Article
Multidisciplinary Sciences
Michelle Fennen, Toni Weinhage, Vanessa Kracke, Johanna Intemann, Georg Varga, Corinna Wehmeyer, Dirk Foell, Adelheid Korb-Pap, Thomas Pap, Berno Dankbar
Summary: The study demonstrated the involvement of myostatin in regulating joint inflammation by recruiting Th17 cells to inflammatory sites. Blockade of the CCL20-CCR6 axis by inhibiting myostatin could be a promising treatment option for chronic inflammatory diseases such as arthritis.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Holger Loerchner, Laia Canes Esteve, Maria Elisa Goes, Roxanne Harzenetter, Nathalie Brachmann, Praveen Gajawada, Stefan Guenther, Nicolas Doll, Jochen Poeling, Thomas Braun
Summary: This study reveals that TNF alpha recruits VEGFA-expressing neutrophils for muscle tissue revascularization through the CCL20-CCR6 axis. This finding provides a promising approach for revascularization, especially in diabetic conditions.
CIRCULATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
David N. Hanna, Paula Marincola Smith, Sergey V. Novitskiy, M. Kay Washington, Jinghuan Zi, Connie J. Weaver, Jalal A. Hamaamen, Keeli B. Lewis, Jing Zhu, Jing Yang, Qi Liu, R. Daniel Beauchamp, Anna L. Means
Summary: Loss of SMAD4 in colonic epithelial cells can increase CCL20 expression and recruitment of CCR6+ immune cells, leading to a greater susceptibility to colon cancer.
Review
Immunology
Heikrujam Thoihen Meitei, Nandadeep Jadhav, Girdhari Lal
Summary: CCR6 and CCL20 play crucial roles in cell migration and inflammatory conditions, with strong associations found between their expression and disease severity in various autoimmune disorders. Targeting the CCR6-CCL20 axis shows promise in controlling autoimmune diseases by preventing immune cell migration and reducing inflammation.
AUTOIMMUNITY REVIEWS
(2021)
Article
Rheumatology
Zhenrui Shi, Emma Garcia-Melchor, Xuesong Wu, Anthony E. Getschman, Mimi Nguyen, Douglas J. Rowland, Machelle Wilson, Flavia Sunzini, Moeed Akbar, Mindy Huynh, Timothy Law, Smriti K. Raychaudhuri, Siba P. Raychaudhuri, Brian F. Volkman, Neal L. Millar, Sam T. Hwang
Summary: The study reveals the pathogenic role of the CCR6/CCL20 axis in enthesitis associated with psoriatic arthritis and psoriasis. Targeting CCL20 expression can alleviate inflammation, presenting a potential novel therapeutic approach for patients with PsO and PsA.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Bomi Lee, Hong Namkoong, Yan Yang, Huang Huang, David Heller, Gregory L. Szot, Mark M. Davis, Sohail Z. Husain, Stephen J. Pandol, Melena D. Bellin, Aida Habtezion
Summary: Single-cell sequencing of pancreatic immune cells in human CP revealed distinct immune characteristics, with significantly enriched CCR6(+) CD4(+) T cells in hereditary CP. This study also showed a reduction in T-cell clonality in hereditary CP due to an increase in CD4(+) T cells. Furthermore, an upregulation of CCR6 ligand (CCL20) expression was observed among monocytes in hereditary CP.
Article
Immunology
Chenchen Ye, Xinxue Guo, Jiani Wu, Minhua Wang, Haiyan Ding, Xianzhi Ren
Summary: Activation and polarization of macrophages mediated by CCL20/CCR6 may promote adenoid epithelial inflammation in adenoid hypertrophy. The CCL20/CCR6 axis could be a critical therapeutic target for treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Urology & Nephrology
Georg R. Herrnstadt, Christoph B. Niehus, Torben Ramcke, Julia Hagenstein, Laura-Isabell Ehnold, Anna Nosko, Matthias T. Warkotsch, Frederic C. Feindt, Simon Melderis, Hans-Joachim Paust, Varshi Sivayoganathan, Saskia-Larissa Jauch-Speer, Milagros N. Wong, Daniela Indenbirken, Christian F. Krebs, Tobias B. Huber, Ulf Panzer, Victor G. Puelles, Malte A. Kluger, Oliver M. Steinmetz
Summary: Previous studies have identified a unique Treg population, known as RORyt+ Tregs, which possess enhanced immunosuppressive capacity and therapeutic potential. However, they are also capable of secreting pro-inflammatory IL-17A. This study investigated the absence of RORyt+ Tregs in glomerulonephritis (GN) and found that their absence significantly aggravated kidney injury, demonstrating their overall kidney-protective properties. Analyses showed that RORyt+ Tregs were broadly immunosuppressive, and their absence had a negative impact on GN.
KIDNEY INTERNATIONAL
(2023)
Article
Oncology
Yi Liu, Daoyan Wei, Yasunori Deguchi, Weiguo Xu, Rui Tian, Fuyao Liu, Min Xu, Fei Mao, Donghui Li, Weidong Chen, Lovie Ann Valentin, Eriko Deguchi, James C. Yao, Imad Shureiqi, Xiangsheng Zuo
Summary: The dysregulation of the PPAR & delta;-mediated Ccl20/Ccr6 axis promotes gastric adenocarcinoma (GAC) by remodeling the gastric tumor microenvironment and suppressing immune response. CCL20 may serve as a potential biomarker for early detection and progression of GAC.
Article
Chemistry, Medicinal
Maria Grazia Martina, Carmine Giorgio, Marika Allodi, Simone Palese, Elisabetta Barocelli, Vigilio Ballabeni, Martyna Szpakowska, Andy Chevigne, Jan Piet van Hamburg, Nadine Davelaar, Erik Lubberts, Simona Bertoni, Marco Radi
Summary: The study identifies a new pharmacological approach for the treatment of inflammatory bowel diseases (IBDs) based on small-molecule CCR6 antagonists. The most promising compound was identified using in silico studies and in vitro assays and its efficacy was validated in mouse models. This research provides a theoretical foundation for the development of orally bioavailable drugs for the treatment of IBD and other diseases regulated by the CCL20/CCR6 axis.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell & Tissue Engineering
Jiahuan Tan, Tenghan Xu, Yanling Gou, Honglin Wang, Zongwen Liang, Yingying Cao, Han Wang, Yangyang Yu, Na Jiao, Zongfeng Zhang
Summary: The study found that macrophages secrete CCL20 to promote CCR6 activation of endometriotic stromal cells (ESCs), leading to proliferation and migration of ESCs. The CCL20/CCR6 axis impairs lysosomal function and blocks the autolysosome degradation process in ESCs. The interaction of CCR6 and TFEB inhibits TFEB nuclear translocation, mediating the role of the CCL20/CCR6 axis in promoting ESC proliferation and migration.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Jingyao Lian, Saisai Liu, Ying Yue, Qingshan Yang, Zhen Zhang, Shengli Yang, Yi Zhang
Summary: This study investigated the role of Eomes in human esophageal squamous cell carcinoma (ESCC), showing that Eomes knockdown reduced cancer cell proliferation and blocked the cell cycle. The Eomes-CCL20-CCR6 pathway was identified as playing a vital role in ESCC progression.
Article
Multidisciplinary Sciences
Manuel Hayn, Andrea Bloetz, Armando Rodriguez, Solange Vidal, Nico Preising, Ludger Staendker, Sebastian Wiese, Christina M. Stuerzel, Mirja Harms, Ruediger Gross, Christoph Jung, Miriam Kiene, Timo Jacob, Stefan Poehlmann, Wolf-Georg Forssmann, Jan Muench, Konstantin M. J. Sparrer, Klaus Seuwen, Beatrice H. Hahn, Frank Kirchhoff
Summary: The study identified an endogenous inhibitor, CysC95-146, that effectively inhibits GPR15-mediated HIV and SIV infection without interfering with the physiological function of the GPCR.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Sara Svensson Akusjarvi, Shuba Krishnan, Bianca B. Jutte, Anoop T. Ambikan, Soham Gupta, Jimmy Esneider Rodriguez, Akos Vegvari, Maike Sperk, Piotr Nowak, Jan Vesterbacka, J. Peter Svensson, Anders Sonnerborg, Ujjwal Neogi
Summary: The study reveals that individuals who naturally control the virus HIV-1 exhibit a unique chemokine receptor profile and lower levels of apoptosis and p53 signaling proteins, indicating a heightened sensitivity to cell death mechanisms. This data sheds light on the mechanisms of natural control of HIV-1 infection in comparison to individuals on suppressive antiretroviral therapy and HIV-negative controls.
COMMUNICATIONS BIOLOGY
(2022)
Article
Dermatology
Zhenrui Shi, Xuesong Wu, Chun-Yi Wu, Satya P. Singh, Timothy Law, Daisuke Yamada, Mindy Huynh, William Liakos, Guiyan Yang, Joshua M. Farber, Yu-Jui Yvonne Wan, Samuel T. Hwang
Summary: Bile acids can improve psoriasiform dermatitis through multiple mechanisms, including direct inhibition of IL-17A production and blockade of CCL20-mediated trafficking. These findings support the potential use of bile acids in the treatment of psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Immunology
Xinying Li, Chen Chen, Lianjun Zhang, Xiaomin Cheng, Huiwu Geng, Qiang Ji, Chao Li, Huili Chen, Heinrich Korner, Xiaoying Liu
Summary: Research has shown that TNF plays a crucial role in immunity against Listeria monocytogenes, supporting the M1 phenotype and blocking M2 polarization in macrophages. TNF promotes the transition from M2 to M1 phenotype, with involvement of the NF-kappa B pathway and PPAR gamma receptor agonists. Competing signaling mechanisms are essential for macrophages to defeat Listeria monocytogenes infections, with TNF driving M1 polarization being a key factor.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Editorial Material
Rheumatology
Ian Liang, Sanjay Swaminathan, Adrian Y. S. Lee
CLINICAL RHEUMATOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Adrian Y. S. Lee, Caroline Lee, David A. Brown, Dan Suan
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Medical Laboratory Technology
Adrian Y. S. Lee, David A. Brown, David McDonald, Ming-Wei Lin
Summary: This study reviewed the stability of antiextractable nuclear antigens (anti-ENAs) over time and found that a significant number of patients had qualitative and quantitative changes in their anti-ENA levels during serial testing. These changes were correlated with erythrocyte sedimentation rate and disease activity, suggesting that anti-ENAs may have value in monitoring disease progression.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)
Letter
Otorhinolaryngology
Adrian Yong Sing Lee
JOURNAL OF AUDIOLOGY AND OTOLOGY
(2022)
Article
Rheumatology
Adrian Y. S. Lee, Ming-Wei Lin, Joanne H. Reed
Summary: This study retrospectively examined a common autoantibody, Anti-Ro52/TRIM21 IgG, in patients with systemic autoimmune diseases. Two subsets were identified: patients with isolated Anti-Ro52/TRIM21 autoantibodies and patients with Anti-Ro52/TRIM21 in conjunction with Anti-Ro60 and/or Anti-La. Patients with isolated Anti-Ro52/TRIM21 had distinct clinical and laboratory characteristics compared to the other subset.
CLINICAL RHEUMATOLOGY
(2022)
Article
Pathology
Adrian Y. S. Lee, Dimitra Beroukas, Louise Wienholt, Tom P. Gordon
Summary: The analytical performance of the immunoblot assay for detecting anti-Ro60 was evaluated, with the counterimmunoelectrophoresis method as the gold standard. The study found that the immunoblot assay has high sensitivity and specificity for anti-Ro60 detection. However, the survey of international laboratories revealed that many of them use the manufacturer's recommended cutoff, which may result in missed detection of this clinically important autoantibody.
Review
Rheumatology
Adrian Y. S. Lee, Jing Jing Wang, Tom P. Gordon, Joanne H. Reed
Summary: Sjogren's disease is a complex autoimmune disorder characterized by exocrine glandular dysfunction. Some patients with severe symptoms and an increased risk of lymphoma have a negative impact on their quality of life and occasionally mortality. The pathogenesis of the disease is poorly understood, and there is a lack of targeted therapies. A staged model is proposed to understand the progression of pathology and develop preventative and therapeutic treatments.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Medicine, General & Internal
Adrian Y. S. Lee, Pei Dai, Leslie Burnett, Xiumei Wei, Fakhria Kakar, Thomas Ohnesorg, Ming-Wei Lin
Summary: We report a curious case of a 45-year-old male who was incidentally found to have both subacute traumatic encephalopathy and congenital immunodeficiency syndrome. Genomic sequencing revealed a mutation in the ATM gene, which contributes to the growing understanding of these interesting immunodeficiencies. This finding is of great importance for further research on immune deficiency pathology.
OXFORD MEDICAL CASE REPORTS
(2023)
Article
Medicine, General & Internal
Adrian Y. S. Lee, Ming Wei Lin
Summary: Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by autoreactive T and B cells, sicca symptoms, and extraglandular manifestations. The presence of specific autoantibodies is important for diagnosis, and patients usually have stable serostatus. However, a rare case was reported where a woman with primary SS developed new autoantibodies through serological epitope spreading without significant clinical changes. This case highlights the importance of molecular features and their implications in understanding autoimmunity.
Letter
Rheumatology
Ian Liang, Lucinda J. Berglund, David A. Brown, Dan Suan, Farid Meybodi, Adrian Y. S. Lee, Sanjay Swaminathan
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Nicholas E. Gazy, Nicole L. Fewings, Jonathan Emerson, Sanjay Swaminathan, Adrian Y. S. Lee, Ming-Wei Lin
Letter
Pathology
Fakhria Kakar, Sanja Swaminathan, David A. A. Brown, Ming-We Lin, David McDonald, Adrian Y. S. Lee
Review
Immunology
Adrian Y. S. Lee
Summary: Anti-histone antibodies (AHAs) are present in systemic autoimmune diseases and have potential use in predicting clinical features of SLE, but their prevalence in DILE may be lower than previously thought.
IMMUNOLOGICAL MEDICINE
(2022)
Letter
Allergy
Adrian Y. S. Lee, Andrew Hannaford, Steve Vucic, Lucinda J. Berglund
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
