Apelin/APJ system: A novel potential therapy target for kidney disease

Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases

(2016) Mei-qing Liu et al.   ACTA PHARMACOLOGICA SINICA

Apelin: A novel inhibitor of vascular calcification in chronic kidney disease

(2016) Xue Han et al.   ATHEROSCLEROSIS

The apelin–APJ axis: A novel potential therapeutic target for organ fibrosis

(2016) Shifang Huang et al.   CLINICA CHIMICA ACTA

PAK1-cofilin phosphorylation mediates human lung adenocarcinoma cells migration induced by apelin-13

(2016) Deguan Lv et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

(2016) Yu Bo Yang Sun et al.   DIFFERENTIATION

Apelin/APJ system: A novel therapeutic target for oxidative stress-related inflammatory diseases (Review)

(2016) QUN ZHOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats

(2016) Burak Bircan et al.   RENAL FAILURE

Evaluation of Fibrosis Markers: Apelin and Transforming Growth Factor-β1 in Autosomal Dominant Polycystic Kidney Disease Patients

(2016) Derya Kocer et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy

(2015) Feng Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Apelin attenuates the osteoblastic differentiation of aortic valve interstitial cells via the ERK and PI3-K/Akt pathways

(2015) Zhao-shun Yuan et al.   AMINO ACIDS

Apelin protects against acute renal injury by inhibiting TGF-β1

(2015) Hong Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Apelin: an antithrombotic factor that inhibits platelet function

(2015) F. Adam et al.   BLOOD

Targeting Drugs to APJ Receptor: The Prospect of Treatment of Hypertension and Other Cardiovascular Diseases

(2015) Jiangang Cao et al.   CURRENT DRUG TARGETS

Origin of myofibroblasts and cellular events triggering fibrosis

(2015) Matthias Mack et al.   KIDNEY INTERNATIONAL

ELABELA: a novel hormone in cardiac development acting as a new endogenous ligand for the APJ receptor

(2014) Feng Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis

(2014) Li-Yan Wang et al.   AMINO ACIDS

The role of adenosine receptors A2A and A2B signaling in renal fibrosis

(2014) Veena S. Roberts et al.   KIDNEY INTERNATIONAL

The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker?

(2014) Serhat Karadag et al.   BMC Nephrology

Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes

(2014) Yoshiro Maezawa et al.   Journal of Diabetes Investigation

Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation

(2013) L. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis

(2013) Deguan Lv et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma

(2013) Eugene Y. Zhen et al.   ANALYTICAL BIOCHEMISTRY

Apelin and its receptor APJ in cardiovascular diseases

(2013) Xiao-Hua Yu et al.   CLINICA CHIMICA ACTA

Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse

(2013) Hong Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Apelin and copeptin: Two opposite biomarkers associated with kidney function decline and cyst growth in autosomal dominant polycystic kidney disease

(2013) Antonio Lacquaniti et al.   PEPTIDES

Promoting Effects of the Adipokine, Apelin, on Diabetic Nephropathy

(2013) Bao-hai Zhang et al.   PLoS One

What Is the Role of Apelin regarding Cardiovascular Risk and Progression of Renal Disease in Type 2 Diabetic Patients with Diabetic Nephropathy?

(2013) Ana Paula Silva et al.   Biomed Research International

Apelin, Plasmatic Osmolality and Hypotension in Dialyzed Patients

(2012) Valeria Cernaro et al.   BLOOD PURIFICATION

Apelin in the Control of Body Fluid Homeostasis and Cardiovascular Functions

(2012) Cecile Galanth et al.   CURRENT PHARMACEUTICAL DESIGN

Apelin receptor expression in ischemic and non- ischemic kidneys and cardiovascular responses to apelin in chronic two‐kidney–one‐clip hypertension in rats

(2012) Hamid Najafipour et al.   REGULATORY PEPTIDES

The Relationship between Apelin and Parathyroid Hormone in Hemodialysis Patients

(2012) Denise Mafra et al.   RENAL FAILURE

Apelin: A Peptide Involved in Cardiovascular Risk in Hemodialysis Patients?

(2012) Viviane O. Leal et al.   RENAL FAILURE

TGF-β Signaling via TAK1 Pathway: Role in Kidney Fibrosis

(2012) Mary E. Choi et al.   SEMINARS IN NEPHROLOGY

Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study

(2012) TAMER SAGIROGLU et al.   Experimental and Therapeutic Medicine

The Antioxidant EPC-K1 Attenuates Renal Ischemia-Reperfusion Injury in a Rat Model

(2011) Shunsuke Yamamoto et al.   AMERICAN JOURNAL OF NEPHROLOGY

Discovery of a Competitive Apelin Receptor (APJ) Antagonist

(2011) N. J. Maximilian Macaluso et al.   ChemMedChem

Apelin in acute myocardial infarction and heart failure induced by ischemia

(2011) Agnieszka M. Tycinska et al.   CLINICA CHIMICA ACTA

Apelin Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells

(2011) Peng-Fei Shan et al.   PLoS One

PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13

(2010) C. Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Translational promise of the apelin-APJ system

(2010) G. Barnes et al.   HEART

Apelin: A potential link between inflammation and cardiovascular disease in end stage renal disease patients

(2010) Amal M. El-Shehaby et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

[Pyr 1 ]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart

(2009) Janet J. Maguire et al.   HYPERTENSION

Type of arteriovenous fistula, NYHA class and apelin in hemodialyzed patients

(2009) Jolanta Malyszko et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension

(2008) Carolina Tiani et al.   JOURNAL OF HEPATOLOGY

Effect of apelin on glomerular hemodynamic function in the rat kidney

(2008) Annette Hus-Citharel et al.   KIDNEY INTERNATIONAL

Apelin, a Novel Adipocytokine, in Relation to Endothelial Function and Inflammation in Kidney Allograft Recipients

(2008) J. Malyszko et al.   TRANSPLANTATION PROCEEDINGS