Article
Gastroenterology & Hepatology
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V. Arancibia-Carcamo, Mark Coles, Eamonn Gaffney, Simon Pl Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N. Sansom, Holm H. Uhlig
Summary: Dysregulated immune responses are the cause of IBDs, with IL-10 and IL-1 identified as critical regulators of monocyte IL-23 production. The study differentiates between homeostatic IL-23 production and hyperinflammation-associated IL-23 production in patients with severe ulcerating active Crohn's disease and anti-TNF treatment non-responsiveness. Subgroups of patients with IBD that might benefit from IL-23p19 and/or IL-1 alpha/IL-1 beta-targeting therapies upstream of IL-23 are identified.
Review
Biochemistry & Molecular Biology
Ioanna Aggeletopoulou, Efthymios P. P. Tsounis, Christos Triantos
Summary: Interleukin-33 (IL-33) is a pleiotropic cytokine with both extracellular and nuclear functions, and its receptor ST2 plays a critical role in regulating inflammatory disorders. The IL-33/ST2 axis is involved in maintaining intestinal homeostasis and mucosal defenses. This review focuses on the pro- and anti-inflammatory effects of the IL-33/ST2 axis in ulcerative colitis and Crohn's disease, as well as the molecular mechanisms underlying its association with IBD pathogenesis. Understanding the IL-33/ST2-mediated mechanisms in IBD has potential for clinical applications as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Zsolt Czimmerer, Laszlo Halasz, Bence Daniel, Zsofia Varga, Krisztian Bene, Apolka Domokos, Marten Hoeksema, Zeyang Shen, Wilhelm K. Berger, Timea Cseh, Karoly Jambrovics, Zsuzsanna Kolostyak, Ferenc Fenyvesi, Judit Varadi, Szilard Poliska, Gyorgy Hajas, Istvan Szatmari, Christopher K. Glass, Attila Bacsi, Laszlo Nagy
Summary: Prior exposure to microenvironmental signals can alter the response of macrophages. IL-4-polarized macrophages were found to exhibit hyperinflammatory gene expression upon LPS exposure, contrary to previous beliefs. This extended synergy was supported by epigenomic remodeling, NF-kappa B-p65 cistrome expansion, and increased enhancer activity.
Article
Immunology
Aldo Ummarino, Alba Pensado-Lopez, Roberta Migliore, Lourdes Alcaide-Ruggiero, Nicholas Cala, Michele Caputo, Francesco M. Gambaro, Clement Anfray, Flavio L. Ronzoni, Elizaveta Kon, Paola Allavena, Fernando Torres Andon
Summary: This study developed and described an in vitro protocol for long-term culture of primary human monocyte-derived macrophages, providing a model for chronically activated inflammatory macrophages. The protocol can be used for screening new compounds to improve the therapy of inflammatory disorders.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Pediatrics
Caterina Strisciuglio, Mara Creoli, Chiara Tortora, Massimo Martinelli, Erasmo Miele, Salvatore Paino, Livio Luongo, Francesca Rossi
Summary: This study analyzed the expression of CB2 and factors associated with IBD inflammatory pathways in intestinal biopsies of pediatric CD and UC patients. The results showed an upregulation of CB2 in pediatric IBD, which could have implications for drug discovery.
PEDIATRIC RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra Korta, Julia Kula, Krzysztof Gomulka
Summary: Interleukin-23 (IL-23) is a proinflammatory cytokine that plays a role in tissue damage. It interacts with both the innate and adaptive immune systems, and the IL-23/Th17 axis appears to be involved in the development of chronic intestinal inflammation. Despite the incomplete understanding of the etiology and pathophysiology of inflammatory bowel disease (IBD), research on IL-23 shows potential for clinical applications as therapeutic targets in IBD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Stanley Cho, Bridget M. Stroup, Savini L. Britto, Wenly Ruan, Deborah Schady, Kristi L. Hoffman, Richard Kellermayer
Summary: This study suggests an inverse correlation between household size and the incidence of inflammatory bowel disease (IBD). Larger households may offer protection against intestinal inflammation through intergenerational microbiome modulation.
