30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature

Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury–Mediated Chronic Kidney DiseaseNovelty and Significance

(2017) Lionel Lattenist et al.   HYPERTENSION

Essential role of ICAM-1 in aldosterone-induced atherosclerosis

(2017) Vincenzo Marzolla et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1

(2017) Jonatan Barrera-Chimal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor

(2016) Quynh N. Dinh et al.   BRAIN RESEARCH

Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in FemalesNovelty and Significance

(2016) Guanghong Jia et al.   CIRCULATION RESEARCH

Activated mineralocorticoid receptor regulates micro-RNA-29b in vascular smooth muscle cells

(2016) Maria Bretschneider et al.   FASEB JOURNAL

Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female MiceNovelty and Significance

(2016) Anne-Cécile Huby et al.   HYPERTENSION

Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial InfarctionNovelty and Significance

(2016) Alexandre Gueret et al.   HYPERTENSION

Vascular structural and functional changes: their association with causality in hypertension: models, remodeling and relevance

(2016) Robert MKW Lee et al.   HYPERTENSION RESEARCH

Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration

(2016) Cristian A. Amador et al.   KIDNEY INTERNATIONAL

CENTRAL SEROUS CHORIORETINOPATHY TREATED WITH MINERALOCORTICOID ANTAGONISTS

(2016) Quraish Ghadiali et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Arterial stiffness, atherosclerosis and cardiovascular risk: Pathophysiologic mechanisms and emerging clinical indications

(2016) Carlo Palombo et al.   VASCULAR PHARMACOLOGY

Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload–Induced Heart Failure

(2016) Ane M. Salvador et al.   Journal of the American Heart Association

Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac FibrosisCLINICAL PERSPECTIVE

(2015) Anne-Cécile Huby et al.   CIRCULATION

Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload–Induced Cardiac InjuryNovelty and Significance

(2015) Nobuhiro Ayuzawa et al.   HYPERTENSION

Deoxycorticosterone Acetate/Salt–Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood PressureNovelty and Significance

(2015) Achim Lother et al.   HYPERTENSION

Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood PressureNovelty and Significance

(2015) Katelee Barrett Mueller et al.   HYPERTENSION

Mineralocorticoid Receptor Antagonism Treats Obesity-Associated Cardiac Diastolic Dysfunction

(2015) S. B. Bender et al.   HYPERTENSION

Sulfenic Acid Modification of Endothelin B Receptor is Responsible for the Benefit of a Nonsteroidal Mineralocorticoid Receptor Antagonist in Renal Ischemia

(2015) J. Barrera-Chimal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake

(2014) Alejandra Tapia-Castillo et al.   AMERICAN JOURNAL OF HYPERTENSION

Overnutrition, mTOR signaling, and cardiovascular diseases

(2014) Guanghong Jia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Retinal Vasculopathy Is Reduced by Dietary Salt Restriction

(2014) Devy Deliyanti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Upregulation of Steroidogenic Acute Regulatory Protein by Hypoxia Stimulates Aldosterone Synthesis in Pulmonary Artery Endothelial Cells to Promote Pulmonary Vascular Fibrosis

(2014) Bradley A. Maron et al.   CIRCULATION

Direct Role for Smooth Muscle Cell Mineralocorticoid Receptors in Vascular Remodeling: Novel Mechanisms and Clinical Implications

(2014) Jenny B. Koenig et al.   CURRENT HYPERTENSION REPORTS

Estrogen Receptor Inhibits Mineralocorticoid Receptor Transcriptional Regulatory Function

(2014) Katelee Barrett Mueller et al.   ENDOCRINOLOGY

Temporary mineralocorticoid receptor antagonism during the development of hypertension improves cerebral artery dilation

(2014) Jonathon L McClain et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Endothelial mineralocorticoid receptor activation enhances endothelial protein C receptor and decreases vascular thrombosis in mice

(2014) Jérémy Lagrange et al.   FASEB JOURNAL

Endothelial Cell Mineralocorticoid Receptors Regulate Deoxycorticosterone/Salt-Mediated Cardiac Remodeling and Vascular Reactivity But Not Blood Pressure

(2014) Amanda J. Rickard et al.   HYPERTENSION

Endothelial Cell Mineralocorticoid Receptors

(2014) Iris Z. Jaffe et al.   HYPERTENSION

Spironolactone for Heart Failure with Preserved Ejection Fraction

(2014) Bertram Pitt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of smooth muscle cell mineralocorticoid receptor in vascular tone

(2014) Antoine Tarjus et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Effectiveness of Spironolactone Plus Ambrisentan for Treatment of Pulmonary Arterial Hypertension (from the [ARIES] Study 1 and 2 Trials)

(2013) Bradley A. Maron et al.   AMERICAN JOURNAL OF CARDIOLOGY

Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension

(2013) Ioana R. Preston et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell Mineralocorticoid Receptors

