, retinopathy, and neuropathy. MicroRNAs (miRNAs) play a crucial role in the pathogenesis of these complications by affecting the kidney, retina, and peripheral neurons through various molecular pathways. This review provides an updated understanding of the involvement of miRNAs in diabetic microvascular complications, with a focus on the key molecular pathways mediating the adverse effects of hyperglycemia on vascular tissues. The review highlights specific miRNAs (miR-126, miR-29b, miR-125a, and miR-146a) and their impact on vascular endothelial growth factors.
MOLECULAR GENETICS AND METABOLISM
(2023)
Review
Pathology
Hesham A. El-Mahdy, Elsayed G. E. Elsakka, Ahmed A. El-Husseiny, Ahmed Ismail, Amr Mohamed Yehia, Nourhan M. Abdelmaksoud, Reham A. A. Elshimy, Mina Noshy, Ahmed S. Doghish
Summary: Bladder cancer is the 11th most popular cancer in females and 4th in males. Efforts have been made to improve BC patients' care, and new approaches have been developed to enhance the efficiency of BC diagnosis, prognosis, therapeutics, and monitoring.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. Abdel-Hamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A. Shaheen, Areej Rushdi, Reem M. Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I. Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert
Summary: Early HCC diagnosis is challenging, especially for AFP-negative cases. miRNA profiles may serve as potential molecular markers for HCC. This study aimed to evaluate the expression levels of four miRNAs (hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p) as biomarkers for HCC in CHCV patients with liver cirrhosis, particularly AFP-negative HCC cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Doaa Fathi, Mohammed S. Elballal, Ahmed E. Elesawy, Ahmed I. Abulsoud, Ahmed Elshafei, Elsayed G. E. Elsakka, Ahmed Ismail, Hesham A. El-Mahdy, Mahmoud A. Elrebehy, Ahmed S. Doghish
Summary: Gastric cancer (GC) ranks fourth globally in terms of incidence and mortality rates. MicroRNAs (miRNAs), among other genetic and epigenetic factors, have been found to impact the initiation and progression of GC. Dysregulation of miRNA expressions is associated with various aspects of GC, including initiation, invasion, apoptosis evasion, angiogenesis, promotion, and epithelial-mesenchymal transition enhancement. Important pathways controlled by miRNAs in GC include Wnt/8-catenin signaling, HMGA2/mTOR/P-gp pathway, PI3K/AKT/c-Myc pathway, VEGFR, and TGFb signaling. Hence, this review aims to provide an updated understanding of the role of miRNAs in GC pathogenesis and their modulatory effects on different GC treatment modalities.
Review
Pathology
Maghawry Hegazy, Mohamed A. Elkady, Amr Mohamed Yehia, Elsayed G. E. Elsakka, Ahmed I. Abulsoud, Nourhan M. Abdelmaksoud, Ahmed Elshafei, Tamer M. Abdelghany, Samy Y. Elkhawaga, Ahmed Ismail, Mahmoud Mohamed Mokhtar, Hesham A. El-Mahdy, Ahmed S. Doghish
Summary: Laryngeal cancer is a malignancy of the larynx and is associated with various risk factors. Dysregulated microRNA expressions play a significant role in LC progression, apoptosis, EMT, and angiogenesis. Furthermore, microRNAs are involved in important signaling pathways and can modulate LC response to different therapies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Shereen Saeid Elshaer, Ahmed I. Abulsoud, Doaa Fathi, Nourhan M. Abdelmaksoud, Mohamed Bakr Zaki, Hesham A. El-Mahdy, Ahmed Ismail, Elsayed G. E. Elsakka, Mai A. Abd-Elmawla, Logyna A. Abulsoud, Ahmed S. Doghish
Summary: This review summarizes the role of microRNAs (miRNAs) in the development of glioblastoma (GBM) and discusses their potential as prognostic biomarkers and therapeutic targets.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Nourhan M. Abdelmaksoud, Hesham A. El-Mahdy, Ahmed Ismail, Elsayed G. E. Elsakka, Ahmed A. El-Husseiny, Emad Gamil Khidr, Esraa M. Ali, Mohammed Helmy Rashed, Fatma El-Saeed El-Demerdash, Ahmed S. Doghish
Summary: Endometrial cancer (EC) is the second most common cancer in females and the most common gynecological cancer. miRNAs have been found to impact various aspects of EC, including initiation, progression, angiogenesis, and resistance to therapy. They regulate the expression of genes involved in EC pathogenesis and influence key signaling pathways. This review aims to explore the link between miRNAs and EC, particularly their effects on signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Ahmed S. Doghish, Ahmed A. El-Husseiny, Nourhan M. Abdelmaksoud, Hesham A. El-Mahdy, Elsayed G. E. Elsakka, Sherif S. Abdel Mageed, Abdulla M. A. Mahmoud, Ahmed Amr Raouf, Mohammed S. Elballal, Walaa A. El-Dakroury, Mohamed M. M. AbdelRazek, Mina Noshy, Hussein M. El-Husseiny, Ahmed I. Abulsoud
Summary: Esophageal cancer is a major cause of cancer-related deaths worldwide, and miRNAs play a crucial role in its pathogenesis and response to treatment. Dysregulation of miRNA expression is associated with various aspects of esophageal cancer, including initiation, progression, evasion of apoptosis, invasion, and epithelial-mesenchymal transition. Key pathways in esophageal cancer, such as Wnt/-catenin signaling, mTOR/P-gp, PI3K/AKT/c-Myc, EGFR, and TGF-β signaling, are modulated by miRNAs. This review provides an updated assessment of the role of miRNAs in esophageal cancer and their potential as therapeutic targets.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Mohammed S. Elballal, Al-Aliaa M. Sallam, Ahmed E. Elesawy, Reem K. Shahin, Heba M. Midan, Mahmoud A. Elrebehy, Ola Elazazy, Rawnaa Mohammed El-Boghdady, Shaimaa Hassan Blasy, Nada Mahmoud Amer, Hadeer Ibrahim Farid, Dina Ashraf Mohammed, Shaymaa Adly Ahmed, Sally Samir Mohamed, Ahmed S. Doghish
Summary: Renal cell carcinoma (RCC) is the most deadly genitourinary cancer, and its prevalence is increasing. Early diagnosis is crucial, and miRNAs show promise as biomarkers for detecting RCC due to their unique properties. MiRNAs in the blood or urine have been proposed as diagnostic or monitoring tools for RCC, and specific miRNA expression profiles have been associated with treatment response.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Amr M. Shehabeldine, Ahmed S. Doghish, Walaa A. El-Dakroury, Mahmoud M. H. Hassanin, Abdulaziz A. Al-Askar, Hamada AbdElgawad, Amr H. Hashem
Summary: In this study, clove oil nanoemulsion (CL-nanoemulsion) and emulsion (CL-emulsion) were prepared using an ecofriendly method. The CL-nanoemulsion showed antibacterial, antifungal, anti-biofilm, and anticancer properties, with minimal inhibitory concentration (MIC) values between 0.31 and 5 mg/mL against bacteria and significant antifungal activity against various fungal strains. The CL-nanoemulsion also exhibited lower IC50 values in MCF-7 breast cancer cells compared to CL-emulsion, indicating its potential as an anticancer agent.
Review
Pharmacology & Pharmacy
Elsayed G. E. Elsakka, Ahmed Elshafei, Mohamed A. Elkady, Amr Mohamed Yehia, Ahmed I. Abulsoud, Reem K. Shahin, Nourhan M. Abdelmaksoud, Samy Y. Elkhawaga, Ahmed Ismail, Mahmoud Mohamed Mokhtar, Mahmoud A. Elrebehy, Maghawry Hegazy, Mohammed S. Elballal, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Walaa A. El-Dakroury, Sherif S. Abdel Mageed, Hesham A. El-Mahdy, Ahmed S. Doghish
Summary: This article consolidates and synthesizes the most recent studies on miRNAs in PCC, discussing their potential clinical utility as diagnostic and prognostic biomarkers while also addressing their limitations.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ehab A. Ragab, Mohammed F. Abd El-Wahab, Ahmed S. Doghish, Rania M. Salama, Nermin Eissa, Samar F. Darwish
Summary: There is growing interest in using naturally occurring substances for the treatment of chronic disorders. Boswellic acid (BA), extracted from the gum resin of Boswellia serrata and Boswellia carteri, has shown potential pharmacological activities in various fields, including anti-cancer and anti-inflammatory effects. The study revealed that BAs may be beneficial for the management of debilitating diseases such as cancer and inflammation.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Eman A. Mady, Ahmed S. Doghish, Walaa A. El-Dakroury, Samy Y. Elkhawaga, Ahmed Ismail, Hesham A. El-Mahdy, Elsayed G. E. Elsakka, Hussein M. El-Husseiny
Summary: The link between the gut microbiome and health has gained significant interest in using it for medicinal purposes. The early microbiota is more flexible and altering it can have significant consequences on human development. Like genetics, the human microbiota can be passed from mother to child, providing information on early acquisition, future development, and intervention chances. This article discusses the succession and acquisition of early-life microbiota, modifications of maternal microbiota, and efforts to understand maternal-infant microbiota transmission. It also explores possible paths for future research in this area to advance knowledge.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Rasha Abdelhady, Sameh Saber, Mustafa Ahmed Abdel-Reheim, Mohannad Mohammad S. Alamri, Jaber Alfaifi, Masoud I. E. Adam, Lobna A. Saleh, Azza I. Farag, Elsayed A. Elmorsy, Hend S. El-Wakeel, Ahmed S. Doghish, Mohamed E. Shaker, Sara H. Hazem, Heba A. Ramadan, Rabab S. Hamad, Osama A. Mohammed
Summary: This study demonstrates the potential therapeutic use of exogenous beta-hydroxybutyrate and ketogenic diet (KD) in alleviating ulcerative colitis (UC) by attenuating disease activity, inhibiting NLRP3 inflammasome activation, and promoting antioxidative and intestinal barrier functions.
FRONTIERS IN PHARMACOLOGY
(2023)
Meeting Abstract
Oncology
Sanjeev Shukla, Mohammed Al-Toubat, Allison H. Feibus, Ahmed Elshafei, Carlos Riveros, Nathalie Meurice, Justyna Gleba, Jonathan Chardon-Robles, Adam M. Kase, John A. Copland, Joachim L. Petit, Teruko Osumi, K. C. Balaji