PEDIATRIC RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Alexa N. Sasson, Ashwin N. Ananthakrishnan, Maitreyi Raman
Summary: The global incidence of inflammatory bowel diseases (IBDs) has increased significantly in the past few decades, with genetic and environmental factors playing a role in the pathogenesis. Diet is a potentially modifiable environmental risk factor for IBD, as it can promote intestinal inflammation through various mechanisms such as dysregulating the immune system and altering intestinal permeability. Dietary changes may be integrated into therapeutic strategies for IBD treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Health Care Sciences & Services
Laura A. Lucaciu, Maria Ilies, Stefan C. Vesa, Radu Seicean, Shahida Din, Cristina Adela Iuga, Andrada Seicean
Summary: Interleukin (IL)-23 and fecal calprotectin levels were significantly elevated in severe inflammatory bowel disease (IBD), while IL-17 and C-reactive protein were associated with disease severity. IL-23 may serve as a promising novel biomarker for severe Crohn's disease, guiding clinical decision-making on biologic therapy. Identifying the main IL pathway involved in IBD severity could provide valuable insights for personalized treatment approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Immunology
Yiyoung Kwon, Yoon Zi Kim, Yon Ho Choe, Mi Jin Kim
Summary: This study found that patients with high monocyte counts at the time of discontinuation were more likely to experience relapse after stopping biologics. The monocyte percentage can be used to predict the risk of relapse within 6 months after discontinuation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Lizi M. Hegarty, Gareth-Rhys Jones, Calum C. Bain
Summary: This Review provides detailed insights into the biology of macrophages in the context of inflammatory bowel disease and discusses future perspectives.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Raissa Timmerman, Ella A. Zuiderwijk-Sick, Jeffrey J. Bajramovic
Summary: TLR-induced signaling triggers inflammatory responses, and the P2Y6 receptor enhances pro-inflammatory cytokine levels, especially in microglia. Through transcriptome analysis, P2Y6 signaling amplifies pro-inflammatory responses in microglia by regulating the expression of target genes through modulation of transcription factors. Additionally, inhibition of P2Y6 signaling strongly induces heat shock protein expression. These findings shed new light on the specific pro-inflammatory role of P2Y6 signaling in neuroinflammation and may provide novel approaches to control brain inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Matthias Friedrich, Mathilde Pohin, Matthew A. Jackson, Ilya Korsunsky, Samuel J. Bullers, Kevin Rue-Albrecht, Zoe Christoforidou, Dharshan Sathananthan, Tom Thomas, Rahul Ravindran, Ruchi Tandon, Raphael Sanches Peres, Hannah Sharpe, Kevin Wei, Gerald F. M. Watts, Elizabeth H. Mann, Alessandra Geremia, Moustafa Attar, Francesca Barone, Francesca Barone, Michael Brenner, Christopher D. Buckley, Mark Coles, Andreas P. Frei, Kara G. Lassen, Fiona M. Powrie, Sarah McCuaig, Lloyd Thomas, Elena Collantes, Holm H. Uhlig, Stephen N. Sansom, Alistair Easton, Soumya Raychaudhuri, Simon P. Travis, Fiona M. Powrie
Summary: Transcriptomic and histological profiling of gut biopsies from multiple cohorts of patients with inflammatory bowel disease revealed distinct histopathological, molecular and cellular features associated with treatment response. The identification of different tissue pathotypes may aid in targeting current therapies more precisely and provides a biological basis for IL-1 signaling blockade in ulcerating disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ricardo Donners, Carmen Zaugg, Julian E. Gehweiler, Tuyana Boldanova, Markus H. Heim, Luigi M. Terracciano, Daniel T. Boll
Summary: This study compared CT and MRI analyses to differentiate between liver steatosis, steatohepatitis, cirrhosis, and normal liver parenchyma. The results showed that multiparametric analyses were effective in distinguishing between different liver parenchymal conditions.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Gastroenterology & Hepatology
Tanay Kaymak, Berna Kaya, Philipp Wuggenig, Sandro Nuciforo, Andreas Goldi, Franz Oswald, Julien Roux, Mario Noti, Hassan Melhem, Petr Hruz, Jan Hendrik Niess
Summary: This study illustrates the importance of the IL-20 subfamily in maintaining the barrier function of the esophagus in the context of EoE. The dysregulation of IL-20 subfamily signaling disrupts the integrity of the esophageal epithelial barrier and promotes the development of EoE. Targeting the IL-20 subfamily signaling pathway may provide a novel strategy for the treatment of EoE.
Article
Gastroenterology & Hepatology
Stephan Miehlke, Christoph Schlag, Alfredo J. Lucendo, Luc Biedermann, Cecilio Santander Vaquero, Christoph Schmoecker, Jamal Hayat, Petr Hruz, Constanza Ciriza de los Rios, Albert Jan Bredenoord, Michael Vieth, Alain Schoepfer, Stephen Attwood, Ralph Mueller, Sarah Burrack, Roland Greinwald, Alex Straumann
Summary: This study confirms the effectiveness and safety of a novel budesonide orodispersible tablet in the treatment of active eosinophilic oesophagitis patients for 6 weeks in an open-label induction treatment.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Biology
Theresa Rohm, Lena Keller, Angela J. T. Bosch, Shefaa AlAsfoor, Zora Baumann, Amandine Thomas, Sophia J. Wiedemann, Laura Steiger, Elise Dalmas, Josua Wehner, Leila Rachid, Catherine Mooser, Bahtiyar Yilmaz, Nerea Fernandez Trigo, Annaise J. Jauch, Stephan Wueest, Daniel Konrad, Sandrine Henri, Jan H. Niess, Petr Hruz, Stephanie C. Ganal-Vonarburg, Julien Roux, Daniel T. Meier, Claudia Cavelti-Weder
Summary: Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the colon improves glucose metabolism. This study highlights the importance of colonic macrophage subpopulations in regulating glucose homeostasis and suggests that pharmacological targeting of these macrophages may be a potential therapy for obesity-related glycemic control.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Felix Bayerl, David A. Bejarano, Giulia Bertacchi, Anne-Claire Doffin, Elisa Gobbini, Margaux Hubert, Lijian Li, Philippa Meiser, Anna-Marie Pedde, Wilfried Posch, Luise Rupp, Andreas Schlitzer, Marc Schmitz, Barbara U. Schraml, Stefan Uderhardt, Jenny Valladeau-Guilemond, Doris Wilflingseder, Viktoria Zaderer, Jan P. Boettcher
Summary: This article is part of a series providing advanced protocols for the study of dendritic cells (DC). It includes procedures for analyzing DC phenotypes, generating DC from various tissues, and studying DC functions using fluorescence microscopy. The protocols cover various methods such as intravital microscopy, multiparameter fluorescence microscopy, and 3D cell culture models. The article has been peer-reviewed by experts and is considered an essential resource for basic and clinical DC immunologists.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Correction
Immunology
Natalie Katzmarski, Jorge Dominguez-Andres, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Haendler, Heidi Theis, Marc Beyer, Jos W. M. van der Meer, Leo A. B. Joosten, Joern Walter, Joachim L. Schultze, Thierry Roger, Evangelos J. Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G. Netea
Article
Gastroenterology & Hepatology
Severin Lautenschlager, Mamadou Pathe Barry, Gerhard Rogler, Luc Biedermann, Philipp Schreiner, Alexander Siebenhuener
Summary: This study aimed to identify lifestyle factors that affect the onset of Crohn's disease and ulcerative colitis. The results showed that patients with inflammatory bowel disease were less likely to engage in regular physical activity during childhood and early adulthood compared to the control group. There was no significant association between intake of refined sugar and the onset of inflammatory bowel disease. Patients with Crohn's disease had a higher rate of overweight during childhood compared to ulcerative colitis and the control group. The study highlights the relevance of environmental factors in the development of inflammatory bowel disease and suggests a protective effect of physical activity on its onset.
BMC GASTROENTEROLOGY
(2023)
Article
Immunology
Jan Devan, Vladimir Nosi, Julian Spagnuolo, Andrew Chancellor, Aisha Beshirova, Jose Pedro Loureiro, Alessandro Vacchini, Jan Hendrik Niess, Raffaele Calogero, Lucia Mori, Gennaro De Libero, Petr Hruz
Summary: By studying the intestinal mucosa of Crohn's disease patients, we have discovered different types of T cells that play distinct roles in inflammation. The abnormally high number of terminally differentiated TCR V delta 1(+) cells in inflamed tissue suggests that they could be a potential target for novel therapies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Cell Biology
Kentaro Miyamoto, Tomohisa Sujino, Yosuke Harada, Hiroshi Ashida, Yusuke Yoshimatsu, Yuki Yonemoto, Yasuhiro Nemoto, Michio Tomura, Hassan Melhem, Jan Hendrik Niess, Toshihiko Suzuki, Toru Suzuki, Shohei Suzuki, Yuzo Koda, Ryuichi Okamoto, Yohei Mikami, Toshiaki Teratani, Kenji Tanaka, Akihiko Yoshimura, Toshiro Sato, Takanori Kanai
Summary: The complex interplay between gut microbes and the onset of experimental autoimmune encephalomyelitis (EAE) is not well understood. This study reveals the similarities between CD4+ T cells in the spinal cord and the small intestine. The collaboration between the microbiota, especially those enriched with the tryptophan metabolism gene EC:1.13.11.11, and intestinal cells leads to the biosynthesis of kynurenic acid (KYNA), which triggers a Th17 immune response and the onset of EAE.
Article
Gastroenterology & Hepatology
Oltin-Tiberiu Pop, Anne Geng, Emilio Flint, Arjuna Singanayagam, Caner Ercan, Lucia Possamai, Vishal C. Patel, Patrizia Kuenzler, Marie -Anne Meier, Savas Soysal, Petr Hruz, Otto Kollmar, Kate C. Tatham, Josie K. Ward, Beat Muellhaupt, Achim Weber, Julia Wendon, Jan Hendrik Niess, Markus Heim, David Semela, Christopher Weston, Charalambos G. Antoniades, Luigi Maria Terracciano, Evangelos Triantafyllou, Robert G. Brenig, Christine Bernsmeier
Summary: This study found that AXL is expressed on tissue macrophages in patients with cirrhosis, but not on tissue-infiltrating liver macrophages, hepatocytes, and sinusoidal endothelial cells. The expression of AXL decreases significantly with cirrhosis progression and is negatively correlated with liver function and C-reactive protein. AXL-expressing liver macrophages show high expression of CD68, HLA-DR, CD16, and CD206. Additionally, AXL expression decreases on gut and peritoneal macrophages in cirrhotic patients but increases in regional lymph nodes. These findings suggest an important role for AXL in the regulation of hepatic immune homeostasis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Immunology
Elvira Mass, Falk Nimmerjahn, Katrin Kierdorf, Andreas Schlitzer
Summary: Macrophages play important roles in host immunity, waste clearance, metabolism regulation, and neuronal functions. They form a 3D network in tissues and phagocytose dying cells, immune complexes, bacteria, and waste products, while also producing growth factors and signaling molecules. Macrophages are involved in physiological processes such as blood vessel formation, adipogenesis, metabolism, and neuronal function. Different tissue-specific macrophage populations have distinct developmental trajectories, transcriptional programs, and life cycles.
NATURE REVIEWS IMMUNOLOGY
(2023)
Meeting Abstract
Medicine, General & Internal
Sara Dylgjeri, Petr Hruz, Hassan Melhem, Jan Hendrik Niess
SWISS MEDICAL WEEKLY
(2022)
Meeting Abstract
Medicine, General & Internal
Christoph Matter, Audrey Fahrny, Marc Fellmann, Jan Hendrik Niess, Emanuel Burri, Luc Biedermann, Stephan Robert Vavricka, Tim Killeen
SWISS MEDICAL WEEKLY
(2022)
