Article
Biochemistry & Molecular Biology
Niels Boegholm, Narcis A. Petriman, Marta Loureiro-Lopez, Jiaolong Wang, Miren Itxaso Santiago Vela, Beibei Liu, Tomoharu Kanie, Roy Ng, Peter K. Jackson, Jens S. Andersen, Esben Lorentzen
Summary: Cilia are important cellular organelles for signaling and motility and are constructed via intraflagellar transport (IFT). RabL2 localizes to the basal body of cilia via an interaction with CEP19 before downstream association with the IFT machinery. Reconstituted pentameric IFT complex containing IFT81/74 enhances the GTP hydrolysis rate of RabL2. Structural models of RabL2-containing IFT complexes validate the architectural understanding of RabL2 incorporation into the IFT complex.
Review
Andrology
Yong-Hong Man, Isabella Warmbrunn, Ling Zhang, Zhi-Bing Zhang
Summary: This review discusses the molecular functions of intraflagellar transport (IFT) protein IFT25 and its interactions with other IFT particle subunits, and how they are involved in mammalian development and fertility.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Review
Cell Biology
Ian James Bell, Matthew Sheldon Horn, Terence John Van Raay
Summary: The non-canonical Wnt signaling pathways have different roles in cancer and development, involving calcium and Vangl2. Cells tend to choose non-canonical Wnt signaling over canonical Wnt signaling when presented with a choice, but this occurs rarely in vivo.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesca Finetti, Anna Onnis, Cosima T. Baldari
Summary: Initially discovered as part of the intraflagellar transport (IFT) system, IFT20 protein is now known to play a role in various unconventional mechanisms. It is important not only in ciliogenesis, but also in vesicular trafficking of membrane receptors and signaling proteins. Its ability to interact with different cellular partners in a cell-type specific manner expands its function to the regulation of intracellular degradative and secretory pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Narcis A. Petriman, Marta Loureiro-Lopez, Michael Taschner, Nevin K. Zacharia, Magdalena M. Georgieva, Niels Boegholm, Jiaolong Wang, Andre Mourao, Robert B. Russell, Jens S. Andersen, Esben Lorentzen
Summary: Cilia are essential organelles for cellular functions such as motility, signaling, and sensory reception. In this study, the researchers used Alphafold to model the structure of the IFT-B complex, which is involved in cilium formation. The results provide insights into the assembly and function of the IFT-B complex.
Review
Cell Biology
Laura Sanchez-Bellver, Vasileios Toulis, Gemma Marfany
Summary: Ciliopathies are a group of heterogeneous inherited disorders caused by dysfunction of the cilium, affecting cells in multiple organs. The unique feature of daily renewal in photoreceptor outer segments and the efficient transport of proteins in ciliary transport are crucial for photoreceptor survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Kelly M. DeMars, Madeleine R. Ross, Alana Starr, Jeremy C. McIntyre
Summary: Neuronal primary cilia play a critical role in central regulation of energy homeostasis. These microtubule-based organelles serve as signaling antennae for metabolic status and impaired ciliary function can lead to obesity-related disorders. In addition to metabolic signaling, primary cilia also modulate catecholamine neuromodulation and shape neuronal circuitry. This review aims to highlight current research on the mechanisms of primary cilium-regulated metabolic drives for maintaining energy homeostasis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joanne L. Usher, Alvaro Sanchez-Martinez, Ana Terriente-Felix, Po-Lin Chen, Juliette J. Lee, Chun-Hong Chen, Alexander J. Whitworth
Summary: The PINK1-Parkin pathway can promote mitochondrial turnover independently of canonical autophagy. The detection of Ser65-phosphorylated ubiquitin (pS65-Ub) can be used to analyze the function of the Pink1-Parkin pathway in Drosophila.
Article
Fisheries
Shagun Sharma, Manmohan Kumar, Jai Kumar, Nidhi Srivastava, Md Arafat Hussain, Asha Shelly, Shibnath Mazumder
Summary: The study investigated the molecular mechanisms of CNS pathology induced by Mycobacterium fortuitum infection in zebrafish, revealing extensive brain damage and compromised blood-brain barrier integrity. It highlighted the involvement of Wnt/beta-catenin pathway in the brain infection process and the critical role of cytokine interplay in the disease progression.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Derek Avery, Lais Morandini, Luke S. Sheakley, Arth H. Shah, Loc Bui, Jefferson O. Abaricia, Rene Olivares-Navarrete
Summary: This study investigates the role of canonical Wnt signaling in the response of macrophages to titanium surface properties. The results show that activating canonical Wnt signaling promotes a pro-inflammatory phenotype, while inhibiting it enhances an anti-inflammatory response.
Article
Multidisciplinary Sciences
David Bauer, Hiroaki Ishikawa, Kimberly A. Wemmer, Nathan L. Hendel, Jane Kondev, Wallace F. Marshall
Summary: Cell-to-cell variation is mainly influenced by cell size, while within-cell variation is caused by dynamic fluctuations. Tubulin assembly is not directly related to intraflagellar transport, and length fluctuations reflect tubulin assembly and disassembly events involving large numbers of tubulin dimers. Length variation increases in long-flagella mutants, consistent with theoretical models for flagellar length regulation.
Article
Biochemistry & Molecular Biology
Xin Zhu, Jieling Wang, Shufen Li, Karl Lechtreck, Junmin Pan
Summary: This study revealed that the IFT-B protein IFT54 interacts with both kinesin-II and IFT dynein, regulating anterograde transport. Deletions of specific residues in IFT54 resulted in disrupted anterograde trafficking of IFT, with accumulations of IFT motors and complexes in different regions of cilia. This suggests a central role for IFT54 in binding IFT motors during anterograde transport.
Article
Multidisciplinary Sciences
Khodor S. Hazime, Zhu Zhou, Ewa Joachimiak, Natalia A. Bulgakova, Dorota Wloga, Jarema J. Malicki
Summary: The base of the cilium serves as a selecting gate to regulate intraflagellar transport-dependent protein trafficking, with various proteins forming clustered rings at the base of the cilia in a ciliate Tetrahymena thermophila. The spatial organization of IFT and TZ proteins plays a key role in cilia formation and function.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Dinu Antony, Han G. Brunner, Miriam Schmidts
Summary: The function of cilia is crucial for vertebrate development and health, and dysfunction can lead to various ciliopathies. Major human ciliopathy cases are caused by malfunction of ciliary dynein motor activity, with different types of dynein dysfunction resulting in different disease phenotypes.
Review
Biochemistry & Molecular Biology
Silvia Muccioli, Valentina Brillo, Leonardo Chieregato, Luigi Leanza, Vanessa Checchetto, Roberto Costa
Summary: The Wnt signaling pathway is crucial in embryonic development for controlling cell proliferation, but aberrant activation in human diseases has been observed. Ion channels, known as modulators of important cellular functions, have been widely researched for their influence on Wnt signaling regulation. This review focuses on the links between ion channels and canonical Wnt signaling, discussing their potential roles in human metabolic diseases, neurological disorders, and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Anatomy & Morphology
Sophie Balmer, Sonja Nowotschin, Anna-Katerina Hadjantonakis
DEVELOPMENTAL DYNAMICS
(2016)
Article
Genetics & Heredity
Neeta Bala Tannan, Giovanna Collu, Ashley C. Humphries, Ekatherina Serysheva, Ursula Weber, Marek Mlodzik
Article
Genetics & Heredity
Giovanna M. Collu, Andreas Jenny, Konstantin Gaengel, Ivana Mirkovic, Meiling Chin, Ursula Weber, Michael J. Smith, Marek Mlodzik
Article
Multidisciplinary Sciences
