Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile

Interpolation method for accurate affinity ranking of arrayed ligand–analyte interactions

(2016) Richard B.M. Schasfoort et al.   ANALYTICAL BIOCHEMISTRY

Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies

(2016) Ngoc Phuong Lan Le et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation

(2016) Qian Gong et al.   mAbs

The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc γ receptor

(2016) Ganesh P. Subedi et al.   mAbs

Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis

(2016) Michel W. P. Tsang-A-Sjoe et al.   RHEUMATOLOGY

Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans

(2016) Gillian Dekkers et al.   Scientific Reports

Phase 1/2 study of mogamulizumab, a defucosylated anti-CCR4 antibody, in previously treated patients with cutaneous T-cell lymphoma

(2015) M. Duvic et al.   BLOOD

Structural analysis of Fc/FcγR complexes: a blueprint for antibody design

(2015) Jose M. M. Caaveiro et al.   IMMUNOLOGICAL REVIEWS

Immunomodulation by IVIg and the Role of Fc-Gamma Receptors: Classic Mechanisms of Action after all?

(2015) Sietse Q. Nagelkerke et al.   Frontiers in Immunology

Inhibition of Fc R-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and Fc RIIb in human macrophages

(2014) S. Q. Nagelkerke et al.   BLOOD

Low anti-RhD IgG-Fc-fucosylation in pregnancy: a new variable predicting severity in haemolytic disease of the fetus and newborn

(2014) Rick Kapur et al.   BRITISH JOURNAL OF HAEMATOLOGY

Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins

(2014) Alysia A. Ahmed et al.   JOURNAL OF MOLECULAR BIOLOGY

Restricted Motion of the Conserved Immunoglobulin G1 N-Glycan Is Essential for Efficient FcγRIIIa Binding

(2014) Ganesh P. Subedi et al.   STRUCTURE

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy

(2013) R. Kapur et al.   BLOOD

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

(2013) Margaret E. Ackerman et al.   JOURNAL OF CLINICAL INVESTIGATION

High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides

(2013) Maja Pučić Baković et al.   JOURNAL OF PROTEOME RESEARCH

Intranasal Administration of Antibody-Bound Respiratory Syncytial Virus Particles Efficiently Primes Virus-Specific Immune Responses in Mice

(2013) D. Kruijsen et al.   JOURNAL OF VIROLOGY

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

(2011) Tsunehiro Mizushima et al.   GENES TO CELLS

Antibody therapy for Adult T-cell leukemia–lymphoma

(2011) Takashi Ishida et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Phenotypic Variation in IgG Receptors by Nonclassical FCGR2C Alleles

(2011) J. van der Heijden et al.   JOURNAL OF IMMUNOLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of therapeutic antibodies with controlled fucosylation

(2010) Naoko Yamane-Ohnuki et al.   mAbs

International consensus report on the investigation and management of primary immune thrombocytopenia

(2009) D. Provan et al.   BLOOD

Intravenous immunoglobulins - understanding properties and mechanisms

(2009) A. Durandy et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Copy number variation at theFCGRlocus includesFCGR3A, FCGR2CandFCGR3Bbut notFCGR2AandFCGR2B

(2009) Willemijn B. Breunis et al.   HUMAN MUTATION

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

(2009) Royston Jefferis   TRENDS IN PHARMACOLOGICAL SCIENCES

Anti-Inflammatory Actions of Intravenous Immunoglobulin

(2008) Falk Nimmerjahn et al.   Annual Review of Immunology

Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells

(2008) M. Peipp et al.   BLOOD

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD