Article
Integrative & Complementary Medicine
Enaim Aida Vargas-Leon, Maribel Soto-Islas, Luis Diaz-Batalla, Humberto Cortes-Lopez, Javier Castro-Rosas, Carlos Alberto Gomez-Aldapa
Summary: The study found that extracts from Heterotheca inuloides Cass., Mexican arnica, have high antioxidant and angiotensin-converting enzyme inhibition capacities, which could play an important role in preventing cardiovascular issues and hypertension.
JOURNAL OF HERBAL MEDICINE
(2022)
Review
Plant Sciences
Xiang Fu, Bing-Hao Shao, Xue Wei, Hui-Hui Wang, Xing Chen, Tian-tian Zhao, Chun-Mei Wang
Summary: Tubiechong, a traditional medicine widely used in China, Japan, and Singapore, has shown promising results in the treatment of various diseases, including bone disease, pain, and skin conditions. Its pharmacological activities, such as promoting blood circulation and protecting liver, heart, brain, and skin, make it a potential candidate for further development and application. However, more research is needed to explore its chemical constituents and molecular pharmacological mechanisms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Deepak Timalsina, Hari Prasad Devkota
Summary: This review summarizes the traditional uses, phytoconstituents, and biological activities of Eclipta prostrata, a medicinal plant widely used in tropical and subtropical regions. The active phytochemicals of E. prostrata include coumestan derivatives, phenolic acid derivatives, flavonoids, triterpenoid and steroid saponins, and substituted thiophenes. Studies on the detailed mechanism and clinical effects of these phytoconstituents are necessary for future research.
Article
Plant Sciences
Hiwot Ayalew, Eyael Tewelde, Besufekad Abebe, Yonatan Alebachew, Solomon Tadesse
Summary: This review provides a comprehensive appraisal of the traditional use, pharmacological properties, and phytochemistry of Ethiopian endemic medicinal plants. It aims to preserve and document indigenous and scientific knowledge and generate an information database for future research in pharmaceutical development.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ping Zhou, Jingyan Li, Qi Chen, Long Wang, Jing Yang, Anguo Wu, Nan Jiang, Yuanzhi Liu, Jianping Chen, Wenjun Zou, Jing Zeng, Jianming Wu
Summary: Genus Sanguisorba, including plants such as Sanguisorba officinalis and Sanguisorba minor, have been extensively studied for their medicinal properties, revealing potential applications in treating various diseases. Researchers have identified active components and pharmacological effects of these plants through in vivo and in vitro experiments.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Applied
Robert Christopher
Summary: The genus Uvaria, known for its ethnobotanical uses such as tumor treatment and fever control, has plant species widely distributed in tropical Africa, Asia, and Australia. This review aims to comprehensively examine the ethnobotanical uses, biological activities, and phytochemistry of Uvaria species, providing a foundation for future studies on this genus. With many compounds from the genus Uvaria still unexplored for their biological activities, this review is expected to be useful for future phytochemical investigations on lead compounds from this genus.
NATURAL PRODUCT RESEARCH
(2022)
Review
Plant Sciences
Yue-Hu Wang
Summary: The study summarized the traditional uses of leaves from 16 Dendrobium species, revealing their effectiveness in treating dermatologic disorders, metabolic syndromes, nervous system disorders, and musculoskeletal system disorders. More than 50 chemical compounds have been identified in the leaves, showing various pharmacological activities. Among Dendrobium species, D. officinale leaves are the most extensively studied.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Raymond John Playford, Michael James Weiser
Summary: Colostrum is the milk produced in the first few days after birth, containing high levels of immunoglobulins, antimicrobial peptides, and growth factors that are important for supporting growth, development, and immunologic defense. Numerous studies have shown therapeutic benefits of bovine colostrum for maintaining wellbeing, treating medical conditions, and in animal husbandry.
Review
Plant Sciences
Qi Wang, Yi-Yu Liang, Kun-Wei Li, Ying Li, Feng-Jv Niu, Sheng-Jun Zhou, Hao-Cheng Wei, Chang-Zheng Zhou
Summary: Herba Siegesbeckiae, also known as Xi-Xian Cao in Chinese, has been traditionally used for treating rheumatic arthralgia in China since the Tang dynasty. Studies have shown that it contains various chemical constituents and exhibits multiple pharmacological activities, including anti-inflammatory, anticancer, antiallergic, and antioxidant effects. Further research on toxicity and quality control is needed for future evaluation of its efficacy and safety.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Elgar Castillo-Mendoza, Alejandro Zamilpa, Manases Gonzalez-Cortazar, Ever A. Ble-Gonzalez, Efrain Tovar-Sanchez
Summary: Mexico is considered a main region for the diversification of oak species, which are important in temperate forests. This study identified and characterized major compounds from three Mexican oak species, including some new compounds. Oak species contain specialized metabolites with medicinal importance, highlighting the relevance of this research from both botanical and human perspectives.
Review
Plant Sciences
Yehua Pan, Xiaomin Luo, Puyang Gong
Summary: This review systematically summarizes the traditional uses, chemical constituents, biological activities, and clinical applications of Spatholobi caulis (SC), an important traditional Chinese medicine. Phytochemical studies have revealed a wide range of chemical compounds in SC, including flavonoids, glycosides, phenolic acids, and volatile oils. Numerous pharmacological studies have demonstrated the anti-tumor, anti-inflammatory, anti-diabetic, and antioxidant effects of SC, among others. However, further research on the toxicological effects, molecular mechanisms, pharmacokinetics, and quality control of SC is needed.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Kashif Ali, Haroon Khan
Summary: The Zygophyllaceae family has multiple genera and species, with Fagonia being an important genus. F. indica, a significant species within the genus, has various medicinal and traditional uses, containing bioactive compounds for anti-diabetic, anti-cancer, anti-inflammatory purposes. Further studies are needed to explore its mechanisms of action.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Pharmacology & Pharmacy
Waqas Alam, Haroon Khan, Sajjad Ali Khan, Sana Nazir, Esra Kupeli Akkol
Summary: Datura metel, commonly known as thorn's apple or devil's trumpet, is an annual herb with pharmacological importance due to its various traditional and pharmacological uses such as hepatoprotective, antiviral, antibacterial, analgesic, and anticancer effects. Further studies are needed to fully understand its pharmacological mechanisms and clinical utility.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Chemistry, Applied
Ju-Tao Wang, Zong-Hui Ma, Guo-Kai Wang, Feng-Qing Xu, Yang Yu, Gang Wang, Dai-Yin Peng, Jin-Song Liu
Summary: Nine compounds were isolated from the endophyte of Paeonia lactiflora, Alternaria alternata, including five new natural compounds and four known ones. Structural elucidation was achieved through intensive analysis of spectroscopic data. Some of the compounds exhibited cytotoxic activities against selected human tumour cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Abebe Dagne Taye, Gizachew Kassahun Bizuneh, Asmamaw Emagn Kasahun
Summary: Euclea (Ebenaceae) is a genus of flowering shrubs and trees found in Africa, the Comoro Islands, and Arabia. This review summarizes the ethnobotanical uses, phytochemistry, and biological activities of Euclea based on available research reports. The extensive literature survey revealed that plants from this genus are used in folkloric medicine for various purposes and more than 40 secondary metabolites have been identified. Euclea plant extracts and their bioactive compounds possess pharmacological properties, including antimalarial, antidiabetic, anticancer, antimicrobial, and antioxidant effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
E. A. Estrella-Parra, A. M. Espinosa-Gonzalez, A. M. Garcia-Bores, S. X. Zamora-Salas, J. C. Benitez-Flores, M. R. Gonzalez-Valle, C. T. Hernandez-Delgado, I. Penalosa-Castro, J. G. Avila-Acevedo
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Chemistry, Organic
Jose Luis Avila, Ericka K. P. Almeida-Aguirre, Carlos A. Mendez-Cuesta, Ruben A. Toscano, Marco A. Cerbon Cervantes, Guillermo Delgado
Article
Agronomy
Jose Luis Rodriguez-Chavez, Yara Suhan Juarez-Campusano, Guillermo Delgado, Juan Ramiro Pacheco Aguilar
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jose Luis Rodriguez-Chavez, Carlos A. Mendez-Cuesta, Teresa Ramirez-Apan, Veronica Egas, Jose Luis Avila, Adriana Neira-Gonzalez, Tzasna Hernandez, Francisco J. Espinosa-Garcia, Guillermo Delgado
BIOORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Maura Gately, Sarah Wong, Jennifer Peoples, Davin Galamay, Guillermo Delgado, Arthur L. Weber, Tammy Campbell
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2020)
Article
Biochemistry & Molecular Biology
Fabiola A. Lopez-Huerta, Antonio Nieto-Camacho, Felix Morales-Flores, Simon Hernandez-Ortega, Maria Isabel Chavez, Carlos A. Mendez Cuesta, Ignacio Martinez, Bertha Espinoza, Francisco J. Espinosa-Garcia, Guillermo Delgado
BIOORGANIC CHEMISTRY
(2020)
Letter
Chemistry, Applied
Fabiola A. Lopez-Huerta, Guillermo Delgado
Summary: The newly discovered compound totaiol could be an important intermediate in the biosynthesis of other triterpenes. Further research is needed to determine the stereochemical and substitutional array of its unique ring structure.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Arturo Cano-Flores, Marina Espinoza, Guillermo Delgado
Summary: Aspergillus niger and Cunninghamella blakesleeana favored the formation of benzofuran derivatives or benzopyran derivatives through biotransformation or acid-catalyzed chemical transformation of glabranin. Compound 6 was further biooxidized at C-4'. The biotransformation of 7-O-methylglabranin mimicked the biosynthesis of the last compound. Some compounds exhibited moderate antiproliferative activity against selected human cancer cell lines, with glabranin being the most active.
