Modeling on-column reduction of trisulfide bonds in monoclonal antibodies during protein A chromatography

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Title
Modeling on-column reduction of trisulfide bonds in monoclonal antibodies during protein A chromatography
Authors
Keywords
Monoclonal antibodies, Trisulfides, Product heterogeneity, Protein A chromatography, Cysteine wash, Model
Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1479, Issue -, Pages 81-86
Publisher
Elsevier BV
Online
2016-11-15
DOI
10.1016/j.chroma.2016.11.019

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