Article
Chemistry, Multidisciplinary
Chiara Argentati, Francesco Morena, Chiara Fontana, Ilaria Tortorella, Carla Emiliani, Loredana Latterini, Giulia Zampini, Sabata Martino
Summary: The study investigated the effects of chemically functionalized nanoparticles on human stem cells, finding that the stem cells exhibited similar growth and viability levels on all types of nanoparticles with morphological changes observed. Gold nanoseeds nanoparticles showed slight genotoxic effects on stem cells but did not impact their behavior.
Article
Chemistry, Multidisciplinary
Huey-Shan Hung, Mei-Lang Kung, Fang-Chung Chen, Yi-Chun Ke, Chiung-Chyi Shen, Yi-Chin Yang, Chang-Ming Tang, Chun-An Yeh, Hsien-Hsu Hsieh, Shan-hui Hsu
Summary: Graphene-based nanocomposites, particularly gold nanoparticle-decorated GO (GO-Au), exhibit excellent physicochemical properties and have potential applications in tissue engineering. In this study, GO-Au (x2) showed significantly increased cell viability of MSCs, good anti-oxidative ability, immune response modulation, and platelet activity inhibition. Moreover, the Au-deposited GO nanocomposites demonstrated superior efficacy in enhancing cell motility, promoting various MSCs-derived cell types of differentiation, and reducing fibrotic formation and M1 macrophage polarization in an implanted animal model. These results suggest that Au-deposited GO nanocomposites have great potential as nanocarriers for tissue engineering and effective strategies for anti-inflammation.
Article
Polymer Science
Huey-Shan Hung, Yi-Chin Yang, Wei-Chien Kao, Chun-An Yeh, Kai-Bo Chang, Cheng-Ming Tang, Hsien-Hsu Hsieh, Hsu-Tung Lee
Summary: The study investigated the biological effects of Polyethylene Glycol (PEG) incorporated with 43.5 ppm of gold (Au) nanoparticles on vascular regeneration through both in vitro and in vivo assessments. The nanocomposites showed potential therapeutic effects by inhibiting inflammation and promoting angiogenesis, making them efficient tools for vascular regeneration grafts.
Article
Cell Biology
Huey-Shan Hung, Yi-Chin Yang, Chih-Hsuan Chang, Kai-Bo Chang, Chiung-Chyi Shen, Chien-Lun Tang, Szu-Yuan Liu, Chung-Hsin Lee, Chun-Ming Yen, Meng-Yin Yang
Summary: The study demonstrates that the composite material of chitosan and gold nanoparticles can enhance the neural differentiation of mesenchymal stem cells and has the potential as a biosafe nanomaterial for neural tissue engineering.
Article
Chemistry, Analytical
Hai Shi, Mengjiao Wang, Youjing Gong, Yue Huang, Limin Ning, Yang Xiang, Yongmei Yin, Genxi Li
Summary: This study achieved cascade assembly of nanoparticles on specific cancer cells by designing a dual-aptamer-weaved molecular AND logic system, allowing precise labeling and rapid acquisition of phenotypic information in a large population of cancer cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Cell Biology
Huey-Shan Hung, Wei-Chien Kao, Chiung-Chyi Shen, Kai-Bo Chang, Cheng-Ming Tang, Meng-Yin Yang, Yi-Chin Yang, Chun-An Yeh, Jia-Jhan Li, Hsien-Hsu Hsieh
Summary: The study created a nanocomposite of PEG with various concentrations of Au nanoparticles, with PEG-Au 43.5 ppm showing superior biocompatibility and biological properties for MSCs, especially in neuronal differentiation. This nanocomposite enhanced cell adhesion, proliferation, and migration in MSCs, prevented apoptosis, inhibited inflammation, and promoted differentiation into various cell types, including nerve cells.
Article
Cell & Tissue Engineering
Jingfang Xiao, Xiaoyuan Gong, Zhenlan Fu, Xiongbo Song, Qinghua Ma, Jingya Miao, Ruili Cai, Zexuan Yan, Shuai Wang, Qian Li, Yaokai Chen, Liu Yang, Xiuwu Bian, Yemiao Chen
Summary: This study analyzed the effects of tissue inflammation on the characteristics of mesenchymal stem cells (MSCs). The results showed that high tissue inflammation decreases the acquisition rate of MSCs and the proportion of certain cells. However, the degree of tissue inflammation may not significantly affect the differentiation potential and proliferative capacity of MSCs. Additionally, MSCs obtained from differing degrees of inflammation retain a stable and similar transcriptomic profile and are safe and effective for tissue repair and regeneration.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Yinjuan Lv, Chenggong Yu, Xiaodi Li, Hongying Bao, Shaoshuai Song, Xiaoling Cao, Haixia Lin, Jie Huang, Zhijun Zhang
Summary: Copper-based nanozyme and gold nanoparticles were encapsulated in oxidation-sensitive dextran to form a novel nanocomposite for ROS scavenging and CT imaging tracking of mesenchymal stem cells (MSCs) in idiopathic pulmonary fibrosis (IPF) treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina V. Silina, Victor A. Stupin, Natalia E. Manturova, Olga S. Ivanova, Anton L. Popov, Elena A. Mysina, Elena B. Artyushkova, Alexey A. Kryukov, Svetlana A. Dodonova, Maria P. Kruglova, Alexey A. Tinkov, Anatoly V. Skalny, Vladimir K. Ivanov
Summary: The study compares the effects of two different methods of cerium dioxide nanoparticle preparation on cells and identifies the optimal concentration of nanoceria sols for achieving the highest metabolic effect in cell cultures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Chenggong Yu, Yinjuan Lv, Xiaodi Li, Hongying Bao, Xiaoling Cao, Jie Huang, Zhijun Zhang
Summary: The development of functionalized nanoplatforms for imaging tracking and therapeutic enhancement of stem cells in stem cell-based therapy is challenging. In this study, superoxide dismutase (SOD)-engineered gold nanoparticles (AuNPs) were developed for oxidative stress damage mitigation and computed tomography (CT) imaging tracking of mesenchymal stem cells (MSCs) in idiopathic pulmonary fibrosis (IPF) therapy. The SOD@Au NS, composed of SOD modified on the surface of AuNPs and encapsulated into polyphosphazene nanospheres, promoted MSC survival by eliminating reactive oxygen species (ROS) in the inflammatory microenvironment and provided strong contrast enhancement in CT imaging. The labeled MSCs could be detected by CT technology for continuous monitoring after transplantation, enabling the development of safe and effective strategies for stem cell-based IPF treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Electrical & Electronic
R. Rathinabala, R. Thamizselvi, Suresh Sagadevan, Kalpana Murugesan, Mahaboob Beevi Mohamed Yusuf
Summary: The current study focuses on synthesizing tin oxide (SnO2) nanoparticles through a green synthesis method and examining their properties using various analytical techniques. Results show that SnO2 NPs synthesized at different temperatures exhibit diverse structural, morphological, optical, and magnetic properties.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Article
Toxicology
Barbora Echalar, Dominika Dostalova, Katerina Palacka, Eliska Javorkova, Barbora Hermankova, Tereza Cervena, Alena Zajicova, Vladimir Holan, Pavel Rossner
Summary: Nanoparticles have wide applications in industry and medicine, particularly for their antimicrobial effects. However, a study found that metal antimicrobial nanoparticles have negative effects on mouse mesenchymal stem cells, affecting their characteristics and function properties. It is important to carefully consider the use of metal nanoparticles in tissue regeneration and stem cell therapy.
TOXICOLOGY IN VITRO
(2023)
Article
Thermodynamics
Ibrahim Zaaroura, Souad Harmand, Julien Carlier, Malika Toubal, Aurelie Fasquelle, Bertrand Nongaillard
Summary: This study investigates the evaporation of gold nanofluid droplets on a heated silicon substrate, analyzing the size effect of gold nanoparticles and the impact of surface coating on heat transfer. The research uses optical, infrared thermography, and acoustic methods to study the evaporation process and reveals that the addition of a surfactant decreases the effectiveness of heat transfer in gold nanofluids.
APPLIED THERMAL ENGINEERING
(2021)
Article
Cell Biology
Viktoria Jakl, Tanja Popp, Julian Haupt, Matthias Port, Reinhild Roesler, Sebastian Wiese, Benedikt Friemert, Markus T. Rojewski, Hubert Schrezenmeier
Summary: This study found that the therapeutic efficacy of mesenchymal stromal cells (MSCs) relies on their immunomodulatory and regenerative properties. To obtain sufficient cell numbers for clinical applications, MSCs need to be expanded ex vivo. Expansion media with xenogeneic-free (XF) growth-promoting supplements, such as human platelet lysate (PL) or serum- and xenogeneic-free (SF/XF) formulations, have been established as safe and efficient, providing different beneficial qualities. The findings of this study support the use of growth media for priming MSCs for specific therapeutic applications.
Article
Biochemistry & Molecular Biology
Ruei-Hong Lin, Hsu-Tung Lee, Chun-An Yeh, Yi-Chin Yang, Chiung-Chyi Shen, Kai-Bo Chang, Bai-Shuan Liu, Hsien-Hsu Hsieh, Hui-Min David Wang, Huey-Shan Hung
Summary: The research shows that using AuNPs at concentrations of 1.25 and 2.5 ppm can enhance cell proliferation, reduce reactive oxygen species generation, and attenuate platelet/monocyte activation. AuNPs can also promote cell adhesion, increase the expression of matrix metalloproteinase (MMP-2/9), decrease cell apoptosis and the release of inflammatory cytokines. Animal model experiments demonstrate that treating with 1.25 and 2.5 ppm AuNPs exhibits better biocompatibility and endothelialization. This suggests that AuNPs can be used as a biocompatible nanomedicine for regeneration research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Artem Kozlovskiy, Maxim Zdorovets, Kairat Kadyrzhanov, Ilya Korolkov, Vyacheslav Rusakov, Larisa Nikolaevich, Olena Fesenko, Oksana Budnyk, Dzmitry Yakimchuk, Alena Shumskaya, Egor Kaniukov
APPLIED NANOSCIENCE
(2019)
Article
Nanoscience & Nanotechnology
Siim Heinsalu, Olena Fesenko, Aleksei Treshchalov, Serhii Kovalchuk, Andrii Yaremkevych, Vladyslav Kavelin, Leonid Dolgov
APPLIED NANOSCIENCE
(2019)
Article
Multidisciplinary Sciences
Dmitry Karpinsky, Olena M. Fesenko, Maxim Silibin, Sergei Dubkov, Mykola Chaika, Andrii Yaremkevich, Anna Lukowiak, Yuri Gerasymchuk, Wieslaw Strek, Andrius Pakalniskis, Ramunas Skaudzius, Aivaras Kareiva, Yevhen M. Fomichov, Vladimir V. Shvartsman, Sergei Kalinin, Nicholas Morozovsky, Anna N. Morozovska
SCIENTIFIC REPORTS
(2019)
Editorial Material
Nanoscience & Nanotechnology
Olena Fesenko
APPLIED NANOSCIENCE
(2019)
Article
Engineering, Biomedical
Iryna Buriak, Roland A. Fleck, Anatoliy Goltsev, Nadiya Shevchenko, Maryna Petrushko, Taisiia Yurchuk, Anton Puhovkin, Svitlana Rozanova, Edgardo Elvio Guibert, Maria Celeste Robert, Leonardo Juan de Paz, Matthew J. Powell-Palm, Barry Fuller
JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME
(2020)
Article
Nanoscience & Nanotechnology
Anatoliy M. Goltsev, Yuriy V. Malyukin, Natalya M. Babenko, Yulia O. Gaevska, Mykola O. Bondarovych, Tatiana G. Dubrava, Igor F. Kovalenko, Maksym V. Ostankov, Vladimir K. Klochkov
APPLIED NANOSCIENCE
(2020)
Review
Cell & Tissue Engineering
Maooz Awan, Iryna Buriak, Roland Fleck, Barry Fuller, Anatoliy Goltsev, Julie Kerby, Mark Lowdell, Pavel Mericka, Alexander Petrenko, Yuri Petrenko, Olena Rogulska, Alexandra Stolzing, Glyn N. Stacey
REGENERATIVE MEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Olena Fesenko, Valeriy Korskanov, Andrii Yaremkevych, Tamara Tsebriinko, Volodimir Dolgoshey
APPLIED NANOSCIENCE
(2020)
Article
Materials Science, Multidisciplinary
Anna N. Morozovska, Dmitry Karpinsky, Denis O. Alikin, Alexander Abramov, Eugene A. Eliseev, Maya D. Glinchuk, Andrii D. Yaremkevich, Olena M. Fesenko, Tamara Tsebrienko, Andrius Pakalniskis, Aivaras Kareiva, Maxim Silibin, Vitali V. Sidski, Sergei Kalinin, Andrei L. Kholkin
Summary: In this study, the physical nature and spatial distributions of FE, FEI, and AFE phases in multiferroic materials near morphotropic phase transitions were explored using LGD phenomenology and FSM models. Experimental observations on dense Bi1-yRyFeO3 ceramics were compared with theoretical predictions, showing that the LGD-FSM approach effectively describes the AFE/FE phase fractions. This combined theoretical and experimental approach provides insight into the origins of morphotropic boundaries and coexisting FE and AFE states in rare-earth doped multiferroics.
Article
Thermodynamics
Valery Korskanov, Olena Fesenko, Tamara Tsebriinko, Oksana Budnyk, Volodimir Dolgoshey, Ponomarenko Sergiy
Summary: This study presents a device for analyzing the thermally stimulated electrical conductivity of composites over a wide temperature range. The main advantage of this device is that it allows experiments in both the mode of measuring thermally stimulated depolarization current (TSDC) at low temperatures and the mode of measuring thermally stimulated conductivity current (TSCC) at high temperatures. The results demonstrate that the TSDC method can be used to analyze temperature transitions in many composite materials at low temperatures and that the described device enables the study of thermal transitions in composites using the TSCC mode at high temperatures.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Biology
D. B. Vvedenskyi, N. O. Volkova, M. S. Yukhta, N. O. Ashukina, A. M. Goltsev
Summary: The study showed that local administration of cryopreserved MMSCs from adipose and cartilage tissues can contribute to the normalization of structural and functional organization of damaged cartilage tissue, while systemic administration had less pronounced effects on regeneration. The data suggest that cryopreserved MMSCs can influence the intensity of regenerative processes in damaged cartilage tissue with both local and systemic administration methods.
REGULATORY MECHANISMS IN BIOSYSTEMS
(2021)
Article
Chemistry, Multidisciplinary
Olena Fesenko, Valery Korskanov, Andrii Yaremkevych, Volodimir Dolgoshey
Summary: The study on thermal conductivity of nanofluids and nanostructures based on water and graphene, as well as water solutions of graphene and gold nanoparticles, showed that the high thermal conductivity values in nanocomposites are due to the enhancement effect of thermoconductive heavy substrate from gold nanoparticles formed through compatible sedimentation with graphene in water.
MOLECULAR CRYSTALS AND LIQUID CRYSTALS
(2021)
Article
Multidisciplinary Sciences
O. M. Fesenko, V. V. Korskanov, O. P. Budnyk, P. P. Pogoretskii
SCIENCE AND INNOVATION
(2020)
Meeting Abstract
Biology
A. M. Goltsev, M. O. Bondarovych, N. M. Babenko, Yu O. Gaevska, M. V. Ostankov