RUNX1 cooperates with FLT3-ITD to induce leukemia

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

(2016) Kira Behrens et al.   BLOOD

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression ofCdkn2a

(2016) Benjamin J. Shields et al.   GENES & DEVELOPMENT

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs

(2016) Amit Mandoli et al.   Cell Reports

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

(2015) Xiongwei Cai et al.   Cell Stem Cell

Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells

(2015) Tomohiro Hirade et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis

(2015) Wan Yee Leong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice

(2015) R K Hyde et al.   LEUKEMIA

A small-molecule inhibitor of the aberrant transcription factor CBF -SMMHC delays leukemia in mice

(2015) A. Illendula et al.   SCIENCE

Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia

(2015) Amy L. Paguirigan et al.   Science Translational Medicine

Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature

(2015) Pierre Cauchy et al.   Cell Reports

A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis

(2014) J. T. Jackson et al.   BLOOD

Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice

(2014) K. Lam et al.   BLOOD

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis

(2014) Maxim Pimkin et al.   GENOME RESEARCH

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Posttranslational modifications of RUNX1 as potential anticancer targets

(2014) S Goyama et al.   ONCOGENE

C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors

(2014) Marie S. Hasemann et al.   PLoS Genetics

Runx1 is essential at two stages of early murine B-cell development

(2013) B. Niebuhr et al.   BLOOD

The evolving molecular genetic landscape in acute myeloid leukaemia

(2013) Mathijs A. Sanders et al.   CURRENT OPINION IN HEMATOLOGY

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

(2013) Susumu Goyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Addiction of t(8;21) and inv(16) Acute Myeloid Leukemia to Native RUNX1

(2013) Oren Ben-Ami et al.   Cell Reports

Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells

(2012) K. Ross et al.   BLOOD

Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis

(2012) V. P. S. Rawat et al.   BLOOD

SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML

(2012) H. Leischner et al.   BLOOD

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm

(2012) S. Haihua Chu et al.   Cell Stem Cell

A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation

(2012) H. Huang et al.   GENES & DEVELOPMENT

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2

(2012) Kai B. Kaufmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model

(2012) K Reckzeh et al.   LEUKEMIA

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

(2012) Jay P. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leukemia Gene Atlas – A Public Platform for Integrative Exploration of Genome-Wide Molecular Data

(2012) Katja Hebestreit et al.   PLoS One

Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF

(2011) N. Nishimoto et al.   BLOOD

Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes

(2011) P. Wong et al.   BLOOD

Transcription factor networks in erythroid cell and megakaryocyte development

(2011) L. C. Dore et al.   BLOOD

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

(2011) Irene Homminga et al.   CANCER CELL

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis

(2011) Kentson Lam   Frontiers in Bioscience-Landmark

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

(2011) V. Grossmann et al.   HAEMATOLOGICA

Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications

(2011) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutic Advances in Acute Myeloid Leukemia

(2011) Alan Burnett et al.   JOURNAL OF CLINICAL ONCOLOGY

NKL homeobox genes in leukemia

(2011) I Homminga et al.   LEUKEMIA

Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells

(2011) Xiongwei Cai et al.   PLoS One

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

(2010) S. Schnittger et al.   BLOOD

Runx Regulation of Sphingolipid Metabolism and Survival Signaling

(2010) A. Kilbey et al.   CANCER RESEARCH

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells

(2010) Grant A. Challen et al.   EXPERIMENTAL HEMATOLOGY

Interplay of transcription factors in T-cell differentiation and function: the role of Runx

(2010) Won Fen Wong et al.   IMMUNOLOGY

Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways

(2010) A Kohlmann et al.   LEUKEMIA

Differentiation therapy of leukemia: 3 decades of development

(2009) D. Nowak et al.   BLOOD

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis

(2009) B. Jacob et al.   BLOOD

Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C

(2009) M. Schwieger et al.   BLOOD

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

(2009) Chunaram Choudhary et al.   MOLECULAR CELL

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

(2008) R. G.W. Verhaak et al.   HAEMATOLOGICA

Gatekeeper function of the RUNX1 transcription factor in acute leukemia

(2007) Birte Niebuhr et al.   BLOOD CELLS MOLECULES AND DISEASES