Recent advance in molecular angiogenesis in glioblastoma: the challenge and hope for anti-angiogenic therapy

Increased level of H19 long noncoding RNA promotes invasion, angiogenesis, and stemness of glioblastoma cells

(2016) Xiaochun Jiang et al.   JOURNAL OF NEUROSURGERY

Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma

(2015) Manabu Onishi et al.   Brain Tumor Pathology

VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFβR signaling-dependent manner

(2015) Kien Pham et al.   CANCER LETTERS

Calpastatin Counteracts Pathological Angiogenesis by Inhibiting Suppressor of Cytokine Signaling 3 Degradation in Vascular Endothelial CellsNovelty and Significance

(2015) Takuro Miyazaki et al.   CIRCULATION RESEARCH

Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factor-binding Protein 1 (IGFBP1) to Promote Angiogenesis

(2015) Mamatha Bangalore Nijaguna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lessons From Anti–Vascular Endothelial Growth Factor and Anti–Vascular Endothelial Growth Factor Receptor Trials in Patients With Glioblastoma

(2015) Christine Lu-Emerson et al.   JOURNAL OF CLINICAL ONCOLOGY

MiR-137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2

(2015) Jie Sun et al.   JOURNAL OF NEURO-ONCOLOGY

Detection of p53 mutations in proliferating vascular cells in glioblastoma multiforme

(2015) Takuma Kawasoe et al.   JOURNAL OF NEUROSURGERY

TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis

(2015) Weon Sup Lee et al.   mAbs

The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma

(2015) Hon-Kit Andus Wong et al.   MOLECULAR THERAPY

VEGF isoforms as outcome biomarker for anti-angiogenic therapy in recurrent glioblastoma

(2015) Q. G. D'Alessandris et al.   NEUROLOGY

A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology

(2015) Courtney M. Tate et al.   PLoS One

Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway

(2015) Emeline Tabouret et al.   Oncotarget

Modulation of cerebral endothelial cell function by TGF-β in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition

(2015) Shanmugarajan Krishnan et al.   Oncotarget

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

(2015) Richard L. Carpenter et al.   Oncotarget

JSI-124 Suppresses Invasion and Angiogenesis of Glioblastoma Cells In Vitro

(2015) Guang Yuan et al.   PLoS One

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma

(2015) John de Groot et al.   Oncotarget

Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma

(2015) Negar Babae et al.   Oncotarget

Human hematopoietic signal peptide-containing secreted 1 (hHSS1) modulates genes and pathways in glioma: implications for the regulation of tumorigenicity and angiogenesis

(2014) Katiana S Junes-Gill et al.   BMC CANCER

Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma

(2014) Hisaaki Takahashi et al.   Brain Tumor Pathology

Antiangiogenic Therapy for Glioblastoma: Current Status and Future Prospects

(2014) T. T. Batchelor et al.   CLINICAL CANCER RESEARCH

VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain

(2014) M. Tillo et al.   DEVELOPMENT

The role of CXCR4 in highly malignant human gliomas biology: Current knowledge and future directions

(2014) Filippo Gagliardi et al.   GLIA

C/EBPβ promotes angiogenesis through secretion of IL-6, which is inhibited by genistein, in EGFRvIII-positive glioblastoma

(2014) Xujie Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Phase 2 study of CT-322, a targeted biologic inhibitor of VEGFR-2 based on a domain of human fibronectin, in recurrent glioblastoma

(2014) David Schiff et al.   INVESTIGATIONAL NEW DRUGS

NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction

(2014) Ki Hyun Kim et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

MiR-7-5p is frequently downregulated in glioblastoma microvasculature and inhibits vascular endothelial cell proliferation by targeting RAF1

(2014) Zhiguo Liu et al.   TUMOR BIOLOGY

 1 Integrin Targeting Potentiates Antiangiogenic Therapy and Inhibits the Growth of Bevacizumab-Resistant Glioblastoma

(2013) W. S. Carbonell et al.   CANCER RESEARCH

AGR2 Expression is Regulated by HIF-1 and Contributes to Growth and Angiogenesis of Glioblastoma

