Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 60, Issue 11, Pages 4573-4576Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.7b00554
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Bacterial resistance to most antibiotics in clinical use has reached alarming proportions. A challenge for modern medicine will be to discover new antibiotics or strategies to combat multidrug resistant bacteria, especially Gram-negative bacteria for which the situation is particularly critical. Vectorization of bactericide compounds by siderophores (iron chelators produced by bacteria) is a promising strategy able to considerably increase the efficacy of drugs. Such a Trojan horse strategy can also extend activity of specific Gram-positive antibiotics to Gram-negative bacteria.
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