Article
Nanoscience & Nanotechnology
Riku Kawasaki, Hidetoshi Hirano, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Kouhei Yoshikawa, Hideki Azuma, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Naoki Tarutani, Kiyofumi Katagiri, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi, Takeshi Nagasaki, Atsushi Ikeda
Summary: Boron neutron capture therapy (BNCT) is a promising cancer treatment, but delivering effective boron agents is challenging. We developed hybrid nanoparticles called HBNGs that can efficiently deliver highly concentrated boron agents, surpassing the effectiveness of clinically used boron agent L-BPA/fructose complex in vitro. HBNGs accumulate in tumors and show high tumor selectivity, allowing for successful BNCT without tumor regrowth. The therapeutic efficacy of HBNGs is superior to L-BPA/fructose complex, making it a promising approach to cancer therapeutics.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Jiwei Jiang, Yuansong Wei, Zhaomin Chen, Jia Xu, Hui Zhang, Bin Dong
Summary: This article introduces a drug carrier that can precisely deliver antibiotics to bacteria and efficiently kill them, thereby avoiding the misuse of antibiotics. The drug carrier can autonomously move in the acidic environment caused by bacterial infection and enhance its affinity to bacteria, enabling it to precisely deliver drugs to bacteria and kill them more effectively.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Ying Lai, Tariq J. Al-Musawi, Uday Abdul-Reda Hussein, Ibrahem Waleed, Hanan Hassan Ahmed, Anwar Qasim Khallawi, Khulood Majid Alsaraf, Mohammed Asiri, Munther Abosaooda, Hashem O. Alsaab
Summary: In recent years, there has been considerable interest in finding new drug-delivery materials. This study conducted a systematic investigation of the interaction between metformin and the surface of pristine B12N12 and group I metals (Li, Na, and K) encapsulation nanoclusters based on DFT calculations. The presence of alkali metals remarkably increased the absorption energy of MF-B12N12, and the addition of alkali metals led to a decrease in Egap and an increase in reactivity.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Nanoscience & Nanotechnology
Rashmi Joshi, Sourav Patra, Manas Srivastava, Bheeshma Pratap Singh, Avik Chakraborty, Sandeep Balu Shelar, Rubel Chakravarty, Sudipta Chakraborty, Raghumani Singh Ningthoujam
Summary: Nearly monodispersed NaGdF4/Ho-Yb upconversion nanoparticles with biocompatible mesoporous silica coating were synthesized. These nanoparticles exhibit red and green bands in the visible range upon excitation at different wavelengths of light. The potential applications of these nanoparticles as drug carriers and therapeutic radionuclide carriers were demonstrated.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Organic
Qing-Shuang Zhang, Lin He, Qiang Liu, Xiang-Yu Chen
Summary: A photoinduced charge transfer complex (CTC) was used to enable photoreduction of carborane phosphonium salts for the cage carbon (hetero)arylation of carboranes. This method offers a convenient approach for introducing a wide range of aryl and heteroaryl groups into carboranes, such as pyrroles, thiophenes, indoles, thianaphthenes, benzofurans, pyridines, and benzenes. It is characterized by operational simplicity, mild reaction conditions, and a broad substrate scope.
Article
Biochemical Research Methods
Fang Tang, Qian Wang, Yi-Nan Gao, Yu-Shan Zhang, Ya-Xuan Liang, Zhong-Lin Lu, Rui Liu, Ai-Xiang Ding
Summary: In this study, a nonviral gene vector with low cytotoxicity, visual tracking ability, and high serum tolerance was constructed using the combination of fluorination and aggregation-induced emission (AIE). The vector, FluoTPA, showed effective delivery of nucleic acids into cells and achieved comparable transfection efficiency under high serum content. The results suggest that FluoTPA could be a reliable theranostic platform for nonviral nucleic acid therapeutics in serum condition.
BIOCONJUGATE CHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Xin-Hui Cao, Ming-Xing Liang, Yang Wu, Kai Yang, Jin-Hai Tang, Wei Zhang
Summary: EVs serve as nano-carriers for antitumor drugs, gene drugs, and other nanomaterials with anticancer capabilities. Improving the preparation methods and drug loading capacity of EVs can enhance their cancer-targeting efficiency. EV-based drug delivery holds promise for precise cancer treatment in the future.
