Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo

The Clathrin-Mediated Endocytic Pathway Participates in dsRNA-Induced IFN-  Production

(2014) K. Itoh et al.   JOURNAL OF IMMUNOLOGY

Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant

(2013) Annina M. Hafner et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer

(2013) Tsukasa Seya et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy

(2013) Andrew M. Intlekofer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA

(2013) Megumi Tatematsu et al.   Nature Communications

Phase I Trial of Overlapping Long Peptides from a Tumor Self-Antigen and Poly-ICLC Shows Rapid Induction of Integrated Immune Response in Ovarian Cancer Patients

(2012) P. Sabbatini et al.   CLINICAL CANCER RESEARCH

Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

(2012) H. Shime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trial Watch

(2012) Lorenzo Galluzzi et al.   OncoImmunology

Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8α+dendritic cells

(2012) Masahiro Azuma et al.   OncoImmunology

DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

(2011) Zhiqiang Zhang et al.   IMMUNITY

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection

(2011) I. Jelinek et al.   JOURNAL OF IMMUNOLOGY

Opposing Effects of Toll-like Receptor (TLR3) Signaling in Tumors Can Be Therapeutically Uncoupled to Optimize the Anticancer Efficacy of TLR3 Ligands

(2010) R. Conforti et al.   CANCER RESEARCH

Dissecting TLR3 signalling in dendritic cells

(2010) M.C. Gauzzi et al.   IMMUNOBIOLOGY

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral CD103+dendritic cells form a unified subset developmentally related to CD8α+conventional dendritic cells

(2010) Brian T. Edelson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Found in translation: the human equivalent of mouse CD8+dendritic cells: Table I.

(2010) Jose A. Villadangos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation

(2010) Takashi Ebihara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR3 and Rig-Like Receptor on Myeloid Dendritic Cells and Rig-Like Receptor on Human NK Cells Are Both Mandatory for Production of IFN-  in Response to Double-Stranded RNA

(2010) I. Perrot et al.   JOURNAL OF IMMUNOLOGY

Poly I:C-Induced Activation of NK Cells by CD8 + Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways

(2009) T. Miyake et al.   JOURNAL OF IMMUNOLOGY

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Structural Studies of an RNA Aptamer Containing GGA Repeats Under Ionic Conditions Using Microchip Electrophoresis, Circular Dichroism, and 1D-NMR

(2009) Fumiko Nishikawa et al.   OLIGONUCLEOTIDES

Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer

(2009) B. Jasani et al.   VACCINE

Cytoplasmic recognition of RNA☆

(2008) M YONEYAMA et al.   ADVANCED DRUG DELIVERY REVIEWS

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

(2008) M MATSUMOTO et al.   ADVANCED DRUG DELIVERY REVIEWS

Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC- -dependent mechanism

(2008) A. Paone et al.   CARCINOGENESIS

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE