Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia

Emerging strategies for the treatment of older patients with acute myeloid leukemia

(2016) Miguel A. Sanz et al.   ANNALS OF HEMATOLOGY

New drugs in acute myeloid leukemia: Table 1.

(2016) T. M. Kadia et al.   ANNALS OF ONCOLOGY

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

(2016) T.-C. Ho et al.   BLOOD

Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia

(2016) Fiona C. Brown et al.   BRITISH JOURNAL OF HAEMATOLOGY

Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia

(2016) Norio Shiba et al.   BRITISH JOURNAL OF HAEMATOLOGY

Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

(2016) Jason E. Farrar et al.   CANCER RESEARCH

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response

(2016) Ernestina Saulle et al.   Journal of Hematology & Oncology

Long non-coding RNAs in the regulation of myeloid cells

(2016) Xinyu Tian et al.   Journal of Hematology & Oncology

Matched and mismatched unrelated donor compared to autologous stem cell transplantation for acute myeloid leukemia in first complete remission: a retrospective, propensity score-weighted analysis from the ALWP of the EBMT

(2016) Francesco Saraceni et al.   Journal of Hematology & Oncology

Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia

(2016) V Madan et al.   LEUKEMIA

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

(2016) Sheng Li et al.   NATURE MEDICINE

Assessment of Minimal Residual Disease in Standard-Risk AML

(2016) Adam Ivey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia

(2016) Pierre Hirsch et al.   Nature Communications

Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing

(2016) Riccardo Masetti et al.   Oncotarget

Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials

(2016) Seongseok Yun et al.   Clinical Epigenetics

Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang

(2016) Hong-Sheng Zhou et al.   Cancer Biology & Medicine

DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders

(2016) Hanae Sato et al.   Frontiers in Oncology

Disease evolution and outcomes in familial AML with germline CEBPA mutations

(2015) K. Tawana et al.   BLOOD

Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse

(2015) M. Garg et al.   BLOOD

Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML

(2015) T. N. Wong et al.   BLOOD

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

(2015) D. Grimwade et al.   BLOOD

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Current standard treatment of adult acute promyelocytic leukaemia

(2015) Francesco Lo-Coco et al.   BRITISH JOURNAL OF HAEMATOLOGY

Management of Newly Diagnosed Acute Myeloid Leukemia in the Elderly: Current Strategies and Future Directions

(2015) David Sanford et al.   DRUGS & AGING

Management of Relapsed/Refractory Acute Myeloid Leukemia in the Elderly: Current Strategies and Developments

(2015) Jeffrey C. Bryan et al.   DRUGS & AGING

Somatic mutational landscape of AML with inv(16) or t(8;21) identifies patterns of clonal evolution in relapse leukemia

(2015) R Sood et al.   LEUKEMIA

AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients

(2015) Tamara Alpermann et al.   LEUKEMIA RESEARCH

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia

(2015) Britta Will et al.   NATURE MEDICINE

Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia

(2015) Amy L. Paguirigan et al.   Science Translational Medicine

Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia

(2015) Jean-Emmanuel Bibault et al.   Oncotarget

Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia

(2015) Iveta Sarova et al.   GENES CHROMOSOMES & CANCER

Comparison of Newly Diagnosed and Relapsed Patients with Acute Promyelocytic Leukemia Treated with Arsenic Trioxide: Insight into Mechanisms of Resistance

(2015) Ezhilarasi Chendamarai et al.   PLoS One

Gene Expression Profiles Associated with Pediatric Relapsed AML

(2015) Costa Bachas et al.   PLoS One

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype

(2014) Simone Feurstein et al.   BMC GENOMICS

Targeting FLT3 to treat leukemia

(2014) Heiko Konig et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis

(2014) M R Corces-Zimmerman et al.   LEUKEMIA

A gene expression profile associated with relapse of cytogenetically normal acute myeloid leukemia is enriched for leukemia stem cell genes

(2014) Hubert Hackl et al.   LEUKEMIA & LYMPHOMA

Induction of the proapoptotic tumor suppressor geneCell Adhesion Molecule 1by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia

(2014) Muriel C. Fisser et al.   MOLECULAR CARCINOGENESIS

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia

(2013) J. Kronke et al.   BLOOD

Identification of emergingFLT3ITD-positive clones during clinical remission and kinetics of disease relapse in acute myeloid leukaemia with mutated nucleophosmin

(2013) Tiziana Ottone et al.   BRITISH JOURNAL OF HAEMATOLOGY

Multidrug resistance in relapsed acute myeloid leukemia: Evidence of biological heterogeneity

(2013) Chirayu Patel et al.   CANCER

CDK1 interacts with RARγ and plays an important role in treatment response of acute myeloid leukemia

(2013) Andreas Hedblom et al.   CELL CYCLE

Identification of a 24-Gene Prognostic Signature That Improves the European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: An International Collaborative Study

(2013) Zejuan Li et al.   JOURNAL OF CLINICAL ONCOLOGY

Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease

(2013) A Kohlmann et al.   LEUKEMIA

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

(2013) Julia A Meyer et al.   NATURE GENETICS

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

(2013) Gannie Tzoneva et al.   NATURE MEDICINE

Minimal residual disease in acute myeloid leukaemia

(2013) Christopher S. Hourigan et al.   Nature Reviews Clinical Oncology

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

The variety of leukemic stem cells in myeloid malignancy

(2013) D H Wiseman et al.   ONCOGENE

Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma

(2013) J. J. Gartner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transglutaminase 2 expression in acute myeloid leukemia: Association with adhesion molecule expression and leukemic blast motility

(2013) Andrew Pierce et al.   PROTEOMICS

Cell lineage analysis of acute leukemia relapse uncovers the role of replication-rate heterogeneity and microsatellite instability

(2012) L. I. Shlush et al.   BLOOD

Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia

(2012) B. Parkin et al.   BLOOD

High-resolution genomic profiling of adult and pediatric core-binding factor acute myeloid leukemia reveals new recurrent genomic alterations

(2012) M. W. M. Kuhn et al.   BLOOD

The myth of the second remission of acute leukemia in the adult

(2012) S. J. Forman et al.   BLOOD

Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML

(2012) Thanh-Trang Vo et al.   CELL

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia

(2012) S Wakita et al.   LEUKEMIA

The role of minor subpopulations within the leukemic blast compartment of AML patients at initial diagnosis in the development of relapse

(2012) C Bachas et al.   LEUKEMIA

How to manage acute promyelocytic leukemia

(2012) J-Q Mi et al.   LEUKEMIA

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

Clonal Architecture of Secondary Acute Myeloid Leukemia

(2012) Matthew J. Walter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide Profiling in AML Patients Relapsing after Allogeneic Hematopoietic Cell Transplantation

(2011) Miguel Waterhouse et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers

(2011) V. Rockova et al.   BLOOD

DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications

(2011) H.-A. Hou et al.   BLOOD

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine

(2010) C. Bachas et al.   BLOOD

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials

(2010) D. Grimwade et al.   BLOOD

Genomic, immunophenotypic, and NPM1/FLT3 mutational studies on 17 patients with normal karyotype acute myeloid leukemia (AML) followed by aberrant karyotype AML at relapse

(2010) Eunice S. Wang et al.   CANCER GENETICS AND CYTOGENETICS

Involvement of Oxidative Stress in the Relapse of Acute Myeloid Leukemia

(2010) Fu-Ling Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia

(2010) Dan-Dan Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia

(2010) W-C Chou et al.   LEUKEMIA

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia

(2009) I. H. I. M. Hollink et al.   BLOOD

Contribution of bone microenvironment to leukemogenesis and leukemia progression

(2009) F Ayala et al.   LEUKEMIA

The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia

(2009) H Seifert et al.   LEUKEMIA

Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis

(2009) L Bullinger et al.   LEUKEMIA

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse

(2008) H. Kroeger et al.   BLOOD

Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia

(2008) M. Raghavan et al.   BLOOD

An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia

(2008) K. H. Metzeler et al.   BLOOD

Preferential loss of mismatch repair function in refractory and relapsed acute myeloid leukemia: potential contribution to AML progression

(2008) Guogen Mao et al.   CELL RESEARCH

Expression and prognostic significance of different mRNA 5′-end variants of the oncogeneEVI1in 266 patients with de novo AML:EVI1andMDS1/EVI1overexpression both predict short remission duration

(2008) Katja Haas et al.   GENES CHROMOSOMES & CANCER

Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML

(2008) I H I M Hollink et al.   LEUKEMIA

Acute Myeloid Leukemia: The Challenge of Capturing Disease Variety

(2008) B. Lowenberg   Hematology-American Society of Hematology Education Program