(2013) Dafina Pruthi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction

(2013) Amil M. Shah et al.   Circulation-Heart Failure

Mineralocorticoid receptors modulate vascular endothelial function in human obesity

(2013) Moon-Hyon Hwang et al.   CLINICAL SCIENCE

Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity

(2013) Nicola Schäfer et al.   EUROPEAN HEART JOURNAL

S100P/RAGE signaling regulates microRNA-155 expression via AP-1 activation in colon cancer

(2013) Benjamin Chidi Onyeagucha et al.   EXPERIMENTAL CELL RESEARCH

Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome

(2013) Verena Drüppel et al.   FASEB JOURNAL

Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: Importance in the control of blood pressure and hypertension

(2013) Bernard C. Rossier et al.   FEBS LETTERS

Fibrosis and cardiac function in obesity: a randomised controlled trial of aldosterone blockade

(2013) Wojciech Kosmala et al.   HEART

Smooth Muscle Cell Mineralocorticoid Receptors Are Mandatory for Aldosterone–Salt to Induce Vascular Stiffness

(2013) Guillaume Galmiche et al.   HYPERTENSION

Protective effects of selective mineralocorticoid receptor antagonist against aortic aneurysm progression in a novel murine model

(2013) Hirotsugu Kurobe et al.   JOURNAL OF SURGICAL RESEARCH

Role of Rac1–mineralocorticoid-receptor signalling in renal and cardiac disease

(2013) Miki Nagase et al.   Nature Reviews Nephrology

Aldosterone Increases Early Atherosclerosis and Promotes Plaque Inflammation Through a Placental Growth Factor‐Dependent Mechanism

(2013) Adam P. McGraw et al.   Journal of the American Heart Association

Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension

(2012) Bradley A. Maron et al.   CIRCULATION

Oxidative Stress Causes Mineralocorticoid Receptor Activation in Rat Cardiomyocytes

(2012) Miki Nagase et al.   HYPERTENSION

Neovascularization Is Attenuated With Aldosterone Synthase Inhibition in Rats With Retinopathy

(2012) Devy Deliyanti et al.   HYPERTENSION

Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy

(2012) Min Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors

(2012) Amy McCurley et al.   NATURE MEDICINE

Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress–Dependent and –Independent Pathways

(2011) Brenna G. Newfell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction

(2011) Daniela Fraccarollo et al.   CIRCULATION

MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

(2011) Reinier A. Boon et al.   CIRCULATION RESEARCH

Mineralocorticoid Receptor Blocker Eplerenone Improves Endothelial Function and Inhibits Rho-Associated Kinase Activity in Patients With Hypertension

(2011) N Fujimura et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mineralocorticoid receptors in vascular function and disease

(2011) Amy McCurley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Randomized Study of the Beneficial Effects of Aldosterone Antagonism on LV Function, Structure, and Fibrosis Markers in Metabolic Syndrome

(2011) Wojciech Kosmala et al.   JACC-Cardiovascular Imaging

Interplay Between miR-155, AT1R A1166C Polymorphism, and AT1R Expression in Young Untreated Hypertensives

(2010) G. Ceolotto et al.   AMERICAN JOURNAL OF HYPERTENSION

Vascular microRNAs

(2010) Angelika Bonauer et al.   CURRENT DRUG TARGETS

Central serous chorioretinopathy: an update on pathogenesis and treatment

(2010) M Gemenetzi et al.   EYE

The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure

(2010) Aurelie Nguyen Dinh Cat et al.   FASEB JOURNAL

Elevated Mineralocorticoid Receptor Activity in Aged Rat Vascular Smooth Muscle Cells Promotes a Proinflammatory Phenotype via Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase and Epidermal Growth Factor Receptor-Dependent Pathways

(2010) Alexander W. Krug et al.   HYPERTENSION

Placental growth factor mediates aldosterone-dependent vascular injury in mice

(2010) Iris Z. Jaffe et al.   JOURNAL OF CLINICAL INVESTIGATION

microRNA Expression Patterns Reveal Differential Expression of Target Genes with Age

(2010) Nicole Noren Hooten et al.   PLoS One

Aldosterone-Induced Activation of Signaling Pathways Requires Activity of Angiotensin Type 1a Receptors

(2009) Catherine A. Lemarié et al.   CIRCULATION RESEARCH

Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib and Off-Target Toxicity

(2008) Menno Vergeer et al.   CIRCULATION

Functional Mineralocorticoid Receptors in Human Vascular Endothelial Cells Regulate Intercellular Adhesion Molecule-1 Expression and Promote Leukocyte Adhesion

(2008) Massimiliano Caprio et al.   CIRCULATION RESEARCH

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse

(2008) Olivia Wendling et al.   GENESIS

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

(2008) Shigeru Shibata et al.   NATURE MEDICINE