NATURAL PRODUCT RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Rocio Crystabel Lopez-Gonzalez, Yara Suhan Juarez-Campusano, Jose Luis Rodriguez-Chavez, Guillermo Delgado-Lamas, Sofia Maria Arvizu Medrano, Ramon Alvar Martinez-Peniche, Juan Ramiro Pacheco-Aguilar
Summary: This study characterized the antagonistic capacity of bacterial populations from different fruit development stages of 'Royal Gala' apples, showing a decrease in bacterial density as the fruit ripens, with Bacillus being a predominant genus. Some Bacillus strains exhibited antagonistic activity in inhibiting the growth of Penicillium expansum, reducing fruit rot effectively. Detection of antifungal lipopeptides indicated the potential mechanism behind the antagonistic activity of these bacteria.
PLANT PATHOLOGY JOURNAL
(2021)
Article
Infectious Diseases
Sebastian Candelaria-Duenas, Rocio Serrano-Parrales, Marisol Avila-Romero, Samuel Meraz-Martinez, Julieta Orozco-Martinez, Jose Guillermo Avila-Acevedo, Ana Maria Garcia-Bores, Carlos L. Cespedes-Acuna, Ignacio Penalosa-Castro, Tzasna Hernandez-Delgado
Summary: In the Tehuacan-Cuicatlan valley of Mexico, essential oils from medicinal plants contain common compounds with antimicrobial activity, with eugenol and carvacrol showing the most significant inhibition zones. Studies have shown that these essential oils have antibacterial and fungicidal properties, providing potential benefits for the local population.
Article
Multidisciplinary Sciences
Francisco J. Espinosa-Garcia, Yolanda M. Garcia-Rodriguez, Angel E. Bravo-Monzon, Ernesto V. Vega-Pena, Guillermo Delgado-Lamas
Summary: The study found no significant negative correlation between the incidence of plant enemies and phytochemical diversity on Hass avocado trees. Results show that trees with lower frequency chemotypes are more prone to attacks by branch borers, and there are differences in the incidence of five plant enemies among the predominant chemotypes.
Article
Chemistry, Medicinal
Fernando Novillo, Estela Velasco-Barrios, Antonio Nieto-Camacho, Fabiola A. Lopez-Huerta, Carlos A. Mendez Cuesta, Maria Teresa Ramirez-Apan, Maria Isabel Chavez, Esteban M. Martinez, Tzasna Hernandez-Delgado, Francisco J. Espinosa-Garcia, Guillermo Delgado
Summary: A new anti-inflammatory compound was isolated from the leaves of Sapium lateriflorum, showing significant anti-inflammatory activity similar to indomethacin, with possible molecular mechanisms identified through docking studies. This compound has potential for treating inflammatory conditions.
Article
Biochemistry & Molecular Biology
Fabiola A. Lopez-Huerta, Maria Teresa Ramirez-Apan, Carlos A. Mendez-Cuesta, Antonio Nieto-Camacho, Simon Hernandez-Ortega, Ericka K. P. Almeida-Aguirre, Marco A. Cerbon, Guillermo Delgado
Summary: The semisynthesis of novel derivatives of lupeol palmitate and 3 beta-palmitoyloxy-olean-12-ene was conducted, and their cytotoxic and anti-inflammatory activities were evaluated. Several derivatives showed significant inhibition of tumor cell lines, and the modification of compound structure affected their anti-inflammatory activity. Further investigation revealed that compounds 7, 10, and 11 may exert their effects by binding to the NF-kappa B receptor, and these compounds have potential for further research.
BIOORGANIC CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
R. Torres-Martinez, A. Moreno-Leon, Y. M. Garcia-Rodriguez, T. Hernandez-Delgado, G. Delgado-Lamas, F. J. Espinosa-Garcia
Summary: We evaluated the activity of Tagetes lucida essential oil (EO) and its main compound mixture against multi-drug resistant bacteria. The EO and its partially reconstituted blend showed antibacterial activity and inhibition of antibiotic resistance in Staphylococcus aureus and Pseudomonas aeruginosa strains. The EO consisted mainly of methyl eugenol, estragole, linalool, and geraniol. The mixture of these compounds at specific proportions exhibited higher antibacterial and modulation of resistance activities than the original EO. This study suggests that the EO and its components have the potential to be alternative options for managing multidrug-resistant pathogens.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Luis J. Romero-Moran, Maria Teresa Ramirez-Apan, Simon Hernandez-Ortega, Diego Martinez-Otero, Guillermo Delgado
Summary: A new natural compound, 25,26,27-trisnor-3P-hydroxy-euphan-24-al (1), was isolated from the leaves of Euphorbia tanquahuete for the first time. In addition, several known compounds and derivatives were also identified. Biological assays showed that compound 1 and semisynthetic compound 8 exhibited the most activity against leukemia cell line (K562).
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)