Article
Endocrinology & Metabolism
Wei Chen, Jia Lu, Leona Plum-Moerschel, Grit Andersen, Eric Zijlstra, Anshun He, Tian Xie, Longling Li, Chunyue Hao, Zhongru Gan, Tim Heise
Summary: Based on three phase 1 trials, it is concluded that GL-Asp, GL-Lis, and GL-Gla show bioequivalence to the respective reference products from the European Union and the United States in terms of pharmacokinetics and pharmacodynamics, with similar safety profiles.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sergio Vencio, Rafael Caiado-Vencio, Leonardo Ferreira Caixeta, Malgorzata Masierek, Wojciech Mlynarski, Jozef Drzewoski, Justin M. Gregory
Summary: This study compared the pharmacokinetic and pharmacodynamic effects of a new insulin produced by Bioton S.A. with Humulin R produced by Eli Lilly. The results showed that both insulins are bioequivalent for treating type 1 diabetes patients.
DIABETES OBESITY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Mohammad Hassan Sohouli, Ghazaleh Eslamian, Nasser Malekpour Alamdari, Maryam Abbasi, Sepideh Fazeli Taherian, Diba Behtaj, Hamid Zand
Summary: The study, conducted on 40 obese adults undergoing bariatric surgery, showed that intervention with NAC for 4 weeks reduced senescence markers and expression of certain genes in visceral adipose tissue. The results also demonstrated the potential beneficial effects of NAC on reducing inflammatory factors and improving insulin resistance.
FRONTIERS IN NUTRITION
(2023)
Review
Infectious Diseases
Cornelia B. Landersdorfer, Amanda Gwee, Roger L. Nation
Summary: Traditionally, ongoing i.v. antibiotic therapy has been believed to be superior to early i.v. to oral switch for severe infections. However, this belief may not be based on robust data and contemporary clinical studies. This review examines the rationale for an early switch and discusses barriers and perceptions related to this practice.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Endocrinology & Metabolism
Qi Pan, Xiaoxia Wang, Wenjia Li, Xiaofeng Chen, Yulei Zhuang, Qinghong Zhou, Yuhui Huang, Yijie Zhou, Li Lan, Zhijie Wang, Wenjia Wang, Juan Hong, Wei-Hua Hao, Yu-Tsai Yang, Lixin Guo
Summary: This study aimed to verify whether the oral insulin N11005 is used as a prandial insulin by comparing its pharmacokinetics (PK), pharmacodynamics (PD), and safety profiles with a short-acting biosynthetic human insulin (Novolin R). A total of 12 healthy Chinese male subjects were enrolled in the study, and the results showed that N11005 has similar PD characteristics to prandial insulins, with a faster onset of action and comparable duration of action to the reference insulin. The study also demonstrated the safety and tolerability of N11005.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yidan Xu, Huiqiu Zhu, Weiwei Li, Danxia Chen, Ying Xu, Aimin Xu, Dewei Ye
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a close link to obesity and related metabolic disorders. Adipokines produced by hypertrophic adipocytes in obesity play crucial roles in regulating glucose and lipid metabolism. Adipokine-targeted drugs may provide new therapeutic strategies for PCOS.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Vinita Singh, Theresa W. Gillespie, Olabisi Lane, Boris Spektor, Ali John Zarrabi, Katherine Egan, Kimberly Curseen, Maya Tsvetkova, Jan H. Beumer, Roman Sniecinski, Jack W. Shteamer, Jeffery Switchenko, R. Donald Harvey
Summary: The objective of this study was to evaluate the safety and pharmacology of intranasal ketamine for uncontrolled cancer-related pain. A total of 10 patients participated in a dose escalation clinical trial and received increasing doses of ketamine. The results showed that all doses provided significant pain relief for intractable cancer-related pain and were well tolerated.
Article
Endocrinology & Metabolism
Tim Heise, Jenny Chien, John M. Beals, Charles Benson, Oliver Klein, Julie S. Moyers, Axel Haupt, Edward John Pratt
Summary: This study investigated the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of basal insulin Fc (BIF) in both healthy participants and people with type 2 diabetes (T2D). The results showed that BIF was well tolerated and had a sustained, dose-dependent decrease in fasting blood glucose. The once-weekly dosing of BIF showed minimal variation in exposure. Overall, BIF has the potential to be developed as a weekly basal insulin in people with diabetes. Rating: 8/10.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Kirsten M. Wright, Melissa Bollen, Jason David, Alex B. Speers, Mikah S. Brandes, Nora E. Gray, Armando Alcazar Magana, Christine McClure, Jan F. Stevens, Claudia S. Maier, Joseph F. Quinn, Amala Soumyanath
Summary: This randomized, double-blind, crossover Phase I trial investigated the oral bioavailability and pharmacokinetics of Centella asiatica aqueous extract product (CAP) in mildly demented older adults. The study showed that the active compounds of CAP had good oral bioavailability and temporal effects on NRF2 gene expression.
Article
Biochemistry & Molecular Biology
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Bluher, Andre Kleinridders
Summary: The intake of high-fat diets leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium can protect against the development of diet-induced insulin resistance. However, selenium might not be able to attenuate insulin resistance in the presence of obesity.
Article
Nutrition & Dietetics
Maria Luisa Ojeda, Fatima Nogales, Olimpia Carreras, Eloisa Pajuelo, Maria Del Carmen Gallego-Lopez, Ines Romero-Herrera, Belen Begines, Jorge Moreno-Fernandez, Javier Diaz-Castro, Ana Alcudia
Summary: This study investigates the effects of low-dose selenite and Se nanoparticles on adipose tissue deposition and insulin secretion in adolescent rats. The results show that low selenite supplementation promotes adipogenesis, while Se nanoparticle administration prevents fat depots and inflammation.
Article
Endocrinology & Metabolism
Irving L. M. H. Aye, Fredrick J. Rosario, Anita Kramer, Oddrun Kristiansen, Trond M. Michelsen, Theresa L. Powell, Thomas Jansson
Summary: Obesity in pregnancy is associated with adipose tissue inflammation, endoplasmic reticulum stress, insulin resistance, increased adiponectin ubiquitination, and decreased total abundance of adiponectin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Infectious Diseases
Alba Calvo, Esther Moreno, Irati Aldalur, Carmen Sanmartin, Esther Larrea, Elena Gonzalez-Penas, Juan Manuel Irache, Socorro Espuelas
Summary: This study evaluated the efficacy and safety of a topical berberine cream in BALB/c mice infected with Leishmania major parasites. The results showed that the cream was able to reduce lesion size, decrease parasite load, and promote wound healing. However, the relationship between drug plasma levels and in vivo effect was unclear.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Nutrition & Dietetics
Eva Hassler, Gunter Almer, Gernot Reishofer, Hannes Deutschmann, Wilfried Renner, Markus Herrmann, Stefan Leber, Alexander Staszewski, Felix Gunzer, Harald Mangge
Summary: This study investigates the association between osteocalcin levels and the distribution of subcutaneous and intermuscular adipose tissue of the mid-thigh, as well as the impact of different training methods on osteocalcin levels. The results show a negative correlation between osteocalcin and the distribution of adipose tissue, as well as muscle area, in the mid-thigh. Additionally, osteocalcin is negatively related to serum insulin. These findings provide further insights into the role of osteocalcin in glucose metabolism.
Review
Medicine, General & Internal
Ivana Budic, Tatjana Jevtovic Stoimenov, Dimitrije Pavlovic, Vesna Marjanovic, Ivona Djordjevic, Marija Stevic, Dusica Simic
Summary: Individual variability in response to anesthesia drugs is common and influenced by genetic and environmental factors. Propofol, the most common intravenous anesthetic, can be affected by genetic factors such as gene polymorphisms. However, there is a need for further research on multiple pathways to understand the individual differences in propofol pharmacokinetics and pharmacodynamics.
FRONTIERS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Anna Sophia Posawetz, Christian Trummer, Marlene Pandis, Felix Aberer, Thomas R. Pieber, Barbara Obermayer-Pietsch, Stefan Pilz, Verena Theiler-Schwetz
Summary: This study compared body composition, glucose, and lipid metabolism parameters between untreated prolactinoma patients and controls, as well as changes after cabergoline therapy initiation. Prolactinoma patients had higher BMI and fat mass, elevated LDL, and decreased HDL levels. Cabergoline treatment significantly reduced total and LDL cholesterol levels, particularly in men.
BMC ENDOCRINE DISORDERS
(2021)
Article
Cell Biology
Sabrina Schroeder, Sebastian J. Hofer, Andreas Zimmermann, Raimund Pechlaner, Christopher Dammbrueck, Tobias Pendl, G. Mark Marcello, Viktoria Pogatschnigg, Martina Bergmann, Melanie Mueller, Verena Gschiel, Selena Ristic, Jelena Tadic, Keiko Iwata, Gesa Richter, Aitak Farzi, Muammer Uecal, Ute Schaefer, Michael Poglitsch, Philipp Royer, Ronald Mekis, Marlene Agreiter, Regine C. Toelle, Peter Sotonyi, Johann Willeit, Barbara Mairhofer, Helga Niederkofler, Irmgard Pallhuber, Gregorio Rungger, Herbert Tilg, Michaela Defrancesco, Josef Marksteiner, Frank Sinner, Christoph Magnes, Thomas R. Pieber, Peter Holzer, Guido Kroemer, Didac Carmona-Gutierrez, Luca Scorrano, Joem Dengjel, Tobias Madl, Simon Sedej, Stephan J. Sigrist, Bence Racz, Stefan Kiechl, Tobias Eisenberg, Frank Madeo
Summary: Dietary spermidine has been shown to enhance cognition by affecting mitochondrial and autophagic function in aged mice and fruit flies. These findings suggest the potential role of dietary spermidine in improving cognitive function.
Article
Endocrinology & Metabolism
Werner Regittnig, Mathias Tschaikner, Alexandru-Cristian Tuca, Amra Simic, Juergen Feiel, Roland Schaller-Ammann, Alexander H. Licht, Miro Jungklaus, Thomas R. Pieber
Summary: The study revealed that insulin leads to a progressive increase in the resistance of subcutaneous tissue to fluid introduction, which has significant implications for the future design of insulin pumps and infusion sets.
DIABETES OBESITY & METABOLISM
(2022)
Letter
Endocrinology & Metabolism
Thomas R. Pieber, Harpreet S. Bajaj, Simon R. Heller, Ting Jia, Kamlesh Khunti, David C. Klonoff, Steen Ladelund, Lawrence A. Leiter, Lily Wagner, Athena Philis-Tsimikas
DIABETES OBESITY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Natascha Schweighofer, Caterina Colantonio, Christoph W. Haudum, Barbara Hutz, Ewald Kolesnik, Ines Mursic, Stefan Pilz, Albrecht Schmidt, Vanessa Stadlbauer, Andreas Zirlik, Thomas R. Pieber, Nicolas Verheyen, Barbara Obermayer-Pietsch
Summary: Sarcopenia is associated with increased risks of falls, osteoporosis, and mortality. However, there is no consensus on the gold standard DXA index for determining muscle mass in the diagnosis of sarcopenia. This study aimed to evaluate the prevalence, agreement, and reliability of sarcopenia diagnosis using various DXA-derived muscle mass indices, and examine the effects of different parameters, adjustments, and cut-off values on these outcomes. The results showed significant variation in sarcopenia prevalence depending on the index and cut-off values used. Height-adjusted parameters exhibited higher agreement in diagnosis, while unadjusted and adjusted indices showed lower agreement. The investigated indices demonstrated comparable reliability in follow-up examinations.
Article
Genetics & Heredity
Olivia Trummer, Ines Foessl, Natascha Schweighofer, Edi Arifi, Christoph W. Haudum, Sharmaine Reintar, Stefan Pilz, Verena Theiler-Schwetz, Christian Trummer, Andreas Zirlik, Albrecht Schmidt, Caterina Colantonio, Ewald Kolesnik, Nicolas Verheyen, Thomas R. Pieber, Barbara Obermayer-Pietsch
Summary: The aim of this study was to assess the differential expression of 9 selected miRNAs related to immunological functions between patients with Hashimoto's thyroiditis (HT) and healthy controls. The results showed that miR21-5p, miR-22-3p, miR-22-5p, miR-142-3p, miR-146a-5p, miR-301-3p, and miR-451 were significantly upregulated in HT patients and altered expressions of miR-22-5p and miR-142-3p were associated with higher levels of thyroid antibodies.
Letter
Endocrinology & Metabolism
Thomas R. Pieber, Ronnie Aronson, Mark P. Christiansen, Bruce Bode, Khaled Junaidi, Valentina Conoscenti
DIABETES OBESITY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Felix Aberer, Thomas R. Pieber, Max L. Eckstein, Harald Sourij, Othmar Moser
Summary: This narrative review examined clinical trials investigating glucose-lowering agents as an adjunct to insulin treatment in individuals with Type 1 diabetes. The results showed that several adjunct agents demonstrated improvements in HbA1c, reductions in hypoglycemia risk, lower insulin requirements, and positive effects on cardiovascular risk factors.
Article
Biochemistry & Molecular Biology
Martina Brunner, Othmar Moser, Reingard Raml, Maximilian Haberlander, Beate Boulgaropoulos, Barbara Obermayer-Pietsch, Eva Svehlikova, Thomas R. Pieber, Harald Sourij
Summary: Methods for glucagon analysis in the past were not specific and had a narrow sensitivity range, leading to inaccurate results. Newer methods have shown that actual glucagon levels are lower than previously thought. This study compared glucagon levels in healthy individuals and diabetes patients using two different methods and found that the choice of method can significantly affect the results.
Article
Endocrinology & Metabolism
Simon Heller, Tadej Battelino, Timothy S. Bailey, Thomas R. Pieber, Ulrike Hoevelmann, Leona Plum-Moerschel, Anita E. Melgaard, Ronnie Aronson, Linda A. DiMeglio, Thue Johansen, Thomas Danne
Summary: This study analyzed the safety and efficacy of dasiglucagon, a glucagon analogue, in treating severe hypoglycemia in patients with type 1 diabetes. The results showed that dasiglucagon had a similar safety profile as reconstituted glucagon and was more effective in glucose recovery compared to placebo.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Max Schuller, Monika Oberhuber, Barbara Prietl, Elmar Zugner, Eva-Maria Prugger, Christoph Magnes, Alexander H. Kirsch, Sabine Schmaldienst, Thomas Pieber, Marianne Brodmann, Alexander R. Rosenkranz, Philipp Eller, Kathrin Eller
Summary: Coronavirus disease 2019 (COVID-19)-induced metabolic alterations can serve as prognostic biomarkers and have potential therapeutic implications. The study examined the metabolic impact of COVID-19 in hemodialysis patients and found that the effects were less significant compared to non-hemodialysis patients. Elevated kynurenine levels and lipid dysregulation were identified as potential universal biomarkers for moderate and severe COVID-19, independent of kidney function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Norbert J. Tripolt, Sebastian J. Hofer, Peter N. Pferschy, Faisal Aziz, Sylvere Durand, Fanny Aprahamian, Nitharsshini Nirmalathasan, Mara Waltenstorfer, Tobias Eisenberg, Anna M. A. Obermayer, Regina Riedl, Harald Kojzar, Othmar Moser, Caren Sourij, Heiko Bugger, Abderrahim Oulhaj, Thomas R. Pieber, Matthias Zanker, Guido Kroemer, Frank Madeo, Harald Sourij
Summary: The effects of fasting on glucose metabolism were examined in non-obese and obese participants and people with type 2 diabetes. The results showed that after 36 hours of fasting, glucose, insulin, and C-peptide levels were significantly decreased. Non-obese participants had higher glucose levels but lower insulin levels after 36 hours of fasting, while no significant differences were observed in obese participants or people with diabetes. Insulin sensitivity improved in all cohorts after 36 hours of fasting. Metabolomics analysis revealed subtle baseline differences and attenuated metabolic response to fasting in obese participants and people with diabetes.
Article
Nutrition & Dietetics
Natascha Schweighofer, Christoph W. W. Haudum, Olivia Trummer, Alice Lind, Ewald Kolesnik, Ines Mursic, Albrecht Schmidt, Daniel Scherr, Andreas Zirlik, Thomas R. R. Pieber, Nicolas Verheyen, Barbara Obermayer-Pietsch
Summary: Sarcopenia is associated with increased risk of falls, osteoporosis, and mortality, and poses a growing problem for healthcare systems. This study finds that dp-ucMGP may be a good biomarker candidate for sarcopenia characterization, as it correlates with sarcopenia parameters such as gait speed, appendicular skeletal muscle mass, and appendicular skeletal muscle mass index.
Article
Endocrinology & Metabolism
Thomas R. Pieber, Kristine N. Arfelt, Roman Cailleteau, Marlies Hart, Soumitra Kar, Ines Mursic, Eva Svehlikova, Martina Urschitz, Hanne Haahr
Summary: This study compared the frequency and recovery of hypoglycemia after double or triple doses of once-weekly insulin icodec and once-daily insulin glargine U100. The study also compared the symptomatic and hormonal responses to hypoglycemia between the two treatments. The results showed that there was no significant difference in the risk of hypoglycemia between icodec and glargine U100, but icodec elicited slightly higher symptomatic and endocrine responses during hypoglycemia compared to glargine U100.
Article
Medicine, General & Internal
Veronika Tandl, Christoph Haudum, Katharina Eberhard, Barbara Hutz, Ines Foessl, Ewald Kolesnik, Andreas Zirlik, Dirk von Lewinski, Daniel Scherr, Nicolas Verheyen, Thomas Pieber, Barbara Obermayer-Pietsch
Summary: Serum concentrations of AMH decrease with increasing BMI, possibly due to either an adverse effect of adiposity on AMH production or dilution from greater blood volume. We investigated the relationships between AMH levels and body composition parameters in adult males and found that body weight, lean mass, and body surface area were better predictors of AMH than measures of adiposity. Since both lean mass and body surface area correlate with plasma volume better than adipose tissue, we conclude that hemodilution of AMH does occur in adult males and should be considered for normalization in future studies.
JOURNAL OF CLINICAL MEDICINE
(2023)