Beta cell response to nutrient overload involves phospholipid remodelling and lipid peroxidation

Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes

(2013) Guy Cohen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive aldehydes – second messengers of free radicals in diabetes mellitus

(2013) M. Jaganjac et al.   FREE RADICAL RESEARCH

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

(2013) Ebru Boslem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomic analysis of pancreatic beta cells following exposure to high glucose

(2012) Martina Wallace et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Age-related distributions of nine fasting plasma free fatty acids in a population of Chinese adults

(2012) Fan Shen et al.   CLINICA CHIMICA ACTA

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes

(2012) E. Bachar-Wikstrom et al.   DIABETES

Role of fatty acid-based functional lipidomics in the development of molecular diagnostic tools

(2012) Carla Ferreri et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction

(2012) Ebru Boslem et al.   Islets

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion

(2011) Guy Cohen et al.   DIABETES

Higher Acute Insulin Response to Glucose May Determine Greater Free Fatty Acid Clearance in African-American Women

(2011) Carson C. Chow et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Eicosanoids, β-cell function, and diabetes

(2011) Pengcheng Luo et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Signaling and cytotoxic functions of 4-hydroxyalkenals

(2010) Yael Riahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator-Activated Receptor  

(2010) Y. Riahi et al.   DIABETES

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

(2010) M. Elsner et al.   DIABETES

Pathological aspects of lipid peroxidation

(2010) Anne Negre-Salvayre et al.   FREE RADICAL RESEARCH

The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats

(2010) Giancarlo Aldini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells

(2010) Kristofer Thörn et al.   Lipids in Health and Disease

Activation of PPARδ promotes mitochondrial energy metabolism and decreases basal insulin secretion in palmitate-treated β-cells

(2010) Li Jiang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Activation of PPARδ up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic β-cells

(2009) Jun Wan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules

(2009) Michael B. Hoppa et al.   Cell Metabolism

Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

(2009) T. Alquier et al.   DIABETES

Adaptation and failure of pancreatic   cells in murine models with different degrees of metabolic syndrome

(2009) G. Medina-Gomez et al.   Disease Models & Mechanisms

PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

(2009) Kim Ravnskjaer et al.   JOURNAL OF LIPID RESEARCH

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

(2009) Etti Bachar et al.   PLoS One

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells

(2008) Elida Lai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

cPLA2phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells

(2008) Zoran Pavicevic et al.   JOURNAL OF LIPID RESEARCH