Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9

Deficiency in the anti-aging gene Klotho promotes aortic valve fibrosis through AMPKα-mediated activation of RUNX2

(2016) Jianglei Chen et al.   AGING CELL

Bone Morphogenetic Protein Signaling Is Required for Aortic Valve CalcificationHighlights

(2016) M. Victoria Gomez-Stallons et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Osteogenic differentiation of human lens epithelial cells might contribute to lens calcification

(2016) Enikő Balogh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1

(2016) Kazuhiko Seya et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

(2015) Marie A. Guerraty et al.   AMERICAN JOURNAL OF CARDIOLOGY

Valve Endothelial Cell–Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated CalcificationSignificance

(2015) Danielle J. Huk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk–Akt pathway

(2015) Qingzhou Yao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine

(2015) Ioana Alesutan et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Solubleα-Klotho Serum Levels in Chronic Kidney Disease

(2015) Silverio Rotondi et al.   International Journal of Endocrinology

Disseminated Arterial Calcification and Enhanced Myogenic Response Are Associated With Abcc6 Deficiency in a Mouse Model of Pseudoxanthoma Elasticum

(2014) Gilles Kauffenstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells

(2014) Rui Song et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Control of chondrogenesis by the transcription factor Sox9

(2014) Haruhiko Akiyama   Modern Rheumatology

Sox9 Potentiates BMP2-Induced Chondrogenic Differentiation and Inhibits BMP2-Induced Osteogenic Differentiation

(2014) Junyi Liao et al.   PLoS One

Notch1 Promotes the Pro-Osteogenic Response of Human Aortic Valve Interstitial Cells via Modulation of ERK1/2 and Nuclear Factor-κB Activation

(2013) Qingchun Zeng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular and Cellular Aspects of Calcific Aortic Valve Disease

(2013) Dwight A. Towler   CIRCULATION RESEARCH

High Mobility Group Box 1 (HMGB1) Mediates High-Glucose-Induced Calcification in Vascular Smooth Muscle Cells of Saphenous Veins

(2013) Yongyi Wang et al.   INFLAMMATION

Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism

(2013) Makoto Kuro-o   Nature Reviews Nephrology

Aortic valve calcification in chronic kidney disease

(2013) M. Rattazzi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Biglycan Induces the Expression of Osteogenic Factors in Human Aortic Valve Interstitial Cells via Toll-Like Receptor-2

(2012) Rui Song et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end products

(2012) Fei Li et al.   BASIC RESEARCH IN CARDIOLOGY

SOX9 and myocardin counteract each other in regulating vascular smooth muscle cell differentiation

(2012) Zhonghui Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cross-Talk Between the Toll-Like Receptor 4 and Notch1 Pathways Augments the Inflammatory Response in the Interstitial Cells of Stenotic Human Aortic Valves

(2012) Q. Zeng et al.   CIRCULATION

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

(2012) Kenneth Lim et al.   CIRCULATION

Differential activation of valvulogenic, chondrogenic, and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease

(2012) Jonathan D. Cheek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanistic Insights into Vascular Calcification in CKD

(2012) R. Shroff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Direct Effects of Phosphate on Vascular Cell Function

(2011) Wei Ling Lau et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Chondrocyte Rather Than Osteoblast Conversion of Vascular Cells Underlies Medial Calcification in Uremic Rats

(2010) Ellen Neven et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reduced Sox9 Function Promotes Heart Valve Calcification Phenotypes In Vivo

(2010) Jacqueline D. Peacock et al.   CIRCULATION RESEARCH

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

(2010) Ming Chang Hu et al.   FASEB JOURNAL

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

Clones of Interstitial Cells From Bovine Aortic Valve Exhibit Different Calcifying Potential When Exposed to Endotoxin and Phosphate

(2008) Marcello Rattazzi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats

(2008) M. Shuvy et al.   CARDIOVASCULAR RESEARCH

Bone regulatory factors NFATc1 and Osterix in human calcific aortic valves

(2008) Alexandros Alexopoulos et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis

(2007) Xianzhong Meng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY