Article
Infectious Diseases
Joseph Meletiadis, Paschalis Paranos, Panagiota-Christina Georgiou, Sofia Vourli, Stavroula Antonopoulou, Aikaterini Michelaki, Eleni Vagiakou, Spyros Pournaras
Summary: Metallo-beta-lactamase (MBL)-producing Gram-negative bacteria are increasing globally, with few effective agents against them. Taniborbactam is a newly developed bicyclic boronate beta-lactamase inhibitor that shows promising activity against MBL-producing isolates when used in combination with cefepime or meropenem.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Biochemistry & Molecular Biology
Sangita Sarma, Banani Deka, Pankaj Pradeep Panyang, Anil Kumar Singh
Summary: The study identified novel mutations of beta-lactamase and their clinical importance in Enterobacteriaceae family, highlighting the resistance pattern and molecular mechanisms in bacteria isolated from acute diarrheal patients. The identified mutations in BlaSHV protein and their interactions with antibiotics provide insight into antibiotic resistance in Klebsiella pneumoniae isolates.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Azhar Salari-jazi, Karim Mahnam, Parisa Sadeghi, Mohamad Sadegh Damavandi, Jamshid Faghri
Summary: The study conducted multi-step virtual screening in the NPASS database to identify potential metallo-beta -lactamase inhibitors. The efficacy of these compounds was evaluated through molecular docking and molecular dynamics simulations, while protein sequence alignment and pharmacophore modeling revealed conserved residues.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Daniela D. Herrera-Balandrano, Trust Beta, Zhi Chai, Xiaoxiao Zhang, Ying Li, Wuyang Huang
Summary: The study demonstrated that the phenolic composition and antioxidant capacity of Burdock roots can be influenced by the harvest time, with changes observed during in vitro digestion.
Article
Biotechnology & Applied Microbiology
Soumya Basu, Sahil Mandar Joshi, Sudha Ramaiah, Anand Anbarasu
Summary: The global healthcare concern of anti-microbial resistance (AMR) necessitates the exploration of therapeutic alternatives. Recent evidence of increasing resistance to membrane-acting anti-microbial peptides (AMPs) by ESKAPE pathogens has led to the design of novel AMPs as potential therapeutic candidates. In this study, a library of 60 AMPs, including natural AMPs and their mutants, was constructed using in-silico methods. The AMPs were evaluated for their physico-chemical properties and subjected to molecular docking against major beta-lactamases in Gram-negative ESKAPE pathogens. One of the AMP mutants, Lactoferricin B-Mutant (M4), showed high affinity to the key enzymes with energies ranging from -842.0Kcal/mol to -1103.3Kcal/mol. Coarse-grained clustering and flexibility analysis further confirmed the stable configurations of the protein-peptide complexes. The study highlights the potential of AMPs as therapeutic agents against drug-resistant pathogens and encourages further experimental validations and similar approaches.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Biochemistry & Molecular Biology
Van-Thanh Tran, Viet-Hung Tran, Dac-Nhan Nguyen, Tran-Giang-Son Do, Thanh-Phuong Vo, Thi-Thao-Nhung Nguyen, Phuong Nguyen Hoai Huynh, Khac-Minh Thai
Summary: Antibiotic resistance is becoming more critical due to the evolving hydrolysis enzymes of bacteria, especially the NDM-1 enzyme which can hydrolyze various antibiotics and inhibitors. This study aims to evaluate the influence of different mutations on the effectiveness of antibiotics and beta-lactamase inhibitors, and the results suggest that substitutions at residues 122 and 124 have the most significant impact on the binding ability of NDM-1 towards inhibitors and antibiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Othman M. Alzahrani, Fakhur Uddin, Samy F. Mahmoud, Amal S. Alswat, Muhammad Sohail, Mona Youssef
Summary: This study investigated the prevalence and antibiotic susceptibility of carbapenem-resistant uropathogens in diabetic patients, finding that the uropathogens showed resistance to multiple antibiotics but lower resistance to non-beta-lactam antibiotics.
Article
Chemistry, Multidisciplinary
Yasemin Budama-Kilinc, Bahar Gok, Serda Kecel-Gunduz, Ebru Altuntas
Summary: This study aimed to develop a nanoemulsion formulation containing chlorogenic acid (CA) for the treatment of hyperpigmentation and evaluate its efficacy and safety through various characterization studies. The results demonstrated that the CA nanoemulsion formulation exhibited high inhibitory activity against melanogenesis and had a favorable safety profile, suggesting its potential as an innovative cosmetic application for skin-lightening effects.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Microbiology
Mojgan Farhadi, Mohammad Ahanjan, Hamid Reza Goli, Mohammad Reza Haghshenas, Mehrdad Gholami
Summary: Klebsiella pneumoniae is increasingly becoming resistant to antibiotics, with many strains showing multi-drug resistance (MDR) and extensive-drug resistance (XDR). It is crucial to choose appropriate antimicrobial regimens based on antibiotic susceptibility patterns in order to combat the rising rate of these resistant isolates.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Biochemistry & Molecular Biology
Olivia M. Gruenzweil, Lauren Palmer, Adriana Cabal, Michael P. Szostak, Werner Ruppitsch, Christian Kornschober, Maciej Korus, Dusan Misic, Tanja Bernreiter-Hofer, Anna D. J. Korath, Andrea T. Fessler, Franz Allerberger, Stefan Schwarz, Joachim Spergser, Elke Mueller, Sascha D. Braun, Stefan Monecke, Ralf Ehricht, Chris Walzer, Hrvoje Smodlaka, Igor Loncaric
Summary: The study aimed to investigate the presence of ESBL- and AmpC-producing Enterobacterales, as well as Salmonella, in marine mammals. Results revealed a high prevalence of multidrug-resistant bacteria and pandemic high-risk clones, indicating anthropogenic antimicrobial pollution in these animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kaiyang Ma, Weixi Sheng, Xinxin Song, Jiangfeng Song, Ying Li, Wuyang Huang, Yuanfa Liu
Summary: This study found that chlorogenic acid from burdock root can reduce the number of lipid droplets and lipid levels in HepG2 cells with steatosis. It activates the AMPK-related signaling pathways to enhance CPT-1 expression and increase the concentrations of Ca2+ and cAMP. Additionally, it enhances beta-oxidation of fatty acids, reduces alanine transaminase and aspartate transaminase, and inhibits apoptosis in HepG2 cells with steatosis.
Article
Multidisciplinary Sciences
Jagir R. Hussan, Stuart G. Irwin, Brya Mathews, Simon Swift, Dustin L. Williams, Jillian Cornish
Summary: This study investigates the role of lactoferrin as an adjuvant in enhancing the efficacy of broad-spectrum antibiotics. The findings suggest that lactoferrin at optimal doses can enhance the effects of β-lactam antibiotics against Staphylococcus aureus, while sub-inhibitory doses of lactoferrin reduce the efficacy of the antibiotics.
Article
Medicine, General & Internal
Sofia Irfan, Aysha Azhar, Asad Bashir, Salman Ahmed, Abdul Haque
Summary: The study found a significant presence of ESBL and carbapenemase producers in both Escherichia coli and Klebsiella pneumoniae, with co-existence of ESBL and genes in the same isolates.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wei Zhu, Fengming Wu, Jindie Hu, Wenjing Wang, Jifeng Zhang, Guoqing Guo
Summary: In this study, the researchers investigated the interaction mechanism between chlorogenic acid (CGA) and alpha-amino-3-hydroxy-5-methyl-4-isooxazolpropionic acid receptor (AMPAR) in relieving chronic pain. They found that CGA can directly bind to the glutamate ionotropic receptor AMPA type subunit 1 (GluA1) and forms a stable binding interaction. The study provides insights into the structural basis of the CGA-GluA1 interaction and its potential in the treatment of chronic pain.
Article
Biology
Peijun Ma, Lorrie L. He, Alejandro Pironti, Hannah H. Laibinis, Christoph M. Ernst, Abigail L. Manson, Roby P. Bhattacharyya, Ashlee M. Earl, Jonathan Livny, Deborah T. Hung
Summary: Genetic factors such as high-level transposon insertional mutagenesis and a broader spectrum of resistance-conferring mutations have been identified as facilitators for the evolution of carbapenem resistance in Klebsiella pneumoniae. Loss of systems that restrict horizontal resistance gene uptake, such as the CRISPR-Cas system, also play a role in resistance evolution. Consideration of both current and future efficacy of antibiotics, as well as the genetic background and antibiotic identity of clinical isolates, are important determinants of the propensity for resistance development.
Article
Biotechnology & Applied Microbiology
S. K. Rajasekharan, A. K. Ray, S. Ramesh, S. Kannappan Mohanvel
LETTERS IN APPLIED MICROBIOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Ponnan Arumugam, Samiraj Ramesh
DRUG AND CHEMICAL TOXICOLOGY
(2011)
Article
Mycology
R. Satish Kumar, S. Ramesh
JOURNAL DE MYCOLOGIE MEDICALE
(2014)
Article
Oncology
Satish Kumar Rajasekharan, Samiraj Ramesh, Dhamodharan Bakkiyaraj
JOURNAL OF CHEMOTHERAPY
(2015)
Article
Urology & Nephrology
Satish Kumar Rajasekharan, Samiraj Ramesh, Dhamodharan Bakkiyaraj, Ramaraj Elangomathavan, Chakkaravarthi Kamalanathan
Letter
Biotechnology & Applied Microbiology
Satish K. Rajasekharan, Samiraj Ramesh
MINERVA BIOTECNOLOGICA
(2016)
Article
Biotechnology & Applied Microbiology
Samiraj Ramesh, Satish K. Rajasekharan, Ramaraj Elangomathavan
MINERVA BIOTECNOLOGICA
(2016)
Article
Microbiology
Satish Kumar Rajasekharan, Samiraj Ramesh
POLISH JOURNAL OF MICROBIOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Samiraj Ramesh, Satish Kumar Rajasekharan, Vinoth Jothiprakasam, Ramaraj Elangomathavan, Subban Patharajan
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2013)