Article
Food Science & Technology
Haixi You, Yu Zhang, Tianliang Wu, Juanrui Li, Liying Wang, Zhipeng Yu, Jingbo Liu, Xuebo Liu, Long Ding
Summary: This study aimed to investigate the DPP-IV inhibitory peptides from rapeseed proteins. The results showed that rapeseed protein hydrolysates had DPP-IV inhibitory activities. In silico approach was used to select potential DPP-IV inhibitory peptides and 12 of them were determined to have inhibitory activities. Four peptides (IPK, LPR, VPHL, and IPNQT) were identified from rapeseed protein hydrolysate, with IPK exhibiting the highest inhibitory activity. IPK acted as a competitive inhibitor and interacted with specific residues in the S1 and S2 pockets of DPP-IV. These findings suggest that rapeseed proteins are a valuable source of DPP-IV inhibitory peptides for the management of type 2 diabetes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Haixi You, Tianliang Wu, Wei Wang, Yiju Li, Xuebo Liu, Long Ding
Summary: This study found that quinoa protein-derived peptides, particularly QPH1 with molecular weight less than 1 kDa, exhibited strong DPP-IV inhibitory activity. Peptides IPI, IPV, VAYPL, and IPIN showed the highest inhibitory activities and were identified as competitive inhibitors of DPP-IV.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemical Research Methods
Phasit Charoenkwan, Chanin Nantasenamat, Md Mehedi Hasan, Mohammad Ali Moni, Pietro Lio, Balachandran Manavalan, Watshara Shoombuatong
Summary: The development of efficient bioinformatics tools for identifying DPP-IV inhibitory peptides is crucial for discovering potential antidiabetic drugs. This study introduces a novel stacking-based ensemble learning predictor, StackDPPIV, which outperforms existing methods by combining different feature encodings and machine learning algorithms. Experimental results demonstrate the superior predictive performance of StackDPPIV on both training and independent datasets.
Article
Biochemistry & Molecular Biology
Yuxiang Gu, Xing Li, Xiaofen Qi, Ying Ma, Eric Chun Yong Chan
Summary: The capacity of buffalo milk proteins to release bioactive peptides was evaluated, and novel bioactive peptides were identified. The sequential similarity between buffalo milk proteins and their cow counterparts was analyzed. In silico proteolysis was used to simulate the release of theoretical peptides from buffalo milk proteins. The potential of selected proteins to release specific bioactive peptides was evaluated, and two ACE inhibitory peptides and four DPP-IV inhibitory peptides were identified.
Review
Chemistry, Medicinal
Anand-Krishna Singh, Dhananjay Yadav, Neha Sharma, Jun-O Jin
Summary: Type 2 diabetes mellitus is characterized by high blood sugar levels, and therapeutic approaches include improving insulin sensitivity and using DPP-IV inhibitors. These inhibitors improve hyperglycemia by stabilizing gut hormones such as glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptides.
Article
Food Science & Technology
Long Ding, Ruidi Ma, Haixi You, Juanrui Li, Qingyang Ge, Zhipeng Yu, Liying Wang
Summary: This study investigates the DPP-IV inhibitory properties of wheat gluten-derived peptides. The hydrolysate by flavourzyme showed the highest DPP-IV inhibitory activity, with MPF and VAVPV being the main contributors. Molecular docking revealed that these peptides might interact with the active site of DPP-IV, indicating their potential as ingredients in functional foods or drugs for prediabetes and Type 2 diabetes mellitus management.
JOURNAL OF CEREAL SCIENCE
(2022)
Article
Food Science & Technology
Daqiao Yang, Chunsheng Li, Laihao Li, Yueqi Wang, Shengjun Chen, Yongqiang Zhao, Xiao Hu, Hui Rong
Summary: DPP-IV inhibitory peptides from fermented foods like Chouguiyu have the potential to alleviate type 2 diabetes mellitus. This study identified 125 DPP-IV inhibitory peptides in Chouguiyu and selected four novel peptides with the lowest docking energy. These peptides possess structures that easily connect with DPP-IV enzyme through hydrogen bond, salt bridge, and alkyl interactions, and show potential for remission of T2DM.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Nutrition & Dietetics
Yuki Shimizu, Hiroshi Hara, Tohru Hira
Summary: Although glucose is the most well-known nutrient to stimulate GLP-1 secretion, dietary peptides also play a significant role in stimulating GLP-1 secretion and inhibiting DPP-4 activity. Whey protein administration resulted in less degradation of GLP-1 compared to other nutrients, indicating a potential protective effect of dietary peptides on GLP-1.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Food Science & Technology
Wei Wang, Xiaoqing Liu, Yiju Li, Haixi You, Zhipeng Yu, Liying Wang, Xuebo Liu, Long Ding
Summary: In this study, different enzymes and simulated digestion were used to investigate the DPP-IV inhibitory activities of oat protein hydrolysates. Neutrase was found to produce oat protein hydrolysate with the most potent DPP-IV inhibitory property, and ten new DPP-IV inhibitory peptides were identified. Molecular docking experiments further confirmed the interaction between these peptides and DPP-IV. Therefore, oat could be a promising source of dietary supplement for type 2 diabetes mellitus (T2DM).
Article
Food Science & Technology
Juan Wang, Yujia Xie, Yuanyuan Luan, Tingting Guo, Shanshan Xiao, Xingxing Zeng, Shaohui Zhang
Summary: The objective of this study was to isolate and identify intracellular bioactive peptides from mouse lymphocytes before and after lipopolysaccharide (LPS) stimulation. A total of 131 novel peptides were discovered, and their bioactivity and function were predicted. Two peptides with better inhibition activity were verified.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Immunology
Zhicheng Zheng, Peiyu Liang, Baohua Hou, Xin Lu, Qianwen Ma, Xiaomin Yu, Song Han, Biwen Peng, Taoxiang Chen, Wanhong Liu, Jun Yin, Xiaohua He
Summary: The study revealed that DPP4 is involved in DAM conversion and epilepsy, and treatment with DPP4 inhibitor sitagliptin can alleviate epilepsy and promote DAM phenotypic transformation, resulting in enhanced morphological features and functions of microglia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Nutrition & Dietetics
Chaitra Rai, Poornima Priyadarshini
Summary: One alternative strategy to combat obesity is to increase active GLP-1 levels, and peptides derived from partial hydrolysis of dietary proteins have inhibitory activity on DPP-4. This study found that whey protein hydrolysate reduced body weight in high-fat diet-induced obesity mice by suppressing appetite through increased GLP-1 levels in both the brain and peripheral circulation.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Food Science & Technology
Soren Drud-Heydary Nielsen, Ningjian Liang, Harith Rathish, Bum Jin Kim, Jiraporn Lueangsakulthai, Jeewon Koh, Yunyao Qu, Hans-Jorg Schulz, David C. Dallas
Summary: Partial digestion of milk proteins produces various bioactive peptides. Our research team constructed the milk bioactive peptide database (MBPDB) by thoroughly reviewing existing literature on milk bioactive peptides across species. This article provides a comprehensive update to the data in the MBPDB, and reviews the current state of research for each functional category, including ACE-inhibitory, antimicrobial, antioxidant, DPP-IV inhibitory, opioid, anti-inflammatory, immunomodulatory, calcium absorption and bone health, and anticancer activity. This information will contribute to future research on the bioactivities of milk peptides.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Physical
Jaya P. Ambhore, Purushottam R. Laddha, Anjali Nandedkar, Prashant V. Ajmire, Deshraj S. Chumbhale, Ashish B. Navghare, Vitthal G. Kuchake, Prashant J. Chaudhari, Vaibhav S. Adhao
Summary: Nowadays, Dipeptidyl peptidase-IV (DPP-IV) has emerged as a promising drug target for the treatment of Type 2 diabetes mellitus (T2DM). Currently available DPP-IV inhibitors effectively lower blood glucose levels in T2DM patients without causing common side effects such as hypoglycemia, weight gain, and gastrointestinal disturbances. This review focuses on the molecular insights, recent developments in design and discovery, and structure-activity relationships of potential DPP-IV inhibitors.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Endocrinology & Metabolism
Shiau Chin Chong, Norlela Sukor, Sarah Anne Robert, Kim Fong Ng, Nor Azmi Kamaruddin
Summary: This study assessed the impact of endogenous GLP-1 levels on the treatment response to DPP-IV inhibitors in individuals with prediabetes and T2D. The results showed that linagliptin significantly reduced HbA1c and glucose levels in individuals with high GLP-1 levels. This suggests that endogenous GLP-1 levels play an important role in determining the efficacy of DPP-IV inhibitors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Food Science & Technology
Qi Sun, Min Du, Yifei Kang, Mei-Jun Zhu
Summary: The prevalence of inflammatory bowel disease (IBD) is increasing. Goji berry, as an ancient tonic food and nutraceutical supplement, has protective effects against IBD by regulating gut microbiota and their metabolites.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Tiange Li, Yue Zhang, Jiajia Song, Lijun Chen, Min Du, Xueying Mao
Summary: The study found that synbiotic yogurt enriched with inulin has potential benefits for alleviating reproductive dysfunction in PCOS mice. It can also modulate the gut microbiota and bile acid profiles.
Article
Food Science & Technology
Jia Sha, Jiajia Song, Yechuan Huang, Yuhong Zhang, Hongwei Wang, Yu Zhang, Huayi Suo
Summary: This study investigated the inhibitory effect and mechanism of 12 LAB strains isolated from Chinese fermented foods on dipeptidyl peptidase-4 (DPP-4) using the Caco-2 cell model. The results showed that the inhibitory effect of cell-free extracts (CFEs) collected from each LAB strain on DPP-4 was higher than that of the cell-free excretory supernatants. The CFEs from Lactobacillus plantarum YE4 (YE4-CFE) exhibited the strongest DPP-4 inhibitory activity (24.33% inhibition). Furthermore, YE4-CFE altered the TNF and MAPK signaling pathways, and the high proportion of adenine, acetylcholine, and L-phenylalanine in YE4-CFE contributed to its inhibitory effect on DPP-4.
Review
Food Science & Technology
Jing Yang, Hong Kuang, Ning Li, Ahmed Mahmoud Hamdy, Jiajia Song
Summary: Probiotic-derived polysaccharide capsules have a significant impact on regulating the immune system and alleviating allergic diseases. They can modulate the Th1/Th2 balance, induce differentiation of T regulatory cells, and activate dendritic cells, thereby providing protection against allergic diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Yao Gao, Liang Zhao, Jun Seok Son, Xiangdong Liu, Yanting Chen, Jeanene Marie Deavila, Mei-Jun Zhu, Gordon K. Murdoch, Min Du
Summary: Maternal exercise promotes thyroid hormone delivery to embryos and enhances embryonic myogenesis through enhanced thyroid hormone signaling.
Article
Nutrition & Dietetics
Alejandro Bravo Iniguez, Qiyu Tian, Min Du, Mei-Jun Zhu
Summary: The metabolite alpha-ketoglutarate (aKG) shows potential for ameliorating colitis by reducing harmful metabolites and promoting goblet cell differentiation, resulting in a stronger mucus layer.
Article
Food Science & Technology
Yang Yang, Yinyin Lian, Shimei Yin, Huayi Suo, Fankun Zeng, Hongwei Wang, Jiajia Song, Yu Zhang
Summary: The formation of white bio-membrane (shenghua) on pickles is a key problem in the Sichuan pickle industry. This study identified Candida parapsilosis as the main strain causing shenghua and explored its membrane-forming ability in different environmental conditions. Lactobacillus fermentum SHY10 was found to inhibit the membrane production of Candida parapsilosis, with the cell-free supernatant showing the strongest inhibitory effects likely due to protein substances. This research provides a safe and consumer-friendly solution for the membrane problem in the fermented vegetable industry.
FOOD SCIENCE & NUTRITION
(2022)
Review
Food Science & Technology
Jing Yang, Hong Kuang, Xiaoli Xiong, Ning Li, Jiajia Song
Summary: Milk is an important source of protein for infants and young children, but it can also be a common allergen. Modern food processing technologies can reduce the allergenicity of milk proteins and improve the quality of life for allergy sufferers.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Food Science & Technology
Zixia Chen, Jiajia Song, Lu Ren, Hongwei Wang, Yu Zhang, Huayi Suo
Summary: The effect of microbial succession on the quality and flavor of Mucor wutungkiao fermented sufu remains unclear. In this study, the changes in physicochemical properties and flavor compounds of Mucor wutungkiao-fermented sufu during fermentation were investigated using Mucor wutungkiao 40477 as a starter culture. The results revealed that the levels of amino acid nitrogen and total acid increased, and the pH, hardness, and elasticity of the sufu decreased. 17 free amino acids and 51 flavor compounds were detected, with umami amino acids and esters being the major contributors, respectively. Unclassified_f_Enterobacteriaceae, Lactococcus, and Aspergillus were the dominant microorganisms during fermentation.
Article
Food Science & Technology
Qian Peng, Jing Yang, Qiang Wang, Huayi Suo, Ahmed Mahmoud Hamdy, Jiajia Song
Summary: The antifungal effect of metabolites produced by a new strain of Lpb. plantarum LPP703, isolated from naturally fermented yak yogurt, was investigated. The metabolites showed strong antifungal activity against Penicillium sp., potentially by damaging the fungal membrane integrity.
Editorial Material
Nutrition & Dietetics
Jiajia Song, Xin Zhao, Kun-young Park, Huayi Suo
FRONTIERS IN NUTRITION
(2023)
Review
Food Science & Technology
Chen Wang, Junying Bai, Xiaoyong Chen, Jiajia Song, Yu Zhang, Hongwei Wang, Huayi Suo
Summary: Host health and disease are affected by changes in intestinal flora. Strategies such as probiotics, prebiotics, diet, fecal microbiota transplantation, antibiotics, and phages can regulate the structure and abundance of microflora. Diets and prebiotics have reduced risk and high security, while phages have high specificity for targeted regulation. Individual variability in microflora and metabolic response should be considered, and future studies should use artificial intelligence and multi-omics to develop personalized intervention strategies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Thermodynamics
Jingyu Zhao, Gai Hang, Jiajia Song, Shiping Lu, Hanqi Ming, Jiaming Chang, Jun Deng, Yanni Zhang, Chi-Min Shu
Summary: This study compared the combustion characteristics of fresh and weathered coal samples and found that fresh coal burns more intensely while weathered coal is more prone to thermal decomposition. The combustion mechanisms of fresh and weathered coal were represented by the Jander and Avrami-Erofeev equations, respectively.
Review
Food Science & Technology
Xue Deng, Jing Yang, Yu Zhang, Xiaoyong Chen, Chen Wang, Huayi Suo, Jiajia Song
Summary: Diet, lifestyle, and gut microbiota composition are key risk factors for the progression of colon cancer. Probiotics can mitigate colon cancer through various mechanisms, including the suppression of cell proliferation, promotion of cancer cell apoptosis, immunomodulation, and modulation of intestinal microorganisms and their metabolism.
Article
Engineering, Environmental
Jingyu Zhao, Xiaocheng Yang, Jiajia Song, Yongli Zhang, Chi-Min Shu
Summary: This study used a simulation platform to investigate the temperature, gas concentration, migration of functional groups, and change rules in the high-temperature region of a coal mine. The research results can be used for disaster prevention and control in mine fires.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
