Article
Nanoscience & Nanotechnology
Easter Ndlovu, Lucas Malpartida, Taranum Sultana, Tanya E. S. Dahms, Etienne Dague
Summary: Candida is a common opportunistic fungal pathogen in humans, and its adhesion to host cells is crucial for parasitic and pathogenic processes. Studies have shown an increased risk of candidiasis when tissue barriers are weakened or immune defenses are compromised, such as during cancer treatment. Using atomic force microscopy, researchers found that there was significant adhesion between Candida and human cells, with a stronger adhesion to cancer cells due to their different mechanical properties. The disruption of cell cytoskeleton affected the adhesion between Candida and human cells, suggesting the manipulation of cell properties as a potential therapeutic strategy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Haojie Wang, Yuan Wang, Wenhua Xu, Haixin Zhang, Jinmeng Lv, Xue Wang, Zhi Zheng, Yanxia Zhao, Le Yu, Quan Yuan, Leixiao Yu, Bo Zheng, Lingyan Gao
Summary: This study demonstrates the modulation of guest reactivity within a macrocyclic cavity using pillar[5]arene, which enhances guest photoactivity and nitric oxide generation. The system shows broad-spectrum antibacterial activity and promotes wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Chantal Selina Ingham, Tobias Engl, Bernal Matarrita-Carranza, Paul Vogler, Bruno Huettel, Natalie Wielsch, Ales Svatos, Martin Kaltenpoth
Summary: Symbiosis with microbes is important for the evolutionary success of insects, and a study on beewolves shows that the host provides a protective barrier against nitric oxide to ensure the survival of symbiotic bacteria during transmission.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jian Luo, Jinzhi Xu, Chaolu Xie, Zuoming Zhao, Junrui Guo, Yuan Wen, Tian Li, Zeyang Zhou
Summary: This study reveals the mechanism by which microsporidia manipulate host mitochondrial fragmentation (HMF), thus providing references for understanding the interactions between microsporidia and host mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Marine
Daniela Amelio, Filippo Garofalo, Elvira Brunelli, Gianfranco Santovito, Daniela Pellegrino
Summary: The Frank-Starling response is a significant intrinsic heart property that is highly noticeable in fish hearts due to their sensitivity to stretch. Nitric oxide plays a crucial role in the Frank-Starling response. Antarctic icefish has lower expression and activation of nitric oxide synthase compared to red-blooded Antarctic teleost species, indicating its unique involvement in the Frank-Starling response.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Microbiology
N. Kavya, M. K. Prasannakumar, Gopal Venkateshbabu, Vidya Niranjan, Akshay Uttarkar, P. Buela Parivallal, Sahana N. Banakar, H. B. Mahesh, Pramesh Devanna, K. G. Manasa, Tagginahalli N. Shivakumara
Summary: In this study, seven novel effectors in Rhizoctonia solani were identified and their functions, reactivity, and stability were evaluated. Target proteins involved in the regulation of rice defense mechanisms were also identified. These findings have implications for the management of sheath blight in rice.
Review
Cell Biology
Dominik Brokatzky, Serge Mostowy
Summary: Pyroptosis is a regulated form of cell death characterized by cell lysis and the release of pro-inflammatory molecules. It plays a crucial role in bacterial infection by promoting an inflammatory response and eliminating intracellular pathogens. Recent studies using various bacterial pathogens have enhanced our understanding of pyroptosis and its importance in host defense.
DISEASE MODELS & MECHANISMS
(2022)
Review
Cell Biology
Ye Mon Soe, Sammy Bedoui, Timothy P. Stinear, Abderrahman Hachani
Summary: Staphylococcus aureus is a major opportunistic human pathogen with virulence factors causing devastating infections. It adopts an intracellular lifestyle to evade host immunity and antibacterial actions, but is exposed to challenges and clearance mechanisms orchestrated by host programmed cell death pathways.
CELLULAR MICROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Leon Kemper, Andreas Hensel
Summary: Campylobacter jejuni, causing severe enteritis, has unique features and adapts effectively to environmental conditions. The review summarizes the strategies of C. jejuni for host-pathogen interaction, providing insights for future drug development.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Supratim Basu, Elena Sineva, Liza Nguyen, Narattam Sikdar, Jong Won Park, Mikhail Sinev, Madhurababu Kunta, Goutam Gupta
Summary: This article introduces a novel therapy for citrus Huanglongbing (HLB) and apple fire blight by enhancing the innate immunity of the host plants. The researchers constructed chimeras with observed or predicted antibacterial activity and demonstrated their effectiveness in clearing the causative bacteria and augmenting the host's immune response.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Microbiology
Krzysztof Grzymajlo
Summary: This review sheds light on the current understanding of the interactions between enteric pathogens, host gut microbiota, and the gastrointestinal tract. It discusses the strengths and limitations of in vitro and in vivo models used in studying Salmonella-host-microbiome interactions, and outlines future challenges and directions.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Liam Caven, Rey Carabeo
Summary: Infection of the female genital tract by Chlamydia trachomatis can lead to severe fibrotic sequelae, and it remains unclear if intrinsic properties of the upper genital tract exacerbate the fibrotic response. This study found that cervical epithelial cells have enhanced expression of fibrosis-associated signal factors and infection-mediated induction of fibrosis-related genes. The activation of YAP, a transcriptional cofactor, by chlamydial infection in cervical epithelial cells was identified as a potential driver of fibrotic gene expression. These findings provide new insights into the mechanism of Chlamydia-induced fibrosis and suggest YAP as a potential therapeutic target for preventing scarring of the female genital tract.
Article
Immunology
Camila Gachet-Castro, Felipe Freitas-Castro, Raul Alexander Gonzales-Cordova, Carol Kobori da Fonseca, Marcelo Damario Gomes, Hellen Cristina Ishikawa-Ankerhold, Munira Muhammad Abdel Baqui
Summary: This study reveals that the parasite Trypanosoma cruzi can modulate host transcription and splicing machinery during infection by appropriating the host cell nucleus, specifically targeting the U2AF35 auxiliary factor.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Plant Sciences
Ruifen Ren, Hao Zhou, Lingling Zhang, Xueru Jiang, Yan Liu
Summary: This study investigated the effects of nitric oxide (NO) on programmed cell death (PCD) in Paeonia lactiflora 'Fen Yu Nu' pollen after cryopreservation, revealing that increased levels of NO correlated with higher apoptosis rates and decreased viability. The findings suggest that NO-induced PCD plays a significant role in the viability decline of pollen after cryopreservation.
PLANT CELL REPORTS
(2021)
Article
Fisheries
C. W. E. Embregts, D. Rigaudeau, L. Tacchi, G. P. Pijlman, L. Kampers, T. Vesely, D. Pokorova, P. Boudinot, G. F. Wiegertjes, M. Forlenza
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Fisheries
Fuguo Liu, Tiehui Wang, Jules Petit, Maria Forlenza, Xinhua Chen, Liangbiao Chen, Jun Zou, Christopher J. Secombes
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Immunology
Annelieke S. Wentzel, Joelle J. E. Janssen, Vincent C. J. de Boer, Wouter G. van Veen, Maria Forlenza, Geert F. Wiegertjes
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
Adria Lopez Nadal, Wakako Ikeda-Ohtsubo, Detmer Sipkema, David Peggs, Charles McGurk, Maria Forlenza, Geert F. Wiegertjes, Sylvia Brugman
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Nienke H. van Teijlingen, Leanne C. Helgers, Esther M. Zijlstra-Willems, John L. van Hamme, Carla M. S. Ribeiro, Karin Strijbis, Teunis B. H. Geijtenbeek
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Immunology
Bernadien M. Nijmeijer, Julia Eder, Catharina J. M. Langedijk, Tanja M. Kaptein, Sofie Meeussen, Pascale Zimmermann, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Annelieke S. Wentzel, Jules Petit, Wouter G. van Veen, Inge Rosenbek Fink, Marleen H. Scheer, M. Carla Piazzon, Maria Forlenza, Herman P. Spaink, Geert F. Wiegertjes
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Alexandra P. M. Cloherty, Andrea D. Olmstead, Carla M. S. Ribeiro, Francois Jean
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Virology
Adithya Sridhar, Salvatore Simmini, Carla M. S. Ribeiro, Caroline Tapparel, Melvin M. Evers, Dasja Pajkrt, Katja Wolthers
Article
Microbiology
Bo Gao, Xiaoqian Gong, Shouguo Fang, Wenlian Weng, Huan Wang, Hongyan Chu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Maria Forlenza, Chan Ding, Ying Liao
Summary: Coronaviruses use the endoribonuclease nsp15 to interfere with the formation of anti-viral stress granules (SGs), reducing viral dsRNA accumulation and antagonizing PKR activation, thereby ensuring productive virus replication. Nsp15s from various coronaviruses interfere with SGs formation, possibly by targeting essential SGs assembly factors, indicating a conserved mechanism among coronaviruses to counteract host antiviral responses. This study highlights the role of nsp15 in suppressing the integral stress response and crosstalk with anti-innate immune response.
Article
Fisheries
Patrycja Jurecka, Geert F. Wiegertjes, Mariola Dietrich, Maria Forlenza, Teresa Kaminska-Gibas, Andrzej Pilarczyk, Huub F. J. Savelkoul, Andrzej Ciereszko, Ilgiz Irnazarow
Summary: The study highlights the critical role of transferrin for parasite growth and demonstrates the significant impact of transferrin polymorphism on Trypanoplasma borreli multiplication. During T. borreli infection in carp, transferrin may play an immunological function as indicated by increased transcription in the head kidney.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biology
Sem H. Jacobs, Eva Doro, Ffion R. Hammond, Mai E. Nguyen-Chi, Georges Lutfalla, Geert F. Wiegertjes, Maria Forlenza
Summary: This study investigated the early response of macrophages and neutrophils to Trypanosoma carassii infection using larval zebrafish, identifying high-infected individuals with foamy macrophages and a strong pro-inflammatory profile. These foamy macrophages were found exclusively in highly infected zebrafish and may be associated with an exacerbated immune response and increased susceptibility to infection.
Article
Immunology
Jules Petit, Irene de Bruijn, Mark R. G. Goldman, Erik van den Brink, Wilbert F. Pellikaan, Maria Forlenza, Geert F. Wiegertjes
Summary: Dietary supplementation of fish with beta-glucans has been found to have immunomodulatory effects, but the exact mechanisms are still unclear. In this study, the researchers identified the active naive microbiota in the intestine of common carp and found that certain bacteria are capable of fermenting dietary beta-glucans. They also observed fermentation of two different beta-glucan preparations in vitro, resulting in the production of distinct short-chain fatty acids (SCFA). Additionally, they demonstrated the potential immunomodulatory effects of SCFAs on head kidney leukocytes, suggesting a possible role in beta-glucan-induced immunomodulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Xue Pan, Qinfang Liu, Shiqi Niu, Dongming Huang, Dawei Yan, Qiaoyang Teng, Xuesong Li, Nancy Beerens, Maria Forlenza, Mart C. M. de Jong, Zejun Li
Summary: Despite the long-term use of vaccines, they have not been successful in controlling H9N2 avian influenza virus in China. Maternal-derived antibodies against the virus have hindered the effectiveness of H9N2 vaccines in poultry. This study aimed to develop a new vaccine that could overcome this interference.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Jules Petit, Erin C. Bailey, Robert T. Wheeler, Carlos A. F. de Oliveira, Maria Forlenza, Geert F. Wiegertjes
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Fisheries
Ratiporn Thongsoi, Siriluk Maskaew, Panumas Puechpon, Benjaporn Noppradit, Napassawan Inaek, Prapaporn Utarabhand, Phanthipha Runsaeng
Summary: In this study, a PPAE gene called FmPPAE1 was cloned and analyzed in banana shrimp. FmPPAE1 plays a vital role in regulating the proPO system, exhibits antibacterial properties, and contributes to the suppression of bacterial proliferation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jishuang Tan, Paizelaiti Sahaer, Huan Li, Wei Han, Hongyan Sun
Summary: Circular RNAs (circRNA) are involved in gene expression and affect cellular processes such as transcription, splicing, and translation by interacting with microRNA and RNA binding proteins. A study identified circDNAJB6 as a circular RNA abundant in chicken macrophages after bacterial infection, and found that circDNAJB6 exacerbates cellular injury and interacts with multiple miRNAs and target genes, potentially impacting autophagy and MAPK signaling pathways.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Rodrigo Guabiraba, Damaris Ribeiro Rodrigues, Paul T. Manna, Melanie Chollot, Vincent Saint-Martin, Sascha Trapp, Marisa Oliveira, Clare E. Bryant, Brian J. Ferguson
Summary: The innate immune response relies on the ability of host cells to detect and respond to microbial nucleic acids. Toll-like receptors (TLRs) play a crucial role in this process by distinguishing self from non-self. This study focused on TLR21, an avian TLR that recognizes bacterial DNA motifs. The findings suggest that avian TLR21 shares similar activation mechanisms to mammalian TLR9, highlighting the conservation of nucleic acid sensing mechanisms across species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Summary: Chickens have a unique immune structure characterized by the absence of draining lymph nodes and the presence of well-developed mucosa-associated lymphoid tissue. The structure and development of chicken lymphoid tissues in the intestine, particularly Peyer's patches, have been poorly studied. However, the use of CSF1R-eGFP reporter transgenic chickens has allowed for the visualization and investigation of the development and distribution of these tissues. This research provides insights that could benefit mucosal vaccination strategies and the development of targeted vaccine delivery systems.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Retraction
Fisheries
G. -g. Li, Z. -z. Guo, X. -f. Ma, N. Cao, S. -n. Geng, Y. -q. Zheng, M. -j. Meng, H. -h. Lin, G. Han, G. -j. Du
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Jinyue Yang, Peng Zhou, Wanrong Wu, Qingxiang Zhang, Dong Chen, Rui Luo
Summary: This study cloned and characterized the full-length sequence of duck MRE11 (duMRE11) for the first time, and found that this protein plays an important role in the innate immune response of ducks.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Yinan Li, Xingye Lian, Wenwen Yang, Jinyuan Leng, Jiejie Sun, Yu Liu, Siqi Fan, Lingling Wang, Linsheng Song
Summary: The DM9-containing protein CgDM9CP-7 plays an important role in the innate immune response of molluscs. It is constitutively expressed in various tissues and is up-regulated in haemocytes after stimulation by Vibrio splendidus and lipopolysaccharide (LPS). CgDM9CP-7 binds to various pathogens and exhibits antimicrobial activity, while also regulating the expression of CgMyD88 and CgIL-17.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Fisheries
Xiuwen Bao, Haoran Song, Liying He, Yong Li, Shuqi Niu, Jinlin Guo
Summary: This study focuses on the interaction between Hepialus xiaojinensis larvae and Ophiocordyceps sinensis during the infection process. The results show that the infected third instar larvae enhance antioxidant defense ability, while the infected fourth instar larvae reduce this ability and allocate more energy to growth and development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)