Lysophosphatidic acid and amitriptyline signal through LPA1R to reduce P-glycoprotein transport at the blood–brain barrier

Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model

(2017) Gary N.Y. Chan et al.   NEUROSCIENCE LETTERS

Current Therapy of Drugs in Amyotrophic Lateral Sclerosis

(2016) Haiyan Lu et al.   Current Neuropharmacology

Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis

(2016) Hisham Qosa et al.   GLIA

Antidepressants activate the lysophosphatidic acid receptor LPA 1 to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts

(2015) Maria C. Olianas et al.   BIOCHEMICAL PHARMACOLOGY

ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis

(2015) Michael Jablonski et al.   BRAIN RESEARCH

Lysophospholipid mediators in the vasculature

(2015) Paul Mueller et al.   EXPERIMENTAL CELL RESEARCH

Lysophosphatidic Acid Signaling in the Nervous System

(2015) Yun C. Yung et al.   NEURON

Role of Rho kinase in lysophosphatidic acid-induced altering of blood-brain barrier permeability

(2014) YING YU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Nrf2 Upregulates ATP Binding Cassette Transporter Expression and Activity at the Blood-Brain and Blood-Spinal Cord Barriers

(2014) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Inhibiting drug efflux transporters improves efficacy of ALS therapeutics

(2014) Michael R. Jablonski et al.   Annals of Clinical and Translational Neurology

Rapid and Reversible Enhancement of Blood–Brain Barrier Permeability Using Lysophosphatidic Acid

(2013) Ngoc H On et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Selective increase of two ABC drug efflux transporters at the blood–spinal cord barrier suggests induced pharmacoresistance in ALS

(2012) Michael R. Jablonski et al.   NEUROBIOLOGY OF DISEASE

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

(2012) R. E. Cannon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autotaxin and LPA receptor signaling in cancer

(2011) Anna J. S. Houben et al.   CANCER AND METASTASIS REVIEWS

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

Rapid, Reversible Modulation of Blood-Brain BarrierP-Glycoprotein Transport Activity by Vascular Endothelial Growth Factor

(2010) B. T. Hawkins et al.   JOURNAL OF NEUROSCIENCE

Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis

(2010) Aline Milane et al.   NEUROSCIENCE LETTERS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance

(2009) Mu-En Lin et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier

(2008) Anika M. S. Hartz et al.   FASEB JOURNAL

Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling

(2007) B. Bauer et al.   MOLECULAR PHARMACOLOGY