(2013) Xing-Yu Hong et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Gene Expression Profile Identifies Tyrosine Kinase c-Met as a Targetable Mediator of Antiangiogenic Therapy Resistance

(2013) A. Jahangiri et al.   CLINICAL CANCER RESEARCH

Antiangiogenic therapy for high-grade gliomas: current concepts and limitations

(2013) Pasquale De Bonis et al.   Expert Review of Neurotherapeutics

Mechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiforme

(2013) Yasushi Soda et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia

(2013) X.-g. Mao et al.   NEURO-ONCOLOGY

Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme

(2013) N. El Hindy et al.   NEURO-ONCOLOGY

Mechanisms of Tumor Development and Anti-angiogenic Therapy in Glioblastoma Multiforme

(2013) Manabu ONISHI et al.   NEUROLOGIA MEDICO-CHIRURGICA

Irradiated normal brain promotes invasion of glioblastoma through vascular endothelial growth and stromal cell-derived factor 1α

(2013) Wei Zhou et al.   NEUROREPORT

Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) Plays a Key Role in Vasculogenic Mimicry Formation, Neovascularization and Tumor Initiation by Glioma Stem-like Cells

(2013) Xiaohong Yao et al.   PLoS One

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nestin: A novel angiogenesis marker and possible target for tumor angiogenesis

(2013) Yoko Matsuda   WORLD JOURNAL OF GASTROENTEROLOGY

The VEGF Pathway in Cancer and Disease: Responses, Resistance, and the Path Forward

(2013) M. W. Kieran et al.   Cold Spring Harbor Perspectives in Medicine

Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice

(2012) Miaojun Han et al.   CANCER LETTERS

Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

(2012) A. McIntyre et al.   CLINICAL CANCER RESEARCH

Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma

(2012) Adrian M Jubb et al.   HISTOPATHOLOGY

Glioblastoma-derived Tumor Cells Induce Vasculogenic Mimicry through Flk-1 Protein Activation

(2012) Ralph Francescone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P14ARF inhibits human glioblastoma–induced angiogenesis by upregulating the expression of TIMP3

(2012) Abdessamad Zerrouqi et al.   JOURNAL OF CLINICAL INVESTIGATION

Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice

(2012) Hanseul Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Transdifferentiation of Glioblastoma Stem-Like Cells into Mural Cells Drives Vasculogenic Mimicry in Glioblastomas

(2012) S. Scully et al.   JOURNAL OF NEUROSCIENCE

Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization

(2012) Lothar C Dieterich et al.   JOURNAL OF PATHOLOGY

Upregulation of SATB1 is associated with the development and progression of glioma

(2012) Sheng-Hua Chu et al.   Journal of Translational Medicine

Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma

(2012) Tiffany A. Doucette et al.   NEURO-ONCOLOGY

Anti-angiogenic gene therapy in the treatment of malignant gliomas

(2012) NaTosha N. Gatson et al.   NEUROSCIENCE LETTERS

Therapy-resistant tumor microvascular endothelial cells contribute to treatment failure in glioblastoma multiforme

(2012) T Borovski et al.   ONCOGENE

The 18 kDa translocator protein influences angiogenesis, as well as aggressiveness, adhesion, migration, and proliferation of glioblastoma cells

(2012) Julia Bode et al.   Pharmacogenetics and Genomics

Glioblastoma Cell-Secreted Interleukin-8 Induces Brain Endothelial Cell Permeability via CXCR2

(2012) Julie Dwyer et al.   PLoS One

Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling

(2011) B. Kigel et al.   BLOOD

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

(2011) R Bonavia et al.   ONCOGENE

Malignant Gliomas: New Translational Therapies

(2010) Joohee Sul et al.   MOUNT SINAI JOURNAL OF MEDICINE

Activated STAT3 Regulates Hypoxia-Induced Angiogenesis and Cell Migration in Human Glioblastoma

(2010) Shin-Hyuk Kang et al.   NEUROSURGERY

Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy

(2008) David A Reardon et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

New molecular targets in angiogenic vessels of glioblastoma tumours

(2008) Joshua C. Anderson et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

An exploratory survival analysis of anti-angiogenic therapy for recurrent malignant glioma

(2008) Andrew D. Norden et al.   JOURNAL OF NEURO-ONCOLOGY