Article
Biochemistry & Molecular Biology
Sandhya Sharma, Tim Sauer, Bilal A. Omer, Thomas Shum, Lisa A. Rollins, Cliona M. Rooney
Summary: The constitutively active IL7 receptor (C7R) enhances the anti-tumor activity of T-cells expressing chimeric antigen receptors (CARs) and T-cells recognizing tumors via their native T-cell receptors (TCRs). C7R-modified EBV-specific T-cells (EBVSTs) show improved expansion capability and faster lymphoma control in a murine xenograft model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Gagan Bajwa, Caroline Arber
Summary: Combining IFN-gamma cytokine capture with retroviral transduction allows for the efficient generation of TCR and CD8 alpha beta transgenic VSTs targeting multiple viral and tumor antigens simultaneously.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Wei Pan, Yaodong Xia, Hongmei Wang, Hongbin He
Summary: Bovine parainfluenza virus 3 (BPIV3) enters host cells mainly through the processes of macropinocytosis and endocytosis. During this process, EGFR (epidermal growth factor receptor) plays a critical role, and activation of EGFR can enhance viral entry into cells. In addition, other downstream signaling pathways such as PI3K-Akt and ERK1/2 are also activated during BPIV3 infection.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Penelope-Georgia Papayanni, Dimitrios Chasiotis, Kiriakos Koukoulias, Aphrodite Georgakopoulou, Anastasia Iatrou, Eleni Gavriilaki, Chrysavgi Giannaki, Militsa Bitzani, Eleni Geka, Polychronis Tasioudis, Diamantis Chloros, Asimina Fylaktou, Ioannis Kioumis, Maria Triantafyllidou, Sotiria Dimou-Besikli, Georgios Karavalakis, Afroditi K. Boutou, Eleni Siotou, Achilles Anagnostopoulos, Anastasia Papadopoulou, Evangelia Yannaki
Summary: The study demonstrates a causal relationship between the expansion of SARS-CoV-2-specific T cells and disease outcome in COVID-19 patients, with insufficient expansion correlating with adverse outcomes in hospitalized patients. T cells generated from convalescent and vaccinated donors showed functional activity against multiple virus variants, while cells from critical patients failed to expand, mirroring the in vivo failure of specific T-cell immunity in controlling infection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Willemijn van der Wulp, Anna M. Gram, Boris Bleijlevens, Renate S. Hagedoorn, Can Araman, Robbert Q. Kim, Jan Wouter Drijfhout, Paul W. H. I. Parren, Richard G. Hibbert, Rob C. Hoeben, Sander I. van Kasteren, Janine Schuurman, Maaike E. Ressing, Mirjam H. M. Heemskerk
Summary: Therapeutic antibody-epitope conjugates (AECs) are a promising treatment modality for delivering immunogenic epitopes and redirecting cancer-specific T-cell activity. This study evaluated different strategies for conjugating an EBV epitope to antibodies and showed that all three conjugates were capable of T-cell activation and target-cell killing. The sequence of the attached epitope appeared to influence its delivery efficiency.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Liliana E. Lucca, Pierre-Paul Axisa, Benjamin Lu, Brian Harnett, Shlomit Jessel, Le Zhang, Khadir Raddassi, Lin Zhang, Kelly Olino, James Clune, Meromit Singer, Harriet M. Kluger, David A. Hafler
Summary: Understanding the relationship between tumor and peripheral immune environments could allow longitudinal immune monitoring in cancer. Analysis of T cells from both tumor and blood in patients with metastatic melanoma revealed that circulating T cells matching clonally expanded tumor-infiltrating T cells show gene signatures of effector functions, while features of exhaustion are predominantly displayed by tumor-exclusive T cells. Circulating TILs have unique transcriptional patterns that may be useful for interrogating T cell function in cancer immunotherapy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Microbiology
Laurine C. Rijsbergen, Katharina S. Schmitz, Lineke Begeman, Jennifer Drew-Bear, Lennert Gommers, Mart M. Lamers, Alexander L. Greninger, Bart L. Haagmans, Matteo Porotto, Rik L. de Swart, Anne Moscona, Rory D. de Vries
Summary: This study evaluated the infection and transmission of HPIV-3 in ferrets and found that ferrets are naturally susceptible to HPIV-3 infection, but the infection is limited and does not cause overt clinical signs or ferret-to-ferret transmission.
Review
Biochemistry & Molecular Biology
Zuzana Nova, Tomas Zemanek, Norbert Botek
Summary: COVID-19 is an immune-related disease with ineffective immune responses leading to inflammation and organ damage. Transplantation of T cells from convalescent individuals may benefit immunocompromised population. Virus-specific T lymphocytes are a promising approach for the treatment and prevention of severe COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jiangping Li, Zhiwen Xiao, Donghui Wang, Lei Jia, Shihong Nie, Xingda Zeng, Wei Hu
Summary: Recent advancements in neoantigen research have accelerated the development of tumor immunotherapies, particularly for solid tumors, including adoptive cell therapies, cancer vaccines, and antibody-based therapies. The use of next-generation sequencing and bioinformatics technology enables the rapid identification and prediction of tumor-specific antigens, which not only provide new targets for personalized tumor immunotherapy but also serve as potential indicators for predicting tumor patient survival, prognosis, and immune checkpoint blockade response.
Article
Oncology
Amani Makkouk, Xue (Cher) Yang, Taylor Barca, Anthony Lucas, Mustafa Turkoz, Jonathan T. S. Wong, Kevin P. Nishimoto, Mary M. Brodey, Maryam Tabrizizad, Smitha R. Y. Gundurao, Lu Bai, Arun Bhat, Zili An, Stewart Abbot, Daulet Satpayev, Blake T. Aftab, Marissa Herrman
Summary: The use of engineered V delta 1 CAR T cells targeting GPC-3 in HCC shows promising efficacy and can overcome challenges faced by traditional T cell therapies in solid tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Faezzah Baharom, Ramiro A. Ramirez-Valdez, Kennedy K. S. Tobin, Hidehiro Yamane, Charles-Antoine Dutertre, Ahad Khalilnezhad, Glennys Reynoso, Vincent L. Coble, Geoffrey M. Lynn, Matthew P. Mule, Andrew J. Martins, John P. Finnigan, Xiao Meng Zhang, Jessica A. Hamerman, Nina Bhardwaj, John S. Tsang, Heather D. Hickman, Florent Ginhoux, Andrew S. Ishizuka, Robert A. Seder
Summary: The study demonstrates that using a self-assembling nanoparticle vaccine and adjuvant can expand stem-like CD8(+) T cells, optimize anti-tumor immunity, and enhance the strength and effectiveness of the anti-tumor response.
Article
Chemistry, Multidisciplinary
Valeria Ukrainskaya, Yuri Rubtsov, Dmitry Pershin, Nadezhda Podoplelova, Stanislav Terekhov, Igor Yaroshevich, Anstasiia Sokolova, Dmitry Bagrov, Elena Kulakovskaya, Victoria Shipunova, Sergey Deyev, Rustam Ziganshin, Aleksandr Chernov, Georgii Telegin, Eugene Maksimov, Oleg Markov, Anastasiya Oshchepkova, Marina Zenkova, Jia Xie, Hongkai Zhang, Alexander Gabibov, Michael Maschan, Alexey Stepanov, Richard Lerner
Summary: The development of CAR-T therapy has achieved success in the treatment of B cell leukemia, but the expansion of CAR-T cells remains challenging with current protocols. A novel approach using cell-derived membrane vesicles has been proposed, showing greater potential in stimulating, proliferating, and enhancing the functional activity of CAR-T cells.
Review
Cell Biology
Sonja I. Buschow, Diahann T. S. L. Jansen
Summary: Research on the impaired T cell responses in chronic hepatitis B patients has mainly focused on CD8(+) T cells, while CD4(+) T cells are crucial in the development of long-lasting effector CD8(+) T cells. This review discusses the importance of including CD4(+) T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.
Article
Immunology
Tengcheng Que, Jing Li, Yugan He, Panyu Chen, Wei Lin, Meihong He, Lei Yu, Aiqiong Wu, Luohao Tan, Yingjiao Li, Yanling Hu, Yigang Tong
Summary: This study investigates the virome composition of pangolins and reveals that pangolins are susceptible to human parainfluenza virus and human respiratory syncytial virus. This finding highlights the potential risk of viral transmission from pangolins to humans and emphasizes the need for public awareness.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Oncology
Michael C. Brown, Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Summary: This study reveals the contribution of pre-existing anti-polio immunity to the effectiveness of polio virotherapy for cancer treatment. Childhood vaccines such as polio and tetanus can enhance antitumor immune responses, particularly by activating CD4(+) T cells and eosinophils.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)