Article
Biochemistry & Molecular Biology
Moniba Sajid, Muhammad Rashid Khan, Muhammad Umar Ijaz, Hammad Ismail, Muhammad Zeeshan Bhatti, Sayed Afzal Shah, Saima Ali, Muhammad Usman Tareen, Saqer S. Alotaibi, Sarah M. Albogami, Gaber El-Saber Batiha
Summary: The study found that extracts of Alnus nitida leaves and fruits showed significant anti-inflammatory and analgesic effects in rats, comparable to standard drugs, with no observed toxicity or mortality.
Article
Plant Sciences
Umer Shaukat, Saeed Ahemad, Mei Wang, Shabana I. Khan, Zulfiqar Ali, Muhammad Imran Tousif, Hassan H. Abdallah, Ikhlas A. Khan, Muhammad Saleem, Mohamad Fawzi Mahomoodally
Summary: The study found that extracts of Alnus nitida possess anti-inflammatory and cytotoxic activities, showing promising results against various cancer cell lines and non-cancerous kidney cell lines, indicating its potential as a candidate for the discovery of novel phytopharmaceutical products and industrial applications.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Immunology
M. Sajid-ur-Rehman, Saiqa Ishtiaq, Mohsin Abbas Khan, Meshal Alshamrani, Muhammad Younus, Ghazala Shaheen, Muhammad Abdullah, Ghulam Sarwar, Muhammad Sohaib Khan, Faraza Javed
Summary: The study confirmed the significant anti-inflammatory, analgesic, and antipyretic potential of Sesuvium sesuvioides (SsCr) extract, supporting its folklore uses.
INFLAMMOPHARMACOLOGY
(2021)
Article
Plant Sciences
Mater H. Mahnashi, Bandar A. Alyami, Yahya S. Alqahtani, Muhammad Saeed Jan, Umer Rashid, Abdul Sadiq, Ali O. Alqarni
Summary: Members of Orchidaceae family, especially Habenaria digitata, have a long history in herbal and Chinese medicines for managing inflammation and analgesia. Through experimental studies, it is confirmed that Habenaria digitata contains several bioactive compounds, with chloroform and ethyl acetate fractions showing the highest activities in managing analgesia and inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Iriny M. Ayoub, Michal Korinek, Mohamed El-Shazly, Bernhard Wetterauer, Hesham A. El-Beshbishy, Tsong-Long Hwang, Bing-Hung Chen, Fang-Rong Chang, Michael Wink, Abdel Nasser B. Singab, Fadia S. Youssef
Summary: The study comprehensively explored the phytoconstituents and biological activities of Chasmanthe aethiopica for the first time, revealing its anti-allergic, anti-inflammatory, and anti-hyperglycemic properties. The leaf extract demonstrated potent inhibitory effects on various biological activities, making it a promising natural remedy for combating inflammation, allergy, and hyperglycemia.
Article
Biochemistry & Molecular Biology
Ali Khan, Aini Pervaiz, Bushra Ansari, Riaz Ullah, Syed Muhammad Mukarram Shah, Haroon Khan, Muhammad Saeed Jan, Fida Hussain, Mohammad Ijaz Khan, Ghadeer M. Albadrani, Ahmed E. Altyar, Mohamed M. Abdel-Daim
Summary: The current study evaluates the phytochemical and pharmacological potential of Cornus macrophylla, demonstrating its antioxidant and anti-inflammatory properties. The ethyl acetate fraction of the plant exhibits the most potent activity.
Article
Immunology
Mohammad Saleem, Muhammad Asif, Anum Parveen, Hafiza Sidra Yaseen, Malik Saadullah, Asiya Bashir, Jawaria Asif, Mehwish Arif, Ikram Ullah Khan, Rizwan Ullah Khan
Summary: Melilotus indicus demonstrates potential anti-inflammatory and anti-angiogenic properties, showing significant inhibition in acute and chronic inflammation models and downregulation of TNF-alpha levels in serum samples.
INFLAMMOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Lin Chen, Luming Xie, Jing Zhang, Yifan Feng, Xia Wu
Summary: In this study, the metabolomics of fatty acids and biological information of related markers in a RAW264.7 cell inflammation model were explored. GC-MS was used to identify 21 fatty acids and significant difference markers were selected. The anti-inflammatory mechanism of ibuprofen involving the NLRP3 inflammasome pathway was explained.
Article
Immunology
Minda Asefa, Nathnael Teshome, Abel Degu
Summary: The 80% methanol root extract of Verbasicum sinaiticum was found to possess peripheral and central analgesic as well as anti-inflammatory activity, possibly due to the presence of phytochemicals.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Plant Sciences
Inga Sile, Melita Videja, Marina Makrecka-Kuka, Dace Tirzite, Karlis Pajuste, Kirill Shubin, Valerija Krizhanovska, Solveiga Grinberga, Osvalds Pugovics, Maija Dambrova
Summary: P. padus flower extract (PPFE) was evaluated in this study for its potential as a source of bioactive compounds with antioxidant, anti-collagenase, and anti-inflammatory activities. The results showed that PPFE contains bioactive compounds and exhibits significant anti-inflammatory properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Liangkun Liao, Shengtao Yang, Ruyi Li, Wei Zhou, Yu Xiao, Yuan Yuan, Yunsheng Cha, Guifang He, Jihua Li
Summary: This study analyzed the composition of steam-distilled essential oil from Amomum tsaoko and evaluated its antioxidant and anti-inflammatory activity. The results showed that the essential oil exhibited strong anti-inflammatory effects in LPS-induced RAW 264.7 cells.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Applied
Xuejie Li, Xiangquan Zeng, Huanlu Song, Yu Xi, Yan Li, Bowen Hui, He Li, Jian Li
Summary: GC x GC-O-TOF-MS and GC-IMS have been increasingly used in complex food flavor analysis, but few studies have applied these techniques to identify the aroma components of tomato pastes. This study comprehensively characterized the aroma profiles of cold and hot break tomato pastes using SAFE-GC-O-MS, SAFE-GC x GC-O-TOF-MS, and HS-GC-IMS for the first time. A total of 274 volatile compounds were identified, which is far more than previously reported.
Article
Pharmacology & Pharmacy
Yan-Qing Xie, Jing-Yao Huang, Yun-Xiu Chen, Qian Zhou, Qi-Xiu Zhou, Zhu-Ya Yang, Shi-Kui Xu, Wen-Hong Tan, Lu Liu
Summary: This study investigates the metabolites in the bark and leaves of Streblus indicus for their anti-inflammatory and analgesic effects. The results provide scientific evidence for the traditional use of S. indicus and offer a theoretical foundation for the development of new anti-inflammatory and analgesic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Farzana Andleeb, Muhammad Asif, Hafiza Sidra Yaseen
Summary: This study evaluated the anti-inflammatory, anti-arthritic, and anti-angiogenic potentials of methanol extract of Viola betonicifolia. The results showed that the extract exhibited significant anti-inflammatory and anti-angiogenic effects through regulation of the expression of various pro- and anti-inflammatory genes.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mahdi Belguidoum, Lilya Harchaoui, Latifa Khattabi, Tatou Touahria, Asma Abid, Wafa Zahnit, Cheyma Bensaci, Walid Boussebaa, Sabah Menaa, Yacine Laichi, Salah Akkal, Hocine Dendougui
Summary: This study aimed to investigate the pharmacological properties of Teucrium pseudochamaepitys L. The results showed that it has antioxidant, anti-inflammatory, and analgesic activities without toxicity.
Article
Plant Sciences
Amir Sultan, Sayed Afzal Shah, Mahrine Rashid
Summary: This article presents the discovery of three new invasive species in the flora of Pakistan, including two new generic records. The descriptions and illustrations of these species are provided for easy identification, and their global ranges are portrayed on maps.
PAKISTAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Bushra Rafique, Saima Kalsoom, Abdulrahim A. Sajini, Hammad Ismail, Mudassir Iqbal
Summary: In this study, five 4-aminophenol derivatives were synthesized and characterized. The synthesized compounds showed broad-spectrum antimicrobial and antidiabetic activities, and were found to interact with human DNA, indicating their potential as anticancer agents.
Article
Biochemistry & Molecular Biology
Muhammad Irfan, Hira Munir, Hammad Ismail
Summary: In this study, zinc oxide nanoparticles (ZnO-NPs) based surgical sutures were developed for accelerated wound healing. The synthesized NPs showed good antibacterial potential against Escherichia coli and Methicillin-resistant staphylococcus aureus (MRSA), and the coated suture exhibited good tensile strength. The designed suture demonstrated excellent wound healing potential in rats, with rapid epithelialization, wound contraction, mild inflammation, and absence of infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Syeda Koukab, Naghmana Rashid, Iqbal Ahmad, Humiara Nadeem, Hammad Ismail
Summary: In this study, two new bi-thiacoumarin derivatives, Tc01 and Tc02, were synthesized and evaluated for their antibacterial, anticancer, anticoagulant, and cytotoxic activities. Molecular docking studies revealed moderate interactions between the compounds and the target. Tc01 and Tc02 showed promising antibacterial and anticoagulant activities, with Tc01 exhibiting moderate cytotoxic activity and Tc02 showing no activity. Additionally, both compounds demonstrated significant antioxidant and antidiabetic activities.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Moniba Sajid, Muhammad Rashid Khan, Muhammad Umar Ijaz, Hammad Ismail, Muhammad Zeeshan Bhatti, Sayed Afzal Shah, Saima Ali, Muhammad Usman Tareen, Saqer S. Alotaibi, Sarah M. Albogami, Gaber El-Saber Batiha
Summary: The study found that extracts of Alnus nitida leaves and fruits showed significant anti-inflammatory and analgesic effects in rats, comparable to standard drugs, with no observed toxicity or mortality.
Review
Pharmacology & Pharmacy
Ali Raza Ishaq, Heba A. S. El-Nashar, Tahira Younis, Muhammad Asad Mangat, Mashal Shahzadi, Amina Shamsheer Ul Haq, Mohamed El-Shazly
Summary: This review summarizes the traditional medicinal uses, nutritional value, phytochemical profile, and biological activities of Lupinus species. Lupinus plants are rich in phytochemicals and have high nutritional value. They also exhibit various pharmacological properties.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tahira Younis, Faiza Jabeen, Ali Hussain, Bilal Rasool, Ali Raza Ishaq, Atif Nawaz, Heba A. S. El-Nashar, Mohamed El-Shazly
Summary: This study aimed to evaluate the antioxidant and pulmonary protective potential of Fraxinus xanthoxyloides bark extract and its fractions. The highest total phenolics, flavonoids, and terpenoids contents were found in the methanol bark extract, ethyl acetate fraction, and chloroform fraction, respectively. The most potent antioxidant capacity was shown by the methanol bark extract and ethyl acetate fraction. The administration of carbon tetrachloride induced oxidative stress and lung tissue damage, but treatment with the bark extract restored these parameters to normal levels and protected the lung tissues.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biotechnology & Applied Microbiology
Hammad Ismail, Dania Khalid, Saad Bin Ayub, Muhammad Umar Ijaz, Samra Akram, Muhammad Zeeshan Bhatti, Malik Mumtaz Taqi, Erum Dilshad, Sadaf Anwaar, Gaber El-Saber Batiha, Sarah S. Aggad, Fatimah M. Yousef, Michel De Waard
Summary: This study evaluates the effect of Phoenix dactylifera seeds extract in treating Alzheimer's disease. Results showed that the extract-treated group had significantly decreased blood glucose levels and improved memory behavior. The levels of enzymes like insulin and choline esterase were also enhanced, indicating the potential of P. dactylifera seeds in treating AD.
BIOMED RESEARCH INTERNATIONAL
(2023)
Article
Biology
Tehreem Raza, Bilal Rasool, Muhammad Asrar, Maleeha Manzoor, Zeeshan Javed, Faiza Jabeen, Tahira Younis
Summary: Polyacrylamide microplastics produced in the environment have adverse effects on aquatic organisms, causing global concern. This study aimed to assess the toxicity of different concentrations of polyacrylamide microplastics on Oreochromis niloticus. Characterization of the microplastics was conducted using Fourier transform infrared and Raman spectroscopy, confirming their presence in the gills of the fish. The microplastics were found to significantly affect antioxidant enzymes, increase oxidative stress levels, and induce histological changes in various organs, highlighting their harmful effects on fish health.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nasima Arshad, Uzma Parveen, Pervaiz Ali Channar, Aamer Saeed, Waseem Sharaf Saeed, Fouzia Perveen, Aneela Javed, Hammad Ismail, Muhammad Ismail Mir, Atteeque Ahmed, Basit Azad, Ishaq Khan
Summary: Three bis-acyl-thiourea derivatives were synthesized and characterized, and their DNA binding, anti-urease, and anticancer activities were explored. The results showed that these derivatives exhibited binding interactions with DNA, with UP-1 showing better inhibitory efficiency against urease and higher cytotoxicity against cancerous and healthy cell lines.
Article
Plant Sciences
Aamir Khan, Mohammad Safdar Baloch, Naimat Ullah, Sheikh Zain Ul Abidin, Muhammad Zeeshan Bhatti, Raees Khan, Asghar Ali Khan, Hammad Ismail, Asma Saeed, Hadia Gul
Summary: This study compared the performance of phosphate solubilizing bacteria (PSB) as bio-fertilizer with commercially available phosphate fertilizers on wheat crop. The results showed that the application of N2-fixing bacteria as PSB had the best effect.
PLANT SCIENCE TODAY
(2023)
Article
Multidisciplinary Sciences
Hammad Ismail, Dania Khalid, Durdana Waseem, Muhammad Umar Ijaz, Erum Dilshad, Milkyas Ihsan-ul Haq, Muhammad Zeeshan Bhatti, Sadaf Anwaar, Madiha Ahmed, Samreen Saleem
Summary: The study revealed that berberine from Berberis lycium exhibited anti-Alzheimer's effects by improving memory, increasing neurotransmitter levels, and reducing beta-secretase expression in the Alzheimer's disease model.
Article
Plant Sciences
Amjad Khan, Amir Sultan, Sayed Afzal Shah
Summary: This article describes and illustrates a new plant species, Astragalus roseocephalus sp. nov., found in Islamabad Capital Territory (Margalla hills), Rawalpindi district, Hazara, and Kashmir. It belongs to the Astragalus section Poliothrix Bunge and is closely related to Astragalus leucocephalus Benth. Morphologically, it differs from A. leucocephalus in various aspects such as height, stipule shape, leaf length, leaflet size, peduncle length, corolla color, standard size and shape, fruit shape, and number of seeds. The article also discusses the anatomy, pollen morphology, distribution, and conservation status of the new species.
NORDIC JOURNAL OF BOTANY
(2023)
Article
Oncology
Taef Hasan Alhussan, Ahmad Hadad, Sayed Agha Ali Shah
Summary: Adenoid cystic carcinoma (ACC) is a rare subtype of breast cancer with distinct histologic patterns. This report presents a rare case of ACC with a cribriform, trabecular growth pattern. While imaging studies are useful for screening and planning, they may not provide specific information. Pathological examination remains the standard reference for diagnosis and treatment decisions. Surgery is currently the primary therapy for breast ACC patients, but there is no clear consensus on the selection of specific surgical treatments.
CLINICAL CANCER INVESTIGATION JOURNAL
(2023)
Article
Entomology
Bilal Rasool, Zahid Mehmood, Muhammad Farooq Ahmad, Javaid Iqbal, Tahira Younis, Rizwan Munir
Summary: This study evaluated the parasitism potential of three parasitoid species on two aphid species. The results showed differences in parasitism among the parasitoid species and host species, and the parasitism was influenced by the host species and nymphal instars.
REVISTA BRASILEIRA DE ENTOMOLOGIA
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)