Johannes W. Bigenzahn, Giovanna M. Collie, Felix Kartnig, Melanie Pieraks, Gregory Vladimer, Leonhard X. Heinez, Vitaly Sedlyarov, Fiorella Schischlik, Astrid Fauster, Manuele Rebsamen, Katja Parapatics, Vincent A. Blomen, Andre C. Muller, Georg E. Winter, Robert Kralovics, Thijn R. Brunlinelkamp, Marek Mlodzik, Giulio Superti-Furga
Editorial Material
Biochemical Research Methods
Emily A. Lescak, Kate M. O'Neill, Giovanna M. Collu, Subhamoy Das
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Maria Thuveson, Konstantin Gaengel, Giovanna M. Collu, Mei-ling Chin, Jaskirat Singh, Marek Mlodzik
Letter
Nutrition & Dietetics
Ivan Herrera-Peco, Beatriz Jimenez-Gomez, Juan Jose Pena-Deudero, Elvira Benitez De Gracia
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Summary: Notch and Wnt are two essential signaling pathways in animals, with typically opposing effects on cell fate decisions. Notch can limit Wnt signaling through mechanisms at the cell membrane and in the cell nucleus, contributing to the robustness of cell fate decisions by sharpening the distinction between opposing Notch/Wnt responses.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Ivan Herrera-Peco, Beatriz Jimenez-Gomez, Carlos Santiago Romero Magdalena, Juan Jose Deudero, Maria Garcia-Puente, Elvira Benitez De Gracia, Carlos Ruiz Nunez
Summary: During the COVID-19 pandemic, a Twitter campaign in Spanish language focused on antivaccination messages has been identified, aiming to undermine the credibility of vaccines and promote conspiracy theories linking vaccines to genetic manipulation. The study revealed the presence of influential users spreading misinformation and attacking vaccine safety, highlighting the need to address this new aspect of vaccine hoaxes in the fight against misinformation.
Article
Biochemistry & Molecular Biology
Rebecca Williams, Stephanie Jobling, Andrew H. Sims, Chunyan Mou, Lorna Wilkinson, Giovanna M. Collu, Charles H. Streuli, Andrew P. Gilmore, Denis J. Headon, Keith Brennan
Summary: This study highlights the significance of EDAR in ER-negative breast carcinomas and its correlation with tumorigenesis in mice. Elevated EDAR signaling leads to mammary tumors with squamous differentiation and increased beta-catenin activity, suggesting a novel mechanism of transformation based on interaction between the WNT and EDA pathways.
Article
Multidisciplinary Sciences
Nabila Founounou, Reza Farhadifar, Giovanna M. Collu, Ursula Weber, Michael J. Shelley, Marek Mlodzik
Summary: The study highlights the critical role of the Nemo molecule in regulating the transition from solid to viscoelastic tissues in the process of cell migration, emphasizing the importance of junctional remodeling regulation for tissue fluidity.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Biology
Giovanna M. Collu, Marek Mlodzik
Summary: New imaging approaches challenge the long-standing model on how geometric patterns are acquired in the eyes of fruit flies.
Editorial Material
Cell Biology
Giovanna M. Collu, Marek Mlodzik
Summary: BMP family ligands can influence cell fate by directing cell division, differentiation, or cell death, depending on the specific hetero-or homodimer combinations and cellular context. In this issue of Developmental Cell, Bauer et al. identify endogenous dimeric ligands in fruit flies and demonstrate that the composition of BMP dimers affects both the range and activity of signaling.
DEVELOPMENTAL CELL
(2023)
Article
Health Care Sciences & Services
Ivan Herrera-Peco, Beatriz Jimenez-Gomez, Juan Jose Pena Deudero, Elvira Benitez De Gracia, Carlos Ruiz-Nunez
Summary: The COVID-19 pandemic has had a significant impact worldwide, leading to a heightened need for health-related information on social media. Healthcare professionals on Twitter have shown limited involvement in the dissemination of information regarding COVID-19 vaccines, with pharmacists, nurses, and physicians being the most active, mainly sharing content from other users.
Article
Health Care Sciences & Services
Diego Ayuso-Murillo, Ana Colomer-Sanchez, Carlos Romero Santiago-Magdalena, Alejandro Lendinez-Mesa, Elvira Benitez De Gracia, Antonio Lopez-Pelaez, Ivan Herrera-Peco