Targeting UBR5 in hepatocellular carcinoma cells and precise treatment via echinacoside nanodelivery

Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis

(2022) Le Lu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Echinacoside Induces Mitochondria-Mediated Pyroptosis through Raf/MEK/ERK Signaling in Non-Small Cell Lung Cancer Cells

(2022) Ye Shi et al.   Journal of Immunology Research

C2orf40 inhibits hepatocellular carcinoma through interaction with UBR5

(2021) Yue Wu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Luteolin attenuates cancer cell stemness in PTX-resistant oesophageal cancer cells through mediating SOX2 protein stability

(2021) Jinzhu Zhao et al.   PHARMACOLOGICAL RESEARCH

Resibufogenin suppresses tumor growth and Warburg effect through regulating miR-143-3p/HK2 axis in breast cancer

(2020) Ying Guo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing

(2020) Lili Yu et al.   Nature Communications

Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway

(2020) Chenghuai Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E3 Ligase, UBR5, HECT domain mutations in lymphoma control maturation of B cells

(2020) Samantha Swenson et al.   BLOOD

USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/β‐catenin pathway via Axin1 deubiquitination

(2020) Tong Huang et al.   CELL BIOLOGY INTERNATIONAL

UBR5 regulates proliferation and radiosensitivity in human laryngeal carcinoma via the p38/MAPK signaling pathway

(2020) Kai Wang et al.   ONCOLOGY REPORTS

Hakin-1, a New Specific Small-Molecule Inhibitor for the E3 Ubiquitin-Ligase Hakai, Inhibits Carcinoma Growth and Progression

(2020) Olaia Martinez-Iglesias et al.   Cancers

Fufang Banmao Capsule, a Traditional Chinese Medicinal Formulation, Enhances the Survival of Patients with Hepatocellular Carcinoma and Vp3–4 Portal Vein Tumor Thrombosis Undergoing Supportive Treatment

(2020) Yao Liu et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Echinacoside promotes the proliferation of human renal tubular epithelial cells by blocking the HBX/TREM2‑mediated NF‑κB signalling pathway

(2020) Yufan Zhang et al.   Molecular Medicine Reports

The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation

(2020) Jian Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E3 ligase SCFSKP2 ubiquitinates and degrades tumor suppressor C/EBPα in acute myeloid leukemia

(2020) Gatha Thacker et al.   LIFE SCIENCES

TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor α

(2020) Jianing Tang et al.   NEOPLASIA

AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation

(2019) Zhen Wang et al.   ONCOGENE

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Maigeng Zhou et al.   LANCET

Mesoporous Silica Nanoparticles for Drug Delivery

(2019) Miguel Manzano et al.   ADVANCED FUNCTIONAL MATERIALS

A global view of hepatocellular carcinoma: trends, risk, prevention and management

(2019) Ju Dong Yang et al.   Nature Reviews Gastroenterology & Hepatology

Bacteria-Targeting Nanoparticles with Microenvironment-Responsive Antibiotic Release To Eliminate Intracellular Staphylococcus aureus and Associated Infection

(2018) Shengbing Yang et al.   ACS Applied Materials & Interfaces

The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs

(2018) Martha L. Slattery et al.   GENOMICS

Hypoxia promotes the migration and invasion of human hepatocarcinoma cells through the HIF-1α–IL-8–Akt axis

(2018) Maoyun Fei et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells

(2018) Ying Ye et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features

(2017) Jing Zhang et al.   HUMAN GENETICS

Phospholipid complex as an approach for bioavailability enhancement of echinacoside

(2015) Fei Li et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment

(2012) Zhenjiang Zhang et al.   ADVANCED MATERIALS

The Roles of Intrinsic Disorder in Orchestrating the Wnt-Pathway

(2012) Bin Xue et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics

(2012) Jillian L. Perry et al.   NANO LETTERS

PEG-templated mesoporous silica nanoparticles exclusively target cancer cells

(2011) Catia Morelli et al.   Nanoscale

Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery

(2010) Miao Guo et al.   BIOMATERIALS

Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery

(2008) Jaeyun Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro

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