The Role of NrF2 in the Regulation of Periodontal Health and Disease

Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis

(2016) Govinda Bhattarai et al.   Acta Biomaterialia

Nuclear Factor Erythroid 2-Related Factor 2 Down-Regulation in Oral Neutrophils Is Associated with Periodontal Oxidative Damage and Severe Chronic Periodontitis

(2016) Corneliu Sima et al.   AMERICAN JOURNAL OF PATHOLOGY

Visualization of Oxidative Stress Induced by Experimental Periodontitis in Keap1-Dependent Oxidative Stress Detector-Luciferase Mice

(2016) Kota Kataoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinct Oral Neutrophil Subsets Define Health and Periodontal Disease States

(2016) N. Fine et al.   JOURNAL OF DENTAL RESEARCH

NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1

(2016) In Soon Kang et al.   Scientific Reports

FOXO1 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis

(2015) Wenmei Xiao et al.   AMERICAN JOURNAL OF PATHOLOGY

The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review

(2015) Francisco Wilker Mustafa Gomes Muniz et al.   ARCHIVES OF ORAL BIOLOGY

Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention

(2015) Bryan Harder et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs

(2015) Ha-Neui Kim et al.   MOLECULAR ENDOCRINOLOGY

Plasma and salivary total antioxidant capacity in healthy controls compared with aggressive and chronic periodontitis patients

(2015) Ulku Baser et al.   SAUDI MEDICAL JOURNAL

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

Neutrophil transcriptional profile changes during transit from bone marrow to sites of inflammation

(2014) Flavia S Lakschevitz et al.   Cellular & Molecular Immunology

Nuclear Nrf2 Induction by Protein Transduction Attenuates Osteoclastogenesis

(2014) Hiroyuki Kanzaki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quantifying oral inflammatory load: oral neutrophil counts in periodontal health and disease

(2014) M. Landzberg et al.   JOURNAL OF PERIODONTAL RESEARCH

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

Overexpression of Sirtuin 6 Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis

(2013) Hwa-Suk Lee et al.   ARTHRITIS AND RHEUMATISM

Translational control of Nrf2 within the open reading frame

(2013) Oscar Perez-Leal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

(2013) Seungha Hyeon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane Restores Cellular Glutathione Levels and Reduces Chronic Periodontitis Neutrophil Hyperactivity In Vitro

(2013) Irundika H. K. Dias et al.   PLoS One

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

(2013) George Hajishengallis   TRENDS IN IMMUNOLOGY

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Oral Inflammatory Diseases and Systemic Inflammation: Role of the Macrophage

(2012) Hatice Hasturk et al.   Frontiers in Immunology

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

(2011) Muhua Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis

(2011) Tomasz M. Stępkowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3

(2011) Ana I. Rojo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Schisandra chinensis α-iso-cubebenol induces heme oxygenase-1 expression through PI3K/Akt and Nrf2 signaling and has anti-inflammatory activity in Porphyromonas gingivalis lipopolysaccharide-stimulated macrophages

(2011) Sun Young Park et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired Phagocytosis in Localized Aggressive Periodontitis: Rescue by Resolvin E1

(2011) Gabrielle Fredman et al.   PLoS One

Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Edith Lubos et al.   ANTIOXIDANTS & REDOX SIGNALING

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

(2010) C. Sangokoya et al.   BLOOD

Refractory Periodontitis Population Characterized by a Hyperactive Oral Neutrophil Phenotype

(2010) Guy M. Aboodi et al.   JOURNAL OF PERIODONTOLOGY

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Human catalase: looking for complete identity

(2010) Madhur M. Goyal et al.   Protein & Cell

Hyper-responsive Phenotype in Localized Aggressive Periodontitis

(2009) L. Shaddox et al.   JOURNAL OF DENTAL RESEARCH

Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: Novel cytoprotective mechanism against oxidative damage

(2008) Ju Hee Lim et al.   PHARMACOLOGICAL RESEARCH