Article
Biotechnology & Applied Microbiology
Redwanul Hasan, Samara Islam Nishi, Rony Mia, Md. Minhazul Islam, Md. Muhibul Hasan, Fahim Ahmed
Summary: Antibacterial materials have gained popularity in the market and everyday life, but the use of synthetic chemicals in these materials negatively impacts the environment and contributes to antibacterial resistance. This study aims to find an eco-friendly solution using natural antibacterial components extracted from neem leaves to treat jute-cotton blended (jutton) yarn. The treated jutton yarn showed strong antibacterial activity against both gram-positive and gram-negative bacteria, and the interaction between the neem leaves and the yarn provided long-lasting antibacterial performance.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Pharmacology & Pharmacy
Sanu K. Shaji, G. Drishya, Damu Sunilkumar, Nanjan Pandurangan, Geetha B. Kumar, Bipin G. Nair
Summary: Less-studied flavonoid Tamarixetin demonstrated significant dose-dependent inhibition of MMP-9 expression and cancer cell migration and invasion potential, indicating its potential as an anti-cancer agent. The compound also inhibits crucial functions necessary for MMP-9 activation and modulates endogenous regulators of MMP-9 activity, suggesting it could be a template for novel therapeutic applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
B. Thangagiri, A. Sakthivel, K. Jeyasubramanian, S. Seenivasan, J. Dhaveethu Raja, Kyusik Yun
Summary: The report details the preparation, characterization, and applications of Neem biochar as an inexpensive adsorbent for Cr(VI) removal in synthetic waste water. The study confirms the effective adsorption performance, regeneration capability, and cost effectiveness of Neem biochar.
Article
Energy & Fuels
Sandeep P. Shewale, Miraj Kapadia, Virendra K. Rathod
Summary: The current study focused on the ultrasound-assisted extraction of total phenolic compounds from Neem leaves powder. By optimizing various process parameters, the highest yield of phenolic compounds was obtained under specific conditions. The experimental outcomes showed that ultrasound-assisted extraction was more efficient and time-saving compared to traditional methods. The Peleg's mathematical model successfully predicted the extraction values and demonstrated a good fit with experimental results.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2022)
Article
Immunology
Chang Chen, Jingya Gu, Jue Wang, Yu Wu, Aihua Yang, Tingting Chen, Tingting Zhou, Zhaoguo Liu
Summary: PSG attenuates liver injury and fibrosis induced by carbon tetrachloride, decreases collagen deposition, and inhibits inflammation. It acts by regulating SIRT3-mediated NF-kappa B P65 nuclear expression, providing a potential therapeutic strategy for liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Aroosa Kanwal, Rizwan Asghar, Maham Babar, Muhammad Amjad Bashir, Asia Fida, Syeda Amber Hameed, Khizar Samiullah, Riffat Yasin, Muhammad Farooq, Hasnain Farooq, Munaza Batool, Snober Gull, Afrah Fahad Alkhuriji, Mohammed Ali Alshehri, Abdulrahman Alasmari, Muhammad Essa
Summary: This study investigated the effects of Azadirachta indica and Moringa oliefera leaf powder as alternative to antibiotic growth promoters on the growth performance, blood biochemistry, and carcass characters in poultry. The results showed that the supplemented groups had lower feed conversion ratio, higher concentration of certain blood parameters, and significant differences in carcass characters compared to the control group.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Bahaa A. Hemdan, Ahmed Mostafa, Marwa M. Elbatanony, Amal M. El-Feky, Tsvetelina Paunova-Krasteva, Stoyanka Stoitsova, Mohamed Azab El-Liethy, Gamila E. El-Taweel, Mobarak Abu Mraheil
Summary: The leaves of Azadirachta indica L. and Melia azedarach L. have medicinal benefits and exhibit antiviral and antibacterial activities. They showed robust anti-SARS-CoV-2 activity and exhibited broad-spectrum medicinal value.
Article
Environmental Sciences
Nadeem Baig, Irshad Kammakakam
Summary: This study demonstrates a simple two-step method to develop a superhydrophobic Azadirachta indica leaves like Ag-decorated electrochemically copper-coated stainless-steel mesh (SH-AIL-Ag-EC-Cu-Mesh) for efficient separation of oil/water mixtures. The SH-AIL-Ag-EC-Cu-Mesh shows excellent selectivity for oil in oil/water mixtures with a separation efficiency of 99.1% and a high flux of 8963 L m(-2)h(-1). It also exhibits good reusability after 15 cycles of separation.
Article
Polymer Science
Afnan S. Batubara, Najla A. Obaid, Hanan M. Alharbi, Turki Mohammed Altalhi, Mohammed Abdullah Alasmari, Ammar Zuhair Alghamdi, Eram Sharmin
Summary: Nanocomposite films were prepared using chitosan, cinnamaldehyde, Nigella sativa or blackseed oil, and silver nanoparticles biosynthesized in Azadirachta indica or neem leaves'extract through a green chemistry route. The films exhibited good resistance to secondary bacterial infection and moderate antibacterial behavior against Staphylococcus aureus and E. coli. They also showed suitable swelling behavior for use as wound dressings and biodegradability in soil, with good thermal stability up to 200 degrees C.
Article
Plant Sciences
Carlos Eduardo Lacerda Ramalho, Diego dos Santos Reis, Graziele Alicia Batista Caixeta, Micaelle Cristina de Oliveira, Danielle Milany Fernandes da Silva, Wilson de Melo Cruvinel, Monatha Natara Guimaraes Teofilo, Clayson Moura Gomes, Priscilla Abdala de Sousa, Leiza Fagundes Soares, Anielly Monteiro de Melo, Jamira Dias Rocha, Elisa Fl avia Luiz Cardoso Bailao, Vanessa Cristiane Santana Amaral, Joelma Abadia Marciano de Paula
Summary: The study aimed to evaluate the genotoxicity and the effect of treatment with dried extract of leaves of Azadirachta indica on maternal toxicity and fetal development. The results showed that the extract had no negative effect on body mass gain, food and water consumption, biochemical parameters, reproductive performance, histopathological analysis, and genotoxicity in pregnant rats. However, supernumerary ossification sites of the sternum were observed, while other skeletal and visceral alterations were not significant.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Vivek Dhar Dwivedi, Ankita Singh, Sherif Aly El-Kafraway, Thamir A. Alandijany, Arwa A. Faizo, Leena Hussein Bajrai, Mohammad Amjad Kamal, Esam Ibraheem Azhar
Summary: This study utilized structure-based virtual screening and molecular dynamics simulation to predict the antiviral activity of compounds from Azadirachta indica against Japanese encephalitis virus RNA-dependent RNA polymerase. The results suggest the potential of these compounds for further development as antiviral drugs.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Ceramics
Chetna C. Chauhan, Abhishek A. Gor, Tanuj Gupta, Martin F. Desimone, Neha Patni, Rajshree B. Jotania
Summary: M-type calcium hexaferrite (CaM) was synthesized using extracts from Azadirachta indica and Murraya koenigii leaves, and the presence of phytochemicals in the extracts was found to significantly influence the properties of CaM hexaferrites. The study provides insights into the structural, optical, magnetic, and dielectric characteristics of CaM hexaferrites synthesized via a greener route.
CERAMICS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Changhai Liu, Mayire Nueraihemaiti, Deng Zang, Salamet Edirs, Guoan Zou, Haji Akber Aisa
Summary: The flavonoid compound quercetin 3-O-(6 ''-O-E-caffeoyl)-beta-D-glucopyranoside (CC7) promotes melanogenesis in B16 cells by activating the expression of key regulatory factors and enzymes involved in melanin synthesis. This effect is mediated through the phosphorylation of p38, JNK, and Akt/GSK-3 beta/beta-catenin signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Viviane Bezerra da Silva, Jose Weverton Almeida-Bezerra, Edy Sousa de Brito, Paulo Riceli Vasconcelos Ribeiro, Luciana Silva Cordeiro, Joao Tavares Calixto Junior, Jose Galberto Martins da Costa, Maria Arlene Pessoa da Silva
Summary: The decomposition of Azadirachta indica leaves can negatively affect the germination and growth of Myracrodruon urundeuva, with lower concentrations showing more significant effects during the first decomposition period. Residues of the leaves also impact the root and stem length, total biomass, and chlorophyll content of M. urundeuva. The study suggests the allelopathic action of compounds in A. indica litter and cautions against its use in areas requiring ecological restoration and in natural environments.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Engineering, Electrical & Electronic
Shashank Sundriyal, Vishal Shrivastav, Prashant Dubey, Mandeep Singh, Akash Deep, Sanjay R. Dhakate
Summary: In this study, activated carbon derived from neem leaves and zirconium oxide derived from UiO-66 were used as electrodes to fabricate hybrid supercapacitors. The results showed that NDAC as the negative electrode and ZO as the positive electrode exhibited high specific capacitance performance. Furthermore, the assembled asymmetrical supercapacitor demonstrated high energy density and long cycle life, opening up new possibilities for the application of low-cost bio-wastes and MOF-derived metal oxides in high-energy-density supercapacitors.
IEEE TRANSACTIONS ON NANOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Meenakshi Singh, Bhakti Umesh Hirlekar, Shagufta Mondal, Suyash Pant, Devendra K. Dhaked, V Ravichandiran, Abhijit Hazra, Yogesh P. Bharitkar
Summary: The aims of this study were to investigate the phytochemical properties and chemical transformation of compounds isolated from the medicinal plant Dolichandrone atrovirens, listed in 'Ayurveda'. Several compounds were isolated from the plant, and a novel spiro-oxindolo-pyrrolizidine adduct was synthesized. The structures were determined using various analytical techniques, and the compounds were evaluated for their potential as future drug candidates using in-silico ADME studies.
NATURAL PRODUCT RESEARCH
(2023)
Article
Computer Science, Information Systems
Mohamed Hassaoui, Mohamed Hanini, Said El Kafhali
Summary: The use of C2 servers in cyberattacks has increased significantly, with attackers using DGA technique to hide their servers. Existing techniques for binary classification of domain names have issues with real-time detection and sensitivity to data. This paper proposes the DTFS-DGA model, which combines neural networks and traditional machine learning models to detect DGA in real-time without relying on reverse engineering and being insensitive to data size.
JOURNAL OF COMPUTER SECURITY
(2023)
Article
Chemistry, Medicinal
Rajdip Misra, Anupam Maity, Shubham Kundu, Mrinmay Bhunia, Banadipa Nanda, Nakul C. Maiti, Uttam Pal
Summary: Molecular mechanics are important for enzyme action and understanding loop motion dynamics is crucial for designing enzyme inhibitors. In this study, we investigated the structural dynamics of NS2B/NS3 dengue protease for the development of new protease inhibitors. The internal dynamics of two regions, fingers 1 and 2, adjacent to the active site triad were found to control the enzyme action. Correlated motions in the beta-turns of these regions modulated the enzyme activity. Perturbation of these motions by cosolvent concentration, temperature, and mutations affected the enzyme kinetics.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Chemistry, Medicinal
Deep Sankar Rudra, Sourav Chatterjee, Uttam Pal, Madhumita Mandal, Susri Ray Chaudhuri, Mrinmay Bhunia, Nakul Chandra Maiti, Shila Elizabeth Besra, Parasuraman Jaisankar, Snehasikta Swarnakar
Summary: We investigated the antiulcer efficacy of 3-indolyl furanoids derived from indomethacin and found that 3g protected against indomethacin-induced gastropathy by inhibiting MMP-9. This study established a chemical modification strategy for the development of safer NSAIDs.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Anupam Maity, Animesh Mondal, Shubham Kundu, Gourav Shome, Rajdip Misra, Aakriti Singh, Uttam Pal, Atin Kumar Mandal, Kaushik Bera, Nakul C. Maiti
Summary: In this study, the impact of a compound called naringenin on the aggregation and fibril formation of α-synuclein, which is linked to the pathology of Parkinson's disease, was investigated. The findings showed that naringenin effectively inhibits aggregation and fibril formation, thereby delaying the progression of Parkinson's disease. The compound was incorporated onto the surface of gold nanoparticles and demonstrated the ability to interact with α-synuclein and alter the absorption spectrum of the nanoparticles. Additionally, naringenin and its nanocomplex did not affect neuronal cell viability.
Article
Materials Science, Multidisciplinary
Sumit Chaudhary, R. N. Rai, Deeti Jyothi, Umesh Prasad Singh
Summary: In this study, an environment friendly solid state synthesis method was used to successfully synthesize a molecular complex, 2-(3-Hydroxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (ANHB), with the highest yield. The compositional behavior of composites in the entire range was determined by analyzing the phase diagram of anthranilamide (AN) 3-hydroxybenzaldehyde (HB) system, which identified the formation of two eutectics and a molecular complex. The novelty and structural behavior of ANHB were studied using various techniques such as FTIR, NMR, UV-vis, fluorescence, DSC, and PXRD. The thermodynamic properties of the eutectics and complex were characterized using the heat of fusion values obtained from DSC. The single crystal XRD (SCXRD) and atomic packing studies confirmed that ANHB crystallizes in a centro-symmetric triclinic space group P 1 with two molecules in the asymmetric unit and four molecules in the unit cell. The synthesized complex exhibited fluorescence emission in the visible region.
Article
Spectroscopy
Gourab Ghosh, Dipanjan Mukherjee, Ria Ghosh, Priya Singh, Uttam Pal, Arpita Chattopadhyay, Mithun Santra, Kyo Han Ahn, P. Mosae Selvakumar, Ranjan Das, Samir Kumar Pal
Summary: A novel benzo[a]phenoxazine-based fluorescent dye LV2 was used to investigate the recognition of a linker histone protein H1 by calf-thymus DNA (DNA). The fluorescence lifetime and rotational relaxation time of LV2 buried in H1 or DNA showed significant changes upon the formation of the H1-DNA complex, indicating successful recognition between H1 and DNA. Molecular docking and molecular dynamics simulations demonstrated that the binding of LV2 in the interface of the H1-DNA complex was energetically more favorable. Through the significant changes in fluorescence lifetime and rotational relaxation time, the benzo[a]phenoxazine-based fluorescent dye reported on the recognition of H1 by DNA.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Esha Pandit, Lopamudra Das, Anoy Kumar Das, Sandip Dolui, Saumen Saha, Uttam Pal, Animesh Mondal, Joydeep Chowdhury, Subhas C. C. Biswas, Nakul C. C. Maiti
Summary: Parkinson's disease is an age-related neurological disorder caused by aggregates of alpha-synuclein (aS) proteins. In this study, the structure and aggregation behavior of two artificial single point mutants of aS were analyzed and compared to the wild-type. The mutants showed enhanced structural stability and alpha-helical propensity, resulting in slower fibril formation and reduced toxicity to neuronal cells.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Afsar Alam, Mohammad Shahzeb Khan, Yash Mathur, Md Nayab Sulaimani, Naqiya Farooqui, Sheikh F. F. Ahmad, Ahmed Nadeem, Dharmendra Kumar Yadav, Taj Mohammad
Summary: Ribosomal protein S6 kinase 1 (S6K1) plays a significant role in cellular signaling pathways and is considered a potential target for drug design and discovery. This study identified Hecogenin and Glabrene as potential S6K1 inhibitors through virtual screening, molecular docking, and drug-likeliness filters. These compounds showed good affinity, specificity, and stable complexes with S6K1, suggesting their potential therapeutic use for diseases such as diabetes, obesity, and cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Chetan Paul Singh, Priyanka Sharma, Manzoor Ahmed, Diljeet Kumar, Yogesh Brijwashi Sharma, Jayanta Samanta, Zabeer Ahmed, Sanket Kumar Shukla, Abhijit Hazra, Yogesh P. Bharitkar
Summary: Natural products are important for drug discovery due to their unique chemical space. Researchers have been using diversity-oriented synthesis to synthesize novel natural product hybrids and analogues. In this study, natural product hybrids of parthenin were synthesized using the weed Parthenium hysterophorus. The synthesized compounds were characterized and evaluated for their cytotoxicity, with compound 6 showing inhibitory effects on HCT-116 cells.
Review
Biochemistry & Molecular Biology
Sunny Kumar, Malini Basu, Pratyasha Ghosh, Uttam Pal, Mrinal K. Ghosh
Summary: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated disease COVID-19. Clinicians are facing significant challenges in treatment due to the lack of specific drugs, leading to the exploration of drug repurposing as a potential solution. Many drugs are being repurposed globally, with some already approved for clinical use and others in various stages of clinical trials.
Review
Biochemistry & Molecular Biology
Desh Deepak Singh, Ihn Han, Eun-Ha Choi, Dharmendra Kumar Yadav
Summary: SARS-CoV-2 causes severe respiratory distress and organ failure, and supportive treatment options are currently used. Targeting viral proteins and enzymes, as well as developing antibodies and antiviral drugs, are effective approaches for COVID-19 treatment. Clinical studies are exploring various therapy categories. This article provides new insights into drug pathophysiology and development.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Moyad Shahwan, Saleha Anwar, Dharmendra Kumar Yadav, Mohd Shahnawaz Khan, Anas Shamsi
Summary: Neuroinflammation is important in the pathogenesis of Alzheimer's disease and other neurodegenerative disorders. Currently, there are no effective drugs for treating these diseases. Therefore, there is increasing interest in using anti-inflammatory compounds and antioxidants to target neuroinflammation. This study investigates the binding and dynamics of the human transferrin (HTF)-apigenin complex, and suggests that apigenin has a neuroprotective effect by binding to HTF and maintaining a stable conformation.
Article
Biochemistry & Molecular Biology
Anas Shamsi, Mohammad Furkan, Rizwan Hasan Khan, Mohd Shahnawaz Khan, Moyad Shahwan, Dharmendra Kumar Yadav
Summary: This study deciphers the binding mechanism between rutin and human transferrin, and suggests that rutin can be used for the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
