Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Medicine, Research & Experimental
Ying Li, Yu Wang, Qinguang Zou, Shouqing Li, Fan Zhang
Summary: KLF3 is overexpressed in gastric cancer and promotes its growth and metastasis by activating the WNT/B-catenin signaling pathway. Inhibition of KLF3 could be a potential therapeutic target for patients with gastric cancer.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Xiaolong Zhang, Lifei Tian, Zeyu Li, Ruiting Liu, Jiao Yu, Bo Liu
Summary: The study demonstrates a cancer-suppressive function of CAMK2N1 in colorectal carcinoma, exerting tumor-inhibiting effects via suppression of the Wnt/β-catenin pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Paria Bayati, Marjan Taherian, Mansoureh Soleimani, Hamid Farajifard, Nazanin Mojtabavi
Summary: This study assessed the potential of induced pluripotent stem cells (IPS) in modulating the expression of cardinal genes involved in the Wnt signaling pathway in a mouse model of idiopathic pulmonary fibrosis (IPF). The results showed that IPS cell treatment significantly alleviated fibrotic lesions and inflammation, and regulated the expression of key genes in the Wnt pathway.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Pharmacology & Pharmacy
Xuetong Shen, Chundi Gao, Huayao Li, Cun Liu, Longyun Wang, Ye Li, Ruijuan Liu, Changgang Sun, Jing Zhuang
Summary: The abnormal activation of the Wnt/beta-catenin pathway is closely related to lung cancer progression and treatment resistance. Targeting this pathway shows potential for lung cancer therapy, but it is challenging due to its complexity and tumor heterogeneity. Natural products and derivatives have been found to inhibit the Wnt pathway and show promising anti-tumor efficacy. They could be a safer and more targeted alternative for lung cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Pratibha Pandey, Fahad Khan, Sara A. Seifeldin, Khalid Alshaghdali, Samra Siddiqui, Mohamed Elfatih Abdelwadoud, Manish Vyas, Mohd Saeed, Avijit Mazumder, Amir Saeed
Summary: The Wnt pathway is crucial for human development and homeostasis. Dysregulation of this pathway has been linked to cancer. Wnt signaling plays a significant role in the development and metastasis of cancer, and targeting this pathway has become an important focus of cancer research. Flavonoids derived from plants have shown anticancer effects by influencing the Wnt pathway and other signaling pathways. This review comprehensively evaluates the impact of flavonoids on cancer development and metastasis through the Wnt pathway, providing evidence of their impact on molecular targets.
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Article
Oncology
Manuel Pedro Jimenez-Garcia, Antonio Lucena-Cacace, Daniel Otero-Albiol, Amancio Carnero
Summary: Sarcomas are a heterogeneous group of tumors with a functional hierarchy controlled by sarcoma stem cells. EMX genes play a role in sarcomagenesis by regulating tumor stem cells, with a negative impact on tumorigenic properties. The relationship between EMX1/EMX2 and stem cell genes in sarcoma involves the canonical Wnt pathway, where EMX genes negatively regulate Wnt signaling to repress stemness and induce sarcomagenesis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Sarah Koushyar, Valerie S. Meniel, Toby J. Phesse, Helen B. Pearson
Summary: Aberrant activation of the Wnt pathway is closely related to tumor formation, progression, and therapeutic resistance in prostate cancer. Targeting the Wnt pathway for prostate cancer treatment has shown potential efficacy. However, the functional consequences of activating the Wnt pathway during different stages of prostate cancer progression are still unclear. Preclinical research on targeting Wnt signaling in the treatment of prostate cancer is crucial for identifying effective treatment strategies and improving patient care.
Review
Genetics & Heredity
Ankita Sharma, Rafeeq Mir, Sanjeev Galande
Summary: This review discusses the role of the Wnt/beta-catenin pathway in cell proliferation, differentiation, and migration, as well as its impact on embryonic development, tissue regeneration, and cancer. It highlights the influence of epigenetic factors on the pathway and the crosstalk with other signaling pathways, particularly the Hippo/YAP pathway. The review also emphasizes recent advances in developing potential therapeutic interventions targeting the epigenetic machinery for treating various cancers and regenerative therapies.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Young-Eun Cho, Jeong-Hee Kim, Young-Hyun Che, Yong-Jun Kim, Ji-Youn Sung, Yoon-Wha Kim, Bong-Geun Choe, Sun Lee, Jae-Hoon Park
Summary: ZKSCAN3 acts as an oncogenic transcription factor in human malignant tumors, and it has been identified as a downstream effector of the Wnt/β-catenin signaling pathway. It upregulates chromosomal instability in colon cancer cells by suppressing MAD2L2 expression. Moreover, the upregulation of ZKSCAN3 is an early event in the adenoma-carcinoma sequence during colon cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Andrew Morris, Piyusha P. Pagare, Jiong Li, Yan Zhang
Summary: The Wnt/8-β-catenin pathway plays a crucial role in cancer treatment, but developing small-molecule inhibitors through traditional methods has proven difficult. Computer-aided drug discovery efforts have shown promise, and a more efficient and cost-effective approach to developing inhibitors for this pathway is needed.
DRUG DISCOVERY TODAY
(2022)
Article
Fisheries
Xiaobo Yan, Simiao Pan, Tao Li, Weibin Huang, Menglong Zhou, Shuang Zhang, Yuanzhi Yang, Beiping Tan, Xiaohui Dong
Summary: Squalene can influence the immunity of grouper by activating the Wnt/β-Catenin signaling pathway, thus improving their antioxidant capacity and disease resistance. The activation of this pathway can inhibit the NF-κB-mediated inflammatory response, leading to improved immunity and disease resistance in grouper.
AQUACULTURE REPORTS
(2023)
Article
Cell Biology
Yanlin Cai, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Shunliang Sheng, Jiayu Zhu
Summary: Globally, ovarian cancer ranks as the second most common cause of gynecologic-related cancer deaths among women, with a poor prognosis. Research has shown that downregulation of AHNAK in ovarian cancer cells can significantly inhibit cell growth and metastasis, partly by dampening the Canonical Wnt cascade. Therefore, AHNAK may serve as a biomarker and potential treatment target for ovarian cancer.
Article
Cell Biology
Mohammad Mahdi Forghanifard, Paniz Kasebi, Mohammad Reza Abbaszadegan
Summary: This study elucidated the crosstalk between SOX2/SALL4 stemness factors and the Notch signaling pathway, revealing their importance in ESCC and their association with invasion and metastasis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Rehabilitation
Neda Mostafaee, Akram Divandari, Hossein Negahban, Amir Reza Kachooei, Ali Moradi, Mohammad Hosein Ebrahimzadeh, Hamed Tabesh, Maryam Daghiani
Summary: This study compared the effects of shoulder and scapula muscle training plus conventional physiotherapy with conventional physiotherapy only in improving pain and functional abilities in patients with lateral elbow tendinopathy. The results showed that the group receiving shoulder and scapula muscle training plus conventional physiotherapy had greater reduction in pain and improvement in functional status compared to the group receiving only conventional physiotherapy.
PHYSIOTHERAPY THEORY AND PRACTICE
(2022)
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Fatemeh Fardi Golyan, Mohammad Mahdi Forghanifard
Summary: The study revealed a significant inverse correlation between low expression of INPP5A and high expression of TWIST1, MMP-2, and EGFR in ESCC patients, suggesting a potential tumor suppressor role for INPP5A in ESCC invasion and metastasis.
ADVANCES IN MEDICAL SCIENCES
(2021)
Article
Chemistry, Applied
Behnaz Hatamluyi, Reihaneh Sadeghian, Farhad Malek, Mohammad Taher Boroushaki
Summary: This study presents an innovative design of a magnetic molecularly imprinted polymer for efficient, fast, and selective determination of sunset yellow in food products. By incorporating porous Fe3O4@UiO-66-NH2 nanocomposite into the molecularly imprinted polymer, an efficient nanosorbent with a short equilibrium time, high adsorption capacity, and good imprinting factor was obtained. The Fe3O4@UiO-66-NH2@MIP also showed good linearity, low detection limit, satisfactory recoveries, and excellent reusability for the quantification of sunset yellow.
Article
Immunology
Amir Abbas Hamidi, Mohammad Mahdi Forghanifard, Mehran Gholamin, Meysam Moghbeli, Bahram Memar, Ali Jangjoo, Mohammad Reza Motie, Fatemeh Molaei, Mohammad Reza Abbaszadegan
Summary: The study revealed that TWIST1 and MAML1 are widely expressed in gastric cancer patients, with a positive correlation between the two genes. Overexpression of MAML1 was associated with advanced tumor staging and nodal metastases, while TWIST1 expression was correlated with patient sex and advanced tumor grading.
MICROBIAL PATHOGENESIS
(2022)
Article
Biophysics
Behnaz Hatamluyi, Majid Rezayi, Saeid Amel Jamehdar, Kobra Salimian Rizi, Majid Mojarrad, Zahra Meshkat, Hamzeh Choobin, Saman Soleimanpour, Mohammad Taher Boroushaki
Summary: This study presents a functionalized carbon electrode with specific antisense DNA oligonucleotide as a promising biosensor for targeting SARS-CoV-2 RNA without nucleic acid amplification. The biosensor showed excellent sensitivity and specificity in detecting the virus, with a lower detection limit compared to RT-PCR. It also exhibited negligible cross-reactivity with other viruses and remained stable for an extended period.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biotechnology & Applied Microbiology
Malihe-Sadat Hashemi-Khah, Nazila Arbab-Soleimani, Mohammad-Mahdi Forghanifard, Omid Gholami, Saba Taheri, Sakineh Amoueian
Summary: This study evaluated the impact of Lactobacillus on esophageal cancer and found that both the supernatant and whole-cell culture of Lactobacillus significantly reduced cancer cell survival, inhibited tumor growth, and decreased the expression of Wnt signaling pathway genes.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Fatemeh Nourmohammadi, Mohammad Mahdi Forghanifard, Mohammad Reza Abbaszadegan, Vajiheh Zarrinpour
Summary: In this study, the researchers investigated the effect of EZH2 expression on miR-200c and genes related to EMT pathway in esophageal squamous cell carcinoma. They found that EZH2 regulates the expression of miR-200c and important EMT genes, which affects the phenotype and migration ability of the cells.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Mohammad Hossein Izadpanah, Mohammad Mahdi Forghanifard
Summary: This study found that TWIST1 regulates the expression of cancer stem cell markers in human esophageal squamous cell carcinoma cells. These results may have important implications for understanding the self-renewal process of cancer stem cells and the potential of TWIST1 as a therapeutic target.
Article
Medicine, Research & Experimental
Sepideh Ardalan Khales, Mohammad Mahdi Forghanifard, Mohammad Reza Abbaszadegan, Seyed Ebrahim Hosseini
Summary: The purpose of this study was to investigate the impact of EZH2 gene on cell signaling pathways in esophageal squamous cell carcinoma and to elucidate its role in gene regulatory networks. The results suggested that EZH2 promotes tumorigenesis in ESCC through the recruitment of important cell signaling pathways.
ADVANCES IN MEDICAL SCIENCES
(2023)
Article
Genetics & Heredity
Mohammad Mahdi Forghanifard, Somayeh Salehi
Summary: The expression levels of SALL4 and HIWI genes are correlated with clinicopathological features in colorectal cancer patients. Overexpression of SALL4 is associated with increased expression of HIWI. Simultaneous expression of SALL4 and HIWI may be indicative of poor prognosis in colorectal cancer.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2022)
Article
Chemistry, Medicinal
Azar Hosseini, Arezoo Rajabian, Fatemeh Forouzanfar, Mahdi Farzadnia, Mohammad Taher Boroushaki
Summary: This research demonstrates that pomegranate seed oil has protective effects against the toxicity of tacrolimus, reducing renal and cardiac damage by scavenging free radicals.
AVICENNA JOURNAL OF PHYTOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Sepideh Ardalan Khales, Mohammad Reza Abbaszadegan, Seyed Ebrahim Hosseini, Mohammad Mahdi Forghanifard
Summary: This study investigated the correlation between TWIST1 and EVX1 mRNA expression in esophageal squamous cell carcinoma (ESCC) patients, as well as the potential regulatory function of TWIST1 on EVX1 expression in human ESCC cell lines. The results showed a significant correlation between TWIST1 and EVX1 expression in ESCC. Overexpression of TWIST1 was associated with advanced tumor stages and lymph node metastasis, while underexpression of EVX1 was associated with lymph node metastasis and invasiveness of the disease.
IRANIAN JOURNAL OF BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fatemeh Forouzanfar, Elham Asadpour, Hossein Hosseinzadeh, Mohammad Taher Boroushaki, Afrouz Adab, Seyedeh Hoda Dastpeiman, Hamid R. Sadeghnia
Summary: Safranal, isolated from saffron, has been shown to possess neuroprotective effects. This study demonstrated that safranal can attenuate ischemia/reperfusion-induced PC12 cell injury by modulating oxidative and apoptotic responses, thereby protecting against neurotoxicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
