Learning health systems, clinical equipoise and the ethics of response adaptive randomisation

PIPELINEs: Creating Comparable Clinical Knowledge Efficiently by Linking Trial Platforms

(2016) MR Trusheim et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The pragmatic clinical trial in a learning health care system

(2016) Roger J Lewis   Clinical Trials

A Bayesian response-adaptive trial in tuberculosis: The endTB trial

(2016) Matteo Cellamare et al.   Clinical Trials

Efficiencies of platform clinical trials: A vision of the future

(2016) Benjamin R Saville et al.   Clinical Trials

I-SPY 2 — A Glimpse of the Future of Phase 2 Drug Development?

(2016) David Harrington et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ethical Considerations in Adaptive Design Clinical Trials

(2016) Thomas Laage et al.   Therapeutic Innovation & Regulatory Science

Statistical controversies in clinical research: scientific and ethical problems with adaptive randomization in comparative clinical trials

(2015) P. Thall et al.   ANNALS OF ONCOLOGY

Are outcome-adaptive allocation trials ethical?

(2015) Spencer Phillips Hey et al.   Clinical Trials

Ethical Considerations for Outcome-adaptive Trial Designs: A Clinical Researcher's Perspective

(2014) Scott Brian Saxman   BIOETHICS

Worth Adapting? Revisiting the Usefulness of Outcome-Adaptive Randomization

(2012) J. J. Lee et al.   CLINICAL CANCER RESEARCH

Adaptive Clinical Trials

(2012) William J. Meurer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Predicting Harms and Benefits in Translational Trials: Ethics, Evidence, and Uncertainty

(2011) Jonathan Kimmelman et al.   PLOS MEDICINE

Adaptive Clinical Trials: The Promise and the Caution

(2010) Donald A. Berry   JOURNAL OF CLINICAL ONCOLOGY

Coherent choice functions under uncertainty

(2009) Teddy Seidenfeld et al.   SYNTHESE