Concentration-dependent metabolic effects of metformin in healthy and Fanconi anemia lymphoblast cells

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice

(2016) Q.-S. Zhang et al.   BLOOD

Why is an energy metabolic defect the common outcome in BMFS?

(2016) Paolo Degan et al.   CELL CYCLE

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATPChannel Activity

(2016) Trillian Gregg et al.   DIABETES

Metformin

(2016) Meng H. Tan et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial

(2016) Takuma Higurashi et al.   LANCET ONCOLOGY

Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine

(2016) Himalee S. Sabnis et al.   LEUKEMIA RESEARCH

Metformin-induced protection against oxidative stress is associated with AKT/mTOR restoration in PC12 cells

(2016) Behzad Khallaghi et al.   LIFE SCIENCES

Sirt1 and the Mitochondria

(2016)   MOLECULES AND CELLS

The radioprotective effect of metformin against cytotoxicity and genotoxicity induced by ionizing radiation in cultured human blood lymphocytes

(2016) Mohsen Cheki et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Repurposing metformin for cancer treatment: current clinical studies

(2016) Young Kwang Chae et al.   Oncotarget

Metformin in obesity, cancer and aging: addressing controversies

(2016) Lev M. Berstein   Aging-US

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

(2015) Masahiro Morita et al.   CELL CYCLE

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Effects of metformin on mitochondrial function of leukocytes from polycystic ovary syndrome patients with insulin resistance

(2015) Victor M Victor et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Oxidative stress in myelin sheath: The other face of the extramitochondrial oxidative phosphorylation ability

(2015) S. Ravera et al.   FREE RADICAL RESEARCH

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

(2015) Mustafa Kinaan et al.   MEDICAL PRINCIPLES AND PRACTICE

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

(2015) Giovanna Bianchi et al.   Oncotarget

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

(2014) D. Grahame Hardie   JOURNAL OF INTERNAL MEDICINE

Metformin inhibits the growth of nasopharyngeal carcinoma cells and sensitizes the cells to radiation via inhibition of the DNA damage repair pathway

(2014) HAIWEN LI et al.   ONCOLOGY REPORTS

Treatment of FANCA Cells with Resveratrol and N-Acetylcysteine: A Comparative Study

(2014) Marta Columbaro et al.   PLoS One

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Mitochondrial respiratory chain Complex I defects in Fanconi anemia complementation group A

(2013) Silvia Ravera et al.   BIOCHIMIE

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial respiratory complex I defects in Fanconi anemia

(2013) Enrico Cappelli et al.   TRENDS IN MOLECULAR MEDICINE

A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells

(2012) Lauren E. Nelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fanconi Anemia Links Reactive Oxygen Species to Insulin Resistance and Obesity

(2012) Jie Li et al.   ANTIOXIDANTS & REDOX SIGNALING

New insights into redox response modulation in Fanconi’s anemia cells by hydrogen peroxide and glutathione depletors

(2012) Paola Cuccarolo et al.   FEBS Journal

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

(2011) S. Larsen et al.   DIABETOLOGIA

Metformin in polycystic ovary syndrome

(2010) Evanthia Diamanti-Kandarakis et al.   Annals of the New York Academy of Sciences

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

(2010) Xinguo Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats

(2010) Daniel A. Kane et al.   FREE RADICAL BIOLOGY AND MEDICINE

Influence of metformin on GLUT1 gene and protein expression in rat streptozotocindiabetes mellitusmodel

(2010) Jelizaveta Sokolovska et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

The genetic and molecular basis of Fanconi anemia

(2008) Johan P. de Winter et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion

(2008) Deborah A. Elder et al.   PEDIATRIC BLOOD & CANCER