Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro

Recent insights into endothelial control of leukocyte extravasation

(2016) Peter L. Hordijk   CELLULAR AND MOLECULAR LIFE SCIENCES

Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF

(2016) David W. Scott et al.   MOLECULAR BIOLOGY OF THE CELL

The regulation of transendothelial migration: new knowledge and new questions

(2015) William A. Muller   CARDIOVASCULAR RESEARCH

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The cell biology of renal filtration

(2015) Rizaldy P. Scott et al.   JOURNAL OF CELL BIOLOGY

Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration

(2015) A. Schaefer et al.   JOURNAL OF CELL SCIENCE

Endothelial Actin-Binding Proteins and Actin Dynamics in Leukocyte Transendothelial Migration

(2015) Michael Schnoor   JOURNAL OF IMMUNOLOGY

Emerging properties of adhesion complexes: what are they and what do they do?

(2015) Jonathan D. Humphries et al.   TRENDS IN CELL BIOLOGY

Integrin-Associated Complexes Form Hierarchically with Variable Stoichiometry in Nascent Adhesions

(2014) Alexia I. Bachir et al.   CURRENT BIOLOGY

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration

(2014) Antje Schaefer et al.   JOURNAL OF CELL SCIENCE

Nanoclustering as a dominant feature of plasma membrane organization

(2014) M. F. Garcia-Parajo et al.   JOURNAL OF CELL SCIENCE

Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance

(2014) R. Martinelli et al.   JOURNAL OF CELL SCIENCE

The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation

(2014) Sachin Kumar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1-Dependent Mechanotransduction in Endothelial Cells To Stimulate Transendothelial Migration

(2014) E. C. Lessey-Morillon et al.   JOURNAL OF IMMUNOLOGY

Similarities and differences in the regulation of leukocyte extravasation and vascular permeability

(2014) Dietmar Vestweber et al.   Seminars in Immunopathology

Rho-GTPase signaling in leukocyte extravasation

(2014) Niels Heemskerk et al.   Cell Adhesion & Migration

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration

(2012) G. Liu et al.   BLOOD

Localized Tensional Forces on PECAM-1 Elicit a Global Mechanotransduction Response via the Integrin-RhoA Pathway

(2012) Caitlin Collins et al.   CURRENT BIOLOGY

CD2AP Links Cortactin and Capping Protein at the Cell Periphery To Facilitate Formation of Lamellipodia

(2012) J. Zhao et al.   MOLECULAR AND CELLULAR BIOLOGY

The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation

(2012) Jos van Rijssel et al.   MOLECULAR BIOLOGY OF THE CELL

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo

(2011) Michael Schnoor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A

(2011) A. J. Ehrlicher et al.   NATURE

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Rac1 Recruits the Adapter Protein CMS/CD2AP to Cell-Cell Contacts

(2010) Trynette J. van Duijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PI3K p110α isoform regulates endothelial adherens junctions via Pyk2 and Rac1

(2010) Robert J. Cain et al.   JOURNAL OF CELL BIOLOGY

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

(2010) Sussan Nourshargh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inside-Out Regulation of ICAM-1 Dynamics in TNF-α-Activated Endothelium

(2010) Jaap D. van Buul et al.   PLoS One

The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration

(2009) A. Gerard et al.   BLOOD

Mechanisms for transcellular diapedesis: probing and pathfinding by `invadosome-like protrusions'

(2009) C. V. Carman   JOURNAL OF CELL SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Mechanical Forces Induced by the Transendothelial Migration of Human Neutrophils

(2008) Aleksandr Rabodzey et al.   BIOPHYSICAL JOURNAL

Filamin B Mediates ICAM-1-driven Leukocyte Transendothelial Migration

(2008) Edwin Kanters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms

(2008) Olga Barreiro et al.   JOURNAL OF CELL BIOLOGY

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS