Review
Biochemistry & Molecular Biology
Hagai Rottenberg
Summary: It is widely reported that the mitochondrial membrane potential, increment ψm, is reduced in aging animals. It was recently suggested that the lower increment ψm in aged animals modulates mitochondrial bioenergetics and that this effect is a major cause of aging since artificially increased increment ψm in C. elegans increased lifespan. The activation of the voltage-gated mitochondrial permeability transition pore (mPTP) is the main cause of the increase in depolarized mitochondria in aged cells, inhibiting oxidative phosphorylation, releasing calcium and mROS, and depleting NAD(+), thereby accelerating degenerative diseases and aging. The reported lifespan extension by artificially generated increment ψm in C. elegans is best explained by inhibition of the voltage-gated mPTP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Joao Monteiro, Clive A. Marks, Patricia C. Braga, Raquel L. Bernardino, Marco G. Alves, Alexandre Lobo-da-Cunha, Arnaldo Videira, Filipe Pereira
Summary: Fluoroacetic acid (FAA) is a commonly used poison for controlling invasive species. Despite its long history as a pesticide, there is currently no effective treatment for accidental poisoning. Research shows that FAA affects mitochondrial function and leads to cell death.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Food Science & Technology
Paulina Patalas-Krawczyk, Dominika Malinska, Jaroslaw Walczak, Gilles Kratzer, Monika Prill, Bernadeta Michalska, Karolina Drabik, Bjorn Titz, Yvan Eb-Levadoux, Thomas Schneider, Jedrzej Szymanski, Julia Hoeng, Manuel C. Peitsch, Jerzy Duszynski, Joanna Szczepanowska, Marco Van der Toorn, Carole Mathis, Mariusz R. Wieckowski
Summary: Mitochondria play an important role in responding to stress factors, and alkaloids from tobacco plants such as nicotine, anatabine, and anabasine can modulate mitochondrial activities differently in mouse brain and liver tissues. These alkaloids affect mitochondrial bioenergetics parameters, including oxygen consumption and swelling rates, with potential toxic effects observed in liver mitochondria. The observed effects are likely independent of nicotinic acetylcholine receptors based on quantitative proteomic analysis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Agronomy
Xintong Guo, Shifeng Cao, Hongfei Wang, Yingying Wei, Yi Chen, Shu Jiang, Xingfeng Shao, Feng Xu
Summary: The influence of mannose treatment on mitochondrial physiological parameters was investigated to postpone broccoli senescence. The results showed that mannose treatment could reduce the level of mitochondrial reactive oxygen species (ROS) to slow down the damage to its ultrastructure. Mannose inhibited malondialdehyde (MDA) accumulation and the decline of cytochrome c/a (Cyt c/a), and delayed the increase of mitochondrial membrane permeability.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xavier R. Chapa-Dubocq, Keishla M. Rodriguez-Graciani, Nelson Escobales, Sabzali Javadov
Summary: Mitochondria, known as the powerhouse of the cell, regulate various cellular processes including ion homeostasis, energy production, and cell death. The inner mitochondrial membrane (IMM) plays a critical role in controlling mitochondrial metabolism and function. The volume of the mitochondrial matrix, regulated by ion transport mechanisms, influences IMM remodeling and can affect mitochondrial respiration and cell survival. Despite extensive research, the mechanisms underlying changes in matrix volume and IMM remodeling in response to energy and oxidative stressors remain poorly understood. This review summarizes previous studies and discusses the interplay between matrix volume regulation and IMM remodeling.
Article
Pharmacology & Pharmacy
Anna Stocco, Natalia Smolina, Patrizia Sabatelli, Justina Sileikyte, Edoardo Artusi, Vincent Mouly, Michael Cohen, Michael Forte, Marco Schiavone, Paolo Bernardi
Summary: High-throughput screening identified isoxazoles as potent but metabolically unstable inhibitors of the mitochondrial permeability transition pore (PTP). We studied the effects of a metabolically stable triazole analog, TR001, which leads to recovery of muscle structure and function of sapje zebrafish, a severe model of Duchenne muscular dystrophy (DMD). PTP inhibition fully restores respiration and improves survival rates, providing a potential treatment option for DMD patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Eun Sol Oh, Hyung Won Ryu, Yu Na Song, Myung-Ji Kang, Yang Hoon Huh, Ji-Yoon Park, Seon Min Oh, Su-Yeon Lee, Yhun Jung Park, Doo-Young Kim, Hyunju Ro, Sung-Tae Hong, Su Ui Lee, Dong-Oh Moon, Mun-Ock Kim
Summary: The recently defined type of cell death, ferroptosis, has attracted significant attention as a potential new approach to cancer treatment due to its more immunogenic nature compared with apoptosis. In this study, a compound called Diplacone (DP), found in the fruit of Paulownia tomentosa, was found to have anti-inflammatory and anti-radical activity, and potential anticancer activity against A549 human lung cancer cells. DP induced a form of cytotoxicity distinct from apoptosis, accompanied by extensive mitochondrial-derived cytoplasmic vacuoles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Giampaolo Morciano, Natalia Naumova, Piotr Koprowski, Sara Valente, Vilma A. Sardao, Yaiza Potes, Alessandro Rimessi, Mariusz R. Wieckowski, Paulo J. Oliveira
Summary: This review summarizes the intriguing phenomenon of the mitochondrial permeability transition pore (mPTP) in cell biology. Despite almost 50 years of research, the mechanisms of mPTP are still not definitively understood. From initially being considered an in vitro artifact to now being recognized for its physiological and pathological implications, the journey of mPTP research has been long and complex.
BIOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Hongji Wang, Chaowen Zhang, Mengnan Li, Chaoran Liu, Jingyi Wang, Xuan Ou, Yuzhu Han
Summary: This paper reviews the molecular mechanisms of antimicrobial peptides (AMPs)-mediated apoptosis by changing the permeability of the mitochondrial membrane, and discusses the roles of AMPs in inducing apoptosis and their potential application prospects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Wattamon Srisakuldee, Barbara E. Nickel, Robert R. Fandrich, Feixong Zhang, Kishore B. S. Pasumarthi, Elissavet Kardami
Summary: Mitochondrial FGF2 isoforms can modulate mPTP opening and affect cell fate. Different molecular weight FGF2 display distinct effects on mitochondria, signaling through interaction with FGFR1.
Article
Biochemistry & Molecular Biology
Mikhail V. Dubinin, Vlada S. Starinets, Eugeny Yu. Talanov, Irina B. Mikheeva, Natalia V. Belosludtseva, Dmitriy A. Serov, Kirill S. Tenkov, Evgeniya V. Belosludtseva, Konstantin N. Belosludtsev
Summary: The study suggests that treatment with alisporivir can alleviate skeletal muscle necrosis and inflammation in mdx mice, with some impact on the cardiac mitochondria function. Alisporivir treatment leads to a decrease in heart weight and affects cardiac excitation transmission.
Article
Biochemistry & Molecular Biology
Mikhail Dubinin, Alena A. Semenova, Anna I. Ilzorkina, Natalia Y. Markelova, Nikita Penkov, Elvira R. Shakurova, Konstantin N. Belosludtsev, Lyudmila Parfenova
Summary: The study synthesized pyridinium derivatives of betulin, showing their effects on artificial membrane systems and cytotoxicity in cell models. The presence of methyl groups in the compounds influenced their ability to permeabilize membranes and affect mitochondrial function. The study highlights the dependence of membranotropic and biological actions on the structure and lipophilicity of the derivatives.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Multidisciplinary Sciences
Vincenzo Algieri, Cristina Algieri, Loredana Maiuolo, Antonio De Nino, Alessandra Pagliarani, Matteo Antonio Tallarida, Fabiana Trombetti, Salvatore Nesci
Summary: The study identified two 1,5-disubstituted 1,2,3-triazole derivatives that inhibit the opening of the mitochondrial permeability transition pore without affecting mitochondrial respiration.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Biophysics
Maria Estephan, Riham El Kurdi, Digambara Patra
Summary: This study elaborates on the physical properties of diarachidonyl phosphatidyl choline (DAPC) liposome using fluorescence method with curcumin as a probe molecule at low concentration. The results show that curcumin has a higher partition coefficient above the phase transition temperature of DAPC liposomes, and the presence of chitosan oligosaccharide lactate layer affects membrane permeability.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Salvatore Nesci, Cristina Algieri, Fabiana Trombetti, Vittoria Ventrella, Micaela Fabbri, Alessandra Pagliarani
Summary: The study reveals that H2S affects the activity of specific enzymes in mitochondria, leading to respiratory chain inhibition and reduced membrane potential, thereby impacting oxidative phosphorylation process.
PHARMACOLOGICAL RESEARCH
(2021)
