Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 209, Issue 7, Pages 1144-1148Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit623
Keywords
Creutzfeldt-Jakob disease; isolates; prion; strain; treatment
Categories
Funding
- Institut de Veille Sanitaire
- Pole de Competitivite Medicen - Paris Region
Ask authors/readers for more resources
In prion diseases, a major issue in therapeutic research is the variability of the effect between strains. Stimulated by the report of an antiprion effect in a scrapie model and by ongoing international clinical trials using doxycycline, we studied the efficacy of cyclines against the propagation of human prions. First, we successfully propagated various Creutzfeldt-Jakob disease (CJD) isolates (sporadic, variant, and iatrogenic CJD) in neuronal cultures expressing the human prion protein. Then, we found that doxycycline was the most effective compound, with important variations between isolates. Isolates from sporadic CJD, the most common form of prion disease, showed the highest sensitivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available