Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor

Greater Dose-Ranging Effects on A1C Levels Than on Glucosuria With LX4211, a Dual Inhibitor of SGLT1 and SGLT2, in Patients With Type 2 Diabetes on Metformin Monotherapy

(2014) Julio Rosenstock et al.   DIABETES CARE

Effects of the Once-Weekly Glucagon-Like Peptide-1 Receptor Agonist Dulaglutide on Ambulatory Blood Pressure and Heart Rate in Patients With Type 2 Diabetes Mellitus

(2014) Keith C. Ferdinand et al.   HYPERTENSION

Comparison of GLP-1 Analogues versus Sitagliptin in the Management of Type 2 Diabetes: Systematic Review and Meta-Analysis of Head-to-Head Studies

(2014) Tiansheng Wang et al.   PLoS One

Study Design and Rationale of a Dose-Ranging Trial of LX4211, a Dual Inhibitor of SGLT1 and SGLT2, in Type 2 Diabetes Inadequately Controlled on Metformin Monotherapy

(2013) Pablo Lapuerta et al.   CLINICAL CARDIOLOGY

Effects of LX4211, a Dual SGLT1/SGLT2 Inhibitor, Plus Sitagliptin on Postprandial Active GLP-1 and Glycemic Control in Type 2 Diabetes

(2013) Brian Zambrowicz et al.   CLINICAL THERAPEUTICS

Effects of LX4211, a Dual Sodium-Dependent Glucose Cotransporters 1 and 2 Inhibitor, on Postprandial Glucose, Insulin, Glucagon-like Peptide 1, and Peptide Tyrosine Tyrosine in a Dose-Timing Study in Healthy Subjects

(2013) Brian Zambrowicz et al.   CLINICAL THERAPEUTICS

Type 1 diabetes, metabolic syndrome and cardiovascular risk

(2013) Juan J. Chillarón et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

(2013) Minsuk Kim et al.   NATURE MEDICINE

Alogliptin after Acute Coronary Syndrome in Patients with Type 2 Diabetes

(2013) William B. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus

(2013) Benjamin M. Scirica et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved glycemic control in mice lacking Sglt1 and Sglt2

(2012) David R. Powell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial

(2012) B Zambrowicz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Biology of Human Sodium Glucose Transporters

(2011) Ernest M. Wright et al.   PHYSIOLOGICAL REVIEWS

Acute Complications and Drug Misuse Are Important Causes of Death for Children and Young Adults With Type 1 Diabetes: Results from the Yorkshire Register of Diabetes in Children and Young Adults

(2008) R. G. Feltbower et al.   DIABETES CARE