Article
Food Science & Technology
Fernanda Luisa Luedtke, Marcella Aparecida Stahl, Renato Grimaldi, Marcus Bruno Soares Forte, Mirna Lucia Gigante, Ana Paula Badan Ribeiro
Summary: This study aimed to optimize the high pressure homogenization (HPH) process conditions and emulsifier formulation to produce nanostructured lipid carriers (NLC). The results showed that using SL, Tween 80, and WPI as emulsifiers, with a pressure of 700 bar and 2 cycles, NLC in the nanometric range could be produced and remained stable during 15 days of storage at 25°C.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
S. Moraes, A. Marinho, S. Lima, A. Granja, J. P. Araujo, S. Reis, C. T. Sousa, C. Nunes
Summary: This study developed folic acid conjugated nanostructured lipid carriers (NLCs) as an effective doxorubicin delivery method targeted to breast cancer cells, with enhanced cellular uptake and targeting potential. In vitro studies showed good release performance and storage stability of the NLCs, indicating the potential for oral administration and targeted doxorubicin delivery to breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Medicinal
Viliana Gugleva, Velichka Andonova
Summary: The challenge faced by researchers in achieving sufficient ocular bioavailability is due to the complex structure of the eye and its protective physiological mechanisms. Low viscosity eye drops and short ocular residence time contribute to low drug concentration at the target site. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are being developed as drug delivery platforms to overcome these challenges and enhance ocular bioavailability. They are biocompatible, biodegradable, and can be sterilized and scaled-up. Surface modifications can prolong ocular residence time, enhance penetration, and improve performance.
Article
Instruments & Instrumentation
Minwoo Jung, Minki Jin, Woo-Jin Jeon, HaeSoo Lee, Haeun Kim, Jong-Hee Won, Hyelim Yoo, Hyoung-Woo Bai, Su-Cheol Han, Hearan Suh, Kyoung Un Kang, Hong-Ki Lee, Cheong-Weon Cho
Summary: In this study, we successfully developed TCG high-loaded nanostructured lipid carrier tablets with sustained release profile and enhanced oral bioavailability.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Juanjuan Sun, Jing Liu, Juanjuan Zhang, Honghui Xia
Summary: Meclizine-loaded nanostructured lipid carriers (NLCs) were developed to improve oral bioavailability of meclizine, showing a potential for effectively managing vomiting and nausea during pregnancy by increasing the oral bioavailability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Chunyang Li, Dian Liu, Meigui Huang, Wuyang Huang, Ying Li, Jin Feng
Summary: In this study, the interfacial structure of nanostructured lipid carriers (NLCs) stabilized by whey protein isolate was modified with polysaccharide. The modified NLCs showed improved stability and drug loading capacity, especially for curcumin.
FOOD HYDROCOLLOIDS
(2022)
Article
Pharmacology & Pharmacy
Sadia Tabassam Arif, Shahiq Uz Zaman, Muhammad Ayub Khan, Tanveer A. Tabish, Muhammad Farhan Sohail, Rabia Arshad, Jin-Ki Kim, Alam Zeb
Summary: The present study aimed to improve the oral bioavailability and prokinetic activity of levosulpiride (LSP) by developing and optimizing LSP-loaded nanostructured lipid carriers (LSP-NLCs). The optimized LSP-NLCs formulation showed improved physicochemical properties and solid-state characterization. In vivo pharmacokinetic evaluation in rats revealed significantly increased AUC and C-max for LSP-NLCs compared to LSP dispersion. Additionally, LSP-NLCs demonstrated enhanced gastric emptying, intestinal transit, and fecal count. These findings suggest that LSP-NLCs could be a promising strategy for the efficient treatment of gastric diseases.
Article
Biophysics
Teenu Sharma, O. P. Katare, Atul Jain, Sanyog Jain, Dasharath Chaudhari, Bonita Borges, Bhupinder Singh
Summary: Bioactives show diverse pharmacological activities, but their low and inconsistent bioavailability hinders their therapeutic potential. Development of nanostructured lipid carriers for chrysin demonstrated improved drug absorption and cellular uptake efficiency, highlighting the high potential of Bio-NLCs for enhanced biopharmaceutical performance.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemical Research Methods
Eman Gomaa, Heba A. Fathi, Noura G. Eissa, Mahmoud Elsabahy
Summary: Construction of nanocarriers, such as NLCs, has great potential in drug delivery systems. NLCs, as a new generation of solid lipid nanoparticles, have higher drug loading efficiency compared to SLNs and offer advantages in terms of preparation and scalability.
Article
Pharmacology & Pharmacy
Shabnam Dolatabadi, Maryam Karimi, Samira Nasirizadeh, Mahdi Hatamipour, Shiva Golmohammadzadeh, Mahmoud Reza Jaafari
Summary: Curcuminoids-loaded solid lipid nanoparticles and nano structured lipid carriers demonstrated significant improvement in pharmacokinetic parameters, suggesting that these new formulations can enhance the bioavailability and absorption of curcuminoids.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Instruments & Instrumentation
Tausif Alam, Mohd Asif Ansari, Sanjula Baboota, Javed Ali
Summary: The study successfully improved the oral bioavailability of isradipine through optimizing the formulation of nanostructured lipid carriers, presenting a promising strategy for long-term management of hypertension. Additionally, the nanostructured lipid carrier of isradipine demonstrated effective cardioprotection in a rat model of myocardial infarction.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Chuan-He Tang, Huan-Le Chen, Jin-Ru Dong
Summary: Although SLNs and NLCs have been used as drug delivery systems, they have been less investigated as food-grade nanovehicles for nutraceuticals. This review comprehensively explores the development and utilization of food-grade SLNs and NLCs as nanosized delivery systems. It discusses issues such as incorporation and release of bioactives, oxidative stability, lipid digestion and absorption, intestinal transport, and encapsulation and delivery of nutraceuticals. The review also highlights the performance of these nanoparticles in improving stability, bioavailability, and bioactivities of curcuminoids.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Sadaf Faiz, Shumaila Arshad, Yousaf Kamal, Sadia Imran, Mulazim Hussain Asim, Arshad Mahmood, Sana Inam, Hafiz Muhammad Irfan, Humayun Riaz
Summary: Pioglitazone-loaded nanostructured lipid carriers (PZ-loaded NLCs) were developed to improve the oral bioavailability of pioglitazone. The PZ-loaded NLCs exhibited small particle size, negative zeta potential, and high drug entrapment efficiency and loading capacity. In vitro and in vivo studies confirmed the enhanced bioavailability of pioglitazone when formulated as PZ-loaded NLCs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yogeeta O. Agrawal, Kiran D. Patil, Kamini R. More, Mohd Usman Mohd Siddique, Saad Alkahtani, Nada H. Aljarba, Md Saquib Hasnain
Summary: This study focused on constructing nanostructured lipid carriers for Azilsartan to improve its oral bioavailability. The optimized AZL-NLCs showed small particle size, appropriate Zeta potential, and high encapsulation efficiency, with a biphasic release pattern. The in-vivo pharmacokinetic experiments confirmed the improved bioavailability and prolonged action of Azilsartan when loaded in NLCs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qing Luo, Jingjing Yang, Haohang Xu, Jieran Shi, Zhen Liang, Rui Zhang, Ping Lu, Guojuan Pu, Ningmin Zhao, Junjie Zhang
Summary: This study successfully developed and optimized SRB-loaded nanostructured lipid carriers (SRB-NLCs) with excellent physicochemical properties and good tolerance, which demonstrated sustained release and enhanced ocular bioavailability. The results suggest that SRB-NLCs have the potential to be safe and effective in the treatment of corneal neovascularization.
Article
Primary Health Care
Begona Calvo Hernaez, Miguel Angel Gastelurrutia Garralda, Amaia Urionaguena de la Iglesia, Arantxazu Isla Ruiz, Ana del Pozo Rodriguez, Maria Angeles Solinis Aspiazu
Summary: Interdisciplinary collaboration is crucial for improving health outcomes, with pharmacists playing a key role in comprehensive management of pharmacotherapy. The Council of Europe resolution promotes pharmaceutical care to ensure appropriate and safe medication use, including detection of drug-related problems and establishment of interprofessional collaboration. This article addresses the challenges of transitioning towards a care-based pharmacy model.
Article
Pharmacology & Pharmacy
Ainhoa Gonzalez-Pujana, Ana Beloqui, Jose Javier Aguirre, Manoli Igartua, Edorta Santos-Vizcaino, Rosa Maria Hernandez
Summary: The ability of mesenchymal stromal cells (MSCs) to release immunomodulatory factors makes them promising candidates for treating inflammatory bowel diseases (IBD). However, nude MSC administration has limitations such as loss of immunomodulatory phenotype and low persistence. In this study, a licensing hydrogel system was designed to overcome these limitations and achieve continuous delivery of bioactive factors. The results showed that encapsulated MSCs in the hydrogel limited the progression of IBD in mice.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Infectious Diseases
Oskar Estrade, Valvanera Vozmediano, Nerea Carral, Arantxa Isla, Margarita Gonzalez, Rachel Poole, Elena Suarez
Summary: Fluoroquinolones play a critical role in urological infections, but their clinical practice is not without challenges such as treatment failure, emergence of resistance, and adverse effects. Understanding the dose-response relation is essential to optimize the effectiveness of these drugs, and selecting the right antibiotic at the right dose and duration is crucial in urological infections.
Article
Critical Care Medicine
Idoia Bilbao-Meseguer, Helena Barrasa, Alicia Rodriguez-Gascon, Eduardo Asin-Prieto, Javier Maynar, Jose Angel Sanchez-Izquierdo, Maria Angeles Solinis, Arantxazu Isla
Summary: Levetiracetam dosage regimens need to be re-evaluated in critically ill patients with augmented renal clearance. This study proposes new dosage recommendations, including extended infusions, continuous infusions, or higher doses than recommended, based on pharmacokinetic aspects and feasibility criteria. Further clinical studies are needed to confirm these results.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Chemistry, Multidisciplinary
Patrik Lundquist, Georgiy Khodus, Zhigao Niu, Lungile Nomcebo Thwala, Fiona McCartney, Ivailo Simoff, Ellen Andersson, Ana Beloqui, Aloise Mabondzo, Sandra Robla, Dominic-Luc Webb, Per M. Hellstroem, asa Keita, Eduardo Sima, Noemi Csaba, Magnus Sundbom, Veronique Preat, David J. Brayden, Maria Jose Alonso, Per Artursson
Summary: Peptide drugs are not orally bioavailable due to their poor stability and permeability, but nanoparticle formulations may provide a solution. In this study, the absorption mechanisms of four insulin-loaded arginine-rich nanoparticles were investigated. One nanoparticle showed significant uptake and is proposed for further investigation for local delivery.
Review
Pharmacology & Pharmacy
Espoir K. Kambale, Joelle Quetin-Leclercq, Patrick B. Memvanga, Ana Beloqui
Summary: Diabetes is a chronic condition with high blood glucose levels that cannot be cured. Managing diabetes involves a healthy lifestyle, exercise, and medication. Nanoparticulate delivery systems have shown promise in enhancing the effectiveness of herbal treatments for diabetes, but further clinical trials are needed.
Article
Pharmacology & Pharmacy
Espoir K. Kambale, Frederick M. Katemo, Joelle Quetin-Leclercc, Patrick B. Memvanga, Ana Beloqui
Summary: This study compared ZnONPs prepared by two different green methods - high temperature heating and low temperature method with suspending agents and pH variations. The low temperature method resulted in ZnONPs with high retention rate and size around 200 nm. These improved ZnONPs showed significant hypoglycemic effects at a lower dosage.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Ines Domingues, Cecilia Bohns Michalowski, Valentina Marotti, Wunan Zhang, Matthias Van Hul, Patrice D. Cani, Isabelle A. Leclercq, Ana Beloqui
Summary: Non-alcoholic fatty liver disease (NAFLD) affects a significant portion of the adult population worldwide and no approved pharmacologic therapy is currently available. A novel drug delivery system called lipid nanocapsules (LNCs) has shown promise in treating NAFLD by inducing the secretion of glucagon-like peptide 1 (GLP-1). This study aimed to compare the efficacy of the LNCs system with subcutaneous injection of a GLP-1 analog in two mouse models of NAFLD. The results demonstrated that chronic administration of the LNCs system improved glucose homeostasis and insulin resistance, and prevented disease progression to a greater extent than subcutaneous injection in both models.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Alicia Rodriguez-Gascon, Ana Alarcia-Lacalle, Maria Angeles Solinis, Ana del Pozo-Rodriguez, Zurine Abajo, Maria Cabero, Andres Canut, Arantxa Isla
Summary: This study evaluated the pharmacokinetics of calcium fosfomycin in urine after oral administration and assessed its effectiveness for the treatment of urinary tract infections (UTIs) caused by Escherichia coli. The results showed that oral calcium fosfomycin at a dose of 1000 mg every 8 hours provided sufficient urine concentrations to ensure efficacy in UTI treatment in women.
Article
Endocrinology & Metabolism
Emilie Moens de Hase, Audrey M. Neyrinck, Julie Rodriguez, Miriam Cnop, Nicolas Paquot, Jean-Paul Thissen, Yining Xu, Ana Beloqui, Laure B. Bindels, Nathalie M. Delzenne, Matthias Van Hul, Patrice D. Cani
Summary: This study investigated the association between the abundance of Dysosmobacter welbionis and metabolic health in individuals with obesity and diabetes, as well as the influence of metformin treatment and prebiotic intervention. The findings suggest that Dysosmobacter welbionis abundance is influenced by metformin treatment and is associated with liver health and glucose metabolism in individuals with obesity and diabetes. This highlights the potential role of Dysosmobacter welbionis in metabolic health.
Article
Hematology
Ana Alarcia-Lacalle, Helena Barrasa, Javier Maynar, Andres Canut-Blasco, Maria Angeles Solinis, Arantxa Isla, Alicia Rodriguez-Gascon
Summary: This study aimed to evaluate the extracorporeal elimination of ceftaroline and avibactam using different continuous renal replacement therapies (CVVH, CVVHD, CVVHDF). The results showed that all three modalities effectively eliminated ceftaroline and avibactam, suggesting that dose adjustment may be necessary in CRRT-treated patients.
BLOOD PURIFICATION
(2023)
Review
Pharmacology & Pharmacy
Cheng Chen, Ana Beloqui, Yining Xu
Summary: This review focuses on the biointeractions of oral nanomedicine in the gastrointestinal tract, discussing the different biointeractions based on the type of oral nanomedicine and advanced strategies used. It also highlights the utilization of pathological characteristics to advance the development of oral nanomedicine in different diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)