Article
Nanoscience & Nanotechnology
Maryam Zarghami Dehaghani, Babak Bagheri, Farrokh Yousefi, Abbasali Nasiriasayesh, Amin Hamed Mashhadzadeh, Payam Zarrintaj, Navid Rabiee, Mojtaba Bagherzadeh, Vanessa Fierro, Alain Celzard, Mohammad Reza Saeb, Ebrahim Mostafavi
Summary: Nanotube-based drug delivery systems are highly promising for drug encapsulation due to their strong penetration capability and large internal volume. Molecular dynamics simulation revealed that cationic antimicrobial peptide cRW3 was encapsulated in biocompatible boron nitride nanotube through van der Waals interaction, with a decrease in vdW interaction strength over time. This study provides valuable insights into the encapsulation behavior of drugs in nanotubes and their potential applications in drug delivery.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Flieger, Mao Takagaki, Natsuko Kondo, Marlon R. Lutz, Yash Gupta, Hiroki Ueda, Yoshinori Sakurai, Graham Moran, Prakasha Kempaiah, Narayan Hosmane, Minoru Suzuki, Daniel P. Becker
Summary: New carborane-bearing hydroxamate matrix metalloproteinase (MMP) ligands with nanomolar potency against MMP-2, -9 and -13 have been synthesized for boron neutron capture therapy (BNCT). In vitro studies showed that these new MMP ligands had high tumoricidal effects in the BNCT assay. This study highlights the importance of targeting MMP enzymes overexpressed on the surface of tumor cells for BNCT efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Ahram Kim, Yuya Suzuki, Yukio Nagasaki
Summary: Boronic acids have potential for biomedical applications, but are limited by rapid excretion and off-target effects. By employing a polymeric carrier, stable encapsulation of boronic acid-containing drugs can be achieved with improved pharmacokinetics and on-target drug release capability. Enhancements in antitumor efficacy and reduction in hepatotoxicity can be achieved through this approach.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Analytical
Yizhong Shen, Tingting Wu, Yuqi Wang, Shao-Lin Zhang, Xueli Zhao, Hong-Yuan Chen, Jing-Juan Xu
Summary: A novel ratiometric fluorescent method was developed to sensitively and specifically report Cathepsin B (CTSB) activity by integrating cancer-targeting recognition moiety and a large emission wavelength shift into a single matrix.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Menghan Wang, Xing Ma, Guoyu Wang, Yanan Song, Miao Zhang, Zhongchao Mai, Borong Zhou, Ying Ye, Wei Xia
Summary: This study found that UBR5 acts as an oncogene in HCC tissues and its expression can be inhibited by ECH. By delivering ECH to HepG2 cells through a nanoparticle-based drug delivery system, the sensitivity of HCC cells to ECH can be improved, promoting cell apoptosis and inhibiting glycolysis. In vivo experiments confirmed that this delivery system enhances the antitumor effects of ECH on HCC cells.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Pharmacology & Pharmacy
Feng-Huei Lin, Yu-Chen Hsu, Kuo-Chi Chang, Yan-Jye Shyong
Summary: The objective of this study was to develop HAp particles for targeted delivery of honokiol to tumor sites after glioma surgical management. Honokiol is released from the HAp-honokiol particles inside cancer cells through endocytosis and acid lysosomal dissolution. HAp-honokiol treatment showed sustained drug release without compromising drug efficacy, leading to a significant reduction in tumor size in a mouse glioma model. These findings suggest that HAp-honokiol particles have potential as an effective drug delivery system for glioma treatment.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Sihao Jiang, Jiayi Bian, Xintong Shi, Yong Hu
Summary: An insoluble thermosensitive microneedle (ITMN) is designed to control insulin release by adjusting temperature, enabling precise treatment of diabetes. The ITMN has good mechanical strength and temperature sensitivity, and can effectively regulate blood glucose in diabetic mice.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Xiaoyou Wang, Chong Li, Yiguang Wang, Huabing Chen, Xinxin Zhang, Cong Luo, Wenhu Zhou, Lili Li, Lesheng Teng, Haijun Yu, Jiancheng Wang
Summary: Nano-drug delivery systems play an important role in cancer treatment, but the balance between improved anticancer efficacy and reduced toxicity to normal tissues remains a challenge. Smart stimuli-responsive delivery strategies offer opportunities for advanced tumor specificity and controlled release behavior. The development of nanotechnology, material sciences, and biomedical sciences has enabled the creation of diverse and versatile smart drug delivery systems.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Physical
Jun Qu, Yulan Han, Kefu Zhang, Yongqi Deng, Yihan Wu, Lifeng Yan
Summary: In this study, multidimensional ternary composite electrocatalysts were used to enhance the performance of direct methanol fuel cells. The catalysts showed high mass activities and improved CO tolerance and stability.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Youliang Tian, Dalong Yin, Lifeng Yan
Summary: This article discusses the J-aggregation of organic dyes and their applications in near-infrared imaging and phototherapy. J-aggregates exhibit unique physical properties, such as enhanced absorption, narrowed spectral bandwidth, and aggregation-induced emission enhancement, which offer great potential for biological applications. However, the rational design of molecular structures to achieve J-aggregation of organic dyes remains a challenging task.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lifeng Yang, Qian Ping, Zhenbo Yuan, Jiejuan Jiang, Baodang Guo, Changmei Liu, Yijian Rao, Jinsong Shi, Yan Zhang
Summary: This study discovered that YjiC, a uridine diphosphate-dependent glycosyltransferase from Bacillus subtilis 168, has the ability to glycosylate rebaudioside A (Reb A) and produce a novel mono beta-1, 6-glycosylated Reb A derivative called rebaudioside L2 (Reb L2), which has improved sweetness compared to Reb A. The researchers also established a cascade reaction by combining YjiC with sucrose synthase AtSuSy from Arabidopsis thaliana, allowing for efficient synthesis of Reb L2 with a yield of 91.34% within 12 hours. This study provides a potential approach for the production and application of the new steviol glycoside Reb L2, expanding the scope of steviol glycosides.
CARBOHYDRATE RESEARCH
(2023)
Article
Environmental Sciences
Ningjia Zhou, Zhiwei Wang, Lifeng Yang, Wenyao Zhou, Zhiwei Qin, Heqian Zhang
Summary: Due to the wide application of plastic products, microplastic pollution in water has become a concern. This study investigated the toxicological effects of different sized polystyrene microplastics (PS-MPs) on shrimp. It was found that smaller particles of PS-MPs had a higher ingestion and egestion effect, causing more damage to the guts and gills. The exposure to larger PS-MPs resulted in higher diversity of intestinal bacteria and enrichment of specific metabolic pathways. The study suggests that the particle size of microplastics should be considered when assessing their toxicity.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Physical
Sai Yang, Xiaodong Hou, Zhiwei Deng, Lifeng Yang, Qian Ping, Zhenbo Yuan, Yan Zhang, Yijian Rao
Summary: In this study, a thermostable YojKM1 mutant was successfully developed for the potential industrial production of Reb D. The mutant exhibited a significantly increased halftime at 50 degrees C and improved catalytic activity. Structural analysis revealed that the enhanced thermostability of YojKM1 was attributed to the formation of new hydrogen bond interactions, salt bridges, and optimization of surface electrostatic charges. A fed-batch reaction using the mutant resulted in a high yield of Reb D at 50 degrees C.
MOLECULAR CATALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Shangzhong Zhang, Yi Duan, Changchang Teng, Hongdong Quan, Xiuguo Yang, Hongyan Li, Xiaohe Li, Lifeng Yan
Summary: The conversion of lignocellulose into valuable chemicals is a key technology in green chemistry. A two-step process has been developed to degrade corncob into xylose and glucose under mild conditions. The total yield of xylose is 97% and glucose is 95%. Additionally, high-quality cellulose and lignin can be obtained.
Article
Chemistry, Multidisciplinary
Youcui Xu, Chang Yang, Yi Wu, Wei Jiang, Quan Cheng, Lifeng Yan, Kaige Chen, Yucai Wang
Summary: Researchers have developed a fluorescent probe called IR1080 to detect micrometastases in cancer patients, which can be used for fluorescence image-guided surgery. IR1080 binds rapidly to albumin in plasma, resulting in increased fluorescence brightness. It also has a high affinity for SPARC, an albumin-binding protein overexpressed in micrometastases. The interaction between SPARC and IR1080 leads to a high detection rate and accurate delineation of tumor margins, making IR1080 an efficient strategy for the diagnosis and image-guided surgery of micrometastases.
Article
Biochemical Research Methods
Lifeng Yang, Zhaojiang Zhang, Xin Wei, Yan Wang
Summary: Non-invasive, portable, and economical dynamic blood glucose monitoring device is essential for diabetes patients. A photoacoustic multispectral near-infrared diagnosis system was used to excite glucose in aqueous solutions and analyze it using a photoacoustic cell. The system was able to predict glucose concentration through various wavelengths.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Engineering, Biomedical
Changchang Teng, Huiping Dang, Yixuan Xu, Dalong Yin, Lifeng Yan
Summary: Due to the excellent deep penetration and high resolution capabilities, the second near-infrared window (NIR-II, 1000-1700 nm) fluorescence (FL) imaging is expected to be useful in clinical applications such as macroscopic imaging for cancer diagnosis and microangiography for vascular-related disease diagnosis. However, most NIR-II fluorescent probes, especially cyanine, are prone to self-quenching in the aggregated state, severely limiting their application in bioimaging.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Juan Wu, Yongqi Deng, Yihan Wu, Lifeng Yan
Summary: In this study, reduced graphene oxide/poly(3,4-ethylenedioxythiophene):poly(sodium styrene sulfonate) composite (rGO/PEDOT:PSS) was prepared through a facile hydrothermal reaction and applied to a symmetric supercapacitor. The optimized composite showed improved electrochemical performance with a specific capacitance 50% higher than pure rGO. It also exhibited excellent photothermal properties with a high photothermal conversion efficiency of 62.0% under 808 nm NIR light illumination. The photothermal effect enhanced the supercapacitor's performance, increasing its specific capacitance and energy density by 1.8 and 1.6 times, respectively, under a low illumination intensity of 0.18 W cm-2. This study provides new design ideas for next-generation flexible and wearable devices and expands the application of light energy.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Yongqi Deng, Hongfei Wang, Minghui Fan, Boxiang Zhan, Lu-Jie Zuo, Cheng Chen, Lifeng Yan
Summary: A novel nanomicellar electrolyte using methylurea (Mu) has been developed to guide the homogeneous deposition of Zn2+ / Mn2+ and inhibit water-splitting-derived side reactions. The modified electrolyte also enhances the reversibility of the Mn2+ / MnO2 conversion reaction by regulating interfacial wettability and improving nucleation kinetics. These improvements result in extended cyclic stability, suppressed dendrites growth, exceptional capacity retention, and a high energy density in Zn-Mn batteries.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Lele Wang, Yongqi Deng, Lifeng Yan
Summary: Zinc ion hybrid supercapacitors (ZIHSs) are reliable alternatives for future energy applications, but the poor cycle reversibility of Zn metal anodes in aqueous electrolytes limits their practical use. In this study, a deep eutectic solvent (DES) prepared by mixing ZnCl2 and urea with a small amount of water showed significantly suppressed side reactions and dendrite growth in ZIHS, resulting in improved electrochemical stability, cycling stability, and coulombic efficiency.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Physical
Yongqi Deng, Yihan Wu, Kefu Zhang, Minghui Fan, Lele Wang, Yapeng He, Lifeng Yan
Summary: A low-cost eutectic electrolyte composed of acetate and urea is reported, expanding the electrochemical stability window to >3.5 V with minimal water content and non-flammability. The water-starved solvation structure protects the zinc anode from dendrite growth and reduces parasitic side reactions, while the wide electrochemical window enables high operating voltage for zinc-based batteries. The optimized eutectogel inherits the advantages of liquid eutectic electrolytes while also providing excellent mechanical properties for flexible batteries under deformation conditions. The eutectic electrolyte has potential applications in high-voltage aqueous zinc ion batteries, combining performance, low cost, safety, and sustainability.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Boxiang Zhan, Long Zhang, Yongqi Deng, Lifeng Yan
Summary: A preparation method for a lignin-based composite adhesive was presented in this paper. The adhesive showed excellent performance, including high adhesive strength, good flame retardance, and outstanding thermal insulation and photothermal properties. It can also be used to process wood chips into regenerated wood.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
