The Role of TLR4 and Fyn Interaction on Lipopolysaccharide-Stimulated PAI-1 Expression in Astrocytes

Therapeutic Potential and Anti-Amyloidosis Mechanisms of Tert-Butylhydroquinone for Alzheimer's Disease

(2018) Hasina Akhter et al.   JOURNAL OF ALZHEIMERS DISEASE

Exogenous t-PA Administration Increases Hippocampal Mature BDNF Levels. Plasmin- or NMDA-Dependent Mechanism?

(2014) Marion Rodier et al.   PLoS One

Valproic acid induces astrocyte-dependent neurite outgrowth from cultured rat primary cortical neuron via modulation of tPA/PAI-1 activity

(2013) Kyu Suk Cho et al.   GLIA

SHPS-1 and a synthetic peptide representing its ITIM inhibit the MyD88, but not TRIF, pathway of TLR signaling through activation of SHP and PI3K in THP-1 cells

(2013) Eun-Ju Kim et al.   INFLAMMATION RESEARCH

Exercise Therapy Downregulates the Overexpression of TLR4, TLR2, MyD88 and NF-κB after Cerebral Ischemia in Rats

(2013) Yuewen Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Sonic Hedgehog Pathway Mediates Brain Plasticity and Subsequent Functional Recovery After Bone Marrow Stromal Cell Treatment of Stroke in Mice

(2013) Xiaoshuang Ding et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

tPA Regulates Neurite Outgrowth by Phosphorylation of LRP5/6 in Neural Progenitor Cells

(2013) Sung Hoon Lee et al.   MOLECULAR NEUROBIOLOGY

Reciprocal Modulation Between Microglia and Astrocyte in Reactive Gliosis Following the CNS Injury

(2013) Zhongwen Gao et al.   MOLECULAR NEUROBIOLOGY

MMP-9 Inhibition: a Therapeutic Strategy in Ischemic Stroke

(2013) Mayank Chaturvedi et al.   MOLECULAR NEUROBIOLOGY

Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

(2013) Antoine Lampron et al.   NEURON

Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG

(2012) Kazuhiko Namekata et al.   GENES TO CELLS

The innate immune system in demyelinating disease

(2012) Lior Mayo et al.   IMMUNOLOGICAL REVIEWS

TRAF6 Protein Couples Toll-like Receptor 4 Signaling to Src Family Kinase Activation and Opening of Paracellular Pathway in Human Lung Microvascular Endothelia

(2012) Anguo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eps8 Protein Facilitates Phagocytosis by Increasing TLR4-MyD88 Protein Interaction in Lipopolysaccharide-stimulated Macrophages

(2012) Yen-Jen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmin system of Alzheimer’s disease patients: CSF analysis

(2012) Alessandro Martorana et al.   JOURNAL OF NEURAL TRANSMISSION

Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity

(2012) Hyejin Jeon et al.   Journal of Neuroinflammation

Dock3 Stimulates Axonal Outgrowth via GSK-3 -Mediated Microtubule Assembly

(2012) K. Namekata et al.   JOURNAL OF NEUROSCIENCE

The immunology of acute stroke

(2012) Ángel Chamorro et al.   Nature Reviews Neurology

Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia–ischemia in mice with neuronal Fyn overexpression

(2012) Renatta Knox et al.   NEUROBIOLOGY OF DISEASE

TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-κB Mediated Transcriptional Up-Regulation of Nox-1

(2012) D. Peter O'Leary et al.   PLoS One

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

Recombinant tissue plasminogen activator induces blood-brain barrier breakdown by a matrix metalloproteinase-9-independent pathway after transient focal cerebral ischemia in mouse

(2011) Jean-Christophe Copin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Regulation of NMDA receptors by the tyrosine kinase Fyn

(2011) Catherine H. Trepanier et al.   FEBS Journal

The regulation of N-methyl-d-aspartate receptors by Src kinase

(2011) Bradley R. Groveman et al.   FEBS Journal

Endovascular Treatment Strategies for Acute Ischemic Stroke

(2011) Jason A. Ellis et al.   International Journal of Stroke

Multipotent Mesenchymal Stromal Cells Increase tPA Expression and Concomitantly Decrease PAI-1 Expression in Astrocytes through the Sonic Hedgehog Signaling Pathway after Stroke (in vitro Study)

(2011) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hck Tyrosine Kinase Regulates TLR4-Induced TNF and IL-6 Production via AP-1

(2011) M. J. Smolinska et al.   JOURNAL OF IMMUNOLOGY

Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel neuroserpin-deficient Alzheimer’s disease transgenic mouse model

(2011) Shay Fabbro et al.   JOURNAL OF NEUROCHEMISTRY

Axonal Regrowth after Spinal Cord Injury via Chondroitinase and the Tissue Plasminogen Activator (tPA)/Plasmin System

(2011) N. Bukhari et al.   JOURNAL OF NEUROSCIENCE

Human Umbilical Mesenchymal Stem Cells Promote Recovery After Ischemic Stroke

(2011) Yu-Ching Lin et al.   STROKE

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

TLR-signaling Networks

(2010) J. Brown et al.   JOURNAL OF DENTAL RESEARCH

Neuron Dysfunction Is Induced by Prion Protein with an Insertional Mutation via a Fyn Kinase and Reversed by Sirtuin Activation in Caenorhabditis elegans

(2010) N. Bizat et al.   JOURNAL OF NEUROSCIENCE

Expression of plasminogen activator inhibitor-1 and protease nexin-1 in human astrocytes: Response to injury-related factors

(2010) Karin Hultman et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application

(2010) Dorit Trudler et al.   MEDIATORS OF INFLAMMATION

Biphasic regulation of tissue plasminogen activator activity in ischemic rat brain and in cultured neural cells: Essential role of astrocyte-derived plasminogen activator inhibitor-1

(2010) Ji Woon Kim et al.   NEUROCHEMISTRY INTERNATIONAL

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Increasing tPA Activity in Astrocytes Induced by Multipotent Mesenchymal Stromal Cells Facilitate Neurite Outgrowth after Stroke in the Mouse

(2010) Hongqi Xin et al.   PLoS One

Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain

(2009) Shay Fabbro et al.   JOURNAL OF NEUROCHEMISTRY

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

(2009) Cindy M Sondag et al.   Journal of Neuroinflammation

Role of Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Neural Cell Adhesion Molecule (NCAM) Interactions in Induction of Neurite Outgrowth and Identification of a Binding Site for NCAM in the Heel Region of GDNF

(2009) J. Nielsen et al.   JOURNAL OF NEUROSCIENCE

Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease

(2009) R.-M. Liu et al.   NEUROBIOLOGY OF AGING

TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY

(2009) Thiruma V. Arumugam et al.   SHOCK

Signalling adaptors used by Toll-like receptors: An update

(2008) Elaine F. Kenny et al.   CYTOKINE

TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia

(2008) Ping Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism

(2007) Ritchie Williamson et al.   FASEB JOURNAL