Plasminogen Activator Inhibitor Type-1 as a Regulator of Fibrosis

Circulating microRNA-192 as a diagnostic biomarker in human chronic lymphocytic leukemia

(2016) S Fathullahzadeh et al.   CANCER GENE THERAPY

Circulating microRNA: a new candidate for diagnostic biomarker in neuroblastoma

(2016) M Mohammadi et al.   CANCER GENE THERAPY

Glioblastoma: exosome and microRNA as novel diagnosis biomarkers

(2016) L Saadatpour et al.   CANCER GENE THERAPY

Epi-Drugs and Epi-miRs: Moving Beyond Current Cancer Therapies

(2016) Reza Salarinia et al.   CURRENT CANCER DRUG TARGETS

Circulating microRNAs as Potential Diagnostic Biomarkers and Therapeutic Targets in Gastric Cancer: Current Status and Future Perspectives

(2016) Hamed Mirzaei et al.   CURRENT MEDICINAL CHEMISTRY

Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers

(2016) Hamid Mirzaei et al.   CURRENT PHARMACEUTICAL DESIGN

Curcumin: A new candidate for melanoma therapy?

(2016) Hamed Mirzaei et al.   INTERNATIONAL JOURNAL OF CANCER

How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin

(2016) Nicola Pozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SiRNA and epigenetic aberrations in ovarian cancer

(2016) HamidReza Mirzaei et al.   Journal of Cancer Research and Therapeutics

Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities

(2015) Sriram Ambadapadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7

(2015) Fujun Yu et al.   LABORATORY INVESTIGATION

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

(2015) Ignazio Caruana et al.   NATURE MEDICINE

SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence

(2014) Yan-Zhen Wan et al.   AGING CELL

The LRP1-independent mechanism of PAI-1-inudced migration in CpG-ODN activated macrophages

(2014) Bikash Thapa et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts

(2014) Jianyong Zhong et al.   LABORATORY INVESTIGATION

The Role of TLR4 and Fyn Interaction on Lipopolysaccharide-Stimulated PAI-1 Expression in Astrocytes

(2014) Hyun Myung Ko et al.   MOLECULAR NEUROBIOLOGY

MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF-β Activated Kinase 1 Binding Protein 1, Implications for Systemic Sclerosis

(2014) Marzena Ciechomska et al.   PLoS One

The linker connecting the two kringles plays a key role in prothrombin activation

(2014) N. Pozzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Levels of microRNA-181b and plasminogen activator inhibitor-1 are associated with hypertensive disorders complicating pregnancy

(2014) YAN-SHAN CHEN et al.   Experimental and Therapeutic Medicine

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

(2013) Li Chen et al.   HEPATOLOGY

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

(2013) Christian Lacks Lino Cardenas et al.   PLoS Genetics

Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice

(2012) Y. Tashiro et al.   BLOOD

miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis

(2012) Christoph Roderburg et al.   JOURNAL OF HEPATOLOGY

Impaired IL-17 Signaling Pathway Contributes to the Increased Collagen Expression in Scleroderma Fibroblasts

(2012) T. Nakashima et al.   JOURNAL OF IMMUNOLOGY

miR-29 Inhibits Bleomycin-induced Pulmonary Fibrosis in Mice

(2012) Jun Xiao et al.   MOLECULAR THERAPY

At the Interface of Fibrinolysis and Inflammation: The Role of Urokinase-Type Plasminogen Activator in the Leukocyte Extravasation Cascade

(2012) Christoph A. Reichel et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Inhibition of neutrophil apoptosis by PAI-1

(2011) Jaroslaw W. Zmijewski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis

(2011) Manabu Ueno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice

(2011) A. J. Courey et al.   BLOOD

PAI-1 in tissue fibrosis

(2011) Asish K. Ghosh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression

(2011) Rohan Samarakoon et al.   PLoS One

PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia

(2010) William M. Armstead et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Coagulation cascade and fibrinolysis in patients with multiple-drug allergy syndrome

(2010) Riccardo Asero et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

REVIEW: Plasminogen Activator Inhibitor-1 (PAI-1): A Key Factor Linking Fibrinolysis and Age-Related Subclinical and Clinical Conditions

(2010) Matteo Cesari et al.   Cardiovascular Therapeutics

MicroRNAs and the regulation of fibrosis

(2010) Xiaoying Jiang et al.   FEBS Journal

Plasminogen activator inhibitor type 1 deficiency

(2010) R. MEHTA et al.   HAEMOPHILIA

Oxidative Modification of Nuclear Mitogen-activated Protein Kinase Phosphatase 1 Is Involved in Transforming Growth Factor β1-induced Expression of Plasminogen Activator Inhibitor 1 in Fibroblasts

(2010) Rui-Ming Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of MicroRNA-192 Promotes Fibrogenesis in Diabetic Nephropathy

(2010) A. Krupa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling

(2010) Paula A. da Costa Martins et al.   NATURE CELL BIOLOGY

Tissue-specific PAI-1 gene expression and glycosylation pattern in insulin-resistant old rats

(2009) R. Serrano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The increase in plasma PAI-1 associated with insulin resistance may be mediated by the presence of hepatic steatosis

(2009) Diego Ardigò et al.   ATHEROSCLEROSIS

Differential control of MMP and t-PA/PAI-1 expressions by sympathetic and renin–angiotensin systems in rat left ventricle

(2009) Houcine Dab et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture

(2009) Z. Xu et al.   BLOOD

TGF- 1 + EGF-Initiated Invasive Potential in Transformed Human Keratinocytes Is Coupled to a Plasmin/MMP-10/MMP-1-Dependent Collagen Remodeling Axis: Role for PAI-1

(2009) C. E. Wilkins-Port et al.   CANCER RESEARCH

Intermittent High Glucose Stimulate MCP-l, IL-18, and PAI-1, but Inhibit Adiponectin Expression and Secretion in Adipocytes Dependent of ROS

(2009) Jiazhong Sun et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption

(2009) Rohan Samarakoon et al.   CELLULAR SIGNALLING

PLASMINOGEN ACTIVATOR INHIBITOR-1 PROMOTES INFLAMMATORY PROCESS INDUCED BY CIGARETTE SMOKE EXTRACTION OR LIPOPOLYSACCHARIDES IN ALVEOLAR EPITHELIAL CELLS

(2009) Xia Xu et al.   EXPERIMENTAL LUNG RESEARCH

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Adenovirus-mediated transfer of siRNA against PAI-1 mRNA ameliorates hepatic fibrosis in rats

(2009) Ping-Fang Hu et al.   JOURNAL OF HEPATOLOGY

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

The canonical E-box motif: A target for glucocorticoid action that drives rhythmic mouse Pai-1 transcription in vitro

(2008) Joanne H. Singletary et al.   GENE

TGF-β1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60c-src/EGFRY845 and Rho/ROCK signaling

(2008) Rohan Samarakoon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PPAR-γ agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-β

(2008) Toru Kawai et al.   LABORATORY INVESTIGATION

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

A natural PPAR-  agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions

(2008) H. Kimura et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCδ, and sphingosine kinase 1 in glioblastoma cells

(2007) Barbara S. Paugh et al.   FASEB JOURNAL