Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria

Cytoskeleton Aberrations in Alkaptonuric Chondrocytes

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Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling

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Arl13b regulates Shh signaling from both inside and outside the cilium

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IFT88 influences chondrocyte actin organization and biomechanics

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Alkaptonuria: An example of a “fundamental disease”—A rare disease with important lessons for more common disorders

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Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis

(2015) Shang-ling Zhu et al.   Cellular & Molecular Immunology

A role for interleukins in ochronosis in a chondrocyte in vitro model of alkaptonuria

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A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation

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Oxidative stress and mechanisms of ochronosis in alkaptonuria

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Chondroptosis in Alkaptonuric Cartilage

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Expression of hedgehog signal pathway in articular cartilage is associated with the severity of cartilage damage in rats with adjuvant-induced arthritis

(2015) Rong Li et al.   Journal of Inflammation-London

Homogentisate 1,2 dioxygenase is expressed in brain: implications in alkaptonuria

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Inhibition of hedgehog signal pathway by cyclopamine attenuates inflammation and articular cartilage damage in rats with adjuvant-induced arthritis

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Primary cilia mechanics affects cell mechanosensation: A computational study

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Ciliary ectosomes: transmissions from the cell's antenna

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Indian Hedgehog signaling pathway members are associated with magnetic resonance imaging manifestations and pathological scores in lumbar facet joint osteoarthritis

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The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

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Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes

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Bardet–Biedl syndrome proteins control the cilia length through regulation of actin polymerization

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Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells

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TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

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Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis

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Supernumerary Centrosomes Nucleate Extra Cilia and Compromise Primary Cilium Signaling

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Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes

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Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

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Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

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Biochemical and proteomic characterization of alkaptonuric chondrocytes

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Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis

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Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins

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Ciliopathies: an expanding disease spectrum

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The Role of Primary Cilia in Mesenchymal Stem Cell Differentiation: A Pivotal Switch in Guiding Lineage Commitment

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Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling

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Cell shape and contractility regulate ciliogenesis in cell cycle–arrested cells

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Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells

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Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis

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Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1–Rac1 cascade during spine formation

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Functional genomic screen for modulators of ciliogenesis and cilium length

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Development of an in vitro model to investigate joint ochronosis in alkaptonuria

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Characterization of PKD Protein-Positive Exosome-Like Vesicles

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Modulating hedgehog signaling can attenuate the severity of osteoarthritis

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Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

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Primary cilia in osteoarthritic chondrocytes: From chondrons to clusters

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Structure and function of mammalian cilia

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THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

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