Review
Biochemistry & Molecular Biology
Constanze Schanbacher, Heike M. M. Hermanns, Kristina Lorenz, Harald Wajant, Isabell Lang
Summary: This review provides a brief summary of the biology of CTRPs and focuses on the structure, receptors, and major signaling pathways of CTRPs. Studies on CTRP knockout mice and CTRP transgenic mice support the anti-inflammatory and insulin-sensitizing effects of CTRPs in autoimmune diseases, obesity, atherosclerosis, and cardiac dysfunction. CTRPs can form different homo- and heterotypic complexes with various activities, and the activation of their receptors and downstream signaling pathways are still largely unknown. The limited knowledge of CTRP redundancy and signal transduction hampers the translational usage of CTRPs as therapeutic targets.
Article
Medicine, Research & Experimental
Yanesko Fernandes Bella, Carlos Rocha Oliveira, Jose Roberto Mateus-Silva, Maysa Alves Rodrigues Brandao-Rangel, Anamei Silva-Reis, Juliana de Melo Batista Santos, Regiane Albertini, Rodrigo Alvaro Brandao Lopes-Martins, Luis Vicente Franco de Oliveira, Rodolfo P. Vieira
Summary: In this study, the effects of Immunity-6TM, a phytocomplex, on leukemia cells were investigated. The results showed that Immunity-6TM can inhibit the release of proinflammatory cytokines and induce the release of anti-inflammatory cytokines, suggesting its potential as an adjuvant in leukemia treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Song Yan, Jie Dong, Chenxi Qian, Shuqiang Chen, Qian Xu, Hui Lei, Xiaohong Wang
Summary: Cellular metabolism affects the function of decidual NK cells, with glycolysis blockage enhancing VEGF-A production but restraining proliferation, and inhibition of glycolysis or oxidative phosphorylation decreasing secretion of IFN-γ and TNF-α. Furthermore, disruption of metabolic processes has minimal effects on secretion and degranulation of dNK cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tomonori Kaifu, Takumi Maruhashi, Soo-Hyun Chung, Kenji Shimizu, Akira Nakamura, Yoichiro Iwakura
Summary: Dendritic cell immunoreceptor (DCIR) is an inhibitory C-type lectin receptor that negatively regulates the immune system and bone metabolism. Previous research has shown that DCIR deficiency enhances osteoclastogenesis and antigen presentation by dendritic cells, and that the interaction between asialo-biantennary N-glycan (NA2) and DCIR suppresses osteoclastogenesis. In this study, the researchers found that DCIR regulates osteoclastogenesis by downregulating M-CSF and RANKL signaling, and that DCIR-mediated signaling may control the expression of glycosylation enzymes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yoichi Takimoto, Po-sung Chu, Nobuhiro Nakamoto, Yuya Hagihara, Yohei Mikami, Kentar Miyamoto, Rei Morikawa, Toshiaki Teratani, Nobuhito Taniki, Sota Fujimori, Takahiro Suzuki, Yuzo Koda, Rino Ishihara, Masataka Ichikawa, Akira Honda, Takanori Kanai
Summary: The resolution process of liver fibrosis after liver injury withdrawal is still not fully understood. In this study, the pro-fibrogenic role of Toll-like receptor 4 (TLR4) signaling in tissue fibroblasts was explored. Interestingly, pharmacological inhibition of TLR4 signaling in vivo in two murine models resulted in a significant delay in fibrosis resolution. Single-cell transcriptome analysis revealed a cluster of Tlr4-expressing myeloid cells that played a restorative role in the resolution process. Further investigation suggested a microbiome-dependent nature of the delayed resolution after gut sterilization. These findings provide insights into the pro-fibrolytic role of myeloid TLR4 signaling and potential targets for anti-fibrotic therapy.
Article
Medicine, Research & Experimental
Wei Ruan, Jiwen Li, Seungwon Choi, Xinxin Ma, Yafen Liang, Ragini Nair, Xiaoyi Yuan, Tingting W. Mills, Holger K. Eltzschig
Summary: Previous studies show that targeting equilibrative nucleoside transporters (ENTs) can increase cardiac adenosine signaling and provide cardioprotection against myocardial ischemia and reperfusion injury (IRI). In mice, the ENT inhibitor dipyridamole attenuated myocardial injury caused by IRI. Specifically, deletion of Ent1 in myocytes resulted in smaller infarct sizes. Measurements of cardiac adenosine levels confirmed the sustained elevation of adenosine after targeting ENTs during reperfusion. Additionally, Adora2b signaling on myeloid-inflammatory cells played a role in the cardioprotection provided by ENT inhibition.
Article
Immunology
Xiqin Tong, Fuling Zhou
Summary: This study analyzed the mutation status of 31 mitochondrial metabolism-related genes in AML patients and constructed a prognosis model based on five genes, which accurately distinguished high-risk and low-risk patients. It was also found that high-risk patients had more immune-cell infiltration and poor immunotherapy response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yiyun Geng, Jingyuan Xu, Weichao Li, Qing Li, Chenjinxin Shen, Zhangshuang Deng, Yiqing Zhou
Summary: We present a quantitative chemoproteomic approach using a clickable photoreactive probe to globally profile celastrol targets, providing a better understanding of celastrol's mode of action.
CHEMICAL COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Xin He, Xinyu Gao, Weidong Xie
Summary: This article reviews the interaction between skin metabolism and aging, covering glucose, protein, and lipid metabolism, and explores relevant strategies for regulating skin metabolism. It is found that skin aging affects the metabolism of glucose, protein, and lipids, and the metabolism of these substances also affects the process of skin aging. Regulating specific metabolic disorders in the skin is an important anti-aging strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yuling Chen, Yuanchun Ye, Pierre-Louis Krauss, Pelle Loewe, Moritz Pfeiffenberger, Alexandra Damerau, Lisa Ehlers, Thomas Buttgereit, Paula Hoff, Frank Buttgereit, Timo Gaber
Summary: Metabolic reprogramming in human memory Th cells during aging increases ROS production and leads to increased expression of proinflammatory cytokines, which may contribute to the pathogenesis of inflammaging.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Benedicte Sjo Tislevoll, Monica Hellesoy, Oda Helen Eck Fagerholt, Stein-Erik Gullaksen, Aashish Srivastava, Even Birkeland, Dimitrios Kleftogiannis, Pilar Ayuda-Duran, Laure Piechaczyk, Dagim Shiferaw Tadele, Jorn Skavland, Baliakas Panagiotis, Randi Hovland, Vibeke Andresen, Ole Morten Seternes, Tor Henrik Anderson Tvedt, Nima Aghaeepour, Sonia Gavasso, Kimmo Porkka, Inge Jonassen, Yngvar Floisand, Jorrit Enserink, Nello Blaser, Bjorn Tore Gjertsen
Summary: In this study, the initial signaling response to standard induction chemotherapy in 32 acute myeloid leukemia (AML) patients was investigated using 36-dimensional mass cytometry. The reduction of extracellular-signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK) phosphorylation in the myeloid cell compartment 24 h post-chemotherapy was found to be a significant predictor of patient 5-year overall survival in this cohort. This study demonstrates the value of mass cytometry in early response evaluation in AML and highlights the potential of functional signaling analyses in precision oncology diagnostics.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Shasha Yin, Liu Liu, Lauren E. Ball, Yalong Wang, Mark T. Bedford, Stephen A. Duncan, Haizhen Wang, Wenjian Gan
Summary: This study identifies protein arginine methyltransferase 1 (PRMT1) as a critical regulator of the GATOR2 complex, which activates the mTORC1 pathway for tumor growth. Inhibition of the CDK5-PRMT1-WDR24 axis suppresses HCC cell proliferation and tumor growth. High PRMT1 protein expression is associated with elevated mTORC1 signaling in patients with HCC.
Article
Cell Biology
Hemn Mohammadpour, Cameron R. MacDonald, Philip L. McCarthy, Scott Abrams, Elizabeth A. Repasky
Summary: The study reveals that beta 2 adrenergic receptor (beta 2-AR) expression on MDSCs increases with tumor growth, and the beta 2-AR stress pathway drives the immune suppressive activity of MDSCs by altering their metabolism. The signaling triggered by beta 2-AR stress is an important physiological regulator of key metabolic pathways in MDSCs, driving their immunosuppressive function.
Article
Cell Biology
Sofya A. Polyanskaya, Rosamaria Y. Moreno, Bin Lu, Ruopeng Feng, Yu Yao, Seema Irani, Olaf Klingbeil, Zhaolin Yang, Yiliang Wei, Osama E. Demerdash, Lukas A. Benjamin, Mitchell J. Weiss, Yan Jessie Zhang, Christopher R. Vakoc
Summary: In acute myeloid leukemia, the phosphatase SCP4 forms a complex with the kinase paralogs STK35 and PDIK1L to promote unlimited proliferation potential, as well as amino acid biosynthesis and transport.
Article
Oncology
Hoibin Jeong, Sehui Kim, Beom-Ju Hong, Chan-Ju Lee, Young-Eun Kim, Seoyeon Bok, Jung-Min Oh, Seung-Hee Gwak, Min Young Yoo, Min Sun Lee, Seock-Jin Chung, Joan Defrene, Philippe Tessier, Martin Pelletier, Hyeongrin Jeon, Tae-Young Roh, Bumju Kim, Ki Hean Kim, Ji Hyeon Ju, Sungjee Kim, Yoon-Jin Lee, Dong-Wan Kim, Il Han Kim, Hak Jae Kim, Jong-Wan Park, Yun-Sang Lee, Jae Sung Lee, Gi Jeong Cheon, Irving L. Weissman, Doo Hyun Chung, Yoon Kyung Jeon, G-One Ahn
Review
Cell Biology
Anne-Laure Chetaille Nezondet, Patrice E. Poubelle, Martin Pelletier
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Environmental Sciences
Cindy Peillex, Anthony Kerever, Asmaa Lachhab, Martin Pelletier
Summary: The study found that BPA, BPS, and their metabolites can affect the energy metabolism and antimicrobial responses of neutrophils. While these chemicals do not impact cell cytotoxicity, phagocytosis, or superoxide anion production, they significantly reduce CXCL8/IL-8 production. BPS and the glucuronidated metabolites of BPA and BPS were found to have higher endocrine-disrupting potential than BPA.
ENVIRONMENTAL RESEARCH
(2021)
Review
Environmental Sciences
Eve Pellerin, Christophe Caneparo, Stephane Chabaud, Stephane Bolduc, Martin Pelletier
Summary: Bisphenols are endocrine-disrupting chemicals that have been linked to cancer progression, particularly prostate cancer. They are found in the urine of the vast majority of the population and could potentially impact the normal physiology and cancer development of the bladder.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Aurelie Lacouture, Camille Lafront, Cindy Peillex, Martin Pelletier, Etienne Audet-Walsh
Summary: EDCs can modulate the functions of sex-steroid receptors, indirectly impact androgen and estrogen pathways, and have multiple cellular targets beyond sex-steroid receptors, leading to various potential effects. This article reviews the association between prostate cancer and the endocrine-disrupting functions of four prominent EDC families, suggesting common guidelines for studying EDCs in the context of endocrine diseases.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Myriam Vaillancourt, Philippe Desaulniers, Guillaume Pare, Nathalie Page, Asmaa Lachhab, Anthony Kerever, Anne-Sophie Julien, Nathalie Amiable, Martin Pelletier, Philippe A. Tessier, Louis Bessette, Laetitia Michou, Paul R. Fortin, Maria J. Fernandes
Summary: The myeloid inhibitory receptor CLEC12A negatively regulates inflammation and its reduced expression is associated with increased inflammation in rheumatoid arthritis. In patients with reduced CLEC12A expression, there is an increase in disease activity index. Furthermore, CLEC12A expression correlates positively with various cytokines in the context of rheumatoid arthritis.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Jean-Claude Tardif, Nadia Bouabdallaoui, Philippe L. L'Allier, Daniel Gaudet, Binita Shah, Michael H. Pillinger, Jose Lopez-Sendon, Protasio da Luz, Lucie Verret, Sylvia Audet, Jocelyn Dupuis, Andre Denault, Martin Pelletier, Philippe A. Tessier, Sarah Samson, Denis Fortin, Jean-Daniel Tardif, David Busseuil, Elisabeth Goulet, Chantal Lacoste, Anick Dubois, Avni Y. Joshi, David D. Waters, Priscilla Hsue, Norman E. Lepor, Frederic Lesage, Nicolas Sainturet, Eve Roy-Clavel, Zohar Bassevitch, Andreas Orfanos, Gabriela Stamatescu, Jean C. Gregoire, Lambert Busque, Christian Lavallee, Pierre-Olivier Hetu, Jean-Sebastien Paquette, Spyridon G. Deftereos, Sylvie Levesque, Marieve Cossette, Anna Nozza, Malorie Chabot-Blanchet, Marie-Pierre Dube, Marie-Claude Guertin, Guy Boivin
Summary: The study aimed to investigate the effect of colchicine on the composite of COVID-19-related death or hospital admission. Among patients with PCR-confirmed COVID-19, colchicine led to a lower rate of the composite of death or hospital admission than placebo.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Oncology
Eve Pellerin, Stephane Chabaud, Frederic Pouliot, Martin Pelletier, Stephane Bolduc
Summary: Our study reveals that bisphenol A could potentially impact the progression of bladder cancer by altering the energy metabolism of stromal cells, promoting cancer invasion. This suggests that endocrine disruptors like bisphenol A could have a role in promoting cancer development by affecting stromal cell metabolism.
Article
Biochemistry & Molecular Biology
Eve Pellerin, Felix-Antoine Pellerin, Stephane Chabaud, Frederic Pouliot, Martin Pelletier, Stephane Bolduc
Summary: The study reveals that glucuronidated BPs have different effects on normal urothelial cells and bladder cancer cells. They decrease the activity of normal cells but increase the bioenergetics and activity of cancer cells. This suggests that the ubiquitous presence of BP metabolites in urine could promote the progression of bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Eve Pellerin, Felix-Antoine Pellerin, Stephane Chabaud, Frederic Pouliot, Stephane Bolduc, Martin Pelletier
Summary: This study evaluated the effects of BPA and BPS on the bioenergetics, proliferation, and migration of bladder urothelial cells and bladder cancer cells. The results showed that chronic exposure to BPA and BPS decreased energy metabolism in urothelial cells while increasing it in bladder cancer cells. This suggests that BPA and BPS exposure could promote bladder cancer development.
Article
Environmental Sciences
Aurelie Lacouture, Yann Breton, Cindy Weidmann, Sarah-Maude Goulet, Lucas Germain, Martin Pelletier, Etienne Audet-Walsh
Summary: This study reveals the impact of estrogens and EDCs on mammary epithelial cell metabolism in monolayer and organoid cultures. It demonstrates that EDCs can alter bioenergetic fluxes and interfere with the regulation of estrogen target genes. The sensitivity of mammary organoids to specific EDCs can also be influenced by past pregnancies. Understanding the metabolic effects of EDCs is important for the development and function of the mammary gland.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Hematology
Martin Pelletier, Yann Breton, Isabelle Allaeys, Yann Becker, Tom Benson, Eric Boilard
Summary: The study reveals that extracellular vesicles released by activated platelets contain mitochondria, which can be captured by neutrophils and monocytes, enhancing their mitochondrial function. These external mitochondria may support other metabolic functions through transcellular bioenergetics.
Article
Biotechnology & Applied Microbiology
Felix-Antoine Pellerin, Christophe Caneparo, Eve Pellerin, Stephane Chabaud, Martin Pelletier, Stephane Bolduc
Summary: The necessity of heat inactivation of bovine sera in cell culture laboratories is still debated due to the improved production process. A study comparing nine populations of fibroblasts from three different organs found that overall, serum inactivation did not provide a significant benefit. This suggests that the benefits of heat inactivation may not outweigh the loss of proteins important for cell culture, particularly in the demanding processes of tissue engineering.
BIOENGINEERING-BASEL
(2021)
Article
Oncology
Patrice E. Poubelle, Nathalie Page, Marie-Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier, Martin Pelletier
CLINICAL AND TRANSLATIONAL MEDICINE
(2019)
Article
Multidisciplinary Sciences
Yann Becker, Renee-Claude Loignon, Anne-Sophie Julien, Genevieve Marcoux, Isabelle Allaeys, Tania Levesque, Emmanuelle Rollet-Labelle, Hadrien Benk-Fortin, Nathalie Cloutier, Imene Melki, Lihi Eder, Eric Wagner, Martin Pelletier, Hassan El Hajj, Marie-Eve Tremblay, Clemence Belleannee, Marie-Josee Hebert, Melanie Dieude, Joyce Rauch, Paul R. Fortin, Eric Boilard
SCIENTIFIC REPORTS
(2019)