Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection

Constitutive Glycolytic Metabolism Supports CD8 + T Cell Effector Memory Differentiation during Viral Infection

(2016) Anthony T. Phan et al.   IMMUNITY

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

(2016) Bertram Bengsch et al.   IMMUNITY

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Host AMPK Is a Modulator of Plasmodium Liver Infection

(2016) Margarida T. Grilo Ruivo et al.   Cell Reports

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity

(2015) Guoliang Cui et al.   CELL

Quiescence of Memory CD8+ T Cells Is Mediated by Regulatory T Cells through Inhibitory Receptor CTLA-4

(2015) Vandana Kalia et al.   IMMUNITY

Inflammatory IL-15 is required for optimal memory T cell responses

(2015) Martin J. Richer et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Effector Cells Survive the Contraction Phase in Malaria Infection and Generate Both Central and Effector Memory T Cells

(2015) Michael M. Opata et al.   JOURNAL OF IMMUNOLOGY

Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells

(2015) Brian J Laidlaw et al.   NATURE IMMUNOLOGY

Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

(2015) Emile B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Fatty acid metabolism in the regulation of T cell function

(2015) Matthias Lochner et al.   TRENDS IN IMMUNOLOGY

Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria

(2015) Emile B. Gordon et al.   mBio

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Futility Sustains Memory T Cells

(2014) Samuel E. Weinberg et al.   IMMUNITY

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

(2014) J. Lee et al.   JOURNAL OF IMMUNOLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Metabolic Reprogramming towards Aerobic Glycolysis Correlates with Greater Proliferative Ability and Resistance to Metabolic Inhibition in CD8 versus CD4 T Cells

(2014) Yilin Cao et al.   PLoS One

Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis

(2014) Xiuying Liu et al.   Nature Communications

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

TOFA suppresses ovarian cancer cell growth in vitro and in vivo

(2013) SHU LI et al.   Molecular Medicine Reports

Pasteur Approach to a Malaria Vaccine May Take the Lead

(2013) M. F. Good   SCIENCE

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens

(2013) Jason Brunton et al.   PLoS Pathogens

Metabolic switching and fuel choice during T-cell differentiation and memory development

(2012) Gerritje J. W. Windt et al.   IMMUNOLOGICAL REVIEWS

IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection

(2012) Béatris Mastelic et al.   Frontiers in Immunology

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection

(2011) Heather D. Marshall et al.   IMMUNITY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate

(2011) Xiao-jun Zhang et al.   JOURNAL OF LIPID RESEARCH

Homeostatic Proliferation and IL-7R Alpha Expression Do Not Correlate with Enhanced T Cell Proliferation and Protection in Chronic Mouse Malaria

(2011) Robin Stephens et al.   PLoS One

The contribution of Plasmodium chabaudi to our understanding of malaria

(2011) Robin Stephens et al.   TRENDS IN PARASITOLOGY

Metabolism in T cell activation and differentiation

(2010) Erika L Pearce   CURRENT OPINION IN IMMUNOLOGY

Early Signals during CD8+ T Cell Priming Regulate the Generation of Central Memory Cells

(2010) J. J. Obar et al.   JOURNAL OF IMMUNOLOGY

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Regulation of intermediary metabolism by protein acetylation

(2010) Kun-Liang Guan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effector Memory Th1 CD4 T Cells Are Maintained in a Mouse Model of Chronic Malaria

(2010) Robin Stephens et al.   PLoS Pathogens

Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events

(2009) Sónia S Albuquerque et al.   BMC GENOMICS

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses

(2009) Axel Kallies et al.   IMMUNITY

A Default Pathway of Memory CD8 T Cell Differentiation after Dendritic Cell Immunization Is Deflected by Encounter with Inflammatory Cytokines during Antigen-Driven Proliferation

(2009) N.-L. L. Pham et al.   JOURNAL OF IMMUNOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues

(2009) J. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surviving the crash: Transitioning from effector to memory CD8+ T cell

(2009) Louise M. D’Cruz et al.   SEMINARS IN IMMUNOLOGY

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

(2008) Ashley M. Vaughan et al.   CELLULAR MICROBIOLOGY

Immunity to malaria: more questions than answers

(2008) Jean Langhorne et al.   NATURE IMMUNOLOGY

Exploring regulatory mechanisms of CD8+ T cell contraction

(2008) M. Prlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA