Article
Pharmacology & Pharmacy
Attila Gaspar, Barbara Hutka, Aliz Judit Ernyey, Brigitta Tekla Tajti, Bence Tamas Varga, Zoltan Sandor Zadori, Istvan Gyertyan
Summary: The Long-Evans strain may be less sensitive to STZ treatment than Wistar rats, requiring higher doses to induce pathological changes. The results underscore the importance of strain diversity in modeling human diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Kelsey R. Thomas, Jessica R. Osuna, Alexandra J. Weigand, Emily C. Edmonds, Alexandra L. Clark, Sophia Holmqvist, Isabel H. Cota, Christina E. Wierenga, Mark W. Bondi, Katherine J. Bangen
Summary: The study examined patterns of regional cerebral blood flow across different stages of Alzheimer's disease, revealing increased blood flow in specific brain regions in participants with subtle cognitive decline, potentially reflecting early neurovascular dysregulation and cognitive inefficiencies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Changming Wang, Zhibin Wang, Beijia Xie, Xinrui Shi, Pengcheng Yang, Lei Liu, Tianshu Qu, Qi Qin, Yi Xing, Wei Zhu, Stefan J. Teipel, Jianping Jia, Guoguang Zhao, Liang Li, Yi Tang
Summary: The study found impairments in binaural processing in Alzheimer's disease and amnestic mild cognitive impairment, with a U-shaped curve change in phase synchrony. The increase in phase synchrony accompanying more severe cognitive stages may reflect neural adaptation for binaural processing, while also being associated with worse memory performance.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Amanda T. Calcetas, Kelsey R. Thomas, Emily C. Edmonds, Sophia L. Holmqvist, Lauren Edwards, Maria Bordyug, Lisa Delano-Wood, Adam M. Brickman, Mark W. Bondi, Katherine J. Bangen, Alzheimers Dis Neuroimaging Initiative
Summary: White matter hyperintensities (WMH), a marker of small vessel cerebrovascular disease, increase the risk of developing mild cognitive impairment (MCI) and Alzheimer's disease (AD). This study found that individuals with objectively-defined subtle cognitive decline (Obj-SCD) had greater WMH in the temporal, occipital, and frontal regions compared to cognitively unimpaired individuals (CU). Those with MCI had higher WMH volume across all regions. The findings support the use of Obj-SCD criteria to capture biologically-based cognitive changes.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Rolando Castillo-Passi, Rodrigo C. Vergara, Nicole K. Rogers, Daniela P. Ponce, Magdalena Bennett, Maria Isabel Behrens
Summary: This study characterizes the trajectories of memory loss in individuals with early amnestic cognitive impairment with and without a history of previous cancer. It identifies two subgroups, fast progressors and slow progressors, and suggests that a history of cancer can slow down the decline in memory specifically in a subgroup of subjects with depression at baseline and accelerated deterioration at follow-up.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Immunology
Xiaojia Li, Xiaoping Wang, Bin Huang, Rui Huang
Summary: This study revealed the protective effect of Sennoside A (SA) against Alzheimer's disease and investigated its mechanism. SA mitigated cognitive impairment, neuronal apoptosis, oxidative stress, and inflammation in AD mice and BV2 cells. SA relieved ferroptosis, inflammation, and cognitive impairment in aging mice through decreasing TRAF6.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Pyry N. Sipila, Nelli Heikkila, Joni Lindbohm, Christian Hakulinen, Jussi Vahtera, Marko Elovainio, Sakari Suominen, Ari Vaananen, Aki Koskinen, Solja T. Nyberg, Jaana Pentti, Timo E. Strandberg, Mika Kivimaki
Summary: Infections requiring hospital treatment have been found to increase the long-term risk of dementia, including vascular dementia and Alzheimer's disease, with no specificity in infection type. The association is driven by general inflammation rather than specific microbes, and there is evidence of dose-response relationships between infectious disease burden and dementia risk.
LANCET INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Rachel Galioto, Gabrielle Macaron, John W. Lace, Daniel Ontaneda, Stephen M. Rao
Summary: The study found that the Processing Speed Test (PST) has excellent sensitivity and specificity in identifying cognitive impairment in patients with multiple sclerosis (pwMS), but is unable to accurately identify cognitively impaired patients without processing speed impairment.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Engineering, Biomedical
Neelam Sharma, Maheshkumar H. Kolekar, Kamlesh Jha
Summary: Dementia is a significant burden in the elderly population, and its diagnosis is challenging. This research focuses on detecting mild cognitive impairment through EEG features classification, achieving high accuracy rates, particularly in the motor speed test (MST) event. The findings suggest that MST could be a reliable tool for dementia diagnosis in clinical settings.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Review
Geriatrics & Gerontology
Shuai Xiang, Jin-Long Ji, Sha Li, Xi-Peng Cao, Wei Xu, Lan Tan, Chen-Chen Tan
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy and safety of probiotic therapy on cognitive function, oxidative stress, and gastrointestinal function in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and Parkinson's disease (PD). The results suggest that probiotics can improve cognitive and gastrointestinal symptoms in these patients, possibly through reducing inflammatory response and improving lipid metabolism.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Kamran Rostami, Arzu Ensari, Michael N. Marsh, Amitabh Srivastava, Vincenzo Villanacci, Antonio Carroccio, Hamid Asadzadeh Aghdaei, Julio C. Bai, Gabrio Bassotti, Gabriel Becheanu, Phoenix Bell, Camillo Di Bella, Anna Maria Bozzola, Moris Cadei, Giovanni Casella, Carlo Catassi, Carolina Ciacci, Delia Gabriela Apostol Ciobanu, Simon S. Cross, Mihai Danciu, Prasenjit Das, Rachele Del Sordo, Michael Drage, Luca Elli, Alessio Fasano, Ada Maria Florena, Nicola Fusco, James J. Going, Stefano Guandalini, Catherine E. Hagen, David T. S. Hayman, Sauid Ishaq, Hilary Jericho, Melanie Johncilla, Matt Johnson, Katri Kaukinen, Adam Levene, Sarah Liptrot, Laura Lu, Govind K. Makharia, Sherly Mathews, Giuseppe Mazzarella, Roxana Maxim, Khun La Win Myint, Hamid Mohaghegh-Shalmani, Afshin Moradi, Chris J. J. Mulder, Ronnie Ray, Chiara Ricci, Mohammad Rostami-Nejad, Anna Sapone, David S. Sanders, Juha Taavela, Umberto Volta, Marjorie Walker, Mohammad Derakhshan
Summary: The histological changes in the duodenal mucosa of patients with non-coeliac gluten sensitivity (NCGS) show distinct alterations consistent with an intestinal response to luminal antigens, even at the Marsh 0 stage of villus architecture.
Article
Health Care Sciences & Services
Takao Yamasaki, Shuzo Kumagai
Summary: Recent studies have focused on using digital technologies, such as wearable and nonwearable sensor-based assessment, to evaluate daily behavioral changes in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Digital technologies provide more objective, quantitative, and realistic evidence of altered daily behavioral patterns compared to traditional assessments. This review highlights the usefulness of nonwearable sensor-based in-home assessment as early biomarkers for MCI and AD.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Seunghee Na, Eek-Sung Lee, Tae-Kyeong Lee
Summary: The study investigated the performance of a computerized cognitive screening test (Inbrain CST) for diagnosing amnestic mild cognitive impairment (aMCI). The Inbrain CST showed sufficient sensitivity and specificity for identifying aMCI. It can be considered as an alternative test to supplement the limitations of existing neuropsychological tests.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Neurosciences
Ashley D. Innis, Magdalena Tolea, James E. Galvin
Summary: This study found that the level of mindfulness in dementia patients and caregivers is closely related to their quality of life and cognitive performance. Better outcomes were observed when both patients and caregivers had higher levels of mindfulness.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Seunghee Na, Sang Won Seo, Young Ju Kim, Heejin Yoo, Eek-Sung Lee
Summary: This study found a significant correlation between the computerized cognitive test (Inbrain CST) and the traditional neuropsychological battery (CERAD-K). Multivariate analysis revealed a significant correlation between the Inbrain CST and the CERAD-K test pairs, even after adjusting for age, educational level, and sex. Therefore, the Inbrain CST can be a reliable tool for detecting cognitive impairment in cognitively unimpaired individuals and patients with mild cognitive impairment. It is a useful, time-efficient, and cost-effective computer-based cognitive test for individuals at risk for cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2023)