Exploring the role of microglia in cortical spreading depression in neurological disease

Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation

(2016) N Pelzer et al.   CEPHALALGIA

KCa3.1-a microglial target ready for drug repurposing?

(2016) Elena Dale et al.   GLIA

High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression

(2016) Tsubasa Takizawa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations

(2016) Jed A Hartings et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

(2016) Jed A Hartings et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Experimental Cortical Spreading Depression Induces NMDA Receptor Dependent Potassium Currents in Microglia

(2016) S. Wendt et al.   JOURNAL OF NEUROSCIENCE

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors

(2015) Susan Brandenburg et al.   ACTA NEUROPATHOLOGICA

Abnormal synaptic Ca2+homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice

(2015) Katharina Eikermann-Haerter et al.   ANNALS OF NEUROLOGY

Temporal profiles of high-mobility group box 1 expression levels after cortical spreading depression in mice

(2015) Tsubasa Takizawa et al.   CEPHALALGIA

Microglia: Multitasking Specialists of the Brain

(2015) Alessandra Maria Casano et al.   DEVELOPMENTAL CELL

Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions

(2015) Jason M. Hinzman et al.   EXPERIMENTAL NEUROLOGY

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

The Stroke-Migraine Depolarization Continuum

(2015) Jens P. Dreier et al.   NEURON

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

(2015) Cenk Ayata et al.   PHYSIOLOGICAL REVIEWS

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

(2015) Katsumori Segawa et al.   TRENDS IN CELL BIOLOGY

From the Cajal alumni Achúcarro and Río-Hortega to the rediscovery of never-resting microglia

(2015) Marie-Ève Tremblay et al.   Frontiers in Neuroanatomy

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

(2015) Douglas G. Walker et al.   Alzheimers Research & Therapy

Tumor necrosis factor reduces the amplitude of rat cortical spreading depressionin vivo

(2014) Frank Richter et al.   ANNALS OF NEUROLOGY

Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment

(2014) Kae M. Pusic et al.   GLIA

Cortical Spreading Depolarization Stimulates Gliogenesis in the Rat Entorhinal Cortex

(2014) Anja Urbach et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

(2014) Daniela Pietrobon et al.   NATURE REVIEWS NEUROSCIENCE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Insulin-like growth factor-1 abrogates microglial oxidative stress and TNF-α responses to spreading depression

(2013) Yelena Y. Grinberg et al.   JOURNAL OF NEUROCHEMISTRY

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

(2013) Lijun Yang et al.   Journal of Translational Medicine

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

(2013) H. Karatas et al.   SCIENCE

Insulin-like growth factor-1 lowers spreading depression susceptibility and reduces oxidative stress

(2012) Yelena Y. Grinberg et al.   JOURNAL OF NEUROCHEMISTRY

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Neurovascular changes in prolonged migraine aura in FHM with a novel ATP1A2 gene mutation

(2011) Takahiro Iizuka et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Spreading Depression Sends Microglia on Lévy Flights

(2011) Yelena Y. Grinberg et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

(2010) Martin Lauritzen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic Penumbra

(2010) W. C. Risher et al.   JOURNAL OF NEUROSCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Sodium channel activity modulates multiple functions in microglia

(2009) Joel A. Black et al.   GLIA

Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation

(2009) Tom Schilling et al.   JOURNAL OF NEUROIMMUNOLOGY

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

Heterogeneity of microglia and TNF signaling as determinants for neuronal death or survival

(2009) Andrew D. Kraft et al.   NEUROTOXICOLOGY

Cathepsin D: A cellular roadmap

(2008) Nousheen Zaidi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TLR accessory molecules

(2008) Sachiko Akashi-Takamura et al.   CURRENT OPINION IN IMMUNOLOGY

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY