Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

(2017) Lhassane Ismaili et al.   PROGRESS IN NEUROBIOLOGY

Insights into (S)-rivastigmine inhibition of butyrylcholinesterase (BuChE): Molecular docking and saturation transfer difference NMR (STD-NMR)

(2016) Patrícia Bacalhau et al.   BIOORGANIC CHEMISTRY

Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase

(2016) Yves Bourne et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, synthesis and biological evaluation of novel 2-phenyl-1-benzopyran-4-one derivatives as potential poly-functional anti-Alzheimer's agents

(2016) Manjinder Singh et al.   RSC Advances

Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone–6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

(2015) Shixian Liao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease

(2015) Zhipei Sang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potential of aryl–urea–benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease

(2015) Belma Zengin Kurt et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

(2014) Tiago Silva et al.   AGEING RESEARCH REVIEWS

Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease

(2014) Natalia Guzior et al.   CURRENT MEDICINAL CHEMISTRY

A review on cholinesterase inhibitors for Alzheimer’s disease

(2013) Preet Anand et al.   ARCHIVES OF PHARMACAL RESEARCH

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

(2013) Florian Nachon et al.   BIOCHEMICAL JOURNAL

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine–Homoisoflavonoid hybrids

(2013) Yang Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Multifunctional tacrine–flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease

(2013) Su-Yi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutics of Alzheimer's disease: Past, present and future

(2013) R. Anand et al.   NEUROPHARMACOLOGY

Homoisoflavonoids: Natural Scaffolds with Potent and Selective Monoamine Oxidase-B Inhibition Properties

(2011) Nicoletta Desideri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease

(2010) Cassia R. Overk et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Cholinesterase inhibitors and memory

(2009) Giancarlo Pepeu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Geissospermum vellosii stembark

(2009) Josélia A. Lima et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR