Review
Biochemistry & Molecular Biology
Wen-hua Chen, Jian-jun Wu, Xue-fei Li, Jie-miao Lu, Wei Wu, Yi-qi Sun, Bo Zhu, Lu-ping Qin
Summary: Dendrobium officinale polysaccharides exhibit a variety of biological effects, including immunomodulatory, anti-tumor, and gastro-protective effects. Further research is needed to explore extraction, purification, and structural characteristics of these polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Wenhua Chen, Jiemiao Lu, Jiahao Zhang, Jianjun Wu, Lilong Yu, Luping Qin, Bo Zhu
Summary: Dendrobium officinale is a well-known plant used as a medicinal and food homologous product, containing various bioactive components and exhibiting diverse biological functions. The review summarizes research progress and aims to better understand the botany, traditional use, phytochemistry, pharmacology, quality control, and safety of D. officinale, providing references and potential directions for further studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Yan Fu, Quansheng Wang, Liang Zhang, Shuping Ling, Huiyan Jia, Yinliang Wu
Summary: Based on the investigation of 12 pesticides in Dendrobium officinale, it was found that the residues were within acceptable limits at different pre-harvest intervals, indicating a low dietary risk.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Shengchang Tao, Zhiyao Ren, Zerui Yang, Shuna Duan, Zhongxian Wan, Jiahui Huang, Chenxing Liu, Gang Wei
Summary: Our study demonstrated that the fraction of Dendrobium officinale polysaccharides with a molecular weight of 389.98 kDa exhibited the strongest antitumor effect against colorectal cancer; the specific fraction DOPW-1 could potentially be developed as a clinical agent for treating CRC; and DOPW-1 inhibits the proliferation of HT-29 cells by regulating the apoptosis pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Jianzhong Yu, Zhenlan Xu, Ji Sun, Xiaoyan Xu, Yuyong Wu, Fengting Sun, Ningning Sang, Xinwang Lv, Changpeng Zhang, Xueping Zhao, Tao Tang
Summary: Bioaccessibility (BA) is a crucial factor for evaluating the absorption of pollutants in the human digestion system, which is of vital importance for risk assessment of pollutants via food intake. Multi-pesticides were detected in Dendrobium officinale Kimura et Migo (D. officinale), a popular dual-use plant with both botanical medicine and food applications. Nevertheless, the BA of pesticides in D. officinale remains unknown, restricting its market size.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Yuhong Liu, Ke Bei, Weiran Zheng, Guoguang Yu, Caixia Sun
Summary: This study investigated pesticide residues in Dendrobium officinale stems and leaves and assessed the associated risk of human exposure. The results showed that although multiple pesticide residues were detected, the short-term, long-term, and cumulative risks to human health were negligible.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Di Zhou, Ying Zhao, Zhilin Chen, Xiuxiang Yan, Yanqiang Zhao, Lu Gao, Lixin Yang
Summary: This study analyzed and compared the chemical composition of fresh stems of Dendrobium officinale and processed D. officinale stems, and investigated the impact of processing on the medicinal efficacy. The results showed that processed D. officinale stems had higher levels of certain metabolites with anti-inflammatory activity compared to fresh stems, supporting its traditional usage for inflammation treatment.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Chengchong Huang, Jiali Yu, Jingjing Da, Rong Dong, Lu Dai, Yuqi Yang, Yiyao Deng, Jing Yuan
Summary: DOP, a primary active component of Dendrobium officinale Kimura & Migo, has been found to have a significant therapeutic effect on renal fibrosis in diabetic kidney disease (DKD). It can protect renal function by inhibiting fibrosis and also has hypoglycemic and anti-inflammatory effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wang Zhang, Xinjie Liu, Xun Sun, Rongchun Han, Nianjun Yu, Juan Liang, An Zhou
Summary: The study compared the antioxidant properties of fresh and dried Dendrobium officinale and their polysaccharides. Results showed that fresh Dendrobium officinale had greater effects in scavenging radicals and protecting against liver damage. The differences in antioxidant activities were attributed to the differences in polysaccharide composition and molecular weight arrangement.
Article
Chemistry, Applied
Zhenlan Xu, Lingxiangyu Li, Yi Xu, Shanshan Wang, Xiaoxia Zhang, Tao Tang, Jianzhong Yu, Huiyu Zhao, Shenggan Wu, Chunrong Zhang, Xueping Zhao
Summary: A method to detect multiple pesticide residues in D. officinale was developed and validated, with analysis of real samples showing no potential health risks from pesticide residues in fresh or dried D. officinale for human consumption.
Article
Biochemistry & Molecular Biology
Da Yang, Yeyang Song, Anjin Lu, Lin Qin, Daopeng Tan, Qianru Zhang, Yuqi He, Yanliu Lu
Summary: This study collected samples of Dendrobium officinale grown through different cultivation methods and analyzed their chemical composition through chemical analysis and metabolomics. The results showed that stone epiphytic cultivation and greenhouse cultivation had higher polysaccharide content compared to live tree epiphytic cultivation. Metabolomic analysis revealed differential metabolite production among the three cultivation methods, with stone epiphytic cultivation showing the highest number of differential metabolites.
Article
Biochemistry & Molecular Biology
Yifan Wen, Hongyu Xiao, Ying Liu, Yiqi Yang, Yumin Wang, Shijie Xu, Song Huang, Shaozhen Hou, Jian Liang
Summary: Dendrobium officinale polysaccharides (DOPS) have a significant protective effect against colitis-induced lung injury by inhibiting inflammation and oxidative stress, promoting antioxidant enzyme activities, and modulating TLR4 and Nrf2 signaling pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Environmental Sciences
Yi Mu, Bangwei Che, Kaifa Tang, Wenjun Zhang, Shenghan Xu, Wei Li, Jun He, Miao Liu, Peng Chen, Siwen Zhong, Guangyu Li
Summary: This study explored the protective effect of Dendrobium officinale polysaccharides (DOPs) on reproductive oxidative stress injury in male mice and its mechanism. The results showed that DOPs effectively reduced the oxidative stress injury of testicular tissue and improved sperm quality and hormone levels. The protective effect of DOPs was mediated by reducing oxidative stress levels, improving the hormone environment in testes, and regulating the expression of specific genes in Sertoli cells and spermatogenic cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xian-Mei Piao, Ming-Feng Feng, Wei-Ping Zhao, Zhi-Hang Wu, Wen-Wen Zhang, Hui-Min Hou, Jin-Hui Wang, Li-Bo Wang, Jian Huang, Yan Zhang
Summary: This study found that dendrocandin U, isolated from Dendrobium officinale, has significant anti-inflammatory activity and acts by inhibiting M1 polarization through the TLR4/MyD88/NF-kappa B signaling pathway.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Agronomy
Yuan Lei, Yuqin Luo, Nan Fang, Yanjie Li, Xiangyun Wang, Hongmei He, Jinhua Jiang, Jianzhong Yu, Changpeng Zhang, Xueping Zhao
Summary: The widespread use of pesticides poses significant risks to food and environmental safety. This study developed a rapid and efficient method for determining the residue of the neonicotinoid insecticide imidacloprid in four minor crops. The results showed that the imidacloprid residues in Chinese agricultural products were far below safety limits, indicating low health risk for consumers.
Article
Biochemistry & Molecular Biology
Meng -Ting Kuang, Jing-Yue Xu, Jin-Yu Li, Liu Yang, Bo Hou, Qi Zhao, Jiang- Miao Hu
Summary: A novel polysaccharide, MSP-1, was isolated and purified from the fruiting body of Morchella sextelata. MSP-1 exhibited significant immunomodulatory activities and had a specific monosaccharide composition.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Zhongquan Cheng, Weiwei Fan, Dan Yang, Jiangmiao Hu
Summary: Two new cadinene-type sesquiterpene glycosides and one known glycoside were isolated from the stems of Dendrobium findlayanum. The structures of these compounds were determined through extensive spectroscopic analyses, and their absolute configurations were confirmed by electronic circular dichroism calculations. These compounds showed no significant cytotoxic activity against human cancer cells at a concentration of 25 μM.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Tin-Long Wong, Li-Feng Li, Ji-Xia Zhang, Quan-Wei Zhang, Xue-Ting Zhang, Li-Shuang Zhou, Hau-Yee Fung, Lei Feng, Hui -Yuan Cheng, Chu-Ying Huo, Man Liu, Wan-Rong Bao, Wen-Jie Wu, Cheuk-Hei Lai, Su -Ping Bai, Shao-Ping Nie, Pema-Tenzin Puno, Clara Bik-San Lau, Ping -Chung Leung, Quan-Bin Han, Han-Dong Sun
Summary: In this study, an oligosaccharide sequencing analysis was used to successfully correct the backbone of Dendrobium officinale polysaccharide (DOP) to mannan. This analysis involved producing oligosaccharide fragments through mild acid hydrolysis of DOP followed by p-aminobenzoic ethyl ester (ABEE) derivatization. The isolated and identified oligosaccharides with varied polymerization degrees (DP = 2-10) confirmed that the backbone of DOP is a beta-D-1,4-mannan. This oligosaccharide analysis is more straightforward and reliable compared to conventional methods.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Hui Ma, Wing-Sum Siu, Chi-Man Koon, Xiao-Xiao Wu, Xiang Li, Wen Cheng, Wai-Ting Shum, Clara Bik-San Lau, Chun-Kwok Wong, Ping-Chung Leung
Summary: NF3 enhances the therapeutic effect of MSCs in the wound healing model and is related to the TGF beta/Smad and Wnt pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Jie Yang, Meng-Ting Kuang, Liu Yang, Wei Huang, Jiang-Miao Hu
Summary: This review provides a systematic analysis of the chemical composition and pharmacological research progress of D. officinale, including over 180 compounds isolated from the plant and summarizing modern pharmacological studies on hypoglycemia, immune regulation, antioxidant, cardiovascular regulation, and gastrointestinal protection. The findings contribute to a better understanding of the traditional and modern pharmaceutical applications of D. officinale.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Ben Chung-Lap Chan, Nilakshi Barua, Clara Bik-San Lau, Ping-Chung Leung, Kwok-Pui Fung, Margaret Ip
Summary: This study found that the combination of kuraridin from Sophora flavescens and epicatechin gallate (ECG) from green tea inhibits the growth of MRSA strains and enhances the antibacterial activities of multiple antibiotics. Kuraridin and ECG also have anti-inflammatory effects and reduce MRSA colonization in a mouse pneumonia model.
Article
Pharmacology & Pharmacy
Leilei Gou, Grace Gar-Lee Yue, Julia Kin -Ming Lee, Pema Tenzin Puno, Clara Bik-San Lau
Summary: Eriocalyxin B (Eri B), an ent-kaurane diterpenoid, inhibits migration and adhesion in triple negative breast cancer (TNBC) cells, reduces ALDH1A1 expression and colony formation in cancer stem cell (CSC) enriched MDA-MB-231 cells. Eri B demonstrates potent anti-metastatic efficacy in breast tumor-bearing mouse models. Gut microbiome analysis reveals changes in diversity and composition of microbiome after Eri B treatment, potentially contributing to its anti-cancer effects.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Philip Wai-Yan Chiu, Grace Gar-Lee Yue, Man Kit Cheung, Hon-Chi Yip, Siu-Kai Chu, Man-Yee Yung, Justin Che-Yuen Wu, Shannon Melissa Chan, Anthony Yuen-Bun Teoh, Enders Kwok-Wai Ng, Hisayoshi Norimoto, Clara Bik-San Lau
Summary: This study investigated the effect of Andrographis paniculata (AP) on palliative care of patients with metastatic esophageal squamous cell carcinoma (ESCC). The results showed that patients who completed AP treatment had significantly longer overall survival periods and maintained a good quality of life. Additionally, the treatment also changed the composition of gut microbiota. This study establishes AP as a safe and effective palliative treatment for squamous cell carcinoma of the esophagus.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Huihai Yang, Tao Zheng, Chuen-Fai Ku, Cheuk Kit Ngai, Grace Gar-Lee Yue, Hung Kay Lee, Clara Bik-San Lau
Summary: In this study, it was found that active components in the water extract of Patrinia villosa Juss. (PVW) could inhibit the proliferation and migration of colon cancer cells. An active compound, 8,9-didehydro-7-hydroxydolichodial (DHD), was identified in PVW and was derived from a natural compound called valerosidate present in PV. Both DHD and valerosidate showed inhibitory effects on cell viability and migration by increasing the expressions of tumor suppressors (p53 and PTEN) in colon cancer cells.
FRONTIERS IN CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Hui Ma, Wing-Sum Siu, Ping-Chung Leung
Summary: A wound disrupts the normal structure and function of the skin, which plays a crucial role in protection, temperature regulation, and water balance. Wound healing is a complex process involving various stages, and factors like infection and chronic diseases can hinder it. Mesenchymal stem cells (MSCs) have shown potential in treating wounds due to their secretome and exosomes, which contain various molecules. Studies suggest that MSCs-based cell-free therapy may be safer and more effective than MSCs in regenerative medicine. This review provides an overview of wound pathophysiology and the potential of MSCs-based cell-free therapy in different stages of wound healing, along with clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ben Chung-Lap Chan, Peiting Li, Miranda Sin-Man Tsang, Johnny Chun-Chau Sung, Keith Wai-Yeung Kwong, Tao Zheng, Sharon Sze-Man Hon, Ching-Po Lau, Wen Cheng, Fang Chen, Clara Bik-San Lau, Ping-Chung Leung, Chun-Kwok Wong
Summary: Vaccination is effective against COVID-19, but fear of needles and side effects hinders its acceptance. Alternative delivery methods, such as using Bacillus subtilis as a vaccine production host and delivery vector, show promise due to their low cost, safety, and oral administration. By engineering B. subtilis to express spike (S) proteins, researchers have successfully generated S spores. Oral administration of these S spores, along with adjuvants Astragalus membranaceus and Coriolus versicolor, induces immune responses against COVID-19 without toxicity. Co-feeding with these adjuvants enhances mucosal IgA responses, and prior administration of S spores boosts IgG responses to the commercial COVID-19 vaccine CoronaVac. In vitro studies demonstrate that AM, CV, and B. subtilis spores activate macrophages and dendritic cells by secreting immune-related factors. This study suggests that a combination of S spores with AM and CV can be developed as a vaccine-like supplement for respiratory infections.
Article
Biochemistry & Molecular Biology
Ya-Li Hu, Grace Gar-Lee Yue, Xing-Ren Li, Gang Xu, Clara Bik-San Lau
Summary: Ten spirocyclic polycyclic polyprenylated acylphloroglucinols (PPAP), named hunascynols A-J (1-10), were isolated from Hypericum ascyron Linn. Compound 1 and 2 share a common spirocyclic PPAP skeleton and were derived from it through Retro-Claisen, keto-enol tautomeric, and esterification reactions. Compound 3, aldolization of normal spirocyclic PPAP, has a caged framework containing a unique 6/5/6/5/6 ring system. The structures of the compounds were determined using spectroscopy and X-ray diffraction. The inhibitory activities of these compounds were tested against human cancer cells and zebrafish, and their mechanisms and target genes were evaluated.
Article
Plant Sciences
Huihai Yang, Grace Gar-Lee Yue, Ka-Ki Yuen, Si Gao, Ping Chung Leung, Chun Kwok Wong, Clara Bik-San Lau
Summary: This study investigated the anti-tumor and anti-metastatic effects of Patrinia villosa on colon cancer. The study revealed that Patrinia villosa regulates TGF-beta-smad2/3-E-cadherin and FAK-cofilin pathways, providing scientific evidence for its clinical use in colon cancer patients.
Article
Chemistry, Medicinal
Wing-Sum Siu, Hui Ma, Wen Cheng, Wai-Ting Shum, Ping-Chung Leung
Summary: This study investigated the effect and mechanism of action of a topical traditional Chinese medicine formula, CDR, on muscle regeneration using in vitro and in vivo experiments. The results showed that CDR was non-cytotoxic and increased cell viability. Histological analysis demonstrated that CDR treatment facilitated muscle repair by increasing the number of new muscle fibers and promoting muscle integrity. Gene expression analysis indicated that CDR treatment accelerated the regeneration and remodeling phases during muscle repair. This study highlighted the effectiveness of topical CDR treatment in facilitating muscle injury repair.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)