Article
Medicine, General & Internal
Mohammad Bosaeed, Ahmad Alharbi, Mohammad Hussein, Mohammed Abalkhail, Khizra Sultana, Abrar Musattat, Hajar Alqahtani, Majid Alshamrani, Ebrahim Mahmoud, Adel Alothman, Abdulrahman Alsaedy, Omar Aldibasi, Khalid Alhagan, Abdullah Mohammed Asiri, Sameera AlJohani, Majed Al-Jeraisy, Ahmed Alaskar
Summary: This study aims to evaluate the efficacy of favipiravir on patients with mild COVID-19, with participants randomly assigned to either a therapy group or a control group. The study includes screening, treatment, and follow-up stages, with an anticipated recruitment of 288 subjects per arm. The study is registered on ClinicalTrials.gov and the results will be published in peer-reviewed journals.
Article
Critical Care Medicine
Mahir Karakas, Ibrahim Akin, Christoph Burdelski, Peter Clemmensen, Hanno Grahn, Dominik Jarczak, Mirjam Kessler, Paulus Kirchhof, Ulf Landmesser, Susanne Lezius, Diana Lindner, Alexandre Mebazaa, Axel Nierhaus, Anil Ocak, Wolfgang Rottbauer, Christoph Sinning, Carsten Skurk, Gerold Soeffker, Dirk Westermann, Antonia Zapf, Elvin Zengin, Tanja Zeller, Stefan Kluge
Summary: This study assessed the treatment of adrecizumab, a non-neutralising adrenomedullin antibody, in patients with cardiogenic shock. The results showed that adrecizumab did not reduce the need for cardiovascular organ support or improve survival in these patients.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Medicine, General & Internal
Jun Mitsui, Takashi Matsukawa, Yukari Uemura, Takuya Kawahara, Ayaka Chikada, Kristine Joyce L. Porto, Hiroya Naruse, Masaki Tanaka, Hiroyuki Ishiura, Tatsushi Toda, Haruko Kuzuyama, Mari Hirano, Ikue Wada, Toshio Ga, Takashi Moritoyo, Yuji Takahashi, Hidehiro Mizusawa, Kinya Ishikawa, Takanori Yokota, Satoshi Kuwabara, Nobukatsu Sawamoto, Ryosuke Takahashi, Koji Abe, Tomohiko Ishihara, Osamu Onodera, Dai Matsuse, Ryo Yamasaki, Jun-Ichi Kira, Masahisa Katsuno, Ritsuko Hanajima, Katsuhisa Ogata, Hiroshi Takashima, Masaaki Matsushima, Ichiro Yabe, Hidenao Sasaki, Shoji Tsuji
Summary: Impaired COQ2 variants are associated with familial MSA and the V393A variant is associated with sporadic MSA. This study is a randomized, double-blinded, placebo-controlled phase 2 trial that shows high-dose ubiquinol can significantly slow down the decline of UMSARS part 2 score.
Article
Multidisciplinary Sciences
Motlabur Rahman, Ponkaj K. Datta, Khairul Islam, Mahfuzul Haque, Reaz Mahmud, Uzzwal Mallik, Pratyay Hasan, Manjurul Haque, Imtiaz Faruq, Mohiuddin Sharif, Rifat H. Ratul, Khan Abul Kalam Azad, Titu Miah, Md Mujibur Rahman
Summary: Colchicine, as an anti-inflammatory drug, may have certain benefits in combating cytokine storms caused by COVID-19, but it does not significantly reduce mortality and the need for mechanical ventilation.
Article
Medicine, General & Internal
Jie Wu, Haiyang Jiang, Shikuan Li, Xiuwen Wu, Peige Wang, Robert Sawyer, Jianan Ren
Summary: This study aims to evaluate the role of antianaerobic antibiotics in the treatment of uncomplicated acute appendicitis and address the lack of consensus on the optimal antibiotic regimen for this condition.
Article
Biochemistry & Molecular Biology
Tine L. Dohlmann, Anja B. Kuhlman, Thomas Morville, Maria Dahl, Magnus Asping, Patrick Orlando, Sonia Silvestri, Luca Tiano, Jorn W. Helge, Flemming Dela, Steen Larsen
Summary: This study investigated whether concurrent administration of CoQ10 with statins increases muscle CoQ10 levels and improves mitochondrial function, as well as whether changes in muscle CoQ10 levels correlate with changes in the intensity of myalgia. The results showed that CoQ10 supplementation had no effect on muscle CoQ10 levels or mitochondrial function, and individual changes in muscle CoQ10 levels were not correlated with changes in intensity of myalgia.
Article
Clinical Neurology
Anne Marit Solheim, Aslaug Rudjord Lorentzen, Audun Olav Dahlberg, Heidi Oyen Flemmen, Synne Brune, Kristine Johanne Nordstrom Forselv, Are Hugo Pripp, Margrete Halvorsen Bo, Randi Eikeland, Harald Reiso, Ase Mygland, Unn Ljostad
Summary: This study compared the efficacy and safety of oral doxycycline for 2 and 6 weeks in European Lyme neuroborreliosis (LNB). The results indicated that there were no benefits of doxycycline treatment beyond 2 weeks in European LNB.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Rheumatology
Pascal Richette, Augustin Latourte, Jeremie Sellam, Daniel Wendling, Muriel Piperno, Philippe Goupille, Yves-Marie Pers, Florent Eymard, Sebastien Ottaviani, Paul Ornetti, Rene-Marc Flipo, Bruno Fautrel, Olivier Peyr, Jean Pierre Bertola, Eric Vicaut, Xavier Chevalier
Summary: The study found that tocilizumab was not more effective than placebo in relieving pain in patients with hand osteoarthritis. Apart from the primary endpoint, there were no significant differences in secondary outcomes between the tocilizumab group and the placebo group.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Brad H. Rovin, Y. K. Onno Teng, Ellen M. Ginzler, Cristina Arriens, Dawn J. Caster, Juanita Romero-Diaz, Keisha Gibson, Joshua Kaplan, Laura Lisk, Sandra Navarra, Samir V. Parikh, Simrat Randhawa, Neil Solomons, Robert B. Huizinga
Summary: This study evaluated the efficacy and safety of voclosporin for the treatment of lupus nephritis, showing a superior complete renal response rate with voclosporin in combination with MMF and low-dose steroids compared to MMF and low-dose steroids alone. The safety profile was comparable between the two groups. This finding represents an important advancement in the treatment of patients with active lupus nephritis.
Article
Plant Sciences
Yuanbin Chen, Xiao Gong, Mingjuan Zhou, Yinji Xu, Feiting Fan, Jingmin Xiao, Liangji Liu, Kehua Shi, Suyun Li, Jinsheng Zhuo, Zhibin Chen, Xuhua Yu, Long Fan, Yaolong Chen, Lei Wu, Lin Lin
Summary: Long-term treatment with JPYF II granules is effective in improving quality of life and exercise capacity, reducing the risk of acute exacerbation, and relieving symptoms in patients with moderate to very severe COPD.
Article
Medicine, General & Internal
Anadeijda J. E. M. C. Landman, Marjon A. de Boer, Laura Visser, Tobias A. J. Nijman, Marieke A. C. Hemels, Christiana N. Naaktgeboren, Marijke C. van der Weide, Ben W. Mol, Judith O. E. H. van Laar, Dimitri N. M. Papatsonis, Mireille N. Bekker, Joris van Drongelen, Marielle G. van Pampus, Marieke Sueters, David P. van der Ham, J. Marko Sikkema, Joost J. Zwart, Anjoke J. M. Huisjes, Marloes E. van Huizen, Gunilla Kleiverda, Janine Boon, Maureen T. M. Franssen, Wietske Hermes, Harry Visser, Christianne J. M. de Groot, Martijn A. Oudijk
Summary: The study aimed to evaluate the effectiveness of low-dose aspirin compared to placebo in preventing preterm birth in women with a previous spontaneous preterm birth. The results showed that low-dose aspirin did not significantly reduce the preterm birth rate. However, a modest reduction in preterm birth with aspirin cannot be ruled out. Further research is needed to determine the potential benefits of low-dose aspirin in women with a previous spontaneous preterm birth.
Article
Medicine, General & Internal
Andrew W. Horne, Stephen Tong, Catherine A. Moakes, Lee J. Middleton, W. Colin Duncan, Ben W. Mol, Lucy H. R. Whitaker, Davor Jurkovic, Arri Coomarasamy, Natalie Nunes, Tom Holland, Fiona Clarke, Ann M. Doust, Jane P. Daniels
Summary: This study evaluated whether oral gefitinib in combination with methotrexate is more effective than methotrexate alone in the treatment of tubal ectopic pregnancy. The results showed that oral gefitinib does not offer clinical benefit over methotrexate and increases minor adverse reactions.
Article
Orthopedics
C. R. Davis, C. D. Ruediger, K. A. Dyer, S. Lester, S. W. Graf, F. P. B. Kroon, S. L. Whittle, C. L. Hill
Summary: The study investigated the effects of 1 mg daily colchicine vs. placebo on hand pain and function in older adults with hand osteoarthritis over 12 weeks. It was found that colchicine did not significantly reduce pain, tender and swollen joint count, or increase grip strength in symptomatic hand osteoarthritis. The results do not support the use of colchicine in hand osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Rheumatology
Renaud Felten, Valerie Devauchelle-Pensec, Raphaele Seror, Pierre Duffau, David Saadoun, Eric Hachulla, Hatron Pierre Yves, Carine Salliot, Aleth Perdriger, Jacques Morel, Arsene Mekinian, Olivier Vittecoq, Jean-Marie Berthelot, Emanuelle Dernis, Veronique Le Guern, Philippe Dieude, Claire Larroche, Christophe Richez, Thierry Martin, Charles Zarnitsky, Gilles Blaison, Pierre Kieffer, Francois Maurier, Azeddine Dellal, Stephanie Rist, Emmanuel Andres, Anne Contis, Emmanuel Chatelus, Christelle Sordet, Jean Sibilia, Cecile Arnold, Mira Y. Tawk, Ouafaa Aberkane, Lise Holterbach, Patrice Cacoub, Alain Saraux, Xavier Mariette, Nicolas Meyer, Jacques-Eric Gottenberg
Summary: This study aimed to demonstrate the efficacy of targeting interleukin 6 receptor in patients with primary Sjogren's syndrome-related systemic complications. However, the results showed that over 24 weeks of treatment, tocilizumab did not improve systemic involvement and symptoms in patients with primary Sjogren's syndrome.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Miranda Morton, Nina Wilson, Tara Marie Homer, Laura Simms, Alison Steel, Rebecca Maier, James Wason, Laura Ternent, Alaa Abouhajar, Maria Allen, Richard Joyce, Victoria Hildreth, Rachel Lakey, Svetlana Cherlin, Adam Walker, Graham Devereux, James D. Chalmers, Adam T. Hill, Charles Haworth, John R. Hurst, Anthony De Soyza
Summary: This trial aims to investigate whether inhaled dual bronchodilators can reduce the number of exacerbations in bronchiectasis patients. It is a multicentre, double-blind, randomised controlled trial involving 600 adult patients with confirmed bronchiectasis. The primary outcome is the number of exacerbations requiring antibiotic treatment during a 12-month period.
