The Novel mTOR Complex 1/2 Inhibitor P529 Inhibits Human Lung Myofibroblast Differentiation

Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation

(2016) Natalie M. Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis. An Update of the 2011 Clinical Practice Guideline

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling

(2015) Xiaohua Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myofibroblasts Exhibit Enhanced Fibronectin Assembly That Is Intrinsic to Their Contractile Phenotype

(2015) Elizabeth E. Torr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC2 promotes cell survival through c-Myc–dependent up-regulation of E2F1

(2015) Zhipeng Zou et al.   JOURNAL OF CELL BIOLOGY

A Critical Role for the mTORC2 Pathway in Lung Fibrosis

(2014) Wenteh Chang et al.   PLoS One

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Clinical significance of mTOR, ZEB1, ROCK1 expression in lung tissues of pulmonary fibrosis patients

(2014) Jong Sun Park et al.   BMC Pulmonary Medicine

Control of Myofibroblast Differentiation by Microtubule Dynamics through a Regulated Localization of mDia2

(2013) Nathan Sandbo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β

(2011) Nathan Sandbo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The TORC1/TORC2 inhibitor, Palomid 529, reduces tumor growth and sensitizes to docetaxel and cisplatin in aggressive and hormone-refractory prostate cancer cells

(2011) G. L. Gravina et al.   ENDOCRINE-RELATED CANCER

Targeting the Akt/mTOR pathway in Brca1-deficient cancers

(2011) T Xiang et al.   ONCOGENE

An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis

(2011) MONIQUE A. MALOUF et al.   RESPIROLOGY

Actin cytoskeleton in myofibroblast differentiation: Ultrastructure defining form and driving function

(2011) Nathan Sandbo et al.   Translational Research

Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-β

(2009) Nathan Sandbo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Palomid 529, a Novel Small-Molecule Drug, Is a TORC1/TORC2 Inhibitor That Reduces Tumor Growth, Tumor Angiogenesis, and Vascular Permeability

(2008) Q. Xue et al.   CANCER RESEARCH

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

(2008) Hong Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE