Human stem cell–derived astrocytes replicate human prions in aPRNPgenotype–dependent manner

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Variant Creutzfeldt–Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129

(2017) Tzehow Mok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration

(2016) James Alibhai et al.   PLOS BIOLOGY

Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact

(2016) Guiliana Soraya Victoria et al.   Scientific Reports

Glia in mammalian development and disease

(2015) J. Bradley Zuchero et al.   DEVELOPMENT

Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1  and TNF- 

(2015) E. Hennessy et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of astrocyte extracellular signaling in Costello syndrome

(2015) Robert Krencik et al.   Science Translational Medicine

Genotype-dependent Molecular Evolution of Sheep Bovine Spongiform Encephalopathy (BSE) Prionsin VitroAffects Their Zoonotic Potential

(2014) Zuzana Krejciova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse Models for Studying the Formation and Propagation of Prions

(2014) Joel C. Watts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence That Bank Vole PrP Is a Universal Acceptor for Prions

(2014) Joel C. Watts et al.   PLoS Pathogens

Human Tonsil-Derived Follicular Dendritic-Like Cells are Refractory to Human Prion Infection in Vitro and Traffic Disease-Associated Prion Protein to Lysosomes

(2013) Zuzana Krejciova et al.   AMERICAN JOURNAL OF PATHOLOGY

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic Neurodegeneration

(2013) Ayodeji A. Asuni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cycline Efficacy on the Propagation of Human Prions in Primary Cultured Neurons is Strain-Specific

(2013) Samia Hannaoui et al.   JOURNAL OF INFECTIOUS DISEASES

Regulation of Microglial Proliferation during Chronic Neurodegeneration

(2013) D. Gomez-Nicola et al.   JOURNAL OF NEUROSCIENCE

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

(2013) A. Serio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug resistance confounding prion therapeutics

(2013) D. B. Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Aspects of Prion Replication In Vitro

(2013) Andrea Grassmann et al.   Viruses-Basel

Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions

(2012) N. R. Deleault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specification of transplantable astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   NATURE BIOTECHNOLOGY

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

All Clinically-Relevant Blood Components Transmit Prion Disease following a Single Blood Transfusion: A Sheep Model of vCJD

(2011) Sandra McCutcheon et al.   PLoS One

The application of in vitro cell-free conversion systems to human prion diseases

(2010) Michael Jones et al.   ACTA NEUROPATHOLOGICA

Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro

(2010) Zuzana Krejciova et al.   JOURNAL OF PATHOLOGY

Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties

(2010) M. T. Bishop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Incidence and spectrum of sporadic Creutzfeldt–Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification

(2009) Piero Parchi et al.   ACTA NEUROPATHOLOGICA

Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology

(2009) Bryony C. Gray et al.   NEUROBIOLOGY OF DISEASE

Mouse-adapted sporadic human Creutzfeldt–Jakob disease prions propagate in cell culture

(2008) Victoria A. Lawson et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Systematic review of therapeutic interventions in human prion disease

(2008) L. A. Stewart et al.   NEUROLOGY