Letter
Rheumatology
Binita Shah, Aaron Z. Reyes, Kelly A. Hu, Jacob Teperman, Theresa L. Wampler Muskardin, Jean-Claude Tardif, Michael H. Pillinger
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Florence Cote, Guy Boivin, Vilayvong Loungnarath, Annie Ruest, Julie Bestman-Smith, Julie Carbonneau, Marie-Eve Hamelin, Marie-Claude Roy
Summary: This study describes 10 COVID-19 patients with severe symptoms who were treated with tocilizumab and dexamethasone. The duration of isolation, which exceeded 21 days for 7 patients, was correlated with the Ct values of nucleic acid amplification tests, clinical condition, and viral culture results.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yohann Rautureau, Marianne Berlatie, Daniel Rivas, Kurunradeth Uy, Alexandre Blanchette, Geraldine Miquel, Marie-Eve Higgins, Melanie Mecteau, Audrey Nault, Louis Villeneuve, Veronique Lavoie, Gabriel Theberge-Julien, Genevieve Brand, Line Lapointe, Maxime Denis, Camille Rosa, Annik Fortier, Lucie Blondeau, Marie-Claude Guertin, Marie-Pierre Dube, Eric Thorin, Jonathan Ledoux, David Rhainds, Eric Rheaume, Jean-Claude Tardif
Summary: ADCY9 gene plays a role in determining atherosclerotic outcomes in patients and in mice it has been shown to potentiate endothelial function and inhibit atherogenesis. The inactivation of Adcy9 leads to increased cAMP accumulation in response to certain activators and enhances endothelial-dependent vasodilation. Additionally, ADCY9 can regulate endothelial permeability and actin cytoskeleton in response to thrombin, affecting the development of atherosclerosis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Infectious Diseases
Mary-Ann Davies, Erna Morden, Petro Rousseau, Juanita Arendse, Jamy-Lee Bam, Linda Boloko, Keith Cloete, Cheryl Cohen, Nicole Chetty, Pierre Dane, Alexa Heekes, Nei-Yuan Hsiao, Mehreen Hunter, Hannah Hussey, Theuns Jacobs, Waasila Jassat, Saadiq Kariem, Reshma Kassanjee, Inneke Laenen, Sue Le Roux, Richard Lessells, Hassan Mahomed, Deborah Maughan, Graeme Meintjes, Marc Mendelson, Ayanda Mnguni, Melvin Moodley, Katy Murie, Jonathan Naude, Ntobeko A. B. Ntusi, Masudah Paleker, Arifa Parker, David Pienaar, Wolfgang Preiser, Hans Prozesky, Peter Raubenheimer, Liezel Rossouw, Neshaad Schrueder, Barry Smith, Mariette Smith, Wesley Solomon, Greg Symons, Jantjie Taljaard, Sean Wasserman, Robert J. Wilkinson, Milani Wolmarans, Nicole Wolter, Andrew Boulle
Summary: The clinical severity of Omicron BA.4/BA.5 infection was compared to BA.1 and earlier variant infections, and it was found that vaccination and previous infection were protective against disease severity.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Ethnic Studies
Marie-Claude Tremblay, Genevieve Olivier-D'Avignon, Laurence Garceau, Sandro Echaquan, Christopher Fletcher, Anne-Marie Leclerc, Marie-Eve Poitras, Eniko Neashish, Lara Maillet, Jean-Sebastien Paquette
Summary: Cultural safety is a transformative approach to healthcare that aims to meet the needs and respect the identities of Indigenous peoples. This review identified three main professional roles for implementing cultural safety: supporting healthcare system navigation, enhancing service offerings, and building organizational capacity. These roles should be complementary and developed in partnership with Indigenous communities.
ALTERNATIVE-AN INTERNATIONAL JOURNAL OF INDIGENOUS PEOPLES
(2023)
Article
Oncology
Maxine Sun, Marie-Christyne Cyr, Johanna Sandoval, Louis-Philippe Lemieux Perreault, Lambert Busque, Jean-Claude Tardif, Marie-Pierre Dube
Summary: This study analyzed a cohort of 48,919 cancer patients from the UK Biobank and found that individuals with mosaic chromosomal alterations (mCA) are at an increased risk of death from cardiovascular disease (CVD), particularly in patients with kidney cancer and breast cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Review
Urology & Nephrology
Lucas Germain, Camille Lafront, Virginie Paquette, Bertrand Neveu, Jean-Sebastien Paquette, Frederic Pouliot, Etienne Audet-Walsh
Summary: Prostate cancer depends on androgen receptor (AR) for growth and survival, making it the main target for pharmacological treatment. However, prostate cancer eventually becomes castration-resistant, with most resistance mechanisms involving reactivation of AR. The definition of preclinical models and cell lines for studying prostate cancer and castration resistance is still unclear. Understanding the limitations and advantages of these models is crucial for effective translation of scientific knowledge to clinical applications. Evaluation: x/10
NATURE REVIEWS UROLOGY
(2023)
Article
Microbiology
Amel Saim-Mamoun, Julie Carbonneau, Chantal Rheaume, Yacine Abed, Guy Boivin
Summary: Baloxavir, the latest antiviral drug approved against seasonal influenza A and B viruses, shows low resistance against the PA-I38T substitution. This study evaluates the impact of this substitution on the fitness of contemporary influenza B viruses. The results indicate that influenza B viruses with the PA-I38T mutation may retain a significant level of fitness, emphasizing the importance of monitoring the emergence of such variant.
Article
Health Care Sciences & Services
Doriane Etienne, Patrick Archambault, Donovan Aziaka, Selma Chipenda-Dansokho, Eve Dube, Catherine S. Fallon, Hina Hakim, Jason Kindrachuk, Dan Krecoum, Shannon E. MacDonald, Ruth Ndjaboue, Magniol Noubi, Jean-Sebastien Paquette, Elizabeth Parent, Holly O. Witteman
Summary: To reduce the transmission of SARS-CoV-2 and COVID-19, many jurisdictions implemented social or physical distancing measures. However, the explanations behind these measures were either too technical or oversimplified. This study aimed to understand the effects of a dynamic visualization on distancing and developed a web application to help people understand the relationship between individual behavior and the spread of infectious diseases.
JMIR FORMATIVE RESEARCH
(2023)
Article
Environmental Sciences
Aurelie Lacouture, Yann Breton, Cindy Weidmann, Sarah-Maude Goulet, Lucas Germain, Martin Pelletier, Etienne Audet-Walsh
Summary: This study reveals the impact of estrogens and EDCs on mammary epithelial cell metabolism in monolayer and organoid cultures. It demonstrates that EDCs can alter bioenergetic fluxes and interfere with the regulation of estrogen target genes. The sensitivity of mammary organoids to specific EDCs can also be influenced by past pregnancies. Understanding the metabolic effects of EDCs is important for the development and function of the mammary gland.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Hematology
Martin Pelletier, Yann Breton, Isabelle Allaeys, Yann Becker, Tom Benson, Eric Boilard
Summary: The study reveals that extracellular vesicles released by activated platelets contain mitochondria, which can be captured by neutrophils and monocytes, enhancing their mitochondrial function. These external mitochondria may support other metabolic functions through transcellular bioenergetics.
Article
Primary Health Care
Matthew Menear, Arnaud Duhoux, Myreille Bedard, Jean-Sebastien Paquette, Marie Baron, Mylaine Breton, Simon Courtemanche, Savannah Dube, Stefany Dufour, Martin Fortin, Ariane Girard, Emilie Larouche-Cote, Audrey L'Esperance, Annie LeBlanc, Marie-Eve Poitras, Sophie Rivet, Maxime Sasseville, Amelie Achim, Patrick Archambault, Virtue Bajurny, Judith Belle Brown, Jean-Daniel Carrier, Nancy Cote, Yves Couturier, Maman Joyce Dogba, Marie-Pierre Gagnon, Sergio Cortez Ghio, Emily Gard Marshall, Anita Kothari, Marie-Therese Lussier, Frances S. Mair, Susan Smith, Brigitte Vachon, Sabrina Wong
Summary: This study aims to improve understanding of the care experiences of people with mental-physical multimorbidity during the COVID-19 pandemic and identify strategies to enhance these experiences. The study will be conducted in four phases, including qualitative interviews, journey mapping exercises, an online survey, and deliberative dialogues. The results of this study will provide valuable evidence on the impacts of the pandemic on care experiences and inform strategies for improving care delivery.
Meeting Abstract
Cardiac & Cardiovascular Systems
Cristina T. Pop, Julie Hussin, Christine Des Rosiers, Nadia Bouabdallaoui
JOURNAL OF CARDIAC FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Myriam Bellemare, Liane Bourcier, Maxime Tremblay-Gravel, Henri Christine, Michel White, Nadia Bouabdallaoui
JOURNAL OF CARDIAC FAILURE
(2023)
Review
Biochemistry & Molecular Biology
Jean-Sebastien Paquette, Caroline Rheaume, Pierre Cordeau, Julie-Alexandra Moulin, Etienne Audet-Walsh, Virginie Blanchette, Jean-Philippe Drouin-Chartier, Alfred-Kodjo Toi, Angelo Tremblay, Vassilis Mougios
Summary: Aging is a natural process, but chronic diseases and geriatric syndrome continue to impact the aging population. Lifestyle medicine aims to increase healthspan and reduce morbidity by making changes to our lifestyle.